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The map label for this gene is prlC [H]

Identifier: 66043316

GI number: 66043316

Start: 45889

End: 47940

Strand: Direct

Name: prlC [H]

Synonym: Psyr_0045

Alternate gene names: 66043316

Gene position: 45889-47940 (Clockwise)

Preceding gene: 66043314

Following gene: 66043317

Centisome position: 0.75

GC content: 61.79

Gene sequence:

>2052_bases
GTGAGCGCGAACAACCCTCTTCTGCAATCGTACGACCTGCCACCCTTTTCGGCGATTCGTGCCGAGCATGTCAAACCTGC
TATCGAACAGATCCTGGCGGATAACCGCGCCGCGATTGCCGACATCCTCGCCAAACAGGGTTCGACACCGACCTGGGCCG
GGCTGGTGCTGACCATGGACGAGCTGAACGACCGCCTGGGCGCTGCCTGGAGCCCCGTCAGCCACCTCAATGCCGTGTGC
AACAGCGCCGAGCTGCGCGAAGCGTATGAATCGTGCCTGCCGGCCTTGAGCGCCTACTCCACCGAGATGGGCCAGAACCG
CGCGCTGTTCCAGGCCTATGAAGCCTTGGCCAATGGCCCCGAGGCCGCCAGTTTCGACGTTGGCCAGAAGACCATTCTGG
AGCAATCGCTGCGTGACTTCCGCCTGTCCGGTATCGATCTGCCGCCTGAGCAGCAGAAGCGCTATGCCGAAGTGCAGAGC
AAGCTGTCGGAGCTGGGCAGCCAGTTTTCCAACCAACTGCTCGATGCCACTCAGGCCTGGACCAAGCTGGTTGCCGATGA
GTCCGCCCTCGCCGGCCTGACCGACTCTGCCAAGCAGCAGATGGCCGCCGCGGCCAAGGCCAAGGATCTGGAAGGCTATC
TGATCACGCTGGAATTTCCGAACTACTACGCGGTGATGACCTACGCCGAAGACCGCGCACTGCGCGAGGAAGTCTATGCG
GCGTACGCCACCCGCGCGTCGGATCAAGGTCCGAACGCCGGCAAGAACGACAACACGCCGGTCATGGAGCAGATCCTCGA
CCTGCGTCAGGAACTCGCGCAATTGCTCGGTTATGCCAACTACGCTGAACTGAGCCTGGCGACCAAGATGGCCGAGTCCA
GCGATCAGGTGCTGAGCTTCCTGCGTGACCTGGCCAAGCGCAGCAAGCCGTTTGCTGCTCAGGACCTGGAGCAGCTCAAG
GCCTATGCCGCCGAACAGGGCTGCCCGGATCTGCAAAGCTGGGACAGCGGTTTCTACGGCGAGAAGCTGCGCGAGCAGCG
CTACAGCGTTTCCCAGGAAATCCTGCGCGCCTACTTCCCAGTCGATAAGGTGCTCGACGGTCTGTTCACCATCGTTCAAC
GCCTGTACGGCATCGAGATTGCCGAGCAGAAAGGCTTCGACACCTGGCATCCGGATGTTCGTCTGTTCGAGATCAAGGAA
AACGGCCAGCACGTCGGGCGCTTCTTCTTCGATCTGTACGCCCGCGCCAACAAGCGTGGTGGTGCCTGGATGGACGGCGC
GCGTGACCGTCGCCGTACGGCGCAAGGCACGTTGCAAAGCCCGGTGGCCAATCTGGTGTGCAACTTCACACCCGCTGTCG
CAGGCAAGCCTGCGCTGCTCACCCACGACGAAGTCACCACGCTGTTCCACGAATTCGGTCATGGCCTGCATCACCTGCTG
ACCCGCGTCGAGCATGCCGGGGTATCCGGTATCAATGGCGTGGCTTGGGACGCGGTCGAGTTGCCGAGCCAGTTCATGGA
AAACTGGTGCTGGGAGCCCGAAGGCCTGGCGCTGATCTCCGGTCATTACGAAACCGGCGAGCCGTTGCCGCAGGATCTGC
TGGAGAAGATGCTCGCTGCCAAGAACTTCCAGTCCGGCCTAATGATGGTGCGCCAGCTGGAGTTCTCGCTGTTCGACTTC
GAACTGCATGCCACGCATGGCGACGGCCGCAGCGTGCTGGAGGTGCTGGAAGGTATTCGCGACGAAGTCTCGGTGATGCG
TCCGCCTGCCTATAACCGTTTCCCGAACAGCTTCGCGCACATCTTCGCAGGCGGTTACGCAGCCGGTTATTACAGCTACA
AGTGGGCTGAAGTGCTGTCCGCCGATGCGTTCTCGAAGTTCGAGGAAGATGGCGTGCTCAACGCTGAAACCGGACGCGCC
TTCCGCGAAGCCATTCTGGCACGTGGCGGTTCGCAGGCACCGATGGTGCTGTTCGTCGACTTCCGCGGACGCGAGCCGTC
GATTGACGCATTGTTGCGTCACAGTGGCTTGAGTGAGGACGCGGCAGCATGA

Upstream 100 bases:

>100_bases
CTTTGGCAGTGATAGGCGTGTAGAGCGGGTTTGGTTGCTGCGGTCGGCGTCGATTGTAATTAAGATGGCTGAGTGTTTCT
TCAAGGCAAGGTGCAAAACC

Downstream 100 bases:

>100_bases
CCGATACACCAGTAGTCATTACCAGGAAACGCTTCATCGCCGGGGCGGTGTGCCCGGCGTGCAGCGAGCCCGACAAACTG
ATGATGTGGAACGAAAACGA

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 683; Mature: 682

Protein sequence:

>683_residues
MSANNPLLQSYDLPPFSAIRAEHVKPAIEQILADNRAAIADILAKQGSTPTWAGLVLTMDELNDRLGAAWSPVSHLNAVC
NSAELREAYESCLPALSAYSTEMGQNRALFQAYEALANGPEAASFDVGQKTILEQSLRDFRLSGIDLPPEQQKRYAEVQS
KLSELGSQFSNQLLDATQAWTKLVADESALAGLTDSAKQQMAAAAKAKDLEGYLITLEFPNYYAVMTYAEDRALREEVYA
AYATRASDQGPNAGKNDNTPVMEQILDLRQELAQLLGYANYAELSLATKMAESSDQVLSFLRDLAKRSKPFAAQDLEQLK
AYAAEQGCPDLQSWDSGFYGEKLREQRYSVSQEILRAYFPVDKVLDGLFTIVQRLYGIEIAEQKGFDTWHPDVRLFEIKE
NGQHVGRFFFDLYARANKRGGAWMDGARDRRRTAQGTLQSPVANLVCNFTPAVAGKPALLTHDEVTTLFHEFGHGLHHLL
TRVEHAGVSGINGVAWDAVELPSQFMENWCWEPEGLALISGHYETGEPLPQDLLEKMLAAKNFQSGLMMVRQLEFSLFDF
ELHATHGDGRSVLEVLEGIRDEVSVMRPPAYNRFPNSFAHIFAGGYAAGYYSYKWAEVLSADAFSKFEEDGVLNAETGRA
FREAILARGGSQAPMVLFVDFRGREPSIDALLRHSGLSEDAAA

Sequences:

>Translated_683_residues
MSANNPLLQSYDLPPFSAIRAEHVKPAIEQILADNRAAIADILAKQGSTPTWAGLVLTMDELNDRLGAAWSPVSHLNAVC
NSAELREAYESCLPALSAYSTEMGQNRALFQAYEALANGPEAASFDVGQKTILEQSLRDFRLSGIDLPPEQQKRYAEVQS
KLSELGSQFSNQLLDATQAWTKLVADESALAGLTDSAKQQMAAAAKAKDLEGYLITLEFPNYYAVMTYAEDRALREEVYA
AYATRASDQGPNAGKNDNTPVMEQILDLRQELAQLLGYANYAELSLATKMAESSDQVLSFLRDLAKRSKPFAAQDLEQLK
AYAAEQGCPDLQSWDSGFYGEKLREQRYSVSQEILRAYFPVDKVLDGLFTIVQRLYGIEIAEQKGFDTWHPDVRLFEIKE
NGQHVGRFFFDLYARANKRGGAWMDGARDRRRTAQGTLQSPVANLVCNFTPAVAGKPALLTHDEVTTLFHEFGHGLHHLL
TRVEHAGVSGINGVAWDAVELPSQFMENWCWEPEGLALISGHYETGEPLPQDLLEKMLAAKNFQSGLMMVRQLEFSLFDF
ELHATHGDGRSVLEVLEGIRDEVSVMRPPAYNRFPNSFAHIFAGGYAAGYYSYKWAEVLSADAFSKFEEDGVLNAETGRA
FREAILARGGSQAPMVLFVDFRGREPSIDALLRHSGLSEDAAA
>Mature_682_residues
SANNPLLQSYDLPPFSAIRAEHVKPAIEQILADNRAAIADILAKQGSTPTWAGLVLTMDELNDRLGAAWSPVSHLNAVCN
SAELREAYESCLPALSAYSTEMGQNRALFQAYEALANGPEAASFDVGQKTILEQSLRDFRLSGIDLPPEQQKRYAEVQSK
LSELGSQFSNQLLDATQAWTKLVADESALAGLTDSAKQQMAAAAKAKDLEGYLITLEFPNYYAVMTYAEDRALREEVYAA
YATRASDQGPNAGKNDNTPVMEQILDLRQELAQLLGYANYAELSLATKMAESSDQVLSFLRDLAKRSKPFAAQDLEQLKA
YAAEQGCPDLQSWDSGFYGEKLREQRYSVSQEILRAYFPVDKVLDGLFTIVQRLYGIEIAEQKGFDTWHPDVRLFEIKEN
GQHVGRFFFDLYARANKRGGAWMDGARDRRRTAQGTLQSPVANLVCNFTPAVAGKPALLTHDEVTTLFHEFGHGLHHLLT
RVEHAGVSGINGVAWDAVELPSQFMENWCWEPEGLALISGHYETGEPLPQDLLEKMLAAKNFQSGLMMVRQLEFSLFDFE
LHATHGDGRSVLEVLEGIRDEVSVMRPPAYNRFPNSFAHIFAGGYAAGYYSYKWAEVLSADAFSKFEEDGVLNAETGRAF
REAILARGGSQAPMVLFVDFRGREPSIDALLRHSGLSEDAAA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=609, Percent_Identity=33.9901477832512, Blast_Score=326, Evalue=6e-89,
Organism=Homo sapiens, GI14149738, Length=611, Percent_Identity=33.2242225859247, Blast_Score=305, Evalue=8e-83,
Organism=Homo sapiens, GI156105687, Length=635, Percent_Identity=25.6692913385827, Blast_Score=198, Evalue=1e-50,
Organism=Escherichia coli, GI1789913, Length=679, Percent_Identity=59.7938144329897, Blast_Score=823, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=698, Percent_Identity=32.8080229226361, Blast_Score=313, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI71999758, Length=560, Percent_Identity=26.0714285714286, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32565901, Length=647, Percent_Identity=22.4111282843895, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319793, Length=686, Percent_Identity=29.5918367346939, Blast_Score=305, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6322715, Length=702, Percent_Identity=23.9316239316239, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21356111, Length=576, Percent_Identity=29.1666666666667, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI20129717, Length=705, Percent_Identity=22.9787234042553, Blast_Score=174, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 75633; Mature: 75501

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANNPLLQSYDLPPFSAIRAEHVKPAIEQILADNRAAIADILAKQGSTPTWAGLVLTMD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHEEEHH
ELNDRLGAAWSPVSHLNAVCNSAELREAYESCLPALSAYSTEMGQNRALFQAYEALANGP
HHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
EAASFDVGQKTILEQSLRDFRLSGIDLPPEQQKRYAEVQSKLSELGSQFSNQLLDATQAW
CCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKLVADESALAGLTDSAKQQMAAAAKAKDLEGYLITLEFPNYYAVMTYAEDRALREEVYA
HHHHHCHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEEHHHHHHHHHHHH
AYATRASDQGPNAGKNDNTPVMEQILDLRQELAQLLGYANYAELSLATKMAESSDQVLSF
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHH
LRDLAKRSKPFAAQDLEQLKAYAAEQGCPDLQSWDSGFYGEKLREQRYSVSQEILRAYFP
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
VDKVLDGLFTIVQRLYGIEIAEQKGFDTWHPDVRLFEIKENGQHVGRFFFDLYARANKRG
HHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
GAWMDGARDRRRTAQGTLQSPVANLVCNFTPAVAGKPALLTHDEVTTLFHEFGHGLHHLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHH
TRVEHAGVSGINGVAWDAVELPSQFMENWCWEPEGLALISGHYETGEPLPQDLLEKMLAA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHH
KNFQSGLMMVRQLEFSLFDFELHATHGDGRSVLEVLEGIRDEVSVMRPPAYNRFPNSFAH
HHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IFAGGYAAGYYSYKWAEVLSADAFSKFEEDGVLNAETGRAFREAILARGGSQAPMVLFVD
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
FRGREPSIDALLRHSGLSEDAAA
ECCCCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SANNPLLQSYDLPPFSAIRAEHVKPAIEQILADNRAAIADILAKQGSTPTWAGLVLTMD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHEEEHH
ELNDRLGAAWSPVSHLNAVCNSAELREAYESCLPALSAYSTEMGQNRALFQAYEALANGP
HHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
EAASFDVGQKTILEQSLRDFRLSGIDLPPEQQKRYAEVQSKLSELGSQFSNQLLDATQAW
CCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKLVADESALAGLTDSAKQQMAAAAKAKDLEGYLITLEFPNYYAVMTYAEDRALREEVYA
HHHHHCHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEEHHHHHHHHHHHH
AYATRASDQGPNAGKNDNTPVMEQILDLRQELAQLLGYANYAELSLATKMAESSDQVLSF
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHH
LRDLAKRSKPFAAQDLEQLKAYAAEQGCPDLQSWDSGFYGEKLREQRYSVSQEILRAYFP
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
VDKVLDGLFTIVQRLYGIEIAEQKGFDTWHPDVRLFEIKENGQHVGRFFFDLYARANKRG
HHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
GAWMDGARDRRRTAQGTLQSPVANLVCNFTPAVAGKPALLTHDEVTTLFHEFGHGLHHLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHH
TRVEHAGVSGINGVAWDAVELPSQFMENWCWEPEGLALISGHYETGEPLPQDLLEKMLAA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHH
KNFQSGLMMVRQLEFSLFDFELHATHGDGRSVLEVLEGIRDEVSVMRPPAYNRFPNSFAH
HHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IFAGGYAAGYYSYKWAEVLSADAFSKFEEDGVLNAETGRAFREAILARGGSQAPMVLFVD
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
FRGREPSIDALLRHSGLSEDAAA
ECCCCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]