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The map label for this gene is rnc

Identifier: 62390909

GI number: 62390909

Start: 2159195

End: 2159938

Strand: Reverse

Name: rnc

Synonym: cg2273

Alternate gene names: 62390909

Gene position: 2159938-2159195 (Counterclockwise)

Preceding gene: 62390910

Following gene: 161486717

Centisome position: 65.8

GC content: 56.59

Gene sequence:

>744_bases
GTGAGCAGGAAAAAGAATCGCCTCACCGGGGTAGACGCACTCAATGAAGCATTCGATGCAGTAGATCATCAGCCGCTGCT
TGACCACCTTGGTGTGGACATCCAGCGCGATCTGTTGGTGCTTGCGTTGACTCACCGCTCTTTCGCCAACGAAAACGGCA
TGCTGCCCAATAATGAGCGCTTGGAGTTCCTCGGCGACGCCGTCTTGGGTCTCTCCGTGGCCAACAAGCTCTATGAGCAG
TACCCCAGCAGCCCTGAATCTGATGTCTCCAAGATGCGCGCTTCAATTGTCAGCCGTTACGGCCTGGCAGATATCGCTCG
CGAAATTGATCTTGGCAACCACATTTTGCTGGGCAAAGGCGAATTGCTCACCGAAGGTCGCAGTAAGGATTCCATTCTTG
CGGACACCACAGAGGCGTTGTTCGGCGCGATTTTCCGCCAGCACGGTTTTGAAACCGCCCGCGACGTAATTTTGCGCCTG
TTTGCCTACAAGATCGATAACGCATCGGCCAGGGGCATTCACCAGGACTGGAAGACCACGCTGCAGGAGGAACTTGCTCA
GCGCAAGCGCCCCATGGCTGAATATTCCGCCACCTCAGTCGGTCCGGATCACGATCTAGTGTTCACCGCCATCGTGACGC
TGGAAGGTGAAGAAATGGGTCGGGGAGAAGGCCCGAACAAGAAGCTGGCCGAGCAGGAAGCAGCGCACCAGGCATTCCGA
AAGCTTCGGGAGTCCCGTGCCTGA

Upstream 100 bases:

>100_bases
CATGCCAGGATGATGAAACGCCAGCTCCTGACGGTGTCTCTGAAGAAGTAGAAGACGAGGAAAAGGTCGATCCGCGCTGG
GCTGGTTTGGAGAAGTTCCT

Downstream 100 bases:

>100_bases
ACTGCCTGAAGTTGAGGTGGTGCGCCGCGGTTTAGAAGATCATATGGTCGGCCACACCATCGTGTCCGCCACAGTGCTTC
ACCCGCGCGCAGCCCGCAAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MSRKKNRLTGVDALNEAFDAVDHQPLLDHLGVDIQRDLLVLALTHRSFANENGMLPNNERLEFLGDAVLGLSVANKLYEQ
YPSSPESDVSKMRASIVSRYGLADIAREIDLGNHILLGKGELLTEGRSKDSILADTTEALFGAIFRQHGFETARDVILRL
FAYKIDNASARGIHQDWKTTLQEELAQRKRPMAEYSATSVGPDHDLVFTAIVTLEGEEMGRGEGPNKKLAEQEAAHQAFR
KLRESRA

Sequences:

>Translated_247_residues
MSRKKNRLTGVDALNEAFDAVDHQPLLDHLGVDIQRDLLVLALTHRSFANENGMLPNNERLEFLGDAVLGLSVANKLYEQ
YPSSPESDVSKMRASIVSRYGLADIAREIDLGNHILLGKGELLTEGRSKDSILADTTEALFGAIFRQHGFETARDVILRL
FAYKIDNASARGIHQDWKTTLQEELAQRKRPMAEYSATSVGPDHDLVFTAIVTLEGEEMGRGEGPNKKLAEQEAAHQAFR
KLRESRA
>Mature_246_residues
SRKKNRLTGVDALNEAFDAVDHQPLLDHLGVDIQRDLLVLALTHRSFANENGMLPNNERLEFLGDAVLGLSVANKLYEQY
PSSPESDVSKMRASIVSRYGLADIAREIDLGNHILLGKGELLTEGRSKDSILADTTEALFGAIFRQHGFETARDVILRLF
AYKIDNASARGIHQDWKTTLQEELAQRKRPMAEYSATSVGPDHDLVFTAIVTLEGEEMGRGEGPNKKLAEQEAAHQAFRK
LRESRA

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=214, Percent_Identity=28.0373831775701, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI155030234, Length=214, Percent_Identity=28.0373831775701, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1788920, Length=182, Percent_Identity=41.7582417582418, Blast_Score=130, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17506883, Length=226, Percent_Identity=30.0884955752212, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193202651, Length=226, Percent_Identity=30.0884955752212, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_CORGL (Q8NNV6)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927154
- RefSeq:   NP_601274.1
- RefSeq:   YP_226311.1
- ProteinModelPortal:   Q8NNV6
- SMR:   Q8NNV6
- World-2DPAGE:   0001:Q8NNV6
- PRIDE:   Q8NNV6
- GeneID:   1020026
- GeneID:   3344302
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2273
- KEGG:   cgl:NCgl1994
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q8NNV6
- ProtClustDB:   PRK00102
- BioCyc:   CGLU196627:CG2273-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 27481; Mature: 27350

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKKNRLTGVDALNEAFDAVDHQPLLDHLGVDIQRDLLVLALTHRSFANENGMLPNNER
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCH
LEFLGDAVLGLSVANKLYEQYPSSPESDVSKMRASIVSRYGLADIAREIDLGNHILLGKG
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
ELLTEGRSKDSILADTTEALFGAIFRQHGFETARDVILRLFAYKIDNASARGIHQDWKTT
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LQEELAQRKRPMAEYSATSVGPDHDLVFTAIVTLEGEEMGRGEGPNKKLAEQEAAHQAFR
HHHHHHHHHCCHHHHHCCCCCCCCCEEEHHHEEECCHHHCCCCCCCHHHHHHHHHHHHHH
KLRESRA
HHHHCCC
>Mature Secondary Structure 
SRKKNRLTGVDALNEAFDAVDHQPLLDHLGVDIQRDLLVLALTHRSFANENGMLPNNER
CCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCH
LEFLGDAVLGLSVANKLYEQYPSSPESDVSKMRASIVSRYGLADIAREIDLGNHILLGKG
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
ELLTEGRSKDSILADTTEALFGAIFRQHGFETARDVILRLFAYKIDNASARGIHQDWKTT
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LQEELAQRKRPMAEYSATSVGPDHDLVFTAIVTLEGEEMGRGEGPNKKLAEQEAAHQAFR
HHHHHHHHHCCHHHHHCCCCCCCCCEEEHHHEEECCHHHCCCCCCCHHHHHHHHHHHHHH
KLRESRA
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626