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The map label for this gene is hisC [H]

Identifier: 62390936

GI number: 62390936

Start: 2186522

End: 2187622

Strand: Reverse

Name: hisC [H]

Synonym: cg2304

Alternate gene names: 62390936

Gene position: 2187622-2186522 (Counterclockwise)

Preceding gene: 62390937

Following gene: 62390935

Centisome position: 66.64

GC content: 54.86

Gene sequence:

>1101_bases
ATGACCAAAATTACTTTGAGCGATTTGCCATTGCGTGAAGAACTGCGCGGTGAGCACGCTTACGGCGCACCCCAGCTCAA
CGTTGATATTCGCCTCAACACCAACGAAAACCCTTACCCACCGTCAGAGGCATTGGTCGCTGACTTGGTTGCCACCGTGG
ATAAGATCGCCACCGAGCTGAACCGCTACCCAGAGCGCGATGCTGTGGAACTGCGTGATGAGTTGGCTGCGTACATCACC
AAGCAAACCGGCGTGGCTGTCACCAGGGATAACCTGTGGGCTGCCAATGGTTCCAATGAAATTCTGCAGCAGCTGCTGCA
GGCTTTTGGTGGACCTGGACGCACCGCGTTGGGATTCCAACCCAGCTATTCCATGCACCCAATTTTGGCTAAAGGCACCC
ACACTGAATTCATTGCGGTGTCCCGAGGTGCTGATTTCCGCATCGATATGGATGTGGCGCTGGAAGAAATTCGTGCAAAG
CAGCCTGACATTGTTTTTGTCACCACCCCGAACAACCCGACCGGTGATGTGACCTCGCTGGACGATGTTGAGCGCATCAT
CAACGTTGCCCCAGGCATCGTGATCGTGGATGAAGCTTATGCGGAATTCTCCCCATCACCTTCAGCAACCACTCTTCTGG
AGAAGTACCCAACCAAGCTGGTGGTGTCCCGCACCATGAGTAAGGCTTTTGATTTCGCAGGTGGACGCCTCGGCTACTTC
GTGGCCAACCCAGCGTTTATCGACGCCGTGATGCTAGTCCGCCTTCCGTATCATCTTTCAGCGCTGAGCCAAGCAGCCGC
AATCGTAGCGCTGCGTCACTCCGCTGACACGCTGGGAACCGTCGAAAAGCTCTCTGTAGAGCGTGTTCGCGTGGCAGCAC
GCTTGGAGGAACTGGGCTACGCTGTGGTTCCAAGTGAGTCCAACTTTGTGTTCTTTGGAGATTTCTCCGATCAGCACGCG
GCATGGCAGGCATTTTTGGATAGGGGAGTGCTCATCCGCGATGTGGGAATCGCTGGGCACTTGCGCACTACCATTGGTGT
GCCTGAGGAAAATGATGCGTTTTTGGACGCAGCTGCAGAGATCATCAAGCTGAACCTGTAA

Upstream 100 bases:

>100_bases
TTGTCATCAACTTTGCCAACGCCGAAGATCTTCCAGCGCACGGCGAAGCAATCCGTGCACGCTTTGAAAACCTCCCCACC
ACCGACGAGGCCTAAGAAAA

Downstream 100 bases:

>100_bases
GAGAGAAGAATTTTTCATGACTGTCGCACCAAGAATTGGTACCGCAACCCGCACCACCAGCGAATCCGACATCACCGTCG
AGATCAACCTGGACGGCACC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MTKITLSDLPLREELRGEHAYGAPQLNVDIRLNTNENPYPPSEALVADLVATVDKIATELNRYPERDAVELRDELAAYIT
KQTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQPSYSMHPILAKGTHTEFIAVSRGADFRIDMDVALEEIRAK
QPDIVFVTTPNNPTGDVTSLDDVERIINVAPGIVIVDEAYAEFSPSPSATTLLEKYPTKLVVSRTMSKAFDFAGGRLGYF
VANPAFIDAVMLVRLPYHLSALSQAAAIVALRHSADTLGTVEKLSVERVRVAARLEELGYAVVPSESNFVFFGDFSDQHA
AWQAFLDRGVLIRDVGIAGHLRTTIGVPEENDAFLDAAAEIIKLNL

Sequences:

>Translated_366_residues
MTKITLSDLPLREELRGEHAYGAPQLNVDIRLNTNENPYPPSEALVADLVATVDKIATELNRYPERDAVELRDELAAYIT
KQTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQPSYSMHPILAKGTHTEFIAVSRGADFRIDMDVALEEIRAK
QPDIVFVTTPNNPTGDVTSLDDVERIINVAPGIVIVDEAYAEFSPSPSATTLLEKYPTKLVVSRTMSKAFDFAGGRLGYF
VANPAFIDAVMLVRLPYHLSALSQAAAIVALRHSADTLGTVEKLSVERVRVAARLEELGYAVVPSESNFVFFGDFSDQHA
AWQAFLDRGVLIRDVGIAGHLRTTIGVPEENDAFLDAAAEIIKLNL
>Mature_365_residues
TKITLSDLPLREELRGEHAYGAPQLNVDIRLNTNENPYPPSEALVADLVATVDKIATELNRYPERDAVELRDELAAYITK
QTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQPSYSMHPILAKGTHTEFIAVSRGADFRIDMDVALEEIRAKQ
PDIVFVTTPNNPTGDVTSLDDVERIINVAPGIVIVDEAYAEFSPSPSATTLLEKYPTKLVVSRTMSKAFDFAGGRLGYFV
ANPAFIDAVMLVRLPYHLSALSQAAAIVALRHSADTLGTVEKLSVERVRVAARLEELGYAVVPSESNFVFFGDFSDQHAA
WQAFLDRGVLIRDVGIAGHLRTTIGVPEENDAFLDAAAEIIKLNL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=378, Percent_Identity=30.4232804232804, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1788722, Length=227, Percent_Identity=26.8722466960352, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=362, Percent_Identity=29.2817679558011, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39919; Mature: 39787

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKITLSDLPLREELRGEHAYGAPQLNVDIRLNTNENPYPPSEALVADLVATVDKIATEL
CCEEECCCCCCHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
NRYPERDAVELRDELAAYITKQTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQ
HHCCCCHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCHHHHHHHHHHHCCCCCCEECCC
PSYSMHPILAKGTHTEFIAVSRGADFRIDMDVALEEIRAKQPDIVFVTTPNNPTGDVTSL
CCCCCCCEEECCCCCEEEEEECCCCEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCCH
DDVERIINVAPGIVIVDEAYAEFSPSPSATTLLEKYPTKLVVSRTMSKAFDFAGGRLGYF
HHHHHHHHHCCCEEEEECHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEE
VANPAFIDAVMLVRLPYHLSALSQAAAIVALRHSADTLGTVEKLSVERVRVAARLEELGY
EECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCE
AVVPSESNFVFFGDFSDQHAAWQAFLDRGVLIRDVGIAGHLRTTIGVPEENDAFLDAAAE
EEECCCCCEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCHHHEECCCCCCCHHHHHHHH
IIKLNL
HHEECC
>Mature Secondary Structure 
TKITLSDLPLREELRGEHAYGAPQLNVDIRLNTNENPYPPSEALVADLVATVDKIATEL
CEEECCCCCCHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
NRYPERDAVELRDELAAYITKQTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQ
HHCCCCHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCHHHHHHHHHHHCCCCCCEECCC
PSYSMHPILAKGTHTEFIAVSRGADFRIDMDVALEEIRAKQPDIVFVTTPNNPTGDVTSL
CCCCCCCEEECCCCCEEEEEECCCCEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCCH
DDVERIINVAPGIVIVDEAYAEFSPSPSATTLLEKYPTKLVVSRTMSKAFDFAGGRLGYF
HHHHHHHHHCCCEEEEECHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEE
VANPAFIDAVMLVRLPYHLSALSQAAAIVALRHSADTLGTVEKLSVERVRVAARLEELGY
EECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCE
AVVPSESNFVFFGDFSDQHAAWQAFLDRGVLIRDVGIAGHLRTTIGVPEENDAFLDAAAE
EEECCCCCEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCHHHEECCCCCCCHHHHHHHH
IIKLNL
HHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA