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The map label for this gene is pdhR [H]

Identifier: 66043569

GI number: 66043569

Start: 318912

End: 319616

Strand: Direct

Name: pdhR [H]

Synonym: Psyr_0299

Alternate gene names: 66043569

Gene position: 318912-319616 (Clockwise)

Preceding gene: 66043563

Following gene: 66043570

Centisome position: 5.23

GC content: 62.55

Gene sequence:

>705_bases
ATGCCGCACACTTCACTCGCAGTACCCGAATCAGCCCTCCGGGCCATTCGCAAATTGATCGCCGAGCAAGGGTACAAGCC
CGGCGAAAGCCTGCCGTCGCAACGCGATCTGGCGGTATTGCTGGGGGTCAGTCGTGCGTCCTTGCGTGAAGCCTTGTCGT
CGCTCAGCGCACTCGGAGTGGTCAGTGTCCAGCCCGGCAAAGGCGTCTTCGTGCAGTCGATTTCTGAACCAGAACAGCGC
ACGGGTGGTTTTTCCTGGCCTTATGAAGCTCAGGTTTCCCCGGCCGACACTTTTCAGTTGCGCTACGCACTGGAAGGTTT
CGCTGCAGGCATGGCCGCCGTGACCCTGACCGCCGACGAGCGCGATGTACTGGAGGACAACGTCGAAGCCATGCGCCTGG
AATTGCGGGCCGGTGACTTCGAGGCTGCGGCGCGGCTGGACTTCGAGTTTCATCGGCACATTCTGGTCGCCAGCGGCAAT
CAGGCGATGCTCGGGATCGTGACTGCCGGGGCCGACATCTTCCTGGAAAGCCAGAAGATGCCGTTCATCCGGGCGGCCAG
GGTCATGGAGACCTGGCAGGAGCACCGCAAGATCCTTCGCGCGCTGGCCCGACATGCGTCAGGGCCTGCGCAAAAGGCCA
TGCAGGACCATATTCGTGGCGCGGCACTGCGCACCGGCATCGTCTTCGTTTCGCCCGCGAACTGA

Upstream 100 bases:

>100_bases
GCGCTTTAAAGCCTTGCCGCCCCAGGGCTGGGCGTCGCTTGCCGAATGTTCGAGATGGGGATAAAAGGGATTTTTACTGG
ACTGACTGGCCTGAACAGTG

Downstream 100 bases:

>100_bases
GCTACTGCCATAACCTCAGTCATGTTCTACGATAGCAAGACTCAATGAAGCTTCGCTTCCTGAATAGCATAAGGACCGCT
ATGATGAGCGTCGTTTTTAG

Product: transcriptional regulator GntR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MPHTSLAVPESALRAIRKLIAEQGYKPGESLPSQRDLAVLLGVSRASLREALSSLSALGVVSVQPGKGVFVQSISEPEQR
TGGFSWPYEAQVSPADTFQLRYALEGFAAGMAAVTLTADERDVLEDNVEAMRLELRAGDFEAAARLDFEFHRHILVASGN
QAMLGIVTAGADIFLESQKMPFIRAARVMETWQEHRKILRALARHASGPAQKAMQDHIRGAALRTGIVFVSPAN

Sequences:

>Translated_234_residues
MPHTSLAVPESALRAIRKLIAEQGYKPGESLPSQRDLAVLLGVSRASLREALSSLSALGVVSVQPGKGVFVQSISEPEQR
TGGFSWPYEAQVSPADTFQLRYALEGFAAGMAAVTLTADERDVLEDNVEAMRLELRAGDFEAAARLDFEFHRHILVASGN
QAMLGIVTAGADIFLESQKMPFIRAARVMETWQEHRKILRALARHASGPAQKAMQDHIRGAALRTGIVFVSPAN
>Mature_233_residues
PHTSLAVPESALRAIRKLIAEQGYKPGESLPSQRDLAVLLGVSRASLREALSSLSALGVVSVQPGKGVFVQSISEPEQRT
GGFSWPYEAQVSPADTFQLRYALEGFAAGMAAVTLTADERDVLEDNVEAMRLELRAGDFEAAARLDFEFHRHILVASGNQ
AMLGIVTAGADIFLESQKMPFIRAARVMETWQEHRKILRALARHASGPAQKAMQDHIRGAALRTGIVFVSPAN

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=169, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790032, Length=219, Percent_Identity=29.6803652968037, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082208, Length=210, Percent_Identity=27.1428571428571, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790780, Length=227, Percent_Identity=28.1938325991189, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789353, Length=221, Percent_Identity=28.0542986425339, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789621, Length=218, Percent_Identity=27.0642201834862, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 25375; Mature: 25244

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHTSLAVPESALRAIRKLIAEQGYKPGESLPSQRDLAVLLGVSRASLREALSSLSALGV
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCE
VSVQPGKGVFVQSISEPEQRTGGFSWPYEAQVSPADTFQLRYALEGFAAGMAAVTLTADE
EEECCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCC
RDVLEDNVEAMRLELRAGDFEAAARLDFEFHRHILVASGNQAMLGIVTAGADIFLESQKM
HHHHHHHHHHHEEECCCCCCHHHHHCCHHHHCEEEEECCCCEEEEEEECCCEEEEECCCC
PFIRAARVMETWQEHRKILRALARHASGPAQKAMQDHIRGAALRTGIVFVSPAN
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCEEEEECCC
>Mature Secondary Structure 
PHTSLAVPESALRAIRKLIAEQGYKPGESLPSQRDLAVLLGVSRASLREALSSLSALGV
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCE
VSVQPGKGVFVQSISEPEQRTGGFSWPYEAQVSPADTFQLRYALEGFAAGMAAVTLTADE
EEECCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCC
RDVLEDNVEAMRLELRAGDFEAAARLDFEFHRHILVASGNQAMLGIVTAGADIFLESQKM
HHHHHHHHHHHEEECCCCCCHHHHHCCHHHHCEEEEECCCCEEEEEEECCCEEEEECCCC
PFIRAARVMETWQEHRKILRALARHASGPAQKAMQDHIRGAALRTGIVFVSPAN
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]