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The map label for this gene is trxA [H]

Identifier: 66043570

GI number: 66043570

Start: 319738

End: 320088

Strand: Direct

Name: trxA [H]

Synonym: Psyr_0300

Alternate gene names: 66043570

Gene position: 319738-320088 (Clockwise)

Preceding gene: 66043569

Following gene: 66043571

Centisome position: 5.25

GC content: 53.28

Gene sequence:

>351_bases
ATGAGTAGCGACCTTATCAAACACGTCACCGACGGCACCTTTGACGCCGAAGTACTCGAGGCTCAGGGTCCTGTGCTTGT
TGACTATTGGGCTGAATGGTGTGGCCCTTGCAAAATGATTGCCCCGGTTCTGGACGAAATCGCCAGCACCTACAAAGGCA
GGCTGACGGTTGCGAAGTTGAACATCGATCAAAACCCGGACACTCCTGCCAAGCATGGTGTTCGTGGTATTCCTACGCTG
ATGCTGTTCAAGGGCGGCAATGTGGAAGCGACCAAAGTTGGTGCGCTGTCGAAGTCGCAGCTGACTGCGTTTCTCGAAGG
AAACGGTATCGACCTTCCTAAACCTGTTTGA

Upstream 100 bases:

>100_bases
ATGTTCTACGATAGCAAGACTCAATGAAGCTTCGCTTCCTGAATAGCATAAGGACCGCTATGATGAGCGTCGTTTTTAGC
CTATGACCTCGGAGACTTCC

Downstream 100 bases:

>100_bases
GACGTTTCAAAGCCCCGCAAAATGCGGGGTTTTTTTCGGGTGTCGTACTAGACGCCTGGAAAATCAGGTGGTACATTCGG
CCCCGCAACGGCTTCTCCGT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 116; Mature: 115

Protein sequence:

>116_residues
MSSDLIKHVTDGTFDAEVLEAQGPVLVDYWAEWCGPCKMIAPVLDEIASTYKGRLTVAKLNIDQNPDTPAKHGVRGIPTL
MLFKGGNVEATKVGALSKSQLTAFLEGNGIDLPKPV

Sequences:

>Translated_116_residues
MSSDLIKHVTDGTFDAEVLEAQGPVLVDYWAEWCGPCKMIAPVLDEIASTYKGRLTVAKLNIDQNPDTPAKHGVRGIPTL
MLFKGGNVEATKVGALSKSQLTAFLEGNGIDLPKPV
>Mature_115_residues
SSDLIKHVTDGTFDAEVLEAQGPVLVDYWAEWCGPCKMIAPVLDEIASTYKGRLTVAKLNIDQNPDTPAKHGVRGIPTLM
LFKGGNVEATKVGALSKSQLTAFLEGNGIDLPKPV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=100, Percent_Identity=36, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI21361657, Length=86, Percent_Identity=37.2093023255814, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI4758304, Length=115, Percent_Identity=32.1739130434783, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=106, Percent_Identity=70.7547169811321, Blast_Score=163, Evalue=3e-42,
Organism=Escherichia coli, GI1788936, Length=103, Percent_Identity=34.9514563106796, Blast_Score=83, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=35.4838709677419, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=39.5348837209302, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=76, Percent_Identity=39.4736842105263, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=76, Percent_Identity=39.4736842105263, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=38.8888888888889, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532380, Length=72, Percent_Identity=38.8888888888889, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=40.6976744186046, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=80, Percent_Identity=40, Blast_Score=69, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639826, Length=92, Percent_Identity=41.304347826087, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=43.2432432432432, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=31.9587628865979, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17648013, Length=84, Percent_Identity=32.1428571428571, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24583090, Length=84, Percent_Identity=32.1428571428571, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=34.5679012345679, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12422; Mature: 12291

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDLIKHVTDGTFDAEVLEAQGPVLVDYWAEWCGPCKMIAPVLDEIASTYKGRLTVAKL
CCCCHHHHHCCCCCCHHEECCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEE
NIDQNPDTPAKHGVRGIPTLMLFKGGNVEATKVGALSKSQLTAFLEGNGIDLPKPV
ECCCCCCCCHHCCCCCCCEEEEEECCCCCEEEECCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SSDLIKHVTDGTFDAEVLEAQGPVLVDYWAEWCGPCKMIAPVLDEIASTYKGRLTVAKL
CCCHHHHHCCCCCCHHEECCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEE
NIDQNPDTPAKHGVRGIPTLMLFKGGNVEATKVGALSKSQLTAFLEGNGIDLPKPV
ECCCCCCCCHHCCCCCCCEEEEEECCCCCEEEECCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]