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The map label for this gene is folK [H]

Identifier: 66044084

GI number: 66044084

Start: 938719

End: 939225

Strand: Reverse

Name: folK [H]

Synonym: Psyr_0829

Alternate gene names: 66044084

Gene position: 939225-938719 (Counterclockwise)

Preceding gene: 66044085

Following gene: 66044083

Centisome position: 15.41

GC content: 62.52

Gene sequence:

>507_bases
GTGAATGAACCGCTGTTGGCCACTGAACGCGTGTACATCGGTCTGGGCAGCAATCTGGCTGACCCTGCCGAGCAATTGCG
CAGCGCCCTCAAGGCCATTGCGCAGTTACCCGATTGTCAGTTGAGCGGCGTGTCGTCCTTCTATATCAGCGACTCGCTGC
TGCCCGGCCAACCGCGCTTCACCAATGCCGTCGCGGCAATCGATACCGCTCTGGCGCCCCTGGCGCTGCTTGATGCGCTA
CAGGCCATCGAACTGGACCAGGGCCGTGAACGCCACGAACGCTGGGGGCCACGCACGCTGGACCTCGATATTCTGCTGTT
CGGCGACCATCTTATCGATGAGCCACGCCTCAAGGTGCCGCATTACCACATGCAGGCCAGGGCATTCGTGCTGTACCCGC
TGGCAGAGCTGGCTCCGGGGCTGACACTGGCCGACGGGCGCCCACTGAATCGTCTACTCGATGAATGCCCGTTCACAGGT
CTTGAGCGTCTGCCCGCCGAGGCATGA

Upstream 100 bases:

>100_bases
GACCTGAGCAACAAGCCCGAGGCGGCCGGCACAGCCCCGCGCAAGCGGCGTCGTAACAGCGGCGCCAAACGCAAGCGCAC
CACGGGCGAGGCGCAAAGCG

Downstream 100 bases:

>100_bases
AGCCTGTCTGTCACCGCGCCGGTGTAACCGCTCCGACGCACAGGTAACACCTTCAATTGACTTCACGTCCCCTCCTCACG
AAGATAGGCCTCCCGCCGCC

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MNEPLLATERVYIGLGSNLADPAEQLRSALKAIAQLPDCQLSGVSSFYISDSLLPGQPRFTNAVAAIDTALAPLALLDAL
QAIELDQGRERHERWGPRTLDLDILLFGDHLIDEPRLKVPHYHMQARAFVLYPLAELAPGLTLADGRPLNRLLDECPFTG
LERLPAEA

Sequences:

>Translated_168_residues
MNEPLLATERVYIGLGSNLADPAEQLRSALKAIAQLPDCQLSGVSSFYISDSLLPGQPRFTNAVAAIDTALAPLALLDAL
QAIELDQGRERHERWGPRTLDLDILLFGDHLIDEPRLKVPHYHMQARAFVLYPLAELAPGLTLADGRPLNRLLDECPFTG
LERLPAEA
>Mature_168_residues
MNEPLLATERVYIGLGSNLADPAEQLRSALKAIAQLPDCQLSGVSSFYISDSLLPGQPRFTNAVAAIDTALAPLALLDAL
QAIELDQGRERHERWGPRTLDLDILLFGDHLIDEPRLKVPHYHMQARAFVLYPLAELAPGLTLADGRPLNRLLDECPFTG
LERLPAEA

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=154, Percent_Identity=51.2987012987013, Blast_Score=150, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324073, Length=136, Percent_Identity=34.5588235294118, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18443; Mature: 18443

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEPLLATERVYIGLGSNLADPAEQLRSALKAIAQLPDCQLSGVSSFYISDSLLPGQPRF
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHEEECCCCCCCCCCH
TNAVAAIDTALAPLALLDALQAIELDQGRERHERWGPRTLDLDILLFGDHLIDEPRLKVP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEEEEEECCHHCCCCCCCCC
HYHMQARAFVLYPLAELAPGLTLADGRPLNRLLDECPFTGLERLPAEA
CHHHHHHHHHEEEHHHHCCCCEECCCCCHHHHHHHCCCCCHHHCCCCC
>Mature Secondary Structure
MNEPLLATERVYIGLGSNLADPAEQLRSALKAIAQLPDCQLSGVSSFYISDSLLPGQPRF
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHEEECCCCCCCCCCH
TNAVAAIDTALAPLALLDALQAIELDQGRERHERWGPRTLDLDILLFGDHLIDEPRLKVP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEEEEEECCHHCCCCCCCCC
HYHMQARAFVLYPLAELAPGLTLADGRPLNRLLDECPFTGLERLPAEA
CHHHHHHHHHEEEHHHHCCCCEECCCCCHHHHHHHCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]