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The map label for this gene is exuT [H]

Identifier: 66043594

GI number: 66043594

Start: 343698

End: 345008

Strand: Direct

Name: exuT [H]

Synonym: Psyr_0325

Alternate gene names: 66043594

Gene position: 343698-345008 (Clockwise)

Preceding gene: 66043592

Following gene: 66043595

Centisome position: 5.64

GC content: 60.87

Gene sequence:

>1311_bases
ATGAAGATAAAAGGCATTCGTTGGTGGATGGTGGGGCTGGTCACGGCCGGCCTGGTGGTCAACTACCTGGCACGCAACAC
ACTGTCCGTCGCAGCTCCGACGCTCATGAGCGAGCTGAGCATTTCCACCGAGCAGTACGCGCACATCGTGGTCGCCTGGC
AACTGTGCTACGCCATCATGCAACCTGTGGCGGGCTACATCATTGATGCGATCGGCACCAAGATGGGCTTTGCGATTTTC
GCCATCGCCTGGTCTGCCGCCTGCGCTGCTGCCGCCTTCGCAACCGGCTGGCAGAGTCTGGCGATCTTCCGCGGCATGCT
CGGCCTGACCGAAGCCGCAGGGCTGCCGGCCGGCGTCAAGGCGACCACTGAATGGTTTCCGGCCAAGGAGCGCTCGGTCG
CCATCGGCTGGTTCAACATCGGTTCGTCGTTCGGCGCATTGCTTGCGCCGCCGCTGGTGGTCTGGGCCATTCTGCAGAGT
GGCTGGGAGCTGGCGTTTCTGATTGTCGGCGGCCTGGGCATTGTGTGGAGCGGCCTGTGGCTGCTGCTGTACAAGCACCC
GCGCGATCAGAAGCGTCTTGGCGATGCCGAACGTGACTACATCCTCAGCGGCCAGGAAGCGCGTCTGAAGGACGCACCTG
CCCAGAAAGGCAGCTGGAAGCGACTGTTCAAAAACCGTAATTTCTACGCGATTGCCTCGGCGCGAATCCTCTCCGAGCCT
GCCTGGCAGACCTTCAATGCGTGGATTCCGCTGTACCTGATGACCGAGCGTCACATGAACATCAAGGAAGTCGCGATGTT
CGCCTGGCTGCCGTTTCTGGCGGCTGACATCGGCTGCGTACTGGGCGGCTACCTGAGCCCGTTGTTCCACAAGTACTGCA
AGGTGTCGCTGTTCACCTCGCGCAAGATGGTCATGCTGTTCGGCTGCTCCTGCATGATCGGGCCAGCGTGCATCGGGCTG
GTCGAAAGTCCCTACACCGCTATTGCCTTGTTGTGCATCGGTGGTTTTGCTCACCAGACCCTGTCGGGCGCGCTGTATTC
GATCACCTCGGATTCATTCGGCAAAAACGAGGTGGCTACGGCGACCGGGATGGGCGGAATGTTCGGCTTTTTCGGGGCGG
CGGCATTCACCATGGTGTTCGGCGTGCTGGTCACCAAAATTGGCTACAGCCCGCTGTTCGTGGTGCTGGCGATTTTCGAC
ATCGTCGCTGCGATTGTGGTGTGGAACGTTGCCCGTGAAGTCCCGCAGTATGACGACACAGTGCCGTTGACTGCGGACGA
GCAGGGTCCGCGTACTGTGCCTGCAACCTGA

Upstream 100 bases:

>100_bases
TTCTGAAGAAAACGTAATCTGAAGTTACACAAAACCAGCCGCCTCACGGCCTTGGCCGCGGGACGCTCATCGCCAATCTA
AAAATAAACAGGGTGAAGAG

Downstream 100 bases:

>100_bases
GGCCGTCGTAATCCTGTAACGAAGTGCGGATAATCTTTGCCCTGAAAGTGATTTTTATTAGAGGCCGTTCCTCGAAGGCA
GGGAGTGGCCTCTTTTTTTG

Product: general substrate transporter:TonB box, N-terminal

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKIKGIRWWMVGLVTAGLVVNYLARNTLSVAAPTLMSELSISTEQYAHIVVAWQLCYAIMQPVAGYIIDAIGTKMGFAIF
AIAWSAACAAAAFATGWQSLAIFRGMLGLTEAAGLPAGVKATTEWFPAKERSVAIGWFNIGSSFGALLAPPLVVWAILQS
GWELAFLIVGGLGIVWSGLWLLLYKHPRDQKRLGDAERDYILSGQEARLKDAPAQKGSWKRLFKNRNFYAIASARILSEP
AWQTFNAWIPLYLMTERHMNIKEVAMFAWLPFLAADIGCVLGGYLSPLFHKYCKVSLFTSRKMVMLFGCSCMIGPACIGL
VESPYTAIALLCIGGFAHQTLSGALYSITSDSFGKNEVATATGMGGMFGFFGAAAFTMVFGVLVTKIGYSPLFVVLAIFD
IVAAIVVWNVAREVPQYDDTVPLTADEQGPRTVPAT

Sequences:

>Translated_436_residues
MKIKGIRWWMVGLVTAGLVVNYLARNTLSVAAPTLMSELSISTEQYAHIVVAWQLCYAIMQPVAGYIIDAIGTKMGFAIF
AIAWSAACAAAAFATGWQSLAIFRGMLGLTEAAGLPAGVKATTEWFPAKERSVAIGWFNIGSSFGALLAPPLVVWAILQS
GWELAFLIVGGLGIVWSGLWLLLYKHPRDQKRLGDAERDYILSGQEARLKDAPAQKGSWKRLFKNRNFYAIASARILSEP
AWQTFNAWIPLYLMTERHMNIKEVAMFAWLPFLAADIGCVLGGYLSPLFHKYCKVSLFTSRKMVMLFGCSCMIGPACIGL
VESPYTAIALLCIGGFAHQTLSGALYSITSDSFGKNEVATATGMGGMFGFFGAAAFTMVFGVLVTKIGYSPLFVVLAIFD
IVAAIVVWNVAREVPQYDDTVPLTADEQGPRTVPAT
>Mature_436_residues
MKIKGIRWWMVGLVTAGLVVNYLARNTLSVAAPTLMSELSISTEQYAHIVVAWQLCYAIMQPVAGYIIDAIGTKMGFAIF
AIAWSAACAAAAFATGWQSLAIFRGMLGLTEAAGLPAGVKATTEWFPAKERSVAIGWFNIGSSFGALLAPPLVVWAILQS
GWELAFLIVGGLGIVWSGLWLLLYKHPRDQKRLGDAERDYILSGQEARLKDAPAQKGSWKRLFKNRNFYAIASARILSEP
AWQTFNAWIPLYLMTERHMNIKEVAMFAWLPFLAADIGCVLGGYLSPLFHKYCKVSLFTSRKMVMLFGCSCMIGPACIGL
VESPYTAIALLCIGGFAHQTLSGALYSITSDSFGKNEVATATGMGGMFGFFGAAAFTMVFGVLVTKIGYSPLFVVLAIFD
IVAAIVVWNVAREVPQYDDTVPLTADEQGPRTVPAT

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI6912666, Length=328, Percent_Identity=28.3536585365854, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI148743791, Length=283, Percent_Identity=26.8551236749117, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI9945322, Length=365, Percent_Identity=25.4794520547945, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI9966811, Length=254, Percent_Identity=27.5590551181102, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI2367193, Length=430, Percent_Identity=54.6511627906977, Blast_Score=493, Evalue=1e-141,
Organism=Escherichia coli, GI87082320, Length=409, Percent_Identity=26.161369193154, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI2367379, Length=339, Percent_Identity=28.6135693215339, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1789515, Length=407, Percent_Identity=28.2555282555283, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1789152, Length=379, Percent_Identity=25.8575197889182, Blast_Score=121, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17560030, Length=279, Percent_Identity=21.8637992831541, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573299, Length=328, Percent_Identity=25.3048780487805, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45550460, Length=330, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24651789, Length=320, Percent_Identity=26.25, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24651787, Length=320, Percent_Identity=26.25, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24583789, Length=273, Percent_Identity=24.9084249084249, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24580790, Length=302, Percent_Identity=26.8211920529801, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24655255, Length=283, Percent_Identity=27.9151943462898, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24639764, Length=368, Percent_Identity=23.3695652173913, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24658658, Length=294, Percent_Identity=23.1292517006803, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281361682, Length=238, Percent_Identity=24.3697478991597, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45550364, Length=288, Percent_Identity=25.3472222222222, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24641682, Length=200, Percent_Identity=27, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130135, Length=332, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24655271, Length=332, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573708, Length=274, Percent_Identity=23.7226277372263, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573707, Length=274, Percent_Identity=23.7226277372263, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47325; Mature: 47325

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKGIRWWMVGLVTAGLVVNYLARNTLSVAAPTLMSELSISTEQYAHIVVAWQLCYAIM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
QPVAGYIIDAIGTKMGFAIFAIAWSAACAAAAFATGWQSLAIFRGMLGLTEAAGLPAGVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ATTEWFPAKERSVAIGWFNIGSSFGALLAPPLVVWAILQSGWELAFLIVGGLGIVWSGLW
CCHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
LLLYKHPRDQKRLGDAERDYILSGQEARLKDAPAQKGSWKRLFKNRNFYAIASARILSEP
HHHHCCCCHHHHCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHCCCCEEEEEHHHHHCCC
AWQTFNAWIPLYLMTERHMNIKEVAMFAWLPFLAADIGCVLGGYLSPLFHKYCKVSLFTS
CHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RKMVMLFGCSCMIGPACIGLVESPYTAIALLCIGGFAHQTLSGALYSITSDSFGKNEVAT
CCEEHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCH
ATGMGGMFGFFGAAAFTMVFGVLVTKIGYSPLFVVLAIFDIVAAIVVWNVAREVPQYDDT
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VPLTADEQGPRTVPAT
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIKGIRWWMVGLVTAGLVVNYLARNTLSVAAPTLMSELSISTEQYAHIVVAWQLCYAIM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
QPVAGYIIDAIGTKMGFAIFAIAWSAACAAAAFATGWQSLAIFRGMLGLTEAAGLPAGVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ATTEWFPAKERSVAIGWFNIGSSFGALLAPPLVVWAILQSGWELAFLIVGGLGIVWSGLW
CCHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
LLLYKHPRDQKRLGDAERDYILSGQEARLKDAPAQKGSWKRLFKNRNFYAIASARILSEP
HHHHCCCCHHHHCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHCCCCEEEEEHHHHHCCC
AWQTFNAWIPLYLMTERHMNIKEVAMFAWLPFLAADIGCVLGGYLSPLFHKYCKVSLFTS
CHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RKMVMLFGCSCMIGPACIGLVESPYTAIALLCIGGFAHQTLSGALYSITSDSFGKNEVAT
CCEEHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCH
ATGMGGMFGFFGAAAFTMVFGVLVTKIGYSPLFVVLAIFDIVAAIVVWNVAREVPQYDDT
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VPLTADEQGPRTVPAT
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]