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The map label for this gene is carA

Identifier: 62390493

GI number: 62390493

Start: 1709171

End: 1710352

Strand: Reverse

Name: carA

Synonym: cg1814

Alternate gene names: 62390493

Gene position: 1710352-1709171 (Counterclockwise)

Preceding gene: 62390494

Following gene: 62390492

Centisome position: 52.1

GC content: 57.45

Gene sequence:

>1182_bases
GTGAGTAAAGACACCACCACCTACCAGGGAGTCACCGAGATCGGATCCGTTCCGGCATACCTGGTTCTTGCAGACGGACG
TACCTTCACCGGATTTGGCTTTGGAGCTATCGGCACCACCCTTGGTGAGGCAGTGTTCACTACCGCCATGACCGGTTACC
AAGAAACCATGACCGATCCTTCCTATCACCGCCAGATTGTTGTGGCTACCGCACCACAGATCGGCAACACCGGCTGGAAC
GATGAGGACAACGAGTCCCGCGACGGCAAGATTTGGGTTGCAGGCCTTGTTATCCGCGACCTCGCAGCACGTGTGTCCAA
CTGGCGCGCCACCACCTCCTTGCAGCAGGAAATGGCAGGCCAGGGCATCGTCGGCATCGGCGGAATCGACACCCGCGCAC
TGGTTCGCCACCTGCGCAATGAAGGTTCCATTGCAGCGGGCATCTTCTCCGGCGCTGACGCACAGCGCCCAGTTGAAGAA
CTCGTAGAGATCGTCAAGAATCAGCCAGCAATGACCGGCGCAAACCTCTCCGTTGAGGTCTCTGCTGATGAAACCTACGT
CATCGAAGCTGAAGGCGAAGAGCGCCACACCGTCGTGGCCTACGACCTGGGCATTAAGCAAAACACCCCACGTCGTTTCT
CTGCACGCGGTGTTCGCACCGTCATCGTGCCTGCTGAAACCCCATTCGAGGATATCAAGCAGTACAACCCATCAGGCGTG
TTCATCTCCAACGGCCCTGGCGATCCTGCAGCAGCAGACGTCATGGTTGATATCGTCCGCGAAGTTCTTGAAGCCGACAT
TCCATTCTTTGGCATCTGCTTCGGCAACCAGATTCTTGGCCGCGCATTCGGCATGGAGACCTACAAGCTGAAGTTCGGCC
ACCGCGGCATCAACGTTCCAGTGAAGAACCACATCACCGGCAAGATCGACATCACCGCCCAGAACCACGGCTTCGCACTC
AAGGGTGAAGCAGGCCAGGAATTCGAGACCGATTTCGGCACTGCAATTGTCACCCACACCTGCCTCAACGACGGCGTCGT
TGAAGGTATTGCGCTGAAGTCCGGACGCGCATACTCCGTTCAGTACCACCCAGAGGCCGCTGCCGGCCCAAATGATGCAA
GCCCCCTGTTTGACCAGTTTGTTGAGCTGATGGATGCAGACGCTCAGAAGAAAGGCGCATAA

Upstream 100 bases:

>100_bases
ATTGCATATAATGCAATGAATTGAATAAACTACATTCAGGGTTATCAACCAGCCAATTTCTTTTAAAAAGGCAGACACAC
GAAAGGCGACAACAGTCACC

Downstream 100 bases:

>100_bases
ATAACATGCCAAAGCGTTCAGATATTAACCACGTCCTCGTCATCGGTTCCGGCCCCATCGTCATTGGCCAGGCATGTGAA
TTCGACTACTCCGGCACCCA

Product: carbamoyl phosphate synthase small subunit

Products: NA

Alternate protein names: Carbamoyl-phosphate synthetase glutamine chain

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSKDTTTYQGVTEIGSVPAYLVLADGRTFTGFGFGAIGTTLGEAVFTTAMTGYQETMTDPSYHRQIVVATAPQIGNTGWN
DEDNESRDGKIWVAGLVIRDLAARVSNWRATTSLQQEMAGQGIVGIGGIDTRALVRHLRNEGSIAAGIFSGADAQRPVEE
LVEIVKNQPAMTGANLSVEVSADETYVIEAEGEERHTVVAYDLGIKQNTPRRFSARGVRTVIVPAETPFEDIKQYNPSGV
FISNGPGDPAAADVMVDIVREVLEADIPFFGICFGNQILGRAFGMETYKLKFGHRGINVPVKNHITGKIDITAQNHGFAL
KGEAGQEFETDFGTAIVTHTCLNDGVVEGIALKSGRAYSVQYHPEAAAGPNDASPLFDQFVELMDADAQKKGA

Sequences:

>Translated_393_residues
MSKDTTTYQGVTEIGSVPAYLVLADGRTFTGFGFGAIGTTLGEAVFTTAMTGYQETMTDPSYHRQIVVATAPQIGNTGWN
DEDNESRDGKIWVAGLVIRDLAARVSNWRATTSLQQEMAGQGIVGIGGIDTRALVRHLRNEGSIAAGIFSGADAQRPVEE
LVEIVKNQPAMTGANLSVEVSADETYVIEAEGEERHTVVAYDLGIKQNTPRRFSARGVRTVIVPAETPFEDIKQYNPSGV
FISNGPGDPAAADVMVDIVREVLEADIPFFGICFGNQILGRAFGMETYKLKFGHRGINVPVKNHITGKIDITAQNHGFAL
KGEAGQEFETDFGTAIVTHTCLNDGVVEGIALKSGRAYSVQYHPEAAAGPNDASPLFDQFVELMDADAQKKGA
>Mature_392_residues
SKDTTTYQGVTEIGSVPAYLVLADGRTFTGFGFGAIGTTLGEAVFTTAMTGYQETMTDPSYHRQIVVATAPQIGNTGWND
EDNESRDGKIWVAGLVIRDLAARVSNWRATTSLQQEMAGQGIVGIGGIDTRALVRHLRNEGSIAAGIFSGADAQRPVEEL
VEIVKNQPAMTGANLSVEVSADETYVIEAEGEERHTVVAYDLGIKQNTPRRFSARGVRTVIVPAETPFEDIKQYNPSGVF
ISNGPGDPAAADVMVDIVREVLEADIPFFGICFGNQILGRAFGMETYKLKFGHRGINVPVKNHITGKIDITAQNHGFALK
GEAGQEFETDFGTAIVTHTCLNDGVVEGIALKSGRAYSVQYHPEAAAGPNDASPLFDQFVELMDADAQKKGA

Specific function: Arginine biosynthesis. Pyrimidine biosynthesis; first step. [C]

COG id: COG0505

COG function: function code EF; Carbamoylphosphate synthase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI18105007, Length=373, Percent_Identity=38.6058981233244, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI169790915, Length=378, Percent_Identity=36.5079365079365, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI21361331, Length=377, Percent_Identity=36.3395225464191, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1786215, Length=381, Percent_Identity=45.6692913385827, Blast_Score=305, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI193204318, Length=375, Percent_Identity=37.0666666666667, Blast_Score=227, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6324878, Length=393, Percent_Identity=36.1323155216285, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6322331, Length=396, Percent_Identity=36.6161616161616, Blast_Score=215, Evalue=9e-57,
Organism=Drosophila melanogaster, GI45555749, Length=386, Percent_Identity=36.5284974093264, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24642586, Length=386, Percent_Identity=36.5284974093264, Blast_Score=215, Evalue=5e-56,

Paralogues:

None

Copy number: 620 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2599 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CARA_CORGL (P58893)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927152
- RefSeq:   NP_600824.1
- RefSeq:   YP_225895.1
- ProteinModelPortal:   P58893
- SMR:   P58893
- GeneID:   1019578
- GeneID:   3343549
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1814
- KEGG:   cgl:NCgl1548
- HOGENOM:   HBG286341
- OMA:   EADIPFF
- ProtClustDB:   PRK12564
- BioCyc:   CGLU196627:CG1814-MONOMER
- BRENDA:   6.3.5.5
- HAMAP:   MF_01209_B
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR006274
- InterPro:   IPR002474
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- PANTHER:   PTHR11405:SF4
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR01368

Pfam domain/function: PF00988 CPSase_sm_chain; PF00117 GATase; SSF52021 CP_synthsmall

EC number: =6.3.5.5

Molecular weight: Translated: 42135; Mature: 42003

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 273-273 ACT_SITE 363-363 ACT_SITE 365-365

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKDTTTYQGVTEIGSVPAYLVLADGRTFTGFGFGAIGTTLGEAVFTTAMTGYQETMTDP
CCCCCCCCCCHHHHCCCCEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHCHHHHCCCC
SYHRQIVVATAPQIGNTGWNDEDNESRDGKIWVAGLVIRDLAARVSNWRATTSLQQEMAG
CCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHCC
QGIVGIGGIDTRALVRHLRNEGSIAAGIFSGADAQRPVEELVEIVKNQPAMTGANLSVEV
CCEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEEE
SADETYVIEAEGEERHTVVAYDLGIKQNTPRRFSARGVRTVIVPAETPFEDIKQYNPSGV
ECCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCCEE
FISNGPGDPAAADVMVDIVREVLEADIPFFGICFGNQILGRAFGMETYKLKFGHRGINVP
EEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCEEEEEEECCCCCCCC
VKNHITGKIDITAQNHGFALKGEAGQEFETDFGTAIVTHTCLNDGVVEGIALKSGRAYSV
CCCCCEEEEEEEECCCCEEEECCCCCCHHHCCCCEEEEHHHHCCCCCCEEEECCCCEEEE
QYHPEAAAGPNDASPLFDQFVELMDADAQKKGA
EECCCCCCCCCCCCHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
SKDTTTYQGVTEIGSVPAYLVLADGRTFTGFGFGAIGTTLGEAVFTTAMTGYQETMTDP
CCCCCCCCCHHHHCCCCEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHCHHHHCCCC
SYHRQIVVATAPQIGNTGWNDEDNESRDGKIWVAGLVIRDLAARVSNWRATTSLQQEMAG
CCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHCC
QGIVGIGGIDTRALVRHLRNEGSIAAGIFSGADAQRPVEELVEIVKNQPAMTGANLSVEV
CCEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEEE
SADETYVIEAEGEERHTVVAYDLGIKQNTPRRFSARGVRTVIVPAETPFEDIKQYNPSGV
ECCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCCEE
FISNGPGDPAAADVMVDIVREVLEADIPFFGICFGNQILGRAFGMETYKLKFGHRGINVP
EEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCEEEEEEECCCCCCCC
VKNHITGKIDITAQNHGFALKGEAGQEFETDFGTAIVTHTCLNDGVVEGIALKSGRAYSV
CCCCCEEEEEEEECCCCEEEECCCCCCHHHCCCCEEEEHHHHCCCCCCEEEECCCCEEEE
QYHPEAAAGPNDASPLFDQFVELMDADAQKKGA
EECCCCCCCCCCCCHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626