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The map label for this gene is gmk [H]

Identifier: 66043481

GI number: 66043481

Start: 225581

End: 226225

Strand: Reverse

Name: gmk [H]

Synonym: Psyr_0211

Alternate gene names: 66043481

Gene position: 226225-225581 (Counterclockwise)

Preceding gene: 66043482

Following gene: 66043480

Centisome position: 3.71

GC content: 60.31

Gene sequence:

>645_bases
ATGACCCATATCACTGGCACCCTGTACATCATTTCCGCTCCGTCCGGCGCGGGCAAGACCAGTCTGGTCAAGGCGCTGAT
GGACGCTCAGCAAGAGCCTCAGCACGGCGCGCAGGCAAAGATTCGCGTCTCTGTCTCGCACACCACGCGCGCCATGCGCC
CCGGCGAAGTGGACGGTGTGAACTACAACTTCGTCGATCGTGCCACGTTCCTGAGCATGATCGAGCACGGCGACTTTCTC
GAGCAGGCCGAGGTCTTCGGCAACCTGTATGGCACGTCGCAGAGCCACTTGCAGCAGACGCTGGACGAAGGCCACGACCT
GATTCTGGAAATCGACTGGCAGGGTGCGCGCCAGGTTCGTGCGCAGATGCCGCAGGCCCGTTCCATCTTCATTTTGCCGC
CGACCCAGCAGGCCTTGCGCCAGCGCCTGACCAATCGCGGCCAGGACAGTGACGAGATCATCGAAGCCCGCATGCGTGAA
GCCGTCAGCGAAATGAGCCACTACAGCGAGTATGAGTACGTCGTGGTCAATGACGACTTTGCCGGCGCGCTGGAAGACCT
CAAGGCGATTTTCCGCGCCAATCGCCTCACTCAACAGCATCAGCAAGAGCAATACAGCGAACTTTTTCAGGAGTTGCTGG
CCTGA

Upstream 100 bases:

>100_bases
GCCTTTGACCCACGCAGCACGCAGGCTGCCGTCAACCTCAAAGTGTTGATCGAGCAGATGCGTGAGCAAGTGCAGAATAT
TGAGTAAGGCTAAACCTGAC

Downstream 100 bases:

>100_bases
TCGAACCGTTTCCAGACATCAGGCAACAGGTTAAAAGCATGCCGTTGGTGGCATGCCGCTTGATGACTGGTGCTGTACGC
TTGTAAACTACCGAGTCCGC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MTHITGTLYIISAPSGAGKTSLVKALMDAQQEPQHGAQAKIRVSVSHTTRAMRPGEVDGVNYNFVDRATFLSMIEHGDFL
EQAEVFGNLYGTSQSHLQQTLDEGHDLILEIDWQGARQVRAQMPQARSIFILPPTQQALRQRLTNRGQDSDEIIEARMRE
AVSEMSHYSEYEYVVVNDDFAGALEDLKAIFRANRLTQQHQQEQYSELFQELLA

Sequences:

>Translated_214_residues
MTHITGTLYIISAPSGAGKTSLVKALMDAQQEPQHGAQAKIRVSVSHTTRAMRPGEVDGVNYNFVDRATFLSMIEHGDFL
EQAEVFGNLYGTSQSHLQQTLDEGHDLILEIDWQGARQVRAQMPQARSIFILPPTQQALRQRLTNRGQDSDEIIEARMRE
AVSEMSHYSEYEYVVVNDDFAGALEDLKAIFRANRLTQQHQQEQYSELFQELLA
>Mature_213_residues
THITGTLYIISAPSGAGKTSLVKALMDAQQEPQHGAQAKIRVSVSHTTRAMRPGEVDGVNYNFVDRATFLSMIEHGDFLE
QAEVFGNLYGTSQSHLQQTLDEGHDLILEIDWQGARQVRAQMPQARSIFILPPTQQALRQRLTNRGQDSDEIIEARMREA
VSEMSHYSEYEYVVVNDDFAGALEDLKAIFRANRLTQQHQQEQYSELFQELLA

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=182, Percent_Identity=36.8131868131868, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4504221, Length=182, Percent_Identity=36.8131868131868, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI226874831, Length=182, Percent_Identity=36.8131868131868, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI38570142, Length=183, Percent_Identity=32.2404371584699, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI14780902, Length=190, Percent_Identity=28.4210526315789, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI111154074, Length=162, Percent_Identity=29.0123456790123, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI21536464, Length=170, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI21361598, Length=203, Percent_Identity=25.615763546798, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1790080, Length=209, Percent_Identity=56.9377990430622, Blast_Score=236, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI193203132, Length=187, Percent_Identity=32.620320855615, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17508835, Length=187, Percent_Identity=32.620320855615, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320662, Length=191, Percent_Identity=39.7905759162304, Blast_Score=130, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21356141, Length=196, Percent_Identity=32.6530612244898, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221330164, Length=133, Percent_Identity=33.0827067669173, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330166, Length=133, Percent_Identity=33.0827067669173, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330162, Length=133, Percent_Identity=33.0827067669173, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640542, Length=184, Percent_Identity=27.7173913043478, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554489, Length=184, Percent_Identity=27.7173913043478, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85724806, Length=174, Percent_Identity=26.4367816091954, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116007136, Length=184, Percent_Identity=27.7173913043478, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554481, Length=174, Percent_Identity=26.4367816091954, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161077626, Length=184, Percent_Identity=27.7173913043478, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24194; Mature: 24063

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHITGTLYIISAPSGAGKTSLVKALMDAQQEPQHGAQAKIRVSVSHTTRAMRPGEVDGV
CCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHCCCCCCCCCC
NYNFVDRATFLSMIEHGDFLEQAEVFGNLYGTSQSHLQQTLDEGHDLILEIDWQGARQVR
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCHHHHH
AQMPQARSIFILPPTQQALRQRLTNRGQDSDEIIEARMREAVSEMSHYSEYEYVVVNDDF
HHCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCH
AGALEDLKAIFRANRLTQQHQQEQYSELFQELLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
THITGTLYIISAPSGAGKTSLVKALMDAQQEPQHGAQAKIRVSVSHTTRAMRPGEVDGV
CCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHCCCCCCCCCC
NYNFVDRATFLSMIEHGDFLEQAEVFGNLYGTSQSHLQQTLDEGHDLILEIDWQGARQVR
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCHHHHH
AQMPQARSIFILPPTQQALRQRLTNRGQDSDEIIEARMREAVSEMSHYSEYEYVVVNDDF
HHCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCH
AGALEDLKAIFRANRLTQQHQQEQYSELFQELLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA