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The map label for this gene is pyrC [H]

Identifier: 66043748

GI number: 66043748

Start: 519207

End: 520478

Strand: Reverse

Name: pyrC [H]

Synonym: Psyr_0481

Alternate gene names: 66043748

Gene position: 520478-519207 (Counterclockwise)

Preceding gene: 66043749

Following gene: 66043746

Centisome position: 8.54

GC content: 67.22

Gene sequence:

>1272_bases
GTGAAGCTCAGCATCCTCGGCGCTCGCGTCATCGACCCGGTCAGCGGGCTGGATCAAATCACTGACCTGCACCTCGAAGC
AGGCAAACTCAGCGCCATCGGTTCGGCCCCGGCGGGTTTCGAGCCCACGCAGACCATCGACGCTACCGGGCTGGTCGCAG
CACCGGGCCTGGTCGACCTCAACGTATCCCTGCGCGAGCCTGGCTACAGTCGCAAGGGCAGCATCGCCAGCGAAACCCGC
GCGGCGGTGGCAGGCGGCGTGACCAGCCTGTGCTGCCCGCCACGTACCAAACCGGTGCTCGACACCTCGGCGGTGGCCGA
GCTGATCCTCGACCGCGCCCGTGAGGCCGGATTCAGCAAGGTGTTCCCCATCGGAGCGCTGAGCAAGGGCCTGGACGGCG
AACAGCTGGCAGAACTGATCGCCCTGCGCGACGCAGGTTGCGTGGCCTTCGGCAACGGTCTGAGCAGCTTCAGCAACACC
CGCACGCTGTGCCGGGCGCTGGAATATGCGGCGACCTTTGACCTGACGGTGATTTTCAACTCGCAGGATCGTGATCTGGC
CGAAGGCGGTCTGGCGCACGATGGTCCGACGGCCAGTTTCCTGGGCCTGGCGGGCATTCCCGAGACGGCCGAGACCGTGG
CGCTGGCTCGCGACCTGTTGCTGGTCGAACAGAGCGGTGTACGCGCGCACTTCAGCCAGCTGACCAGTGCCCGTGGCGCG
GCGCTGATCGCCCAGGCGCAGGCACGCGGTCTGCCGGTAACGGCGGATGTCGCGCTGTATCAGTTGATTCTGACTGACGA
GGCGCTGATCGATTTCTCCAGCCTCTATCACGTCCAGCCGCCGCTGCGCACCCGCGCTGACCGCGATGGCCTGCGTGAAG
CGGTGAAGAGCGGTGTCATCCAGGCGATTTCCAGCCATCACCAGCCGCACGAACGCGATGCCAAGCTGGCACCGTTTGGC
GCTACGGAGCCGGGCATCAGCAGCGTCGAACTGCTGCTGCCGCTGGCCATGACGCTGGTGGATGACGGCCTGCTGGACCT
GCCGACCCTGATCGCCCGCCTGAGCAGCGGCCCGGCCGCCGCGCTGCGCCTGCCGGCCGGCAAGCTGAGCGCAGGAGCGC
CTGCCGACATCGTCCTGTTCGACCCGGCCGCCTCGACGGTTGCCGGCGAGACCTGGCTGTCAAAAGGCGAAAACTGCCCC
TTCATCGGCCACTGCCTGCCCGGCTCGGTACGCTACACACTGGTGGATGGACGGATCAGCTACAGCCGCTGA

Upstream 100 bases:

>100_bases
TCAATCAAGTGACTTACGGTATCGCGATCCGCATGGCGGTGCTGTCCATGGCCATGAGCGGACAAAACGCACAACGCCAA
TTCGAACAGGAGAACGCCCA

Downstream 100 bases:

>100_bases
GCCCGCTCCGGGCTCTCGCTCCCGCACAGAGCGCTCATCGTTATGCACAAGTCCGCTTTTGATTCTGGCCGAAGGCCGTG
GGAGCGAACTTGTTCGCGAA

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 44 kDa Non-catalytic chain [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKLSILGARVIDPVSGLDQITDLHLEAGKLSAIGSAPAGFEPTQTIDATGLVAAPGLVDLNVSLREPGYSRKGSIASETR
AAVAGGVTSLCCPPRTKPVLDTSAVAELILDRAREAGFSKVFPIGALSKGLDGEQLAELIALRDAGCVAFGNGLSSFSNT
RTLCRALEYAATFDLTVIFNSQDRDLAEGGLAHDGPTASFLGLAGIPETAETVALARDLLLVEQSGVRAHFSQLTSARGA
ALIAQAQARGLPVTADVALYQLILTDEALIDFSSLYHVQPPLRTRADRDGLREAVKSGVIQAISSHHQPHERDAKLAPFG
ATEPGISSVELLLPLAMTLVDDGLLDLPTLIARLSSGPAAALRLPAGKLSAGAPADIVLFDPAASTVAGETWLSKGENCP
FIGHCLPGSVRYTLVDGRISYSR

