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The map label for this gene is hisI [H]

Identifier: 66043653

GI number: 66043653

Start: 414888

End: 415280

Strand: Reverse

Name: hisI [H]

Synonym: Psyr_0386

Alternate gene names: 66043653

Gene position: 415280-414888 (Counterclockwise)

Preceding gene: 66043654

Following gene: 66043652

Centisome position: 6.81

GC content: 56.23

Gene sequence:

>393_bases
ATGAAAGACTGGCTGGACGAGATTCACTGGAACAGCGACGGTCTGGTGCCTGCAATCGCTCAGGATCACAAGACCGGCCG
GGTATTGATGATGGCCTGGATGAACCGCGAGGCCCTGAGCCTGACCGCGGCCGAGAACCGTGCCATCTATTGGTCGCGTT
CGCGTGGCAAACTCTGGCGCAAAGGTGAAGAATCGGGTCATGTGCAAAAGCTGCATGAACTGCGCCTGGACTGTGACGCC
GACGTCATTATCCTGATGGTCGAGCAGATCGGTGGCATCGCTTGCCATACCGGCCGCGAAAGTTGCTTCTACCGAGTGTA
TGAAAAGTCAGGCTGGAAGACCGTAGACCCGGTTCTGAAAGATCCTGATGCTATTTACCCTGCAGGCCATTGA

Upstream 100 bases:

>100_bases
ATCGCCGGGCTGTATCTGATCGTTCGCCGATAGCCAGCAGCGAATGGCGCTGGCACACTGTTCAATCCGCCGGGCATGAA
AGCCGGCTGCCGGAGTAGAT

Downstream 100 bases:

>100_bases
ACATGACTGATACGTTGTCCCGTCTGGCCGAAGTGCTGGAATCACGCAAGGACGCCGCTGCCGACAGCTCCTATGTCGCA
AGCCTGTATCACAAGGGCCT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MKDWLDEIHWNSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWRKGEESGHVQKLHELRLDCDA
DVIILMVEQIGGIACHTGRESCFYRVYEKSGWKTVDPVLKDPDAIYPAGH

Sequences:

>Translated_130_residues
MKDWLDEIHWNSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWRKGEESGHVQKLHELRLDCDA
DVIILMVEQIGGIACHTGRESCFYRVYEKSGWKTVDPVLKDPDAIYPAGH
>Mature_130_residues
MKDWLDEIHWNSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWRKGEESGHVQKLHELRLDCDA
DVIILMVEQIGGIACHTGRESCFYRVYEKSGWKTVDPVLKDPDAIYPAGH

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=98, Percent_Identity=39.7959183673469, Blast_Score=84, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319819, Length=91, Percent_Identity=36.2637362637363, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 14892; Mature: 14892

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDWLDEIHWNSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWR
CCCHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCEEEEEECCCCCCCC
KGEESGHVQKLHELRLDCDADVIILMVEQIGGIACHTGRESCFYRVYEKSGWKTVDPVLK
CCCCCCHHHHHHHHHCCCCCCEEEEEEHHHCCEEEECCCCHHEEEEECCCCCEEECCCCC
DPDAIYPAGH
CCCCCCCCCC
>Mature Secondary Structure
MKDWLDEIHWNSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWR
CCCHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCEEEEEECCCCCCCC
KGEESGHVQKLHELRLDCDADVIILMVEQIGGIACHTGRESCFYRVYEKSGWKTVDPVLK
CCCCCCHHHHHHHHHCCCCCCEEEEEEHHHCCEEEECCCCHHEEEEECCCCCEEECCCCC
DPDAIYPAGH
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA