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The map label for this gene is pyrC

Identifier: 62390494

GI number: 62390494

Start: 1710482

End: 1711825

Strand: Reverse

Name: pyrC

Synonym: cg1815

Alternate gene names: 62390494

Gene position: 1711825-1710482 (Counterclockwise)

Preceding gene: 62390495

Following gene: 62390493

Centisome position: 52.15

GC content: 57.66

Gene sequence:

>1344_bases
GTGGTTGACAGCAACACCCAGTATCCAGAAACCGGCGCACTGGCACCGGCTCCTGCAGACTCACTCCTAATCAGCAACGT
TTTGGTCTACGGCGAAGGCGAGCCAACGAATGTGTTTGTTAAAGATGGTGTGATCGCAGCTATCGGCGGCACTCATGAGG
CTGACCGCACCATCGACGGCAATGGGGGAGTTCTCCTTCCAGGTTTCGTGGACATGCACGTTCACCTGCGTGAGCCAGGC
CGCGAAGACACTGAAACCATTGCCACTGGTTCTGCCGCCGCAGCCAAGGGCGGATTCACCGCAGTATTCACCATGGCGAA
CACCACTCCAGTGATGGATCAGCCGGTTATCGCGGAATCCGTATGGTTCAAGGGCCAAAACATTGGCCTGTGCGACGTGC
ATCCAGTTGGATCCATCACCAAGGGTCTTGAGGGCAAGGAGCTTACTGAGTTCGGCATGATGGCTCGCTCTGAAGCCAAG
GTGCGCATGTTCTCTGATGATGGCAAGTGCGTCGATGATCCTCAGGTCATGCGCCGCGCGCTGGAATACGCCAAGGGCAT
GGACGTTTTGATCGCCCAGCACGCTGAGGATCACCGCCTGACTGAGGGCGCTTCAGCACACGAGGGTGAAAACGCAGCTC
GTCTGGGTCTGCGCGGCTGGCCACGTGTGGCTGAGGAATCCATCGTGGTGCGCGATGCCATCATGGCTCGTGACTACGGC
AACCGCGTGCACATCTGCCACGCCTCCACTGAAGGCACCGTGGAGTTGCTTCGTTGGGCTAAGTCCCAGGGCATTCCAAT
CACCGCGGAAGTCACCCCGCACCACCTCACCTTGACCGATGAGCGCCTGGAAACCTACGACGCGGTCAACAAAGTCAATC
CGCCACTGCGCGAAAGCCGCGATGCCGAAGCGCTCAAGAAGGCGCTTCTCGACGGCACCATCGATGTTGTTGCAACCGAC
CACGCTCCTCACGGTTCCGAAGATAAGTGCTGTGAATTCGAAAACGCCAAGCCAGGCATGCTCGGATTGGAAACCTCACT
GTCCATCATCGTGGACACCTTCGTTGCCACCGGACTTGCAGACTGGCGCTTTGTTGCGCGCGTGATGAGTGAACGCCCAG
CAGAAATCACCCGTCTACCAGGCCAGGGTCGCCCAATCGCAGAAGGTGAGCCAGCAAACCTCGCGATTGTTGATCCAGGA
AAAACCTGGACAGCATCCGGTGCAGACTTTGCGTCCAAGGCTGAAAATACCCCATTTGAGGGCCAAGAATTCAGTGCCAA
GGTCACACACACCGTGCTTCGTGGCAAGGTGACTTGTGCAGACGGAGTTGCACAAAACGCTTAA

Upstream 100 bases:

>100_bases
ATGGCCATTTTGTTCGCCCTGGTCGCAGGCTCTGACGCGACTATCTAATCGCGACCATCTGATCGCGAAATTCTAGAAAA
GGTAACGAGGGATTAAAGAA

Downstream 100 bases:

>100_bases
CGGGTGGGTGCATAGTATGCACGCGCCACATTGCATATAATGCAATGAATTGAATAAACTACATTCAGGGTTATCAACCA
GCCAATTTCTTTTAAAAAGG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MVDSNTQYPETGALAPAPADSLLISNVLVYGEGEPTNVFVKDGVIAAIGGTHEADRTIDGNGGVLLPGFVDMHVHLREPG
REDTETIATGSAAAAKGGFTAVFTMANTTPVMDQPVIAESVWFKGQNIGLCDVHPVGSITKGLEGKELTEFGMMARSEAK
VRMFSDDGKCVDDPQVMRRALEYAKGMDVLIAQHAEDHRLTEGASAHEGENAARLGLRGWPRVAEESIVVRDAIMARDYG
NRVHICHASTEGTVELLRWAKSQGIPITAEVTPHHLTLTDERLETYDAVNKVNPPLRESRDAEALKKALLDGTIDVVATD
HAPHGSEDKCCEFENAKPGMLGLETSLSIIVDTFVATGLADWRFVARVMSERPAEITRLPGQGRPIAEGEPANLAIVDPG
KTWTASGADFASKAENTPFEGQEFSAKVTHTVLRGKVTCADGVAQNA

Sequences:

>Translated_447_residues
MVDSNTQYPETGALAPAPADSLLISNVLVYGEGEPTNVFVKDGVIAAIGGTHEADRTIDGNGGVLLPGFVDMHVHLREPG
REDTETIATGSAAAAKGGFTAVFTMANTTPVMDQPVIAESVWFKGQNIGLCDVHPVGSITKGLEGKELTEFGMMARSEAK
VRMFSDDGKCVDDPQVMRRALEYAKGMDVLIAQHAEDHRLTEGASAHEGENAARLGLRGWPRVAEESIVVRDAIMARDYG
NRVHICHASTEGTVELLRWAKSQGIPITAEVTPHHLTLTDERLETYDAVNKVNPPLRESRDAEALKKALLDGTIDVVATD
HAPHGSEDKCCEFENAKPGMLGLETSLSIIVDTFVATGLADWRFVARVMSERPAEITRLPGQGRPIAEGEPANLAIVDPG
KTWTASGADFASKAENTPFEGQEFSAKVTHTVLRGKVTCADGVAQNA
>Mature_447_residues
MVDSNTQYPETGALAPAPADSLLISNVLVYGEGEPTNVFVKDGVIAAIGGTHEADRTIDGNGGVLLPGFVDMHVHLREPG
REDTETIATGSAAAAKGGFTAVFTMANTTPVMDQPVIAESVWFKGQNIGLCDVHPVGSITKGLEGKELTEFGMMARSEAK
VRMFSDDGKCVDDPQVMRRALEYAKGMDVLIAQHAEDHRLTEGASAHEGENAARLGLRGWPRVAEESIVVRDAIMARDYG
NRVHICHASTEGTVELLRWAKSQGIPITAEVTPHHLTLTDERLETYDAVNKVNPPLRESRDAEALKKALLDGTIDVVATD
HAPHGSEDKCCEFENAKPGMLGLETSLSIIVDTFVATGLADWRFVARVMSERPAEITRLPGQGRPIAEGEPANLAIVDPG
KTWTASGADFASKAENTPFEGQEFSAKVTHTVLRGKVTCADGVAQNA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=381, Percent_Identity=32.0209973753281, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4503051, Length=450, Percent_Identity=24.6666666666667, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI62422571, Length=450, Percent_Identity=24.6666666666667, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI190194363, Length=454, Percent_Identity=24.2290748898678, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI19923821, Length=441, Percent_Identity=24.2630385487528, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786722, Length=430, Percent_Identity=28.6046511627907, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI87082175, Length=453, Percent_Identity=25.1655629139073, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI193204318, Length=378, Percent_Identity=28.042328042328, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71989490, Length=438, Percent_Identity=22.8310502283105, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322218, Length=400, Percent_Identity=27, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24642586, Length=386, Percent_Identity=30.3108808290155, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI18859883, Length=464, Percent_Identity=26.7241379310345, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137462, Length=432, Percent_Identity=25.2314814814815, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_CORGL (Q8NQ39)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927152
- RefSeq:   NP_600825.1
- RefSeq:   YP_225896.1
- ProteinModelPortal:   Q8NQ39
- SMR:   Q8NQ39
- GeneID:   1019579
- GeneID:   3343550
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1815
- KEGG:   cgl:NCgl1549
- HOGENOM:   HBG724623
- OMA:   PRVAEES
- PhylomeDB:   Q8NQ39
- ProtClustDB:   PRK09357
- BioCyc:   CGLU196627:CG1815-MONOMER
- BRENDA:   3.5.2.3
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 47827; Mature: 47827

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDSNTQYPETGALAPAPADSLLISNVLVYGEGEPTNVFVKDGVIAAIGGTHEADRTIDG
CCCCCCCCCCCCCCCCCCCHHHEEEEEEEEECCCCCEEEEECCEEEEECCCCCCCCEECC
NGGVLLPGFVDMHVHLREPGREDTETIATGSAAAAKGGFTAVFTMANTTPVMDQPVIAES
CCCEEECCEEEEEEEECCCCCCCHHHHCCCCCHHCCCCCEEEEEECCCCCCCCCCCHHHH
VWFKGQNIGLCDVHPVGSITKGLEGKELTEFGMMARSEAKVRMFSDDGKCVDDPQVMRRA
HEECCCCCCEECCCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
LEYAKGMDVLIAQHAEDHRLTEGASAHEGENAARLGLRGWPRVAEESIVVRDAIMARDYG
HHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHCCCHHHHHHHHHCCC
NRVHICHASTEGTVELLRWAKSQGIPITAEVTPHHLTLTDERLETYDAVNKVNPPLRESR
CEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHHHCCCCHHHCC
DAEALKKALLDGTIDVVATDHAPHGSEDKCCEFENAKPGMLGLETSLSIIVDTFVATGLA
CHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCH
DWRFVARVMSERPAEITRLPGQGRPIAEGEPANLAIVDPGKTWTASGADFASKAENTPFE
HHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCEECCCCCHHHHCCCCCCC
GQEFSAKVTHTVLRGKVTCADGVAQNA
CCCCHHHHHHHHHHCEEEECCCCCCCC
>Mature Secondary Structure
MVDSNTQYPETGALAPAPADSLLISNVLVYGEGEPTNVFVKDGVIAAIGGTHEADRTIDG
CCCCCCCCCCCCCCCCCCCHHHEEEEEEEEECCCCCEEEEECCEEEEECCCCCCCCEECC
NGGVLLPGFVDMHVHLREPGREDTETIATGSAAAAKGGFTAVFTMANTTPVMDQPVIAES
CCCEEECCEEEEEEEECCCCCCCHHHHCCCCCHHCCCCCEEEEEECCCCCCCCCCCHHHH
VWFKGQNIGLCDVHPVGSITKGLEGKELTEFGMMARSEAKVRMFSDDGKCVDDPQVMRRA
HEECCCCCCEECCCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
LEYAKGMDVLIAQHAEDHRLTEGASAHEGENAARLGLRGWPRVAEESIVVRDAIMARDYG
HHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHCCCHHHHHHHHHCCC
NRVHICHASTEGTVELLRWAKSQGIPITAEVTPHHLTLTDERLETYDAVNKVNPPLRESR
CEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHHHCCCCHHHCC
DAEALKKALLDGTIDVVATDHAPHGSEDKCCEFENAKPGMLGLETSLSIIVDTFVATGLA
CHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCH
DWRFVARVMSERPAEITRLPGQGRPIAEGEPANLAIVDPGKTWTASGADFASKAENTPFE
HHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCEECCCCCHHHHCCCCCCC
GQEFSAKVTHTVLRGKVTCADGVAQNA
CCCCHHHHHHHHHHCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626