Sequences:

>Translated_423_residues
MKLSILGARVIDPVSGLDQITDLHLEAGKLSAIGSAPAGFEPTQTIDATGLVAAPGLVDLNVSLREPGYSRKGSIASETR
AAVAGGVTSLCCPPRTKPVLDTSAVAELILDRAREAGFSKVFPIGALSKGLDGEQLAELIALRDAGCVAFGNGLSSFSNT
RTLCRALEYAATFDLTVIFNSQDRDLAEGGLAHDGPTASFLGLAGIPETAETVALARDLLLVEQSGVRAHFSQLTSARGA
ALIAQAQARGLPVTADVALYQLILTDEALIDFSSLYHVQPPLRTRADRDGLREAVKSGVIQAISSHHQPHERDAKLAPFG
ATEPGISSVELLLPLAMTLVDDGLLDLPTLIARLSSGPAAALRLPAGKLSAGAPADIVLFDPAASTVAGETWLSKGENCP
FIGHCLPGSVRYTLVDGRISYSR
>Mature_423_residues
MKLSILGARVIDPVSGLDQITDLHLEAGKLSAIGSAPAGFEPTQTIDATGLVAAPGLVDLNVSLREPGYSRKGSIASETR
AAVAGGVTSLCCPPRTKPVLDTSAVAELILDRAREAGFSKVFPIGALSKGLDGEQLAELIALRDAGCVAFGNGLSSFSNT
RTLCRALEYAATFDLTVIFNSQDRDLAEGGLAHDGPTASFLGLAGIPETAETVALARDLLLVEQSGVRAHFSQLTSARGA
ALIAQAQARGLPVTADVALYQLILTDEALIDFSSLYHVQPPLRTRADRDGLREAVKSGVIQAISSHHQPHERDAKLAPFG
ATEPGISSVELLLPLAMTLVDDGLLDLPTLIARLSSGPAAALRLPAGKLSAGAPADIVLFDPAASTVAGETWLSKGENCP
FIGHCLPGSVRYTLVDGRISYSR

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=411, Percent_Identity=29.683698296837, Blast_Score=119, Evalue=7e-27,
Organism=Escherichia coli, GI1786722, Length=422, Percent_Identity=22.9857819905213, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193204318, Length=423, Percent_Identity=26.241134751773, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322218, Length=390, Percent_Identity=27.4358974358974, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642586, Length=415, Percent_Identity=25.7831325301205, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.3

Molecular weight: Translated: 43997; Mature: 43997

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSILGARVIDPVSGLDQITDLHLEAGKLSAIGSAPAGFEPTQTIDATGLVAAPGLVDL
CEEEEECHHHHCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCEEECCCEEEE
NVSLREPGYSRKGSIASETRAAVAGGVTSLCCPPRTKPVLDTSAVAELILDRAREAGFSK
EEEECCCCCCCCCCCHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
VFPIGALSKGLDGEQLAELIALRDAGCVAFGNGLSSFSNTRTLCRALEYAATFDLTVIFN
CCCCHHHHCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHEEEEEEEEC
SQDRDLAEGGLAHDGPTASFLGLAGIPETAETVALARDLLLVEQSGVRAHFSQLTSARGA
CCCCHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCH
ALIAQAQARGLPVTADVALYQLILTDEALIDFSSLYHVQPPLRTRADRDGLREAVKSGVI
HEEEHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHH
QAISSHHQPHERDAKLAPFGATEPGISSVELLLPLAMTLVDDGLLDLPTLIARLSSGPAA
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCE
ALRLPAGKLSAGAPADIVLFDPAASTVAGETWLSKGENCPFIGHCLPGSVRYTLVDGRIS
EEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECEEC
YSR
CCC
>Mature Secondary Structure
MKLSILGARVIDPVSGLDQITDLHLEAGKLSAIGSAPAGFEPTQTIDATGLVAAPGLVDL
CEEEEECHHHHCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCEEECCCEEEE
NVSLREPGYSRKGSIASETRAAVAGGVTSLCCPPRTKPVLDTSAVAELILDRAREAGFSK
EEEECCCCCCCCCCCHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
VFPIGALSKGLDGEQLAELIALRDAGCVAFGNGLSSFSNTRTLCRALEYAATFDLTVIFN
CCCCHHHHCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHEEEEEEEEC
SQDRDLAEGGLAHDGPTASFLGLAGIPETAETVALARDLLLVEQSGVRAHFSQLTSARGA
CCCCHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCH
ALIAQAQARGLPVTADVALYQLILTDEALIDFSSLYHVQPPLRTRADRDGLREAVKSGVI
HEEEHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHH
QAISSHHQPHERDAKLAPFGATEPGISSVELLLPLAMTLVDDGLLDLPTLIARLSSGPAA
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCE
ALRLPAGKLSAGAPADIVLFDPAASTVAGETWLSKGENCPFIGHCLPGSVRYTLVDGRIS
EEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECEEC
YSR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7896697 [H]