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The map label for this gene is purD

Identifier: 62391439

GI number: 62391439

Start: 2739464

End: 2740729

Strand: Reverse

Name: purD

Synonym: cg2878

Alternate gene names: 62391439

Gene position: 2740729-2739464 (Counterclockwise)

Preceding gene: 62391441

Following gene: 62391438

Centisome position: 83.49

GC content: 56.64

Gene sequence:

>1266_bases
ATGCGCATTCTGGTAATCGGCTCGGGCGCCCGTGAGCACGCCCTCCTCCGTGGACTGTCAACTGACCCTGCAACCACTGA
ACTCCACGTTGCCCCAGGTAACGCTGGTCTTGGATCGATCGCAACTGTCCACCCTGGCATCAAGGCTGATGATCCAGAGG
CTGTCACTGCGTTGGCTAAAGAACTGAACTCTGATCTGGTTGTTATCGGCCCAGAGATCCCTTTGGTTGCGGGTGTTGCT
GATGCACTTCGCGCGGCGGGTATCGCTGTGTTTGGTCCTAACAAGGACGCTGCTCGTATCGAGGGCTCCAAGGCTTTCGC
TAAGGATGTCATGGCTGCGCAGGGTGTTCGTACTGCTCATGCTGAGGCTATTACTCCTGGTGCGTCTTCTGAAGATATTG
ATGCTGCCATCGATCGTTTCGGCCCAACCTGGGTTGTGAAGGATGATGGTTTGGCTGCGGGCAAGGGTGTTGTGGTTACC
CCCGATCGTGCAGCAGCACGTGCTCACGTAGATGCAGTGCTTGAGGGCGGAAATCCAGTTTTGCTGGAGTCCTTCCTTGA
TGGCCCTGAGGTTTCCCTGTTCTGCCTGGTTGATGGCGAGACGGTAGTTCCTCTGCTGCCAGCGCAGGATCACAAGCGTG
CGTACGACAACGATGAGGGCCCAAACACTGGTGGCATGGGTGCTTATGCGCCGCTTCCTTGGCTGCCTGAAGATGGCGTC
CAGCGCATTGTCGATGAGGTCTGCGTTCCTGTTGCTCGTGAGATGGTGGCACGTGGTTGCGCGTACTCCGGTCTGCTTTA
CGCAGGTATCGCATGGGGTGCAGAAGGCCCTGCAGTAGTGGAGTTCAACTGCCGCTTCGGCGATCCAGAAACCCAGGCTG
TACTGGCACTACTGAAGACTCCTCTAGCAGTACTGCTCAACGCAGTTGCTACTGGAACCTTGGCAGAGCAGCCAGCACTG
GAGTGGGAGGATGCTTACGCCCTGACTGTGGTGTTGGCTTCTTACAACTACCCAGAGGCACCTCGTACTGGTGATGTCAT
CCGCAACGCTGATGCAGATAACGTTCTTCACGCTGGTACCGCACTCAATGCTGAAGGCGAGCTGGTCTCTGCGGGCGGTC
GTGTTCTTAACGTGATCGGTGTGGGTGAGACCCTGGAGGCTGCACGCGATAACGCGTACACCACCATCAAGGACATTGAA
CTTGAGGGAAGCCACTACCGCAGCGATATCGCATTGGCTGCATTAGAGGGTCGTATCTCGATCTAA

Upstream 100 bases:

>100_bases
TCATTTTAAGGCGCTTTTCGACGCCACTTTCAACCATTTCCGAACCGCCAAGAATACTGGAATAGCTTGGATCAAGTTTT
GCAGGATAAACTGTGCAACC

Downstream 100 bases:

>100_bases
AAGCAGTACGCAGATAGGCTTGTCTCTTATGAAGCCAAGCACTAGAAGCAATGTTCAGCCGTTTCGCGTCATGCAGATGT
TGGACCGAGTCCACCGTCGC

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MRILVIGSGAREHALLRGLSTDPATTELHVAPGNAGLGSIATVHPGIKADDPEAVTALAKELNSDLVVIGPEIPLVAGVA
DALRAAGIAVFGPNKDAARIEGSKAFAKDVMAAQGVRTAHAEAITPGASSEDIDAAIDRFGPTWVVKDDGLAAGKGVVVT
PDRAAARAHVDAVLEGGNPVLLESFLDGPEVSLFCLVDGETVVPLLPAQDHKRAYDNDEGPNTGGMGAYAPLPWLPEDGV
QRIVDEVCVPVAREMVARGCAYSGLLYAGIAWGAEGPAVVEFNCRFGDPETQAVLALLKTPLAVLLNAVATGTLAEQPAL
EWEDAYALTVVLASYNYPEAPRTGDVIRNADADNVLHAGTALNAEGELVSAGGRVLNVIGVGETLEAARDNAYTTIKDIE
LEGSHYRSDIALAALEGRISI

Sequences:

>Translated_421_residues
MRILVIGSGAREHALLRGLSTDPATTELHVAPGNAGLGSIATVHPGIKADDPEAVTALAKELNSDLVVIGPEIPLVAGVA
DALRAAGIAVFGPNKDAARIEGSKAFAKDVMAAQGVRTAHAEAITPGASSEDIDAAIDRFGPTWVVKDDGLAAGKGVVVT
PDRAAARAHVDAVLEGGNPVLLESFLDGPEVSLFCLVDGETVVPLLPAQDHKRAYDNDEGPNTGGMGAYAPLPWLPEDGV
QRIVDEVCVPVAREMVARGCAYSGLLYAGIAWGAEGPAVVEFNCRFGDPETQAVLALLKTPLAVLLNAVATGTLAEQPAL
EWEDAYALTVVLASYNYPEAPRTGDVIRNADADNVLHAGTALNAEGELVSAGGRVLNVIGVGETLEAARDNAYTTIKDIE
LEGSHYRSDIALAALEGRISI
>Mature_421_residues
MRILVIGSGAREHALLRGLSTDPATTELHVAPGNAGLGSIATVHPGIKADDPEAVTALAKELNSDLVVIGPEIPLVAGVA
DALRAAGIAVFGPNKDAARIEGSKAFAKDVMAAQGVRTAHAEAITPGASSEDIDAAIDRFGPTWVVKDDGLAAGKGVVVT
PDRAAARAHVDAVLEGGNPVLLESFLDGPEVSLFCLVDGETVVPLLPAQDHKRAYDNDEGPNTGGMGAYAPLPWLPEDGV
QRIVDEVCVPVAREMVARGCAYSGLLYAGIAWGAEGPAVVEFNCRFGDPETQAVLALLKTPLAVLLNAVATGTLAEQPAL
EWEDAYALTVVLASYNYPEAPRTGDVIRNADADNVLHAGTALNAEGELVSAGGRVLNVIGVGETLEAARDNAYTTIKDIE
LEGSHYRSDIALAALEGRISI

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI28416899, Length=431, Percent_Identity=40.6032482598608, Blast_Score=299, Evalue=4e-81,
Organism=Homo sapiens, GI4503915, Length=426, Percent_Identity=41.3145539906103, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI209869995, Length=426, Percent_Identity=41.3145539906103, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI209869993, Length=426, Percent_Identity=41.3145539906103, Blast_Score=298, Evalue=7e-81,
Organism=Escherichia coli, GI1790438, Length=429, Percent_Identity=42.4242424242424, Blast_Score=306, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17567511, Length=424, Percent_Identity=36.7924528301887, Blast_Score=240, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6321203, Length=444, Percent_Identity=36.7117117117117, Blast_Score=248, Evalue=1e-66,
Organism=Drosophila melanogaster, GI62471619, Length=434, Percent_Identity=40.0921658986175, Blast_Score=267, Evalue=9e-72,
Organism=Drosophila melanogaster, GI24582400, Length=434, Percent_Identity=40.0921658986175, Blast_Score=266, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PUR2_CORGL (Q8NMH3)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927155
- RefSeq:   NP_601800.1
- RefSeq:   YP_226841.1
- ProteinModelPortal:   Q8NMH3
- SMR:   Q8NMH3
- GeneID:   1020546
- GeneID:   3343136
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2878
- KEGG:   cgl:NCgl2511
- HOGENOM:   HBG404060
- OMA:   GVPIVIK
- ProtClustDB:   PRK00885
- BioCyc:   CGLU196627:CG2878-MONOMER
- BRENDA:   6.3.4.13
- HAMAP:   MF_00138
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.90.600.10
- Gene3D:   G3DSA:3.40.50.20
- TIGRFAMs:   TIGR00877

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N; SSF52440 PreATP-grasp-like; SSF51246 Rudmnt_hyb_motif

EC number: =6.3.4.13

Molecular weight: Translated: 43546; Mature: 43546

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: PS50975 ATP_GRASP; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVIGSGAREHALLRGLSTDPATTELHVAPGNAGLGSIATVHPGIKADDPEAVTALAK
CEEEEEECCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHH
ELNSDLVVIGPEIPLVAGVADALRAAGIAVFGPNKDAARIEGSKAFAKDVMAAQGVRTAH
HHCCCEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCEECCCHHHHHHHHHHCCCCHHH
AEAITPGASSEDIDAAIDRFGPTWVVKDDGLAAGKGVVVTPDRAAARAHVDAVLEGGNPV
HHHCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHEEECCCEE
LLESFLDGPEVSLFCLVDGETVVPLLPAQDHKRAYDNDEGPNTGGMGAYAPLPWLPEDGV
EEHHHCCCCCEEEEEEECCCEEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHH
QRIVDEVCVPVAREMVARGCAYSGLLYAGIAWGAEGPAVVEFNCRFGDPETQAVLALLKT
HHHHHHHHHHHHHHHHHHCCHHCCHHHHHEEECCCCCEEEEEEECCCCCHHHHHHHHHHH
PLAVLLNAVATGTLAEQPALEWEDAYALTVVLASYNYPEAPRTGDVIRNADADNVLHAGT
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHCCCCCCCEEECCE
ALNAEGELVSAGGRVLNVIGVGETLEAARDNAYTTIKDIELEGSHYRSDIALAALEGRIS
EECCCCCEEECCCEEEEEEECCHHHHHHCCCCEEEEEEEEECCCCCCCCEEEEEECCCCC
I
C
>Mature Secondary Structure
MRILVIGSGAREHALLRGLSTDPATTELHVAPGNAGLGSIATVHPGIKADDPEAVTALAK
CEEEEEECCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHH
ELNSDLVVIGPEIPLVAGVADALRAAGIAVFGPNKDAARIEGSKAFAKDVMAAQGVRTAH
HHCCCEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCEECCCHHHHHHHHHHCCCCHHH
AEAITPGASSEDIDAAIDRFGPTWVVKDDGLAAGKGVVVTPDRAAARAHVDAVLEGGNPV
HHHCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHEEECCCEE
LLESFLDGPEVSLFCLVDGETVVPLLPAQDHKRAYDNDEGPNTGGMGAYAPLPWLPEDGV
EEHHHCCCCCEEEEEEECCCEEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHH
QRIVDEVCVPVAREMVARGCAYSGLLYAGIAWGAEGPAVVEFNCRFGDPETQAVLALLKT
HHHHHHHHHHHHHHHHHHCCHHCCHHHHHEEECCCCCEEEEEEECCCCCHHHHHHHHHHH
PLAVLLNAVATGTLAEQPALEWEDAYALTVVLASYNYPEAPRTGDVIRNADADNVLHAGT
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHCCCCCCCEEECCE
ALNAEGELVSAGGRVLNVIGVGETLEAARDNAYTTIKDIELEGSHYRSDIALAALEGRIS
EECCCCCEEECCCEEEEEEECCHHHHHHCCCCEEEEEEEEECCCCCCCCEEEEEECCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626