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The map label for this gene is hisD

Identifier: 62390937

GI number: 62390937

Start: 2187628

End: 2188956

Strand: Reverse

Name: hisD

Synonym: cg2305

Alternate gene names: 62390937

Gene position: 2188956-2187628 (Counterclockwise)

Preceding gene: 62390939

Following gene: 62390936

Centisome position: 66.68

GC content: 57.11

Gene sequence:

>1329_bases
ATGTTGAATGTCACTGACCTGCGAGGTCAAACACCATCCAAGAGCGACATCCGACGTGCTTTGCCACGTGGTGGCACTGA
CGTGTGGTCTGTGCTTCCCATAGTGCAGCCTGTTGTAGAAGATGTCCAAAACCGCGGCGCTGAAGCTGCTTTGGATTACG
GCGAGAAGTTCGACCATATTCGCCCCGCCTCGGTGCGGGTGCCAGCTGAGGTTATTGCTGCAGCAGAAAACACCTTAGAT
CCGTTGGTGCGTGAATCGATTGAAGAGTCGATTCGTCGCGTCCGCAAGGTTCACGCTGAGCAAAAGCCATCCGAGCACAC
CACTGAACTTTCACCAGGTGGCACCGTCACTGAGCGTTTCATGCCGATTGATCGCGTGGGACTGTACGTTCCAGGCGGCA
ATGCGGTGTACCCATCAAGCGTGATTATGAATACTGTCCCAGCTCAAGAGGCTGGTGTGAACTCCCTTGTGGTTGCGTCG
CCTCCTCAGGCTGAGCACGGTGGCTGGCCTCACCCCACCATTTTGGCGGCGTGTTCCATCTTGGGTGTTGATGAGGTGTG
GGCTGTCGGCGGCGGTCAGGCCGTGGCGTTGCTGGCTTATGGTGATGACGCTGCAGGTCTCGAGCCTGTGGATATGATCA
CTGGACCTGGCAATATCTTTGTCACCGCTGCGAAGCGCCTGGTCAGGGGAGTGGTAGGTACTGATTCTGAGGCTGGCCCT
ACAGAAATCGCTGTGCTTGCTGATGCCTCTGCCAACGCCGTCAACGTTGCCTACGATCTGATCAGCCAAGCAGAACACGA
TGTCATGGCTGCGTCCGTGCTCATCACTGACTCCGAGCAGCTTGCCAAGGACGTAAACAGGGAAATCGAGGCGCGTTACT
CAATCACGCGCAACGCCGAGCGCGTCGCAGAAGCTTTGCGCGGGGCCCAGAGTGGCATCGTGCTTGTCGACGACATTTCC
GTGGGTATCCAAGTAGCCGATCAATACGCAGCGGAACACCTGGAAATCCACACTGAGAACGCGCGCGCCGTAGCAGAGCA
GATCACCAACGCGGGTGCGATCTTCGTGGGCGATTTCTCACCAGTACCACTGGGTGATTACTCCGCAGGATCCAACCACG
TGCTGCCAACCTCTGGATCCGCTCGTTTCTCCGCAGGTCTATCCACGCACACGTTCCTTCGCCCAGTCAACCTCATTGAA
TACGATGAGGCTGCTCTGAAGGACGTCTCGCAGGTTGTCATCAACTTTGCCAACGCCGAAGATCTTCCAGCGCACGGCGA
AGCAATCCGTGCACGCTTTGAAAACCTCCCCACCACCGACGAGGCCTAA

Upstream 100 bases:

>100_bases
GGTAAACATGCGGGCTTAAGAACTTGTGTTGAGGCCGCTTGGATTCGGGCACCGAGCTCGAAGAATTTCGATTCAACCTT
TTAAGGGAGAACTTTTCGCC

Downstream 100 bases:

>100_bases
GAAAAATGACCAAAATTACTTTGAGCGATTTGCCATTGCGTGAAGAACTGCGCGGTGAGCACGCTTACGGCGCACCCCAG
CTCAACGTTGATATTCGCCT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MLNVTDLRGQTPSKSDIRRALPRGGTDVWSVLPIVQPVVEDVQNRGAEAALDYGEKFDHIRPASVRVPAEVIAAAENTLD
PLVRESIEESIRRVRKVHAEQKPSEHTTELSPGGTVTERFMPIDRVGLYVPGGNAVYPSSVIMNTVPAQEAGVNSLVVAS
PPQAEHGGWPHPTILAACSILGVDEVWAVGGGQAVALLAYGDDAAGLEPVDMITGPGNIFVTAAKRLVRGVVGTDSEAGP
TEIAVLADASANAVNVAYDLISQAEHDVMAASVLITDSEQLAKDVNREIEARYSITRNAERVAEALRGAQSGIVLVDDIS
VGIQVADQYAAEHLEIHTENARAVAEQITNAGAIFVGDFSPVPLGDYSAGSNHVLPTSGSARFSAGLSTHTFLRPVNLIE
YDEAALKDVSQVVINFANAEDLPAHGEAIRARFENLPTTDEA

Sequences:

>Translated_442_residues
MLNVTDLRGQTPSKSDIRRALPRGGTDVWSVLPIVQPVVEDVQNRGAEAALDYGEKFDHIRPASVRVPAEVIAAAENTLD
PLVRESIEESIRRVRKVHAEQKPSEHTTELSPGGTVTERFMPIDRVGLYVPGGNAVYPSSVIMNTVPAQEAGVNSLVVAS
PPQAEHGGWPHPTILAACSILGVDEVWAVGGGQAVALLAYGDDAAGLEPVDMITGPGNIFVTAAKRLVRGVVGTDSEAGP
TEIAVLADASANAVNVAYDLISQAEHDVMAASVLITDSEQLAKDVNREIEARYSITRNAERVAEALRGAQSGIVLVDDIS
VGIQVADQYAAEHLEIHTENARAVAEQITNAGAIFVGDFSPVPLGDYSAGSNHVLPTSGSARFSAGLSTHTFLRPVNLIE
YDEAALKDVSQVVINFANAEDLPAHGEAIRARFENLPTTDEA
>Mature_442_residues
MLNVTDLRGQTPSKSDIRRALPRGGTDVWSVLPIVQPVVEDVQNRGAEAALDYGEKFDHIRPASVRVPAEVIAAAENTLD
PLVRESIEESIRRVRKVHAEQKPSEHTTELSPGGTVTERFMPIDRVGLYVPGGNAVYPSSVIMNTVPAQEAGVNSLVVAS
PPQAEHGGWPHPTILAACSILGVDEVWAVGGGQAVALLAYGDDAAGLEPVDMITGPGNIFVTAAKRLVRGVVGTDSEAGP
TEIAVLADASANAVNVAYDLISQAEHDVMAASVLITDSEQLAKDVNREIEARYSITRNAERVAEALRGAQSGIVLVDDIS
VGIQVADQYAAEHLEIHTENARAVAEQITNAGAIFVGDFSPVPLGDYSAGSNHVLPTSGSARFSAGLSTHTFLRPVNLIE
YDEAALKDVSQVVINFANAEDLPAHGEAIRARFENLPTTDEA

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=410, Percent_Identity=35.3658536585366, Blast_Score=237, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6319819, Length=430, Percent_Identity=34.8837209302326, Blast_Score=244, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_CORGL (Q8NNT5)

Other databases:

- EMBL:   AF160480
- EMBL:   BA000036
- EMBL:   BX927154
- RefSeq:   NP_601301.1
- RefSeq:   YP_226339.1
- ProteinModelPortal:   Q8NNT5
- SMR:   Q8NNT5
- GeneID:   1020053
- GeneID:   3343227
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2305
- KEGG:   cgl:NCgl2021
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- PhylomeDB:   Q8NNT5
- ProtClustDB:   PRK00877
- BioCyc:   CGLU196627:CG2305-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46772; Mature: 46772

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 332-332 ACT_SITE 333-333 BINDING 129-129 BINDING 193-193 BINDING 218-218 BINDING 241-241 BINDING 263-263 BINDING 266-266 BINDING 333-333 BINDING 366-366 BINDING 420-420 BINDING 425-425

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNVTDLRGQTPSKSDIRRALPRGGTDVWSVLPIVQPVVEDVQNRGAEAALDYGEKFDHI
CCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
RPASVRVPAEVIAAAENTLDPLVRESIEESIRRVRKVHAEQKPSEHTTELSPGGTVTERF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHC
MPIDRVGLYVPGGNAVYPSSVIMNTVPAQEAGVNSLVVASPPQAEHGGWPHPTILAACSI
CCHHHEEEEECCCCCCCCCHHHHCCCCCHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
LGVDEVWAVGGGQAVALLAYGDDAAGLEPVDMITGPGNIFVTAAKRLVRGVVGTDSEAGP
CCCHHHHCCCCCCEEEEEEECCCCCCCCCHHEEECCCCEEHHHHHHHHHHHCCCCCCCCC
TEIAVLADASANAVNVAYDLISQAEHDVMAASVLITDSEQLAKDVNREIEARYSITRNAE
CEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEEEECHHHHHHHHHHHHHHHHHHHCCHH
RVAEALRGAQSGIVLVDDISVGIQVADQYAAEHLEIHTENARAVAEQITNAGAIFVGDFS
HHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHEEECCHHHHHHHHHCCCCEEEEECCC
PVPLGDYSAGSNHVLPTSGSARFSAGLSTHTFLRPVNLIEYDEAALKDVSQVVINFANAE
CCCCCCCCCCCCCEECCCCCCCEECCCCHHHHHCCCCCEECCHHHHHHHHHHHHHHCCCC
DLPAHGEAIRARFENLPTTDEA
CCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLNVTDLRGQTPSKSDIRRALPRGGTDVWSVLPIVQPVVEDVQNRGAEAALDYGEKFDHI
CCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
RPASVRVPAEVIAAAENTLDPLVRESIEESIRRVRKVHAEQKPSEHTTELSPGGTVTERF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHC
MPIDRVGLYVPGGNAVYPSSVIMNTVPAQEAGVNSLVVASPPQAEHGGWPHPTILAACSI
CCHHHEEEEECCCCCCCCCHHHHCCCCCHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
LGVDEVWAVGGGQAVALLAYGDDAAGLEPVDMITGPGNIFVTAAKRLVRGVVGTDSEAGP
CCCHHHHCCCCCCEEEEEEECCCCCCCCCHHEEECCCCEEHHHHHHHHHHHCCCCCCCCC
TEIAVLADASANAVNVAYDLISQAEHDVMAASVLITDSEQLAKDVNREIEARYSITRNAE
CEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEEEECHHHHHHHHHHHHHHHHHHHCCHH
RVAEALRGAQSGIVLVDDISVGIQVADQYAAEHLEIHTENARAVAEQITNAGAIFVGDFS
HHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHEEECCHHHHHHHHHCCCCEEEEECCC
PVPLGDYSAGSNHVLPTSGSARFSAGLSTHTFLRPVNLIEYDEAALKDVSQVVINFANAE
CCCCCCCCCCCCCEECCCCCCCEECCCCHHHHHCCCCCEECCHHHHHHHHHHHHHHCCCC
DLPAHGEAIRARFENLPTTDEA
CCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626