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The map label for this gene is tpiA [H]

Identifier: 62390468

GI number: 62390468

Start: 1681797

End: 1682576

Strand: Reverse

Name: tpiA [H]

Synonym: cg1789

Alternate gene names: 62390468

Gene position: 1682576-1681797 (Counterclockwise)

Preceding gene: 62390469

Following gene: 62390467

Centisome position: 51.26

GC content: 57.56

Gene sequence:

>780_bases
ATGGCACGTAAGCCACTTATCGCTGGTAACTGGAAGATGAACCTGGATCACCAGCAGGCAATCGGCACTGTTCAGAAGCT
TGCATTCGCCCTTCCAAAGGAATACTTCGAGAAGGTTGACGTTGCAGTCACCGTTCCTTTCACTGACATCCGCTCCGTCC
AGACTCTCGTTGAGGGCGACAAGCTTGAGGTCACTTTCGGTGCTCAGGACGTCTCCCAGCACGAGTCCGGTGCGTACACC
GGTGAAGTTTCTGCAAGCATGCTGGCAAAGTTGAACTGCTCTTGGGTTGTCGTTGGACACTCCGAGCGCCGCGAGTACCA
CAACGAGTCTGATGAGTTGGTTGCTGCGAAGGCAAAGGCAGCTCTGTCCAACGGCATCAGCCCGATCGTCTGCGTTGGTG
AGCCACTGGAAATCCGTGAAGCTGGCACCCACGTTGAGTACGTCGTCGAGCAGACCCGTAAGTCCCTTGCTGGCCTGGAT
GCTGCTGAGCTGGCCAACACCGTTATCGCGTATGAGCCAGTGTGGGCTATCGGCACCGGTAAGGTTGCTTCCGCAGCTGA
CGCTCAGGAAGTGTGCAAGGCTATCCGCGGTCTGATCGTGGAGCTTGCAGGCGACGAGGTCGCTGAGGGCCTGCGTATTC
TTTACGGTGGTTCTGTTAAGGCAGAAACCGTCGCTGAGATCGTCGGTCAGCCTGACGTCGACGGCGGACTTGTCGGTGGC
GCTTCCCTCGACGGTGAAGCATTCGCCAAGCTGGCTGCCAACGCTGCGAGCGTTGCTTAA

Upstream 100 bases:

>100_bases
CGTTGCAATTCTCGCTCAGTAAATCCGACACGGCCCTTTGTTAGAAAACAAAACATAAAGGGCCACCGGGAAACTTTTTT
AAGAAAGGTGTGTTTCACAC

Downstream 100 bases:

>100_bases
AGTACAGAGCTTTAAAGCACAGCCTTAAAGCACAGCCTTAAAGCACAAGCACTGTAGAAGTGCGGTTTTGATGAGCCCAT
GAAAGCCATCGAAATCAATC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MARKPLIAGNWKMNLDHQQAIGTVQKLAFALPKEYFEKVDVAVTVPFTDIRSVQTLVEGDKLEVTFGAQDVSQHESGAYT
GEVSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLD
AAELANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGG
ASLDGEAFAKLAANAASVA

Sequences:

>Translated_259_residues
MARKPLIAGNWKMNLDHQQAIGTVQKLAFALPKEYFEKVDVAVTVPFTDIRSVQTLVEGDKLEVTFGAQDVSQHESGAYT
GEVSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLD
AAELANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGG
ASLDGEAFAKLAANAASVA
>Mature_258_residues
ARKPLIAGNWKMNLDHQQAIGTVQKLAFALPKEYFEKVDVAVTVPFTDIRSVQTLVEGDKLEVTFGAQDVSQHESGAYTG
EVSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDA
AELANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGA
SLDGEAFAKLAANAASVA

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=248, Percent_Identity=41.5322580645161, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI4507645, Length=248, Percent_Identity=41.5322580645161, Blast_Score=173, Evalue=1e-43,
Organism=Escherichia coli, GI1790353, Length=247, Percent_Identity=43.3198380566802, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17536593, Length=252, Percent_Identity=44.047619047619, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6320255, Length=247, Percent_Identity=41.2955465587045, Blast_Score=173, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28572008, Length=247, Percent_Identity=40.080971659919, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI28572006, Length=247, Percent_Identity=40.080971659919, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI28572004, Length=246, Percent_Identity=40.650406504065, Blast_Score=168, Evalue=4e-42,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 27203; Mature: 27072

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKPLIAGNWKMNLDHQQAIGTVQKLAFALPKEYFEKVDVAVTVPFTDIRSVQTLVEGD
CCCCCEEECCEEECCCHHHHHHHHHHHHHHCCHHHHHHCCEEEEECHHHHHHHHHHHCCC
KLEVTFGAQDVSQHESGAYTGEVSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKA
EEEEEECCHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECHHHHHHCCCCHHHHHHHHHH
ALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDAAELANTVIAYEPVWAIGTG
HHHCCCCEEEEECCCCHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHEEECCEEEECCC
KVASAADAQEVCKAIRGLIVELAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGG
CCCCCCCHHHHHHHHHHHHHHHCCHHHHCCEEEEECCCCCHHHHHHHHCCCCCCCCEECC
ASLDGEAFAKLAANAASVA
CCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARKPLIAGNWKMNLDHQQAIGTVQKLAFALPKEYFEKVDVAVTVPFTDIRSVQTLVEGD
CCCCEEECCEEECCCHHHHHHHHHHHHHHCCHHHHHHCCEEEEECHHHHHHHHHHHCCC
KLEVTFGAQDVSQHESGAYTGEVSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKA
EEEEEECCHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECHHHHHHCCCCHHHHHHHHHH
ALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDAAELANTVIAYEPVWAIGTG
HHHCCCCEEEEECCCCHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHEEECCEEEECCC
KVASAADAQEVCKAIRGLIVELAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGG
CCCCCCCHHHHHHHHHHHHHHHCCHHHHCCEEEEECCCCCHHHHHHHHCCCCCCCCEECC
ASLDGEAFAKLAANAASVA
CCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]