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The map label for this gene is bioA [H]

Identifier: 66043721

GI number: 66043721

Start: 489548

End: 490954

Strand: Reverse

Name: bioA [H]

Synonym: Psyr_0454

Alternate gene names: 66043721

Gene position: 490954-489548 (Counterclockwise)

Preceding gene: 66043725

Following gene: 66043720

Centisome position: 8.06

GC content: 61.27

Gene sequence:

>1407_bases
ATGGGCCTCAATGACCAGTGGATGCAACGTGACCTGAAGGTCCTGTGGCACCCCTGCACCCAGATGAAAGACCACGAAAA
TCTGCCGTTGATACCGATCAAGCGTGGTGAAGGCGTATGGCTTGAAGACTTCGAGGGCAAGCGCTATCTGGACGCTGTCA
GCTCCTGGTGGGTCAACGTTTTCGGACACGCCAACCCGCGCATCAATCAGCGCATCAAGGATCAGGTTGACCAGCTGGAG
CACGTGATCCTCGCCGGTTTCAGCCATCAGCCAGTGATCGAGCTGTCCGAACGGCTGGTCAAACTCACGCCTGACGGACT
GACCCGCTGCTTCTACGCCGATAACGGCTCGTCGTGCATCGAAGTCGCGCTGAAAATGAGCTTTCATTACTGGCTCAATC
GCGGCCAGCCGGACAAGAAACGCTTCGTCACCCTGACCAACAGCTACCACGGCGAGACCATGGCGGCGATGTCGGTCGGT
GATGTGCCGCTGTTCACCGAAACCTACAAGGCGCTGCTGCTCGATACCATCAAGGTGCCGAGCCCCGATTGCTACCATCG
CCCGGACGGCATGAGCTGGGAAGAGCATTCGCGCAACATGTTCGTCGCCATGGAGCAGACCCTCGCCGAGCACCACGCCA
GCGTTGCAGCGGTGATCGTCGAGCCGCTGATCCAGGGCGCGGGCGGCATGCGCATGTATCACCCGATCTACCTCAAGCTG
CTGCGCGACGCCTGCGACCGCTATGGCGTGCACCTGATCCACGACGAAATCGCTGTCGGTTTCGGCCGTACCGGGACCAT
GTTCGCCTGCGAACAGGCCGGCATTCGTCCGGACTTCCTGTGCCTGTCCAAGGCGCTGACCGGTGGCTACCTGCCGCTGG
CCGCCTGCCTGACCACCGACGATGTGTACGACGCGTTCTACGACGACTACCCGACCCTGCGTGCGTTTCTGCACTCGCAC
AGTTACACCGGTAACCCGCTGGCCTGTGCGGCGGCGCTGGCGACCCTGGATATCTTCGAGCAGGACAACGTTATCGAAAA
CAACAAGGCCCTTGCGCAACGCATGGCGACGGCCACTGCGCATCTGGTGGATCATCCGCACGTCGCGGAAGTGCGTCAGA
CCGGCATGGCCATCGCCATCGAAATGGTTCAGGACAAGGCCACCAAGACCGCCTACCCGTGGCAGGAACGCCGCGGCATG
AAGGTCTTCCAGCATGCGCTGGAACGTGGCGCACTGCTGCGGCCGCTGGGCAGTGTGGTGTATTTCCTGCCGCCGTACGT
GATCACGCCGGAGCAGATCGACTTCCTCGCCGAGGTGGCCAGCGAAGGCATTGATATCGCGACGCGCAGCAGTGTCAGTG
TTGCGGTGCGCGAAAACTTTCATCCGGACTTTCGCGATCCGGGTTAA

Upstream 100 bases:

>100_bases
CGTTAAAACTGCATCAAAGGTTGTTCCGCAGCCGGGCATTGCATAGGCTTGCGCGATTGTTCGTCCTCGCATCAGGCGAG
TCGCTACCCGGAGATTGAAA

Downstream 100 bases:

>100_bases
GGGCTGAAATTGCGGCGTCATGACTGACGCCTTCGCGGACAAGTCCGCTCCTACAGGGGCCTGGCTGCACATGCGGGAGC
GAGCCGGGTGACGACACCCT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MGLNDQWMQRDLKVLWHPCTQMKDHENLPLIPIKRGEGVWLEDFEGKRYLDAVSSWWVNVFGHANPRINQRIKDQVDQLE
HVILAGFSHQPVIELSERLVKLTPDGLTRCFYADNGSSCIEVALKMSFHYWLNRGQPDKKRFVTLTNSYHGETMAAMSVG
DVPLFTETYKALLLDTIKVPSPDCYHRPDGMSWEEHSRNMFVAMEQTLAEHHASVAAVIVEPLIQGAGGMRMYHPIYLKL
LRDACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIRPDFLCLSKALTGGYLPLAACLTTDDVYDAFYDDYPTLRAFLHSH
SYTGNPLACAAALATLDIFEQDNVIENNKALAQRMATATAHLVDHPHVAEVRQTGMAIAIEMVQDKATKTAYPWQERRGM
KVFQHALERGALLRPLGSVVYFLPPYVITPEQIDFLAEVASEGIDIATRSSVSVAVRENFHPDFRDPG

Sequences:

>Translated_468_residues
MGLNDQWMQRDLKVLWHPCTQMKDHENLPLIPIKRGEGVWLEDFEGKRYLDAVSSWWVNVFGHANPRINQRIKDQVDQLE
HVILAGFSHQPVIELSERLVKLTPDGLTRCFYADNGSSCIEVALKMSFHYWLNRGQPDKKRFVTLTNSYHGETMAAMSVG
DVPLFTETYKALLLDTIKVPSPDCYHRPDGMSWEEHSRNMFVAMEQTLAEHHASVAAVIVEPLIQGAGGMRMYHPIYLKL
LRDACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIRPDFLCLSKALTGGYLPLAACLTTDDVYDAFYDDYPTLRAFLHSH
SYTGNPLACAAALATLDIFEQDNVIENNKALAQRMATATAHLVDHPHVAEVRQTGMAIAIEMVQDKATKTAYPWQERRGM
KVFQHALERGALLRPLGSVVYFLPPYVITPEQIDFLAEVASEGIDIATRSSVSVAVRENFHPDFRDPG
>Mature_467_residues
GLNDQWMQRDLKVLWHPCTQMKDHENLPLIPIKRGEGVWLEDFEGKRYLDAVSSWWVNVFGHANPRINQRIKDQVDQLEH
VILAGFSHQPVIELSERLVKLTPDGLTRCFYADNGSSCIEVALKMSFHYWLNRGQPDKKRFVTLTNSYHGETMAAMSVGD
VPLFTETYKALLLDTIKVPSPDCYHRPDGMSWEEHSRNMFVAMEQTLAEHHASVAAVIVEPLIQGAGGMRMYHPIYLKLL
RDACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIRPDFLCLSKALTGGYLPLAACLTTDDVYDAFYDDYPTLRAFLHSHS
YTGNPLACAAALATLDIFEQDNVIENNKALAQRMATATAHLVDHPHVAEVRQTGMAIAIEMVQDKATKTAYPWQERRGMK
VFQHALERGALLRPLGSVVYFLPPYVITPEQIDFLAEVASEGIDIATRSSVSVAVRENFHPDFRDPG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=424, Percent_Identity=29.9528301886792, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI13994255, Length=438, Percent_Identity=28.7671232876712, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI37574042, Length=445, Percent_Identity=25.8426966292135, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI226442705, Length=445, Percent_Identity=25.1685393258427, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI284507298, Length=334, Percent_Identity=29.3413173652695, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI226442709, Length=415, Percent_Identity=25.5421686746988, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI24119277, Length=375, Percent_Identity=25.3333333333333, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1786991, Length=439, Percent_Identity=41.6856492027335, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI145693181, Length=426, Percent_Identity=31.2206572769953, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789759, Length=410, Percent_Identity=30.4878048780488, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789016, Length=455, Percent_Identity=27.4725274725275, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1788044, Length=412, Percent_Identity=28.8834951456311, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1787560, Length=412, Percent_Identity=27.6699029126214, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786349, Length=390, Percent_Identity=25.3846153846154, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=437, Percent_Identity=26.5446224256293, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25144271, Length=421, Percent_Identity=28.0285035629454, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25144274, Length=261, Percent_Identity=31.8007662835249, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=421, Percent_Identity=22.3277909738717, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324386, Length=469, Percent_Identity=31.5565031982942, Blast_Score=226, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6324432, Length=426, Percent_Identity=28.6384976525822, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323470, Length=453, Percent_Identity=26.0485651214128, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI21357415, Length=434, Percent_Identity=28.110599078341, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI161085790, Length=463, Percent_Identity=27.2138228941685, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574759, Length=456, Percent_Identity=27.6315789473684, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21356575, Length=419, Percent_Identity=26.7303102625298, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 52702; Mature: 52571

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLNDQWMQRDLKVLWHPCTQMKDHENLPLIPIKRGEGVWLEDFEGKRYLDAVSSWWVNV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHHHH
FGHANPRINQRIKDQVDQLEHVILAGFSHQPVIELSERLVKLTPDGLTRCFYADNGSSCI
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHEEEEEECCCCHHH
EVALKMSFHYWLNRGQPDKKRFVTLTNSYHGETMAAMSVGDVPLFTETYKALLLDTIKVP
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCC
SPDCYHRPDGMSWEEHSRNMFVAMEQTLAEHHASVAAVIVEPLIQGAGGMRMYHPIYLKL
CCCCCCCCCCCCHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LRDACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIRPDFLCLSKALTGGYLPLAACLTTD
HHHHHHHCCEEEEEHHHHHCCCCCCCEEEEHHCCCCHHHHHHHHHHCCCCHHHHHHHCCH
DVYDAFYDDYPTLRAFLHSHSYTGNPLACAAALATLDIFEQDNVIENNKALAQRMATATA
HHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
HLVDHPHVAEVRQTGMAIAIEMVQDKATKTAYPWQERRGMKVFQHALERGALLRPLGSVV
HHCCCCCHHHHHHCCHHEEHHHHHHHHHCCCCCHHHHCCHHHHHHHHHCCHHHHHHHHHH
YFLPPYVITPEQIDFLAEVASEGIDIATRSSVSVAVRENFHPDFRDPG
HHCCCEEECHHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
GLNDQWMQRDLKVLWHPCTQMKDHENLPLIPIKRGEGVWLEDFEGKRYLDAVSSWWVNV
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHHHH
FGHANPRINQRIKDQVDQLEHVILAGFSHQPVIELSERLVKLTPDGLTRCFYADNGSSCI
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHEEEEEECCCCHHH
EVALKMSFHYWLNRGQPDKKRFVTLTNSYHGETMAAMSVGDVPLFTETYKALLLDTIKVP
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCC
SPDCYHRPDGMSWEEHSRNMFVAMEQTLAEHHASVAAVIVEPLIQGAGGMRMYHPIYLKL
CCCCCCCCCCCCHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LRDACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIRPDFLCLSKALTGGYLPLAACLTTD
HHHHHHHCCEEEEEHHHHHCCCCCCCEEEEHHCCCCHHHHHHHHHHCCCCHHHHHHHCCH
DVYDAFYDDYPTLRAFLHSHSYTGNPLACAAALATLDIFEQDNVIENNKALAQRMATATA
HHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
HLVDHPHVAEVRQTGMAIAIEMVQDKATKTAYPWQERRGMKVFQHALERGALLRPLGSVV
HHCCCCCHHHHHHCCHHEEHHHHHHHHHCCCCCHHHHCCHHHHHHHHHCCHHHHHHHHHH
YFLPPYVITPEQIDFLAEVASEGIDIATRSSVSVAVRENFHPDFRDPG
HHCCCEEECHHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]