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The map label for this gene is mcmA [H]

Identifier: 62390412

GI number: 62390412

Start: 1615915

End: 1617765

Strand: Reverse

Name: mcmA [H]

Synonym: cg1726

Alternate gene names: 62390412

Gene position: 1617765-1615915 (Counterclockwise)

Preceding gene: 62390415

Following gene: 62390411

Centisome position: 49.28

GC content: 54.51

Gene sequence:

>1851_bases
TTGACTGATCTCACAAAGACTGCGGTGCCCGAGGAACTTTCAGAGAACCTCGAAACTTGGTACAAGGCTGTGGCCGGTGT
TTTCGCGCGCACACAGAAAAAAGACATCGGCGACATTGCCGTAGATGTGTGGAAGAAACTCATCGTCACTACACCGGATG
GTGTTGATATCAATCCGCTGTACACCAGAGCAGATGAGTCCCAGAGGAAATTCACTGAGGTTCCTGGTGAGTTTCCCTTC
ACTAGGGGAACCACTGTTGATGGTGAACGCGTTGGTTGGGGTGTTACTGAGACTTTCGGACATGACAGCCCGAAGAATAT
CAACGCTGCGGTGCTGAATGCTCTGAATTCTGGCACCACCACATTGGGTTTTGAGTTCTCTGAGGAATTCACGGCAGCTG
ATCTTAAAGTTGCTCTCGAAGGCGTGTATCTCAACATGGCTCCGTTGCTGATTCATGCGGGTGGATCCACGTCAGAGGTT
GCAGCGGCGTTGTATACGTTGGCGGAGGAAGCCGGAACGTTTTTTGCTGCGTTGACCTTGGGTTCTCGTCCTTTGACGGC
GCAGGTTGATGGTTCGCACAGTGACACCATTGAAGAAGCAGTTCAGTTGGCAGTGAATGCTTCCAAGCGTGCGAATGTGC
GCGCTATCTTGGTGGATGGTTCCAGTTTTTCCAACCAGGGCGCGTCGGATGCTCAAGAAATTGGTCTAAGTATCGCCGCC
GGTGTGGATTATGTCCGTCGCTTGGTCGATGCAGGCCTTTCCACGGAAGCTGCACTTAAGCAGGTGGCGTTCCGTTTTGC
GGTCACCGATGAGCAGTTCGCGCAGATTTCTAAGCTGCGTGTGGCTCGACGTCTGTGGGCCAGGGTGTGTGAGGTGCTTG
GTTTTCCAGAGCTGGCCGTAGCACCACAGCATGCGGTGACTGCACGAGCGATGTTTAGCCAGCGTGATCCGTGGGTGAAT
ATGCTGCGCAGTACTGTTGCAGCTTTCGCTGCAGGCGTCGGTGGAGCAACCGATGTGGAGGTTCGTACTTTTGATGATGC
GATCCCAGATGGAGTTCCTGGAGTGTCGAGGAATTTCGCTCACCGCATCGCGCGCAATACTAATTTGTTGTTGCTAGAAG
AGTCACATCTTGGTCACGTGGTTGATCCTGCTGGTGGATCATATTTCGTGGAGAGCTTCACCGATGATCTAGCGGAGAAG
GCGTGGGCTGTGTTCAGTGGCATCGAAGCTGAGGGCGGATACAGTGCAGCTTGTGCATCCGGCACGGTGACTGCCATGCT
TGATCAGACGTGGGAGCAGACTCGCGCTGATGTGGCGTCGAGAAAGAAGAAGCTCACTGGAATTAATGAGTTCCCGAACT
TGGCGGAGTCTCCGCTGCCAGCTGATCGTCGGGTAGAACCTGCAGGTGTGCGTCGATGGGCAGCGGATTTTGAAGCGCTG
CGCAATCGTTCGGATGCTTTCTTGGAAAAGAACGGCGCGAGGCCACAGATCACGATGATTCCTCTGGGACCGTTGTCCAA
GCACAATATTCGCACTGGTTTTACTTCCAACCTGTTGGCTTCCGGTGGCATTGAAGCAATCAACCCGGGTCAACTTGTTC
CCGGCACTGACGCTTTTGCAGAAGCTGCACAGGCCGCAGGCATTGTAGTGGTGTGTGGAACGGACCAAGAGTATGCCGAA
ACGGGGGAGGGAGCCGTCGAAAAGCTCCGCGAAGCGGGCGTTGAGCGCATCCTGCTTGCTGGCGCGCCGAAGAGCTTTGA
GGGCAGCGCGCATGCGCCCGATGGTTATTTGAACATGACAATTGATGCCGCGGCGACGCTGGCTGACCTGCTAGATGCTT
TGGGAGCTTAA

Upstream 100 bases:

>100_bases
TTTTCGTAGGTAAACACAGGTGAAGGCTTTACAAGCTTGTGAACTCCCTACACAAAAGCAATCCAATAGCTATCCATAAG
CAAGAGAAAGTAAGTCTACG

Downstream 100 bases:

>100_bases
ATCATGACGTCGATCCCTAATTTTTCAGACATCCCATTGACTGCTGAGACACGTGCATCGGAGTCACACAACGTTGACGC
CGGCAAGGTGTGGAACACTC

Product: methylmalonyl-COA mutase small subunit

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MTDLTKTAVPEELSENLETWYKAVAGVFARTQKKDIGDIAVDVWKKLIVTTPDGVDINPLYTRADESQRKFTEVPGEFPF
TRGTTVDGERVGWGVTETFGHDSPKNINAAVLNALNSGTTTLGFEFSEEFTAADLKVALEGVYLNMAPLLIHAGGSTSEV
AAALYTLAEEAGTFFAALTLGSRPLTAQVDGSHSDTIEEAVQLAVNASKRANVRAILVDGSSFSNQGASDAQEIGLSIAA
GVDYVRRLVDAGLSTEAALKQVAFRFAVTDEQFAQISKLRVARRLWARVCEVLGFPELAVAPQHAVTARAMFSQRDPWVN
MLRSTVAAFAAGVGGATDVEVRTFDDAIPDGVPGVSRNFAHRIARNTNLLLLEESHLGHVVDPAGGSYFVESFTDDLAEK
AWAVFSGIEAEGGYSAACASGTVTAMLDQTWEQTRADVASRKKKLTGINEFPNLAESPLPADRRVEPAGVRRWAADFEAL
RNRSDAFLEKNGARPQITMIPLGPLSKHNIRTGFTSNLLASGGIEAINPGQLVPGTDAFAEAAQAAGIVVVCGTDQEYAE
TGEGAVEKLREAGVERILLAGAPKSFEGSAHAPDGYLNMTIDAAATLADLLDALGA

Sequences:

>Translated_616_residues
MTDLTKTAVPEELSENLETWYKAVAGVFARTQKKDIGDIAVDVWKKLIVTTPDGVDINPLYTRADESQRKFTEVPGEFPF
TRGTTVDGERVGWGVTETFGHDSPKNINAAVLNALNSGTTTLGFEFSEEFTAADLKVALEGVYLNMAPLLIHAGGSTSEV
AAALYTLAEEAGTFFAALTLGSRPLTAQVDGSHSDTIEEAVQLAVNASKRANVRAILVDGSSFSNQGASDAQEIGLSIAA
GVDYVRRLVDAGLSTEAALKQVAFRFAVTDEQFAQISKLRVARRLWARVCEVLGFPELAVAPQHAVTARAMFSQRDPWVN
MLRSTVAAFAAGVGGATDVEVRTFDDAIPDGVPGVSRNFAHRIARNTNLLLLEESHLGHVVDPAGGSYFVESFTDDLAEK
AWAVFSGIEAEGGYSAACASGTVTAMLDQTWEQTRADVASRKKKLTGINEFPNLAESPLPADRRVEPAGVRRWAADFEAL
RNRSDAFLEKNGARPQITMIPLGPLSKHNIRTGFTSNLLASGGIEAINPGQLVPGTDAFAEAAQAAGIVVVCGTDQEYAE
TGEGAVEKLREAGVERILLAGAPKSFEGSAHAPDGYLNMTIDAAATLADLLDALGA
>Mature_615_residues
TDLTKTAVPEELSENLETWYKAVAGVFARTQKKDIGDIAVDVWKKLIVTTPDGVDINPLYTRADESQRKFTEVPGEFPFT
RGTTVDGERVGWGVTETFGHDSPKNINAAVLNALNSGTTTLGFEFSEEFTAADLKVALEGVYLNMAPLLIHAGGSTSEVA
AALYTLAEEAGTFFAALTLGSRPLTAQVDGSHSDTIEEAVQLAVNASKRANVRAILVDGSSFSNQGASDAQEIGLSIAAG
VDYVRRLVDAGLSTEAALKQVAFRFAVTDEQFAQISKLRVARRLWARVCEVLGFPELAVAPQHAVTARAMFSQRDPWVNM
LRSTVAAFAAGVGGATDVEVRTFDDAIPDGVPGVSRNFAHRIARNTNLLLLEESHLGHVVDPAGGSYFVESFTDDLAEKA
WAVFSGIEAEGGYSAACASGTVTAMLDQTWEQTRADVASRKKKLTGINEFPNLAESPLPADRRVEPAGVRRWAADFEALR
NRSDAFLEKNGARPQITMIPLGPLSKHNIRTGFTSNLLASGGIEAINPGQLVPGTDAFAEAAQAAGIVVVCGTDQEYAET
GEGAVEKLREAGVERILLAGAPKSFEGSAHAPDGYLNMTIDAAATLADLLDALGA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=480, Percent_Identity=25.625, Blast_Score=142, Evalue=1e-33,
Organism=Escherichia coli, GI1789284, Length=475, Percent_Identity=25.4736842105263, Blast_Score=151, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25144500, Length=444, Percent_Identity=27.7027027027027, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 65433; Mature: 65302

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLTKTAVPEELSENLETWYKAVAGVFARTQKKDIGDIAVDVWKKLIVTTPDGVDINPL
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCCCCCCCCC
YTRADESQRKFTEVPGEFPFTRGTTVDGERVGWGVTETFGHDSPKNINAAVLNALNSGTT
CCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHCCCCE
TLGFEFSEEFTAADLKVALEGVYLNMAPLLIHAGGSTSEVAAALYTLAEEAGTFFAALTL
EEEEECCCHHHHHHHHHHHHHHEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEEE
GSRPLTAQVDGSHSDTIEEAVQLAVNASKRANVRAILVDGSSFSNQGASDAQEIGLSIAA
CCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHCHHHHH
GVDYVRRLVDAGLSTEAALKQVAFRFAVTDEQFAQISKLRVARRLWARVCEVLGFPELAV
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHC
APQHAVTARAMFSQRDPWVNMLRSTVAAFAAGVGGATDVEVRTFDDAIPDGVPGVSRNFA
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHH
HRIARNTNLLLLEESHLGHVVDPAGGSYFVESFTDDLAEKAWAVFSGIEAEGGYSAACAS
HHHHCCCCEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCC
GTVTAMLDQTWEQTRADVASRKKKLTGINEFPNLAESPLPADRRVEPAGVRRWAADFEAL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RNRSDAFLEKNGARPQITMIPLGPLSKHNIRTGFTSNLLASGGIEAINPGQLVPGTDAFA
HCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHH
EAAQAAGIVVVCGTDQEYAETGEGAVEKLREAGVERILLAGAPKSFEGSAHAPDGYLNMT
HHHHHCCEEEEECCCHHHHHCCCHHHHHHHHCCHHEEEEECCCCCCCCCCCCCCCEEEEE
IDAAATLADLLDALGA
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDLTKTAVPEELSENLETWYKAVAGVFARTQKKDIGDIAVDVWKKLIVTTPDGVDINPL
CCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCCCCCCCCC
YTRADESQRKFTEVPGEFPFTRGTTVDGERVGWGVTETFGHDSPKNINAAVLNALNSGTT
CCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHCCCCE
TLGFEFSEEFTAADLKVALEGVYLNMAPLLIHAGGSTSEVAAALYTLAEEAGTFFAALTL
EEEEECCCHHHHHHHHHHHHHHEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEEE
GSRPLTAQVDGSHSDTIEEAVQLAVNASKRANVRAILVDGSSFSNQGASDAQEIGLSIAA
CCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHCHHHHH
GVDYVRRLVDAGLSTEAALKQVAFRFAVTDEQFAQISKLRVARRLWARVCEVLGFPELAV
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHC
APQHAVTARAMFSQRDPWVNMLRSTVAAFAAGVGGATDVEVRTFDDAIPDGVPGVSRNFA
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHH
HRIARNTNLLLLEESHLGHVVDPAGGSYFVESFTDDLAEKAWAVFSGIEAEGGYSAACAS
HHHHCCCCEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCC
GTVTAMLDQTWEQTRADVASRKKKLTGINEFPNLAESPLPADRRVEPAGVRRWAADFEAL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RNRSDAFLEKNGARPQITMIPLGPLSKHNIRTGFTSNLLASGGIEAINPGQLVPGTDAFA
HCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHH
EAAQAAGIVVVCGTDQEYAETGEGAVEKLREAGVERILLAGAPKSFEGSAHAPDGYLNMT
HHHHHCCEEEEECCCHHHHHCCCHHHHHHHHCCHHEEEEECCCCCCCCCCCCCCCEEEEE
IDAAATLADLLDALGA
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]