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The map label for this gene is glmS [H]

Identifier: 62391112

GI number: 62391112

Start: 2373816

End: 2375693

Strand: Reverse

Name: glmS [H]

Synonym: cg2492

Alternate gene names: 62391112

Gene position: 2375693-2373816 (Counterclockwise)

Preceding gene: 62391114

Following gene: 62391109

Centisome position: 72.37

GC content: 53.62

Gene sequence:

>1878_bases
ATGCGCATGTGTGGAATTGTTGGATATATTGGCCAAGCGGGCGACTCCCGTGATTACTTTGCTCTAGATGTAGTTGTTGA
AGGACTACGTCGCCTGGAATACCGCGGATATGACTCCGCAGGTATTGCTATTCACGCCAATGGTGAGATTAGCTACCGAA
AGAAGGCCGGAAAGGTTGCTGCACTAGATGCAGAAATCGCTAAAGCACCTCTTCCAGATTCTATTTTGGGAATTGGACAC
ACCCGTTGGGCAACTCATGGTGGCCCAACCGATGTCAACGCTCACCCCCACGTTGTTTCCAATGGCAAGCTTGCCGTAGT
ACACAACGGCATCATCGAAAACTTTGCGGAACTGCGCTCTGAGCTTTCCGCTAAGGGCTACAACTTTGTATCCGATACCG
ATACCGAAGTTGCTGCTTCTTTGCTTGCTGAAATTTACAATACTCAGGCAAACGGTGACCTCACCCTTGCTATGCAGCTG
ACCGGTCAGCGCCTTGAGGGTGCTTTCACCCTGCTAGCTATTCATGCTGATCACGATGACCGCATCGTTGCAGCTCGTCG
TAACTCTCCTTTGGTTATCGGCGTCGGCGAGGGCGAGAACTTCCTCGGATCTGACGTTTCTGGCTTTATTGATTACACCC
GCAAGGCTGTAGAGCTGGCTAATGACCAGGTTGTTACCATCACCGCTGATGATTACGCCATCACCAACTTTGATGGATCA
GAAGCAGTTGGCAAGCCTTTCGACGTGGAGTGGGACGCTGCAGCTGCTGAAAAGGGTGGCTTCGGTTCCTTCATGGAGAA
GGAAATCCACGATCAGCCAGCAGCTGTTCGCGATACCCTGATGGGCCGTCTTGATGAAGATGGCAAGCTCGTTCTTGATG
AGCTGCGCATCGATGAAGCTATTCTGCGTAGTGTCGACAAGATCGTCATTGTTGCTTGTGGTACTGCAGCTTATGCAGGC
CAGGTTGCTCGTTACGCCATTGAGCACTGGTGCCGCATCCCAACCGAGGTGGAGCTGGCTCACGAGTTCCGTTACCGCGA
CCCAATCCTCAACGAGAAGACCCTTGTTGTGGCATTGTCCCAGTCCGGCGAGACCATGGATACCCTCATGGCTGTTCGCC
ACGCACGTGAGCAGGGTGCCAAGGTTGTTGCTATTTGTAACACTGTTGGATCCACTCTTCCACGTGAAGCAGATGCGTCC
CTGTACACCTACGCTGGCCCTGAGATCGCTGTGGCGTCCACCAAGGCGTTCTTGGCTCAGATCACTGCTTCTTACTTGCT
TGGCCTGTACTTGGCTCAGCTGCGCGGCAACAAGTTCGCTGATGAGGTTTCTTCCATTCTGGACAGCCTGCGTGAGATGC
CTGAGAAGATTCAGCAGGTCATCGATGCAGAAGAGCAGATCAAGAAGCTTGGCCAAGATATGGCAGATGCTAAGTCTGTG
CTGTTCCTGGGCCGCCACGTTGGTTTCCCAGTTGCGCTTGAGGGTGCGTTGAAGCTCAAGGAGATCGCATACCTGCACGC
TGAAGGTTTCGCTGCAGGCGAGCTCAAGCACGGCCCAATTGCTTTGGTTGAGGAAGGCCAGCCGATCTTCGTTATCGTGC
CTTCACCTCGTGGTCGCGATTCCCTGCACTCCAAGGTTGTCTCCAACATTCAGGAGATCCGTGCACGTGGCGCTGTCACC
ATCGTGATTGCAGAGGAAGGCGATGAGGCTGTCAACGATTACGCCAACTTCATCATCCGCATTCCTCAGGCCCCAACCCT
GATGCAGCCTCTGCTGTCCACCGTGCCTCTGCAGATCTTTGCGTGCGCTGTGGCAACCGCAAAGGGCTACAACGTGGATC
AGCCTCGTAACCTGGCAAAGTCTGTCACCGTCGAATAA

Upstream 100 bases:

>100_bases
TTGCGTGCTGCAACTTAATTATGGTCCTCCCAGCTCAGTGTGCTGTGTGGATTGTTTATTCTCGTCCATTAAGTGATCGA
GAAAAAGTTGTTGTAAAGTC

Downstream 100 bases:

>100_bases
AAAGATTTCGCTTCTCGACGCCAAGTGCCGCCCCAAGGGGCGGCACTTGTGGTGTTTTTAGCGACGGTTGAAGCGCAGAT
CAACGCCTAGATCATCGCAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MRMCGIVGYIGQAGDSRDYFALDVVVEGLRRLEYRGYDSAGIAIHANGEISYRKKAGKVAALDAEIAKAPLPDSILGIGH
TRWATHGGPTDVNAHPHVVSNGKLAVVHNGIIENFAELRSELSAKGYNFVSDTDTEVAASLLAEIYNTQANGDLTLAMQL
TGQRLEGAFTLLAIHADHDDRIVAARRNSPLVIGVGEGENFLGSDVSGFIDYTRKAVELANDQVVTITADDYAITNFDGS
EAVGKPFDVEWDAAAAEKGGFGSFMEKEIHDQPAAVRDTLMGRLDEDGKLVLDELRIDEAILRSVDKIVIVACGTAAYAG
QVARYAIEHWCRIPTEVELAHEFRYRDPILNEKTLVVALSQSGETMDTLMAVRHAREQGAKVVAICNTVGSTLPREADAS
LYTYAGPEIAVASTKAFLAQITASYLLGLYLAQLRGNKFADEVSSILDSLREMPEKIQQVIDAEEQIKKLGQDMADAKSV
LFLGRHVGFPVALEGALKLKEIAYLHAEGFAAGELKHGPIALVEEGQPIFVIVPSPRGRDSLHSKVVSNIQEIRARGAVT
IVIAEEGDEAVNDYANFIIRIPQAPTLMQPLLSTVPLQIFACAVATAKGYNVDQPRNLAKSVTVE

Sequences:

>Translated_625_residues
MRMCGIVGYIGQAGDSRDYFALDVVVEGLRRLEYRGYDSAGIAIHANGEISYRKKAGKVAALDAEIAKAPLPDSILGIGH
TRWATHGGPTDVNAHPHVVSNGKLAVVHNGIIENFAELRSELSAKGYNFVSDTDTEVAASLLAEIYNTQANGDLTLAMQL
TGQRLEGAFTLLAIHADHDDRIVAARRNSPLVIGVGEGENFLGSDVSGFIDYTRKAVELANDQVVTITADDYAITNFDGS
EAVGKPFDVEWDAAAAEKGGFGSFMEKEIHDQPAAVRDTLMGRLDEDGKLVLDELRIDEAILRSVDKIVIVACGTAAYAG
QVARYAIEHWCRIPTEVELAHEFRYRDPILNEKTLVVALSQSGETMDTLMAVRHAREQGAKVVAICNTVGSTLPREADAS
LYTYAGPEIAVASTKAFLAQITASYLLGLYLAQLRGNKFADEVSSILDSLREMPEKIQQVIDAEEQIKKLGQDMADAKSV
LFLGRHVGFPVALEGALKLKEIAYLHAEGFAAGELKHGPIALVEEGQPIFVIVPSPRGRDSLHSKVVSNIQEIRARGAVT
IVIAEEGDEAVNDYANFIIRIPQAPTLMQPLLSTVPLQIFACAVATAKGYNVDQPRNLAKSVTVE
>Mature_625_residues
MRMCGIVGYIGQAGDSRDYFALDVVVEGLRRLEYRGYDSAGIAIHANGEISYRKKAGKVAALDAEIAKAPLPDSILGIGH
TRWATHGGPTDVNAHPHVVSNGKLAVVHNGIIENFAELRSELSAKGYNFVSDTDTEVAASLLAEIYNTQANGDLTLAMQL
TGQRLEGAFTLLAIHADHDDRIVAARRNSPLVIGVGEGENFLGSDVSGFIDYTRKAVELANDQVVTITADDYAITNFDGS
EAVGKPFDVEWDAAAAEKGGFGSFMEKEIHDQPAAVRDTLMGRLDEDGKLVLDELRIDEAILRSVDKIVIVACGTAAYAG
QVARYAIEHWCRIPTEVELAHEFRYRDPILNEKTLVVALSQSGETMDTLMAVRHAREQGAKVVAICNTVGSTLPREADAS
LYTYAGPEIAVASTKAFLAQITASYLLGLYLAQLRGNKFADEVSSILDSLREMPEKIQQVIDAEEQIKKLGQDMADAKSV
LFLGRHVGFPVALEGALKLKEIAYLHAEGFAAGELKHGPIALVEEGQPIFVIVPSPRGRDSLHSKVVSNIQEIRARGAVT
IVIAEEGDEAVNDYANFIIRIPQAPTLMQPLLSTVPLQIFACAVATAKGYNVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=690, Percent_Identity=35.0724637681159, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI205277386, Length=686, Percent_Identity=36.0058309037901, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI29570798, Length=198, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790167, Length=626, Percent_Identity=44.7284345047923, Blast_Score=489, Evalue=1e-139,
Organism=Escherichia coli, GI87082251, Length=328, Percent_Identity=22.5609756097561, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539970, Length=718, Percent_Identity=32.8690807799443, Blast_Score=359, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17532899, Length=724, Percent_Identity=33.0110497237569, Blast_Score=354, Evalue=7e-98,
Organism=Caenorhabditis elegans, GI17532897, Length=738, Percent_Identity=32.9268292682927, Blast_Score=347, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6322745, Length=436, Percent_Identity=38.7614678899083, Blast_Score=280, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6323731, Length=432, Percent_Identity=28.4722222222222, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=41.9512195121951, Blast_Score=147, Evalue=6e-36,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=34.593023255814, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI28573187, Length=145, Percent_Identity=33.7931034482759, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67503; Mature: 67503

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMCGIVGYIGQAGDSRDYFALDVVVEGLRRLEYRGYDSAGIAIHANGEISYRKKAGKVA
CCCCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEHHCCCCEE
ALDAEIAKAPLPDSILGIGHTRWATHGGPTDVNAHPHVVSNGKLAVVHNGIIENFAELRS
EECHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEECHHHHHHHHHHH
ELSAKGYNFVSDTDTEVAASLLAEIYNTQANGDLTLAMQLTGQRLEGAFTLLAIHADHDD
HHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCC
RIVAARRNSPLVIGVGEGENFLGSDVSGFIDYTRKAVELANDQVVTITADDYAITNFDGS
EEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCC
EAVGKPFDVEWDAAAAEKGGFGSFMEKEIHDQPAAVRDTLMGRLDEDGKLVLDELRIDEA
CCCCCCCCCCCCCHHCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCEEHHHHHHHHH
ILRSVDKIVIVACGTAAYAGQVARYAIEHWCRIPTEVELAHEFRYRDPILNEKTLVVALS
HHHCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
QSGETMDTLMAVRHAREQGAKVVAICNTVGSTLPREADASLYTYAGPEIAVASTKAFLAQ
CCCCHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCCEEEECCCCEEEHHHHHHHHH
ITASYLLGLYLAQLRGNKFADEVSSILDSLREMPEKIQQVIDAEEQIKKLGQDMADAKSV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LFLGRHVGFPVALEGALKLKEIAYLHAEGFAAGELKHGPIALVEEGQPIFVIVPSPRGRD
HHHHHHCCCCEEECCHHHHHHHHEECCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCH
SLHSKVVSNIQEIRARGAVTIVIAEEGDEAVNDYANFIIRIPQAPTLMQPLLSTVPLQIF
HHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHH
ACAVATAKGYNVDQPRNLAKSVTVE
HHHHHHCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MRMCGIVGYIGQAGDSRDYFALDVVVEGLRRLEYRGYDSAGIAIHANGEISYRKKAGKVA
CCCCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEHHCCCCEE
ALDAEIAKAPLPDSILGIGHTRWATHGGPTDVNAHPHVVSNGKLAVVHNGIIENFAELRS
EECHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEECHHHHHHHHHHH
ELSAKGYNFVSDTDTEVAASLLAEIYNTQANGDLTLAMQLTGQRLEGAFTLLAIHADHDD
HHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCC
RIVAARRNSPLVIGVGEGENFLGSDVSGFIDYTRKAVELANDQVVTITADDYAITNFDGS
EEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCC
EAVGKPFDVEWDAAAAEKGGFGSFMEKEIHDQPAAVRDTLMGRLDEDGKLVLDELRIDEA
CCCCCCCCCCCCCHHCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCEEHHHHHHHHH
ILRSVDKIVIVACGTAAYAGQVARYAIEHWCRIPTEVELAHEFRYRDPILNEKTLVVALS
HHHCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
QSGETMDTLMAVRHAREQGAKVVAICNTVGSTLPREADASLYTYAGPEIAVASTKAFLAQ
CCCCHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCCEEEECCCCEEEHHHHHHHHH
ITASYLLGLYLAQLRGNKFADEVSSILDSLREMPEKIQQVIDAEEQIKKLGQDMADAKSV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LFLGRHVGFPVALEGALKLKEIAYLHAEGFAAGELKHGPIALVEEGQPIFVIVPSPRGRD
HHHHHHCCCCEEECCHHHHHHHHEECCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCH
SLHSKVVSNIQEIRARGAVTIVIAEEGDEAVNDYANFIIRIPQAPTLMQPLLSTVPLQIF
HHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHH
ACAVATAKGYNVDQPRNLAKSVTVE
HHHHHHCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]