Click here to switch to the map view.

The map label for this gene is uvrC [H]

Identifier: 62390474

GI number: 62390474

Start: 1688568

End: 1690658

Strand: Reverse

Name: uvrC [H]

Synonym: cg1795

Alternate gene names: 62390474

Gene position: 1690658-1688568 (Counterclockwise)

Preceding gene: 62390475

Following gene: 62390473

Centisome position: 51.5

GC content: 56.58

Gene sequence:

>2091_bases
GTGGCTGATCCAACAACTTATCGCCCGGCTCCAGGAACAATTCCAACGGAGCCGGGTGTTTATAAATTCAGGGACGAAAA
CCGCCGCGTGATCTACGTGGGCAAGGCCAAAAACTTGCGTTCGCGGTTGTCGAACTATTTCCAGGATGTCACCCAACTGC
ATCCGCGCACCCGCCAAATGGTGTTCGCAGCGTCGTCTGTGGAGTGGACCGTGGTGTCCAGCGAAGTCGAGGCGCTGCAG
CTGGAATACACCTGGATTAAACGTTTTGATCCGCGGTTTAACGTAAAATACCGCGACGATAAAACCTATCCCATGCTGGC
AGTATCCACAGGGGAGAGGTTCCCGCGCGCGTTCTTCTTCCGAGGTCCGCGCCGCAAAGGTGTGCGCTATTTCGGACCGT
ATTCCCACGCGTGGGCAGTGCGGGAAACCCTTGATCTTCTCACCCGCGTTTTCCCCATGCGCACCTGTTCAAAGGGTGTG
TTTAACCGCCACGAAAGCCTCGGCCGGCCGTGTTTGTTGGGCTATATCGATAAATGTGCGGCCCCGTGCGTGGGCCGCGT
GAGCGAAGAGGAACACCGCGAAATCGTTGACGGTTTCACCTCTTTCATGGCTGGTCACACCGACAAAGTCACTCGCAAAC
TCAACGCCGACATGATGGCTGCGGCCGAGGAACTCGATTTCGAGCGCGCGGCCCGCCTGCGCGATGATCTGGAAGCCATT
GACAAGGTCATGGAAAAACAGGCCGTCGTCCTTGGCGATGGCACCGACGCCGACATCATCGCATTCGCCACCGATCAGCT
AGAAGCCGCCGTGCAAGTCTTCAACATCCGAGGTGGCCGAATCCGCGGCCAGCGCGGCTGGGTTGTGGAAAAGCCCGGCG
ACTACGCCGGATTGCTTGTCGACGCTACGACCCAACCTGAGGGTGATGCCCCGGAAACAGATCCCGCACTGCCATTTTTG
ATGCAAGATTTCCTCGTTCAGTTTTATGGCGACGCCGTCGAGCGTGCTGAAACTGAGGCTAAGGAAGATGCTGCGGTGAT
CGAGCGACGTGGCGTCGATAAGCATTCTTTTGAAGAGGCAGCCCCAGTGACGCGCGCTTCGGTCGTGCCCCGTGAAATCC
TCGTGCAAGTTGCGCCCAATGAAGCTGAGCAAACCCTGAAAGTACTGGAGGAATTGCGCGGTGCTGGCGTTGATGCCCGC
GTGCCACAGCGCGGTGACAAGCGTGCGCTCATGGAAACTGTGGAGCGCAACGCCAAAGAGCTGCTGAAACAACACAAGCT
TAAGCGTGTCGGTGATCTCACCGCGCGTTCAGCTGCACTGCAGGAATTGCAGGAAGCGCTGGACATGGAGCAGGCTCCGC
TGCGCATCGAATGTACCGATATTTCCCATATTCAGGGCACCGATGTGGTGGCATCCCTGGTGGTTTTTGAAGATGGTTTG
CCTCGAAAATCGGACTACCGACGCTATCGAGTCAAAGAAGCCGCAGGCGATGGACATTCCAACGACGTGGCATCCATTGC
GGAAATCACCAGGCGCCGCTTCCTGCGCCACAACCAAGACAAACTTGCTGTTCCCGAAGCCGAAGAGTTTGACGGCTCGA
CCTTCAGCGATGAAAAAGTCGAGGAAATGAGCACCGACGCCAGGCGTTTTGCATACCCTCCTCAGATTTTTATCGTCGAT
GGTGGTGCCCCGCAGGTAGCTGCAGCCCAAGAAGTCTTTGATGAATTAGGCATCGTTGACGTGGTGCTCATTGGCCTAGC
CAAGCGCTTGGAAGAAATCTGGCTGCCCGGCGACCCCGATCCCGTCATCTTGCCGAGAAACTCCCAAGCACTGTTTTTGC
TCCAGCAAATCCGTGACGAAGCCCACCGCTTTGCCATCACCTACCACCGCCAGCAACGATCCAAGCGCATGCGTGTTTCC
GAGCTAGATAGCATCAAGGGCCTTGGCCAGAGCCGTCGCACTGAACTAGTCAAGCACTTTGGATCCGTGGCAAAACTGAA
AGAGGCAAGCGTTGAGGACATTTCCCAAGTGAAAGGCTTCGGCCCGAAACTTGCGGAGGCTGTCTATGAAGGTCTTCACG
CGTCAAAATAA

Upstream 100 bases:

>100_bases
ATGTGGGCTTTCCAGTCCCGCGATGGAGAAGATGTGGTGCGCGCGGTTGCGACCTTCCGCGACCTCGAAAACAAGTACAT
GCCAGAGGACTAATTAAGCT

Downstream 100 bases:

>100_bases
GTAGATCGCTAGGATGTAACCATGATTCAATCCACTGGGGTCACGCACACTGATAAGTCTGCACAAGAAAATCCTGTGAA
GTACAGGGACAATTTCACAC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MADPTTYRPAPGTIPTEPGVYKFRDENRRVIYVGKAKNLRSRLSNYFQDVTQLHPRTRQMVFAASSVEWTVVSSEVEALQ
LEYTWIKRFDPRFNVKYRDDKTYPMLAVSTGERFPRAFFFRGPRRKGVRYFGPYSHAWAVRETLDLLTRVFPMRTCSKGV
FNRHESLGRPCLLGYIDKCAAPCVGRVSEEEHREIVDGFTSFMAGHTDKVTRKLNADMMAAAEELDFERAARLRDDLEAI
DKVMEKQAVVLGDGTDADIIAFATDQLEAAVQVFNIRGGRIRGQRGWVVEKPGDYAGLLVDATTQPEGDAPETDPALPFL
MQDFLVQFYGDAVERAETEAKEDAAVIERRGVDKHSFEEAAPVTRASVVPREILVQVAPNEAEQTLKVLEELRGAGVDAR
VPQRGDKRALMETVERNAKELLKQHKLKRVGDLTARSAALQELQEALDMEQAPLRIECTDISHIQGTDVVASLVVFEDGL
PRKSDYRRYRVKEAAGDGHSNDVASIAEITRRRFLRHNQDKLAVPEAEEFDGSTFSDEKVEEMSTDARRFAYPPQIFIVD
GGAPQVAAAQEVFDELGIVDVVLIGLAKRLEEIWLPGDPDPVILPRNSQALFLLQQIRDEAHRFAITYHRQQRSKRMRVS
ELDSIKGLGQSRRTELVKHFGSVAKLKEASVEDISQVKGFGPKLAEAVYEGLHASK

Sequences:

>Translated_696_residues
MADPTTYRPAPGTIPTEPGVYKFRDENRRVIYVGKAKNLRSRLSNYFQDVTQLHPRTRQMVFAASSVEWTVVSSEVEALQ
LEYTWIKRFDPRFNVKYRDDKTYPMLAVSTGERFPRAFFFRGPRRKGVRYFGPYSHAWAVRETLDLLTRVFPMRTCSKGV
FNRHESLGRPCLLGYIDKCAAPCVGRVSEEEHREIVDGFTSFMAGHTDKVTRKLNADMMAAAEELDFERAARLRDDLEAI
DKVMEKQAVVLGDGTDADIIAFATDQLEAAVQVFNIRGGRIRGQRGWVVEKPGDYAGLLVDATTQPEGDAPETDPALPFL
MQDFLVQFYGDAVERAETEAKEDAAVIERRGVDKHSFEEAAPVTRASVVPREILVQVAPNEAEQTLKVLEELRGAGVDAR
VPQRGDKRALMETVERNAKELLKQHKLKRVGDLTARSAALQELQEALDMEQAPLRIECTDISHIQGTDVVASLVVFEDGL
PRKSDYRRYRVKEAAGDGHSNDVASIAEITRRRFLRHNQDKLAVPEAEEFDGSTFSDEKVEEMSTDARRFAYPPQIFIVD
GGAPQVAAAQEVFDELGIVDVVLIGLAKRLEEIWLPGDPDPVILPRNSQALFLLQQIRDEAHRFAITYHRQQRSKRMRVS
ELDSIKGLGQSRRTELVKHFGSVAKLKEASVEDISQVKGFGPKLAEAVYEGLHASK
>Mature_695_residues
ADPTTYRPAPGTIPTEPGVYKFRDENRRVIYVGKAKNLRSRLSNYFQDVTQLHPRTRQMVFAASSVEWTVVSSEVEALQL
EYTWIKRFDPRFNVKYRDDKTYPMLAVSTGERFPRAFFFRGPRRKGVRYFGPYSHAWAVRETLDLLTRVFPMRTCSKGVF
NRHESLGRPCLLGYIDKCAAPCVGRVSEEEHREIVDGFTSFMAGHTDKVTRKLNADMMAAAEELDFERAARLRDDLEAID
KVMEKQAVVLGDGTDADIIAFATDQLEAAVQVFNIRGGRIRGQRGWVVEKPGDYAGLLVDATTQPEGDAPETDPALPFLM
QDFLVQFYGDAVERAETEAKEDAAVIERRGVDKHSFEEAAPVTRASVVPREILVQVAPNEAEQTLKVLEELRGAGVDARV
PQRGDKRALMETVERNAKELLKQHKLKRVGDLTARSAALQELQEALDMEQAPLRIECTDISHIQGTDVVASLVVFEDGLP
RKSDYRRYRVKEAAGDGHSNDVASIAEITRRRFLRHNQDKLAVPEAEEFDGSTFSDEKVEEMSTDARRFAYPPQIFIVDG
GAPQVAAAQEVFDELGIVDVVLIGLAKRLEEIWLPGDPDPVILPRNSQALFLLQQIRDEAHRFAITYHRQQRSKRMRVSE
LDSIKGLGQSRRTELVKHFGSVAKLKEASVEDISQVKGFGPKLAEAVYEGLHASK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=704, Percent_Identity=32.9545454545455, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1788037, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 78349; Mature: 78217

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPTTYRPAPGTIPTEPGVYKFRDENRRVIYVGKAKNLRSRLSNYFQDVTQLHPRTRQM
CCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHH
VFAASSVEWTVVSSEVEALQLEYTWIKRFDPRFNVKYRDDKTYPMLAVSTGERFPRAFFF
EEEECCCEEEEEECCHHHHEEEEHHHHHCCCCCCEEECCCCCCCEEEECCCCCCCHHHHC
RGPRRKGVRYFGPYSHAWAVRETLDLLTRVFPMRTCSKGVFNRHESLGRPCLLGYIDKCA
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
APCVGRVSEEEHREIVDGFTSFMAGHTDKVTRKLNADMMAAAEELDFERAARLRDDLEAI
CHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCHHHHHHHHHHHHHH
DKVMEKQAVVLGDGTDADIIAFATDQLEAAVQVFNIRGGRIRGQRGWVVEKPGDYAGLLV
HHHHHHCEEEEECCCCCCEEEEEHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCEEEEE
DATTQPEGDAPETDPALPFLMQDFLVQFYGDAVERAETEAKEDAAVIERRGVDKHSFEEA
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
APVTRASVVPREILVQVAPNEAEQTLKVLEELRGAGVDARVPQRGDKRALMETVERNAKE
CCCHHHHHCCHHHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LLKQHKLKRVGDLTARSAALQELQEALDMEQAPLRIECTDISHIQGTDVVASLVVFEDGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCC
PRKSDYRRYRVKEAAGDGHSNDVASIAEITRRRFLRHNQDKLAVPEAEEFDGSTFSDEKV
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHH
EEMSTDARRFAYPPQIFIVDGGAPQVAAAQEVFDELGIVDVVLIGLAKRLEEIWLPGDPD
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PVILPRNSQALFLLQQIRDEAHRFAITYHRQQRSKRMRVSELDSIKGLGQSRRTELVKHF
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHH
GSVAKLKEASVEDISQVKGFGPKLAEAVYEGLHASK
HHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADPTTYRPAPGTIPTEPGVYKFRDENRRVIYVGKAKNLRSRLSNYFQDVTQLHPRTRQM
CCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHH
VFAASSVEWTVVSSEVEALQLEYTWIKRFDPRFNVKYRDDKTYPMLAVSTGERFPRAFFF
EEEECCCEEEEEECCHHHHEEEEHHHHHCCCCCCEEECCCCCCCEEEECCCCCCCHHHHC
RGPRRKGVRYFGPYSHAWAVRETLDLLTRVFPMRTCSKGVFNRHESLGRPCLLGYIDKCA
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
APCVGRVSEEEHREIVDGFTSFMAGHTDKVTRKLNADMMAAAEELDFERAARLRDDLEAI
CHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCHHHHHHHHHHHHHH
DKVMEKQAVVLGDGTDADIIAFATDQLEAAVQVFNIRGGRIRGQRGWVVEKPGDYAGLLV
HHHHHHCEEEEECCCCCCEEEEEHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCEEEEE
DATTQPEGDAPETDPALPFLMQDFLVQFYGDAVERAETEAKEDAAVIERRGVDKHSFEEA
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
APVTRASVVPREILVQVAPNEAEQTLKVLEELRGAGVDARVPQRGDKRALMETVERNAKE
CCCHHHHHCCHHHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LLKQHKLKRVGDLTARSAALQELQEALDMEQAPLRIECTDISHIQGTDVVASLVVFEDGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCC
PRKSDYRRYRVKEAAGDGHSNDVASIAEITRRRFLRHNQDKLAVPEAEEFDGSTFSDEKV
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHH
EEMSTDARRFAYPPQIFIVDGGAPQVAAAQEVFDELGIVDVVLIGLAKRLEEIWLPGDPD
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PVILPRNSQALFLLQQIRDEAHRFAITYHRQQRSKRMRVSELDSIKGLGQSRRTELVKHF
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHH
GSVAKLKEASVEDISQVKGFGPKLAEAVYEGLHASK
HHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA