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The map label for this gene is mutM1 [H]

Identifier: 161486717

GI number: 161486717

Start: 2158342

End: 2159202

Strand: Reverse

Name: mutM1 [H]

Synonym: cg2272

Alternate gene names: 161486717

Gene position: 2159202-2158342 (Counterclockwise)

Preceding gene: 62390909

Following gene: 62390907

Centisome position: 65.78

GC content: 54.36

Gene sequence:

>861_bases
GTGCCTGAACTGCCTGAAGTTGAGGTGGTGCGCCGCGGTTTAGAAGATCATATGGTCGGCCACACCATCGTGTCCGCCAC
AGTGCTTCACCCGCGCGCAGCCCGCAATCAACTCGGCGGTGGCCCCGAAATCGAGGCCAACATCGCAGGGCTTAGGGTCA
GCGCTGCCAAGCGACGCGGCAAATTCCTCTGGCTTGAGCTTATCGACGCACCCTCCGGCGAAACCCGTCCCGATTTAGGG
CTACTGGTTCACCTTGGGATGAGTGGACAAATGCTCATCAAAGAACCAGATGCACCAATTAGTCCACACCTTCGAGCCAA
AGTCGAGCTAGATAATGGCGATGAAGTGTGGTTTGTCGATCAACGCACCTTCGGTTATTGGTGGCTCGGCGACCTAGTTG
ATGGAGTACCCGAACGCGTCTCTCACATTGCCACAGATGTATTGGATGAGTCTGCTGATTTCTCTGCGATTGCGCGGAAT
TTGAAATCTCGGAAATCGGAGATCAAACGCCTCCTGCTTAACCAAGAGATCGTCTCCGGCATCGGAAATATCTATGCCGA
TGAAATGCTCTGGCAAGCAAAAATTCACCCATTGCAACGTGCCGATCGACTGTCCCTAGCTCGCTTGGAAGAACTTCTTC
AAGCTGGCAAAGACGTGATGACCAAAGCACTTGCTCAAGGTGGCACCTCTTTCGACGCGCTCTATGTCAACGTCAATGGC
AACTCCGGCTACTTTGCGCTGTCATTGAATGCTTATGCGCAAACCGGGGAGCCGTGCGGACGCTGCGGAACATTAATCAT
CCGGGAGAGTTTCATGAACCGCGGCTCCCACTACTGCCCAAACTGCCAGAAGCGGCGCTAG

Upstream 100 bases:

>100_bases
ACGCTGGAAGGTGAAGAAATGGGTCGGGGAGAAGGCCCGAACAAGAAGCTGGCCGAGCAGGAAGCAGCGCACCAGGCATT
CCGAAAGCTTCGGGAGTCCC

Downstream 100 bases:

>100_bases
CTGATGAGCGAAGCTTTTGATGCAACCAAAGTGCGCAAAGCTGTGCTCACCGTCGCGCTGCTTAACTTCGCTTATTTCTT
TGTAGAATTCTTTATTGCAT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MPELPEVEVVRRGLEDHMVGHTIVSATVLHPRAARNQLGGGPEIEANIAGLRVSAAKRRGKFLWLELIDAPSGETRPDLG
LLVHLGMSGQMLIKEPDAPISPHLRAKVELDNGDEVWFVDQRTFGYWWLGDLVDGVPERVSHIATDVLDESADFSAIARN
LKSRKSEIKRLLLNQEIVSGIGNIYADEMLWQAKIHPLQRADRLSLARLEELLQAGKDVMTKALAQGGTSFDALYVNVNG
NSGYFALSLNAYAQTGEPCGRCGTLIIRESFMNRGSHYCPNCQKRR

Sequences:

>Translated_286_residues
MPELPEVEVVRRGLEDHMVGHTIVSATVLHPRAARNQLGGGPEIEANIAGLRVSAAKRRGKFLWLELIDAPSGETRPDLG
LLVHLGMSGQMLIKEPDAPISPHLRAKVELDNGDEVWFVDQRTFGYWWLGDLVDGVPERVSHIATDVLDESADFSAIARN
LKSRKSEIKRLLLNQEIVSGIGNIYADEMLWQAKIHPLQRADRLSLARLEELLQAGKDVMTKALAQGGTSFDALYVNVNG
NSGYFALSLNAYAQTGEPCGRCGTLIIRESFMNRGSHYCPNCQKRR
>Mature_285_residues
PELPEVEVVRRGLEDHMVGHTIVSATVLHPRAARNQLGGGPEIEANIAGLRVSAAKRRGKFLWLELIDAPSGETRPDLGL
LVHLGMSGQMLIKEPDAPISPHLRAKVELDNGDEVWFVDQRTFGYWWLGDLVDGVPERVSHIATDVLDESADFSAIARNL
KSRKSEIKRLLLNQEIVSGIGNIYADEMLWQAKIHPLQRADRLSLARLEELLQAGKDVMTKALAQGGTSFDALYVNVNGN
SGYFALSLNAYAQTGEPCGRCGTLIIRESFMNRGSHYCPNCQKRR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=284, Percent_Identity=35.9154929577465, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1786932, Length=292, Percent_Identity=23.972602739726, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31649; Mature: 31517

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVVRRGLEDHMVGHTIVSATVLHPRAARNQLGGGPEIEANIAGLRVSAAKRRG
CCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECEEEEHHHHHCC
KFLWLELIDAPSGETRPDLGLLVHLGMSGQMLIKEPDAPISPHLRAKVELDNGDEVWFVD
CEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEEE
QRTFGYWWLGDLVDGVPERVSHIATDVLDESADFSAIARNLKSRKSEIKRLLLNQEIVSG
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGNIYADEMLWQAKIHPLQRADRLSLARLEELLQAGKDVMTKALAQGGTSFDALYVNVNG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEC
NSGYFALSLNAYAQTGEPCGRCGTLIIRESFMNRGSHYCPNCQKRR
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVEVVRRGLEDHMVGHTIVSATVLHPRAARNQLGGGPEIEANIAGLRVSAAKRRG
CCCCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECEEEEHHHHHCC
KFLWLELIDAPSGETRPDLGLLVHLGMSGQMLIKEPDAPISPHLRAKVELDNGDEVWFVD
CEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEEE
QRTFGYWWLGDLVDGVPERVSHIATDVLDESADFSAIARNLKSRKSEIKRLLLNQEIVSG
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGNIYADEMLWQAKIHPLQRADRLSLARLEELLQAGKDVMTKALAQGGTSFDALYVNVNG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEC
NSGYFALSLNAYAQTGEPCGRCGTLIIRESFMNRGSHYCPNCQKRR
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA