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The map label for this gene is hsaA [H]

Identifier: 66043602

GI number: 66043602

Start: 353004

End: 354185

Strand: Direct

Name: hsaA [H]

Synonym: Psyr_0333

Alternate gene names: 66043602

Gene position: 353004-354185 (Clockwise)

Preceding gene: 66043601

Following gene: 66043603

Centisome position: 5.79

GC content: 61.42

Gene sequence:

>1182_bases
ATGCTTGAGCCTGCCGAGCAAGCGTTCCAGCGTAACGTAGTGTCCTTGATGTGTCAGCGGGCGGTCGCGTATCTGCCTTT
GTGGCGAGAGCGGGCTGCTGTGGCCGAAACAAATCGCCGGCTGAGCAGTAGCACATTCGACGAACTGTTTACCGAAGGCT
GGCTGGATCTGGTGTCGCCACGCGCGCCTGTCACACGTACGGGTCACTGGCCCACTCTGGTAGAAAGCGCACGGATTGCG
GCTCGGGCGTGTGCCTCCACAGGCTGGATGCTGGCGTTGGTGGGTGGTCACGGCTCAATCGCCCGGCGACTGCCCCCCGC
CTGCGTAGACCAGCTTTACAGCCATGGCCCACGACAGTTGTTCGCTTCAGCATCTACCAGTACCGATAGCCTGCTGTCCT
TTGAACCAGAAGGTGTTCGGGTTGACGGGCGCTGGCGCTTCAGTTCGGGCATTGAGGATGCTACCTGGTTAATGCTCAAC
GCCCCCTGCGCTGACCACCCTGAAGCCGCTTGCACCCCGCGCTTTCTGGTGCTGGTCGCCGCCAACGAAGTGGAGAGGCT
TCACAATTGGGACAGCTGCGGTATGGCGGCAACCGGTTCTCACGACGTGCTGCTCCGGCGGTTGTTGGTGCCGCATGACC
GCGTCTTCGCGCTGCATGAAGTGTTTGCGCAGGACCCGCTTGCATTGGCGTGCGACTACATCGACAGGTTGCCCCTCGTG
CCCTATCTGACCACCTCGATCATTGGCCCGCTACTGGGCTGTGCAGAGGGTGCTCTTGCCGCGTTTGTAGCGGCCTTCAA
CAGTTCATCGGCGGTAAGTGATCCCCGGATCGCCGAACAGGCTGCACACTCGGCCGCACAGCTCTACAGCGTCGAGCTGT
TGTATGACTCGTTGATCTCCCGGCTGCACGAGGCGGGACTCAGTGACCGGGTTCTGGACGCAGCGCAATTGTTGCAGCTC
AAGCGCGACCGCGCCTATCTGGCGCAACAATGCGTGCAGGCCGTGCACCGGTTAGTGGAAAGGCTCGGTGCGTCTTCCTT
GGTTGCCAGTAACCCGCTTCAGCGTCACTGGCGTGATATCCAGGCGATGGCCGCGCACCGAGACGTGACCTGGAACGAAA
CGATGCAGGCCTGTGGCGACGCGATTCTGCGGCCTGCCACTGACAACGCTCAAAAGAATTGA

Upstream 100 bases:

>100_bases
GATCTACTGGGCCCGACAGTCCAGCCAGCGGATTTTTGCTTTGAACGTTCGCGTCTTGGCGCCATAGCTCCTTCGCAAAA
AGGTGTTGTGGAGTTTGGCG

Downstream 100 bases:

>100_bases
GTTTTTTCCCGTCGGCCACCTCAGAGAGGTTTCACATGTTTGTTCGCAACAAAACCGATGTCGAGAACACCCCTTATTTC
GTCGAATGGGGCGCCGGAAC

Product: hypothetical protein

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MLEPAEQAFQRNVVSLMCQRAVAYLPLWRERAAVAETNRRLSSSTFDELFTEGWLDLVSPRAPVTRTGHWPTLVESARIA
ARACASTGWMLALVGGHGSIARRLPPACVDQLYSHGPRQLFASASTSTDSLLSFEPEGVRVDGRWRFSSGIEDATWLMLN
APCADHPEAACTPRFLVLVAANEVERLHNWDSCGMAATGSHDVLLRRLLVPHDRVFALHEVFAQDPLALACDYIDRLPLV
PYLTTSIIGPLLGCAEGALAAFVAAFNSSSAVSDPRIAEQAAHSAAQLYSVELLYDSLISRLHEAGLSDRVLDAAQLLQL
KRDRAYLAQQCVQAVHRLVERLGASSLVASNPLQRHWRDIQAMAAHRDVTWNETMQACGDAILRPATDNAQKN

Sequences:

>Translated_393_residues
MLEPAEQAFQRNVVSLMCQRAVAYLPLWRERAAVAETNRRLSSSTFDELFTEGWLDLVSPRAPVTRTGHWPTLVESARIA
ARACASTGWMLALVGGHGSIARRLPPACVDQLYSHGPRQLFASASTSTDSLLSFEPEGVRVDGRWRFSSGIEDATWLMLN
APCADHPEAACTPRFLVLVAANEVERLHNWDSCGMAATGSHDVLLRRLLVPHDRVFALHEVFAQDPLALACDYIDRLPLV
PYLTTSIIGPLLGCAEGALAAFVAAFNSSSAVSDPRIAEQAAHSAAQLYSVELLYDSLISRLHEAGLSDRVLDAAQLLQL
KRDRAYLAQQCVQAVHRLVERLGASSLVASNPLQRHWRDIQAMAAHRDVTWNETMQACGDAILRPATDNAQKN
>Mature_393_residues
MLEPAEQAFQRNVVSLMCQRAVAYLPLWRERAAVAETNRRLSSSTFDELFTEGWLDLVSPRAPVTRTGHWPTLVESARIA
ARACASTGWMLALVGGHGSIARRLPPACVDQLYSHGPRQLFASASTSTDSLLSFEPEGVRVDGRWRFSSGIEDATWLMLN
APCADHPEAACTPRFLVLVAANEVERLHNWDSCGMAATGSHDVLLRRLLVPHDRVFALHEVFAQDPLALACDYIDRLPLV
PYLTTSIIGPLLGCAEGALAAFVAAFNSSSAVSDPRIAEQAAHSAAQLYSVELLYDSLISRLHEAGLSDRVLDAAQLLQL
KRDRAYLAQQCVQAVHRLVERLGASSLVASNPLQRHWRDIQAMAAHRDVTWNETMQACGDAILRPATDNAQKN

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Also catalyzes the o-hydroxylation of a range of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 43107; Mature: 43107

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEPAEQAFQRNVVSLMCQRAVAYLPLWRERAAVAETNRRLSSSTFDELFTEGWLDLVSP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RAPVTRTGHWPTLVESARIAARACASTGWMLALVGGHGSIARRLPPACVDQLYSHGPRQL
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCHHHHHHHHCCCCHHH
FASASTSTDSLLSFEPEGVRVDGRWRFSSGIEDATWLMLNAPCADHPEAACTPRFLVLVA
HHCCCCCCCHHEEECCCCEEECCEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEE
ANEVERLHNWDSCGMAATGSHDVLLRRLLVPHDRVFALHEVFAQDPLALACDYIDRLPLV
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCH
PYLTTSIIGPLLGCAEGALAAFVAAFNSSSAVSDPRIAEQAAHSAAQLYSVELLYDSLIS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RLHEAGLSDRVLDAAQLLQLKRDRAYLAQQCVQAVHRLVERLGASSLVASNPLQRHWRDI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHH
QAMAAHRDVTWNETMQACGDAILRPATDNAQKN
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLEPAEQAFQRNVVSLMCQRAVAYLPLWRERAAVAETNRRLSSSTFDELFTEGWLDLVSP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RAPVTRTGHWPTLVESARIAARACASTGWMLALVGGHGSIARRLPPACVDQLYSHGPRQL
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCHHHHHHHHCCCCHHH
FASASTSTDSLLSFEPEGVRVDGRWRFSSGIEDATWLMLNAPCADHPEAACTPRFLVLVA
HHCCCCCCCHHEEECCCCEEECCEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEE
ANEVERLHNWDSCGMAATGSHDVLLRRLLVPHDRVFALHEVFAQDPLALACDYIDRLPLV
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCH
PYLTTSIIGPLLGCAEGALAAFVAAFNSSSAVSDPRIAEQAAHSAAQLYSVELLYDSLIS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RLHEAGLSDRVLDAAQLLQLKRDRAYLAQQCVQAVHRLVERLGASSLVASNPLQRHWRDI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHH
QAMAAHRDVTWNETMQACGDAILRPATDNAQKN
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]