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The map label for this gene is qor [C]

Identifier: 62391853

GI number: 62391853

Start: 3178526

End: 3179539

Strand: Reverse

Name: qor [C]

Synonym: cg3332

Alternate gene names: 62391853

Gene position: 3179539-3178526 (Counterclockwise)

Preceding gene: 62391856

Following gene: 62391852

Centisome position: 96.86

GC content: 50.89

Gene sequence:

>1014_bases
ATGAGCGCGCAAATGGATACCCCTGATCCCACTATGTCTGCTGTTGCAATGTTAGATTCCATCCCTTCTGATCAACCAGA
TTTCCTGATCGATGTAGAAGTAGATCGACCAACTCCCGGACCACATGATCTGCTAGTCCACATTGAGGCGGTCTCAATTA
ACCCTGTTGATACCAAGGTACGCATGCGGGCCGGGAAGCAAAAGCATCCTAAAATTTTAGGTTTTGATGCTGCAGGTGAG
GTGGTGGCTGTTGGATCGCAGGTCACGCTCTTCAATGTTGGTGACAAAGTGTTCTACGCAGGATCCAATCAGCGTCCAGG
AAGTAACGCAGAGTACCAGGTGGTGGATGAACGGCTGGTGGGTCACGCACCACAAAGCTTGGGGGCACACGACGCCGCTG
CTCTCCCACTTGTCGCGCTCACTGCATGGGAGTCACTTTTTGACCGATTGGGAGTAACTCAGTCAACTACTGGAACACTG
TTGGTCTTGGGCGGTTCAGGAGGTGTGCCTTCAGCTCTTATTCAACTTGCTCGAGCTCTCACTGGTCTGAAAGTAGTGGC
AACAGCTTCTCGCCCTGAATCACAAGAATGGGTGACAAAGCTCGGTGCTCATGAGGTGATTGATCACTCCAAGGATTTGA
GTGAGCAAATCTCCGACGTGGATTTTGTTTTCAGCTCGTGGACTACTGGGCGTGAAGTAGAGCTCGCCACGTTGATGAAA
CCCCAGTCCCACCTAGTGCTCATCGATGATCCAGTGGATCCCAATTTGGGCGCTTTTAAGCAAAAAGCGATCGCTTTGCA
CTGGGAGTTCATGTTTACCCGCGCTATGTTCAACACTCCTGATATGGGTGAACAAGGGAAAATTCTGAATAAGATCGCCG
ACATGGTTGATCGGGGTCAGTTTGAGTCCGTGACAGCAACGGTGCTGGATGGGCTCAACGCTGCAAACATCATGGAGGGG
CACCGGCTCGTTGAGCAGGGTAAAACCTCAGGAAAAATTGTTGTGAGGGTATAA

Upstream 100 bases:

>100_bases
GGCGTGCTAAAAAAGCACGTCAAATACAGAATCGGCAGATTACATCGCTGAGCAGAGAAAACACGGGCATGAAACGTACC
CAAGGGCTAACATCGGGGGC

Downstream 100 bases:

>100_bases
AGAGGACTTGAAAAATGCACCATCTACGCTATGAATCACCAATCGGAGAGCTTCTTCTTGTTGCAAGTGACCAAGGGCTA
ACCTATGTGGCATTCTCCGA

Product: hypothetical protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSAQMDTPDPTMSAVAMLDSIPSDQPDFLIDVEVDRPTPGPHDLLVHIEAVSINPVDTKVRMRAGKQKHPKILGFDAAGE
VVAVGSQVTLFNVGDKVFYAGSNQRPGSNAEYQVVDERLVGHAPQSLGAHDAAALPLVALTAWESLFDRLGVTQSTTGTL
LVLGGSGGVPSALIQLARALTGLKVVATASRPESQEWVTKLGAHEVIDHSKDLSEQISDVDFVFSSWTTGREVELATLMK
PQSHLVLIDDPVDPNLGAFKQKAIALHWEFMFTRAMFNTPDMGEQGKILNKIADMVDRGQFESVTATVLDGLNAANIMEG
HRLVEQGKTSGKIVVRV

Sequences:

>Translated_337_residues
MSAQMDTPDPTMSAVAMLDSIPSDQPDFLIDVEVDRPTPGPHDLLVHIEAVSINPVDTKVRMRAGKQKHPKILGFDAAGE
VVAVGSQVTLFNVGDKVFYAGSNQRPGSNAEYQVVDERLVGHAPQSLGAHDAAALPLVALTAWESLFDRLGVTQSTTGTL
LVLGGSGGVPSALIQLARALTGLKVVATASRPESQEWVTKLGAHEVIDHSKDLSEQISDVDFVFSSWTTGREVELATLMK
PQSHLVLIDDPVDPNLGAFKQKAIALHWEFMFTRAMFNTPDMGEQGKILNKIADMVDRGQFESVTATVLDGLNAANIMEG
HRLVEQGKTSGKIVVRV
>Mature_336_residues
SAQMDTPDPTMSAVAMLDSIPSDQPDFLIDVEVDRPTPGPHDLLVHIEAVSINPVDTKVRMRAGKQKHPKILGFDAAGEV
VAVGSQVTLFNVGDKVFYAGSNQRPGSNAEYQVVDERLVGHAPQSLGAHDAAALPLVALTAWESLFDRLGVTQSTTGTLL
VLGGSGGVPSALIQLARALTGLKVVATASRPESQEWVTKLGAHEVIDHSKDLSEQISDVDFVFSSWTTGREVELATLMKP
QSHLVLIDDPVDPNLGAFKQKAIALHWEFMFTRAMFNTPDMGEQGKILNKIADMVDRGQFESVTATVLDGLNAANIMEGH
RLVEQGKTSGKIVVRV

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=336, Percent_Identity=29.7619047619048, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI194239674, Length=207, Percent_Identity=34.2995169082126, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI13236495, Length=207, Percent_Identity=34.2995169082126, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI194239676, Length=207, Percent_Identity=34.2995169082126, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17507255, Length=187, Percent_Identity=37.4331550802139, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71987554, Length=168, Percent_Identity=30.952380952381, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323493, Length=206, Percent_Identity=31.5533980582524, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319945, Length=206, Percent_Identity=31.5533980582524, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36236; Mature: 36104

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQMDTPDPTMSAVAMLDSIPSDQPDFLIDVEVDRPTPGPHDLLVHIEAVSINPVDTKV
CCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCCHHH
RMRAGKQKHPKILGFDAAGEVVAVGSQVTLFNVGDKVFYAGSNQRPGSNAEYQVVDERLV
HHHCCCCCCCEEEEECCCCCEEEECCEEEEEECCCEEEECCCCCCCCCCCCCEEHHHHHH
GHAPQSLGAHDAAALPLVALTAWESLFDRLGVTQSTTGTLLVLGGSGGVPSALIQLARAL
CCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
TGLKVVATASRPESQEWVTKLGAHEVIDHSKDLSEQISDVDFVFSSWTTGREVELATLMK
CCEEEEEECCCCCHHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHCCCCCCEEEEHEECC
PQSHLVLIDDPVDPNLGAFKQKAIALHWEFMFTRAMFNTPDMGEQGKILNKIADMVDRGQ
CCCCEEEEECCCCCCCCHHHHHHEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
FESVTATVLDGLNAANIMEGHRLVEQGKTSGKIVVRV
CHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
SAQMDTPDPTMSAVAMLDSIPSDQPDFLIDVEVDRPTPGPHDLLVHIEAVSINPVDTKV
CCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCCHHH
RMRAGKQKHPKILGFDAAGEVVAVGSQVTLFNVGDKVFYAGSNQRPGSNAEYQVVDERLV
HHHCCCCCCCEEEEECCCCCEEEECCEEEEEECCCEEEECCCCCCCCCCCCCEEHHHHHH
GHAPQSLGAHDAAALPLVALTAWESLFDRLGVTQSTTGTLLVLGGSGGVPSALIQLARAL
CCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
TGLKVVATASRPESQEWVTKLGAHEVIDHSKDLSEQISDVDFVFSSWTTGREVELATLMK
CCEEEEEECCCCCHHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHCCCCCCEEEEHEECC
PQSHLVLIDDPVDPNLGAFKQKAIALHWEFMFTRAMFNTPDMGEQGKILNKIADMVDRGQ
CCCCEEEEECCCCCCCCHHHHHHEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
FESVTATVLDGLNAANIMEGHRLVEQGKTSGKIVVRV
CHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA