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The map label for this gene is ubiB [H]

Identifier: 66043654

GI number: 66043654

Start: 415348

End: 416967

Strand: Reverse

Name: ubiB [H]

Synonym: Psyr_0387

Alternate gene names: 66043654

Gene position: 416967-415348 (Counterclockwise)

Preceding gene: 66043655

Following gene: 66043653

Centisome position: 6.84

GC content: 61.98

Gene sequence:

>1620_bases
ATGAAGCTGCTTGCCGTCCGCCGTCTGTTTCGCATTCAACGTGTCGTTATCCGCTATCGCCTTGATGACCTGTTGTTCGC
CCTGCCCCTGCCGTGGTGGATGCTCGCGCTGCGTTTCGTGCTGCCCTGGCGCTGGCTGCCCCGGCGCAAATCCGAGCTGA
GCCGTGGCGTACGCTTTCGCCTGGCGCTCCAGGACCTGGGGCCGATTTTCATCAAGTTCGGGCAACTGCTGTCCACCCGG
CGCGACCTGCTGCCCGAGGACATCGCCGACGAGCTGATGCTGCTGCAGGATCGCGTGCCGCCGTTCGATCAGCAATTGGC
GATCAAGCTGATCGAAGAACAGCTCGGCGCGCGCATCTGTGACGTGTTCAGCCGCTTCGACGAGAAGCCGCTGGCATCCG
CTTCGGTCGCCCAGGTGCATGCCGCCTGCCTGAAGACCGGCGAAGAAGTCGTGGTCAAGGTGGTACGCCCCGGCCTCAAG
CCGATCATCGGTCAGGACCTGGCGTGGCTGTTCATTCTGGCCCGCATGGCCGAGCGCGTATCTGCCGATGCCCGCCTGCT
GCACCCGGTGCAGGTGGTGATGGATTATGAAAAGACCATCTACGACGAACTCGACCTGCTGCGTGAAGCGGCCAACGCCA
GCCAGTTGCGACGCAACTTCGAAGGCTCCGACCTGCTTTACGTGCCACAAGTCTACTGGGACTGGTGCCGCCCGAAAGTG
CTGGTCATGGAGCGTATCTACGGCCTGCAGGTCACCGACATGGCCGGGCTGGCGGATCAGCGCACCGACATGAAATTACT
GGCCGAGCGCGGCGTGGAGATCTTCTTCACGCAGATTTTTCGCGACAGCTTCTTCCATGCCGACATGCACCCCGGCAACA
TTTTCGTCAGCACGGTCAACCCGTGGGCGCCGAAGTACATTGCCATCGACTGCGGTATCGTCGGCAGCCTGACCCCGGAA
GATCAGGATTACCTGGCGCGTAACCTGTTTGCCTTTTTCAAACGTGATTATCGTCGCGTTGCGCAACTGCACATCGATTC
GGGCTGGGTGCCGGCAGAGACCAAGCTCAATGAATTCGAAGCGGCCATCCGCACGGTCTGCGAGCCGATTTTCGAGAAGC
CGCTCAAGGATATTTCCTTCGGTCAGGTGCTGATGCGCCTGTTCCAGACCGCACGCCGCTTCAATATGGAAGTCCAGCCG
CAACTGGTTCTGCTGCAAAAGACCCTGCTCAACATCGAGGGGCTGGGTCGTCAGCTGTACCCTGAACTGGACCTGTGGAG
CACCGCGCAGCCTTATCTGGAGCGCTGGATGCGTGAACGGGTCAGCCCGAAAACCCTGCTGGGCAATCTGCAATCACAGG
TCGAGCAATTGCCGCACATCGCCGGCATGACCCGTGACCTGCTGGAACGCATGTCCCGCCCGCACGCCTCGGACCCGCCA
CGCCCATGGCACGATCGCAAGGACGAGCCGGTCCTGCGGCTGATCGGTGCTGCATTGCTGGTCGGCGGCGCGATACAGGG
CTGGGTGATGAGCGAGGCCGCCACCCAGTTGCTGACGCTCACCGCGTGGCCGGCCGCGATCATGCTGATCGCCGGGCTGT
ATCTGATCGTTCGCCGATAG

Upstream 100 bases:

>100_bases
AAGCACGATTCGCCGAACTCGATCAGATCAAACTCGATCTGGAACGCCTCGAGGCGCGCTTTGCCCGCCTTGCCCACTCC
CTCAATACCAGCGATAACGC

Downstream 100 bases:

>100_bases
CCAGCAGCGAATGGCGCTGGCACACTGTTCAATCCGCCGGGCATGAAAGCCGGCTGCCGGAGTAGATATGAAAGACTGGC
TGGACGAGATTCACTGGAAC

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MKLLAVRRLFRIQRVVIRYRLDDLLFALPLPWWMLALRFVLPWRWLPRRKSELSRGVRFRLALQDLGPIFIKFGQLLSTR
RDLLPEDIADELMLLQDRVPPFDQQLAIKLIEEQLGARICDVFSRFDEKPLASASVAQVHAACLKTGEEVVVKVVRPGLK
PIIGQDLAWLFILARMAERVSADARLLHPVQVVMDYEKTIYDELDLLREAANASQLRRNFEGSDLLYVPQVYWDWCRPKV
LVMERIYGLQVTDMAGLADQRTDMKLLAERGVEIFFTQIFRDSFFHADMHPGNIFVSTVNPWAPKYIAIDCGIVGSLTPE
DQDYLARNLFAFFKRDYRRVAQLHIDSGWVPAETKLNEFEAAIRTVCEPIFEKPLKDISFGQVLMRLFQTARRFNMEVQP
QLVLLQKTLLNIEGLGRQLYPELDLWSTAQPYLERWMRERVSPKTLLGNLQSQVEQLPHIAGMTRDLLERMSRPHASDPP
RPWHDRKDEPVLRLIGAALLVGGAIQGWVMSEAATQLLTLTAWPAAIMLIAGLYLIVRR

Sequences:

>Translated_539_residues
MKLLAVRRLFRIQRVVIRYRLDDLLFALPLPWWMLALRFVLPWRWLPRRKSELSRGVRFRLALQDLGPIFIKFGQLLSTR
RDLLPEDIADELMLLQDRVPPFDQQLAIKLIEEQLGARICDVFSRFDEKPLASASVAQVHAACLKTGEEVVVKVVRPGLK
PIIGQDLAWLFILARMAERVSADARLLHPVQVVMDYEKTIYDELDLLREAANASQLRRNFEGSDLLYVPQVYWDWCRPKV
LVMERIYGLQVTDMAGLADQRTDMKLLAERGVEIFFTQIFRDSFFHADMHPGNIFVSTVNPWAPKYIAIDCGIVGSLTPE
DQDYLARNLFAFFKRDYRRVAQLHIDSGWVPAETKLNEFEAAIRTVCEPIFEKPLKDISFGQVLMRLFQTARRFNMEVQP
QLVLLQKTLLNIEGLGRQLYPELDLWSTAQPYLERWMRERVSPKTLLGNLQSQVEQLPHIAGMTRDLLERMSRPHASDPP
RPWHDRKDEPVLRLIGAALLVGGAIQGWVMSEAATQLLTLTAWPAAIMLIAGLYLIVRR
>Mature_539_residues
MKLLAVRRLFRIQRVVIRYRLDDLLFALPLPWWMLALRFVLPWRWLPRRKSELSRGVRFRLALQDLGPIFIKFGQLLSTR
RDLLPEDIADELMLLQDRVPPFDQQLAIKLIEEQLGARICDVFSRFDEKPLASASVAQVHAACLKTGEEVVVKVVRPGLK
PIIGQDLAWLFILARMAERVSADARLLHPVQVVMDYEKTIYDELDLLREAANASQLRRNFEGSDLLYVPQVYWDWCRPKV
LVMERIYGLQVTDMAGLADQRTDMKLLAERGVEIFFTQIFRDSFFHADMHPGNIFVSTVNPWAPKYIAIDCGIVGSLTPE
DQDYLARNLFAFFKRDYRRVAQLHIDSGWVPAETKLNEFEAAIRTVCEPIFEKPLKDISFGQVLMRLFQTARRFNMEVQP
QLVLLQKTLLNIEGLGRQLYPELDLWSTAQPYLERWMRERVSPKTLLGNLQSQVEQLPHIAGMTRDLLERMSRPHASDPP
RPWHDRKDEPVLRLIGAALLVGGAIQGWVMSEAATQLLTLTAWPAAIMLIAGLYLIVRR

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=253, Percent_Identity=32.4110671936759, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI41393593, Length=274, Percent_Identity=29.9270072992701, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI217035081, Length=209, Percent_Identity=31.5789473684211, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI34147522, Length=196, Percent_Identity=30.1020408163265, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI27363457, Length=196, Percent_Identity=29.0816326530612, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI217416386, Length=151, Percent_Identity=30.4635761589404, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI2367309, Length=533, Percent_Identity=54.5966228893058, Blast_Score=542, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17559152, Length=248, Percent_Identity=31.0483870967742, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32565180, Length=307, Percent_Identity=24.1042345276873, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325148, Length=433, Percent_Identity=23.094688221709, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6323282, Length=249, Percent_Identity=30.1204819277108, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=191, Percent_Identity=31.413612565445, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22024280, Length=250, Percent_Identity=32, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24662575, Length=230, Percent_Identity=33.0434782608696, Blast_Score=132, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62258; Mature: 62258

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLAVRRLFRIQRVVIRYRLDDLLFALPLPWWMLALRFVLPWRWLPRRKSELSRGVRFR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEE
LALQDLGPIFIKFGQLLSTRRDLLPEDIADELMLLQDRVPPFDQQLAIKLIEEQLGARIC
EHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DVFSRFDEKPLASASVAQVHAACLKTGEEVVVKVVRPGLKPIIGQDLAWLFILARMAERV
HHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SADARLLHPVQVVMDYEKTIYDELDLLREAANASQLRRNFEGSDLLYVPQVYWDWCRPKV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCEEEECHHHHHHCCHHH
LVMERIYGLQVTDMAGLADQRTDMKLLAERGVEIFFTQIFRDSFFHADMHPGNIFVSTVN
HHHHHHHCCCCHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECC
PWAPKYIAIDCGIVGSLTPEDQDYLARNLFAFFKRDYRRVAQLHIDSGWVPAETKLNEFE
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
AAIRTVCEPIFEKPLKDISFGQVLMRLFQTARRFNMEVQPQLVLLQKTLLNIEGLGRQLY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHC
PELDLWSTAQPYLERWMRERVSPKTLLGNLQSQVEQLPHIAGMTRDLLERMSRPHASDPP
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RPWHDRKDEPVLRLIGAALLVGGAIQGWVMSEAATQLLTLTAWPAAIMLIAGLYLIVRR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLLAVRRLFRIQRVVIRYRLDDLLFALPLPWWMLALRFVLPWRWLPRRKSELSRGVRFR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEE
LALQDLGPIFIKFGQLLSTRRDLLPEDIADELMLLQDRVPPFDQQLAIKLIEEQLGARIC
EHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DVFSRFDEKPLASASVAQVHAACLKTGEEVVVKVVRPGLKPIIGQDLAWLFILARMAERV
HHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SADARLLHPVQVVMDYEKTIYDELDLLREAANASQLRRNFEGSDLLYVPQVYWDWCRPKV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCEEEECHHHHHHCCHHH
LVMERIYGLQVTDMAGLADQRTDMKLLAERGVEIFFTQIFRDSFFHADMHPGNIFVSTVN
HHHHHHHCCCCHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECC
PWAPKYIAIDCGIVGSLTPEDQDYLARNLFAFFKRDYRRVAQLHIDSGWVPAETKLNEFE
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
AAIRTVCEPIFEKPLKDISFGQVLMRLFQTARRFNMEVQPQLVLLQKTLLNIEGLGRQLY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHC
PELDLWSTAQPYLERWMRERVSPKTLLGNLQSQVEQLPHIAGMTRDLLERMSRPHASDPP
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RPWHDRKDEPVLRLIGAALLVGGAIQGWVMSEAATQLLTLTAWPAAIMLIAGLYLIVRR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA