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The map label for this gene is lysS [H]

Identifier: 62391524

GI number: 62391524

Start: 2833810

End: 2835390

Strand: Reverse

Name: lysS [H]

Synonym: cg2974

Alternate gene names: 62391524

Gene position: 2835390-2833810 (Counterclockwise)

Preceding gene: 62391525

Following gene: 62391523

Centisome position: 86.37

GC content: 58.06

Gene sequence:

>1581_bases
GTGACTAATTCCAATCCCACTTCCAAGAACAATTCCGCCGATTTGCCTGAGCAGCTGCGAATTCGTCGCGAAAAGCGCGA
GCGCATTCTGGACAGTGGATTGGACGCCTACCCAGTCGAGGTTGATCGCACCATCTCAATCTCTGACCTGCGCTCCCAAT
TTGTTGTCATTACAGAAGACCTCCAAGAGCGCGAAGAAGGCGTAACCTACCTCGAAGTAGGCGAAGAAACCGACGTTGAG
GTCGCAATCGCTGGCCGCGTCATGTTCGTTCGCAACACCGGCAAGCTCTGCTTCGCATCCATCCAAGAAGGAAACGGCAC
CACCGTCCAAGCAATGCTGTCCCTGGCAGCAGTCGGTGAAGAATCCCTCAAGGCCTGGAAAGCCGATGTGGACATGGGTG
ACATCGTTTCCGTCCGCGGCAAAGTAATCTCCTCCAAGCGTGGCGAACTCTCCGTGATGGCTGACTCCTGGCACATGGCC
TCCAAGTCCCTGCGCCCACTGCCAGTCGCATTCGCGGACCTCAGCGAAGACACCCGCGTCCGCCACCGCTACACCGACCT
CATCATGCGCGAACAAGCCCGCACCAACGCGCTCACCCGCATCAAGGTCATGCGTGCACTCCGCCACTACCTCGAAGACC
AAGACTTCCTTGAGGTAGAAACCCCCATGCTGCAAACCCTCCACGGTGGCGCAGCAGCACGACCATTCGAAACCCACTCC
AACGCCCTCGACATTGACCTCTACCTGCGCATCGCACCAGAGCTTTACCTCAAGCGCTGCGTTGTCGGCGGCATCGAGCG
CGTCTTCGAAGTCAACCGCAACTTCCGCAACGAAGGCGTCGACTCCTCCCACTCCCCAGAATTCGCCATGCTCGAAACCT
ACGAAGCCTGGGGAACCTACGAAACCGGCGCGAAACTGATCAAGGGTCTCGTCCAATCCGTCGCCCAAGAAGTCTTCGGA
ACCACCCTGGTCACCCTCGCAGACGGCACCGAATACGACCTCGGCGGCGAGTGGAAAGTCATCGAGATGTACCCTTCCCT
CAACGAAGCCCTCGCACGCAAATTCCCAGGACAACCAGAAGTAACCATCGACTCCACCGTCGAAGAACTCCGCGAAATCG
CCAAGGTAATCGGCCTCTCCGTCCCCGAAAACGGCGGCTGGGGACACGGCAAACTCGTCGAAGAAATCTGGGAACTCCTC
TGCGAAGACCAACTCTACGGACCAATCTTTGTCAAAGACTTCCCAGTAGAAACCTCCCCACTCACACGCCAACACCGCAC
CAAGCCAGGCGTCACCGAAAAGTGGGACCTCTACGTCCGCGGATTTGAACTAGCAACCGGATACTCCGAACTCATCGACC
CAGTCATCCAACGCGAACGCTTCGAAGACCAAGCCCGCCTCGCCGCCGACGGAGACGACGAAGCCATGGTCCTCGACGAA
GACTTCCTCACCGCAATGGAACAAGGCATGCCACCAACCTCCGGCAACGGCATGGGAATCGACCGCCTCCTCATGGCCCT
CACCGGCCTCGGAATCCGCGAAACCGTACTCTTCCCAATGGTGAAACCAGAACAAAAGTAG

Upstream 100 bases:

>100_bases
CACGACAACGTCGGCCTACCCCTTGGAATCGGCTTCAAAAACATCGAAGGCTGATCCCGGTTTACCCAGTTCGCATACCT
TTCGACTACCCTAGGAAATC

Downstream 100 bases:

>100_bases
GTTTTTGCTCTTTGTGCTTGGGATGGACTGGAGTTTGAGCTGTTTGACTCCAAGGACCTCCGGCTTGCCGGGGATCTTTT
AGTGGCTGAAGGGGCGACAT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MTNSNPTSKNNSADLPEQLRIRREKRERILDSGLDAYPVEVDRTISISDLRSQFVVITEDLQEREEGVTYLEVGEETDVE
VAIAGRVMFVRNTGKLCFASIQEGNGTTVQAMLSLAAVGEESLKAWKADVDMGDIVSVRGKVISSKRGELSVMADSWHMA
SKSLRPLPVAFADLSEDTRVRHRYTDLIMREQARTNALTRIKVMRALRHYLEDQDFLEVETPMLQTLHGGAAARPFETHS
NALDIDLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYEAWGTYETGAKLIKGLVQSVAQEVFG
TTLVTLADGTEYDLGGEWKVIEMYPSLNEALARKFPGQPEVTIDSTVEELREIAKVIGLSVPENGGWGHGKLVEEIWELL
CEDQLYGPIFVKDFPVETSPLTRQHRTKPGVTEKWDLYVRGFELATGYSELIDPVIQRERFEDQARLAADGDDEAMVLDE
DFLTAMEQGMPPTSGNGMGIDRLLMALTGLGIRETVLFPMVKPEQK

Sequences:

>Translated_526_residues
MTNSNPTSKNNSADLPEQLRIRREKRERILDSGLDAYPVEVDRTISISDLRSQFVVITEDLQEREEGVTYLEVGEETDVE
VAIAGRVMFVRNTGKLCFASIQEGNGTTVQAMLSLAAVGEESLKAWKADVDMGDIVSVRGKVISSKRGELSVMADSWHMA
SKSLRPLPVAFADLSEDTRVRHRYTDLIMREQARTNALTRIKVMRALRHYLEDQDFLEVETPMLQTLHGGAAARPFETHS
NALDIDLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYEAWGTYETGAKLIKGLVQSVAQEVFG
TTLVTLADGTEYDLGGEWKVIEMYPSLNEALARKFPGQPEVTIDSTVEELREIAKVIGLSVPENGGWGHGKLVEEIWELL
CEDQLYGPIFVKDFPVETSPLTRQHRTKPGVTEKWDLYVRGFELATGYSELIDPVIQRERFEDQARLAADGDDEAMVLDE
DFLTAMEQGMPPTSGNGMGIDRLLMALTGLGIRETVLFPMVKPEQK
>Mature_525_residues
TNSNPTSKNNSADLPEQLRIRREKRERILDSGLDAYPVEVDRTISISDLRSQFVVITEDLQEREEGVTYLEVGEETDVEV
AIAGRVMFVRNTGKLCFASIQEGNGTTVQAMLSLAAVGEESLKAWKADVDMGDIVSVRGKVISSKRGELSVMADSWHMAS
KSLRPLPVAFADLSEDTRVRHRYTDLIMREQARTNALTRIKVMRALRHYLEDQDFLEVETPMLQTLHGGAAARPFETHSN
ALDIDLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYEAWGTYETGAKLIKGLVQSVAQEVFGT
TLVTLADGTEYDLGGEWKVIEMYPSLNEALARKFPGQPEVTIDSTVEELREIAKVIGLSVPENGGWGHGKLVEEIWELLC
EDQLYGPIFVKDFPVETSPLTRQHRTKPGVTEKWDLYVRGFELATGYSELIDPVIQRERFEDQARLAADGDDEAMVLDED
FLTAMEQGMPPTSGNGMGIDRLLMALTGLGIRETVLFPMVKPEQK

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=528, Percent_Identity=37.5, Blast_Score=328, Evalue=1e-89,
Organism=Homo sapiens, GI194272210, Length=528, Percent_Identity=37.5, Blast_Score=327, Evalue=1e-89,
Organism=Escherichia coli, GI1790571, Length=531, Percent_Identity=38.9830508474576, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1789256, Length=529, Percent_Identity=39.6975425330813, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI87082379, Length=333, Percent_Identity=30.03003003003, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788173, Length=178, Percent_Identity=28.0898876404494, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535927, Length=520, Percent_Identity=36.3461538461538, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17535925, Length=520, Percent_Identity=36.3461538461538, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI71994340, Length=519, Percent_Identity=36.8015414258189, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17551876, Length=486, Percent_Identity=23.8683127572016, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI32566633, Length=216, Percent_Identity=26.8518518518519, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320242, Length=475, Percent_Identity=37.8947368421053, Blast_Score=302, Evalue=7e-83,
Organism=Saccharomyces cerevisiae, GI6324256, Length=502, Percent_Identity=27.6892430278884, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24640849, Length=510, Percent_Identity=38.0392156862745, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24640851, Length=502, Percent_Identity=38.2470119521912, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI17136276, Length=484, Percent_Identity=23.9669421487603, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 58928; Mature: 58796

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSNPTSKNNSADLPEQLRIRREKRERILDSGLDAYPVEVDRTISISDLRSQFVVITED
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHCCCEEEEEHH
LQEREEGVTYLEVGEETDVEVAIAGRVMFVRNTGKLCFASIQEGNGTTVQAMLSLAAVGE
HHHHHCCCEEEEECCCCCEEEEEECEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCH
ESLKAWKADVDMGDIVSVRGKVISSKRGELSVMADSWHMASKSLRPLPVAFADLSEDTRV
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHCCCCCCCEEECCCCCHHHH
RHRYTDLIMREQARTNALTRIKVMRALRHYLEDQDFLEVETPMLQTLHGGAAARPFETHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHCCCCCCCCCCCCC
NALDIDLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYEAWGTY
CEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHCCCH
ETGAKLIKGLVQSVAQEVFGTTLVTLADGTEYDLGGEWKVIEMYPSLNEALARKFPGQPE
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCC
VTIDSTVEELREIAKVIGLSVPENGGWGHGKLVEEIWELLCEDQLYGPIFVKDFPVETSP
EEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC
LTRQHRTKPGVTEKWDLYVRGFELATGYSELIDPVIQRERFEDQARLAADGDDEAMVLDE
CCHHHCCCCCCCCCEEEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECH
DFLTAMEQGMPPTSGNGMGIDRLLMALTGLGIRETVLFPMVKPEQK
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHEECCCCCCCC
>Mature Secondary Structure 
TNSNPTSKNNSADLPEQLRIRREKRERILDSGLDAYPVEVDRTISISDLRSQFVVITED
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHCCCEEEEEHH
LQEREEGVTYLEVGEETDVEVAIAGRVMFVRNTGKLCFASIQEGNGTTVQAMLSLAAVGE
HHHHHCCCEEEEECCCCCEEEEEECEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCH
ESLKAWKADVDMGDIVSVRGKVISSKRGELSVMADSWHMASKSLRPLPVAFADLSEDTRV
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHCCCCCCCEEECCCCCHHHH
RHRYTDLIMREQARTNALTRIKVMRALRHYLEDQDFLEVETPMLQTLHGGAAARPFETHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHCCCCCCCCCCCCC
NALDIDLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYEAWGTY
CEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHCCCH
ETGAKLIKGLVQSVAQEVFGTTLVTLADGTEYDLGGEWKVIEMYPSLNEALARKFPGQPE
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCC
VTIDSTVEELREIAKVIGLSVPENGGWGHGKLVEEIWELLCEDQLYGPIFVKDFPVETSP
EEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC
LTRQHRTKPGVTEKWDLYVRGFELATGYSELIDPVIQRERFEDQARLAADGDDEAMVLDE
CCHHHCCCCCCCCCEEEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECH
DFLTAMEQGMPPTSGNGMGIDRLLMALTGLGIRETVLFPMVKPEQK
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA