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The map label for this gene is thiD2 [H]

Identifier: 62391917

GI number: 62391917

Start: 3255652

End: 3256122

Strand: Reverse

Name: thiD2 [H]

Synonym: cg3400

Alternate gene names: 62391917

Gene position: 3256122-3255652 (Counterclockwise)

Preceding gene: 62391920

Following gene: 62391916

Centisome position: 99.19

GC content: 55.2

Gene sequence:

>471_bases
TTGAAGATACGATGGTGTGAACTTTATTCCACAACGGGGAAAGATCAAGGGGTAGAACTTCTGCCTCAAGCAACCGTCGT
TACCCCAAATAACTTCGAGGCTTCCACCCTCTCCGGCCTTGAGAAGCTTGAGACCGTCGAGGACCTCAAGGAGGCTGCCC
GCCTCATTTATGAGCAAGGCCCCCAGTACGTAGTCGTCAAGGGTGGCATGGACTTCCCCGGCGAGAACGCCGTGGATGTG
CTTTTCGACGGATCCTCCTACCACGTCTTCTCTGAGCCAAAGATTGGTGAAGAGCGCGTTTCCGGCGCAGGCTGCACCTT
CGCAGCTGTTATCACCGCAGAGCTCGCAAAGGGTGCTGAGGTTGTAGACGCAGTGGCAACCGCAAAGCGTGTGGTTACCC
GTGCGGTTCAAGATGCTGTTGCATCCAACGCACCTTTTACCTCCGTATGGCTTGCTGAGGACAACAAGTAG

Upstream 100 bases:

>100_bases
TTTAGTACTGGGTGTTCAGCAAGATGGTTACCAATGGACTGAGCATTTGTTCCGGCTGCCACTGCAACATCTCCGTAACT
CGCCCAATGACCTGCAGGGA

Downstream 100 bases:

>100_bases
AGTTTTAAAATACCGATCAAATCCCCGTGTTAGTGACTGCTAACACGGGGATTTCCGCTGCTTAAAGCACCTATTGCCTA
AGTAGACCAATAGGTCTATG

Product: phosphomethylpyrimidine kinase (C-terminal fragment)

Products: NA

Alternate protein names: PN/PL/PM kinase; Pyridoxal kinase; Pyridoxamine kinase; Vitamin B6 kinase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MKIRWCELYSTTGKDQGVELLPQATVVTPNNFEASTLSGLEKLETVEDLKEAARLIYEQGPQYVVVKGGMDFPGENAVDV
LFDGSSYHVFSEPKIGEERVSGAGCTFAAVITAELAKGAEVVDAVATAKRVVTRAVQDAVASNAPFTSVWLAEDNK

Sequences:

>Translated_156_residues
MKIRWCELYSTTGKDQGVELLPQATVVTPNNFEASTLSGLEKLETVEDLKEAARLIYEQGPQYVVVKGGMDFPGENAVDV
LFDGSSYHVFSEPKIGEERVSGAGCTFAAVITAELAKGAEVVDAVATAKRVVTRAVQDAVASNAPFTSVWLAEDNK
>Mature_156_residues
MKIRWCELYSTTGKDQGVELLPQATVVTPNNFEASTLSGLEKLETVEDLKEAARLIYEQGPQYVVVKGGMDFPGENAVDV
LFDGSSYHVFSEPKIGEERVSGAGCTFAAVITAELAKGAEVVDAVATAKRVVTRAVQDAVASNAPFTSVWLAEDNK

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates. Can also use hydroxymethylpyrimidine (HMP) as substrate [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 16729; Mature: 16729

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRWCELYSTTGKDQGVELLPQATVVTPNNFEASTLSGLEKLETVEDLKEAARLIYEQG
CCEEEEEEECCCCCCCCCEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PQYVVVKGGMDFPGENAVDVLFDGSSYHVFSEPKIGEERVSGAGCTFAAVITAELAKGAE
CCEEEEECCCCCCCCCCEEEEECCCEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHCCHH
VVDAVATAKRVVTRAVQDAVASNAPFTSVWLAEDNK
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
>Mature Secondary Structure
MKIRWCELYSTTGKDQGVELLPQATVVTPNNFEASTLSGLEKLETVEDLKEAARLIYEQG
CCEEEEEEECCCCCCCCCEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PQYVVVKGGMDFPGENAVDVLFDGSSYHVFSEPKIGEERVSGAGCTFAAVITAELAKGAE
CCEEEEECCCCCCCCCCEEEEECCCEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHCCHH
VVDAVATAKRVVTRAVQDAVASNAPFTSVWLAEDNK
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]