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The map label for this gene is argD

Identifier: 62390282

GI number: 62390282

Start: 1468843

End: 1470018

Strand: Direct

Name: argD

Synonym: cg1583

Alternate gene names: 62390282

Gene position: 1468843-1470018 (Clockwise)

Preceding gene: 62390281

Following gene: 62390283

Centisome position: 44.74

GC content: 57.65

Gene sequence:

>1176_bases
ATGAGCACGCTGGAAACTTGGCCACAGGTCATTATTAATACGTACGGCACCCCACCAGTTGAGCTGGTGTCCGGCAAGGG
CGCAACCGTCACTGATGACCAGGGCAATGTCTACATCGACTTGCTCGCGGGCATCGCAGTCAACGCGTTGGGCCACGCCC
ACCCGGCGATCATCGAGGCGGTCACCAACCAGATCGGCCAACTTGGTCACGTCTCAAACTTGTTCGCATCCAGGCCCGTC
GTCGAGGTCGCCGAGGAGCTCATCAAGCGTTTTTCGCTTGACGACGCCACCCTCGCCGCGCAAACCCGGGTTTTCTTCTG
CAACTCGGGCGCCGAAGCAAACGAGGCTGCTTTCAAGATTGCACGCTTGACTGGTCGTTCCCGGATTCTGGCTGCAGTTC
ATGGTTTCCACGGCCGCACCATGGGTTCCCTCGCGCTGACTGGCCAGCCAGACAAGCGTGAAGCGTTCCTGCCAATGCCA
AGCGGTGTGGAGTTCTACCCTTACGGCGACACCGATTACTTGCGCAAAATGGTAGAAACCAACCCAACGGATGTGGCTGC
TATCTTCCTCGAGCCAATCCAGGGTGAAACGGGCGTTGTTCCAGCACCTGAAGGATTCCTCAAGGCAGTGCGCGAGCTGT
GCGATGAGTACGGCATCTTGATGATCACCGATGAAGTCCAGACTGGCGTTGGCCGTACCGGCGATTTCTTTGCACATCAG
CACGATGGCGTTGTTCCCGATGTGGTGACCATGGCCAAGGGACTTGGCGGCGGTCTTCCCATCGGTGCTTGTTTGGCCAC
TGGCCGTGCAGCTGAATTGATGACCCCAGGCAAGCACGGCACCACTTTCGGTGGCAACCCAGTTGCTTGTGCAGCTGCCA
AGGCAGTGCTGTCTGTTGTCGATGACGCTTTCTGCGCAGAAGTTGCCCGCAAGGGCGAGCTGTTCAAGGAACTTCTTGCC
AAGGTTGACGGCGTTGTAGACGTCCGTGGCAGGGGCTTGATGTTGGGCGTGGTGCTGGAGCGCGACGTCGCAAAGCAAGC
TGTTCTTGATGGTTTTAAGCACGGCGTTATTTTGAATGCACCGGCGGACAACATTATCCGTTTGACCCCGCCGCTGGTGA
TCACCGACGAAGAAATCGCAGACGCAGTCAAGGCTATTGCCGAGACAATCGCATAA

Upstream 100 bases:

>100_bases
GGGTGGAATTGGCACGATGGTGCTGCCGGATGTTTTTGATCGGGAGAATTATCCTGAAGGCACCGTTTTTAGAAAAGACG
ACAAGGATGGGGAACTGTAA

Downstream 100 bases:

>100_bases
AGGACTCAAACTTATGACTTCACAACCACAGGTTCGCCATTTTCTGGCTGATGATGATCTCACCCCTGCAGAGCAGGCAG
AGGTTTTGACCCTAGCCGCA

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSTLETWPQVIINTYGTPPVELVSGKGATVTDDQGNVYIDLLAGIAVNALGHAHPAIIEAVTNQIGQLGHVSNLFASRPV
VEVAEELIKRFSLDDATLAAQTRVFFCNSGAEANEAAFKIARLTGRSRILAAVHGFHGRTMGSLALTGQPDKREAFLPMP
SGVEFYPYGDTDYLRKMVETNPTDVAAIFLEPIQGETGVVPAPEGFLKAVRELCDEYGILMITDEVQTGVGRTGDFFAHQ
HDGVVPDVVTMAKGLGGGLPIGACLATGRAAELMTPGKHGTTFGGNPVACAAAKAVLSVVDDAFCAEVARKGELFKELLA
KVDGVVDVRGRGLMLGVVLERDVAKQAVLDGFKHGVILNAPADNIIRLTPPLVITDEEIADAVKAIAETIA

Sequences:

>Translated_391_residues
MSTLETWPQVIINTYGTPPVELVSGKGATVTDDQGNVYIDLLAGIAVNALGHAHPAIIEAVTNQIGQLGHVSNLFASRPV
VEVAEELIKRFSLDDATLAAQTRVFFCNSGAEANEAAFKIARLTGRSRILAAVHGFHGRTMGSLALTGQPDKREAFLPMP
SGVEFYPYGDTDYLRKMVETNPTDVAAIFLEPIQGETGVVPAPEGFLKAVRELCDEYGILMITDEVQTGVGRTGDFFAHQ
HDGVVPDVVTMAKGLGGGLPIGACLATGRAAELMTPGKHGTTFGGNPVACAAAKAVLSVVDDAFCAEVARKGELFKELLA
KVDGVVDVRGRGLMLGVVLERDVAKQAVLDGFKHGVILNAPADNIIRLTPPLVITDEEIADAVKAIAETIA
>Mature_390_residues
STLETWPQVIINTYGTPPVELVSGKGATVTDDQGNVYIDLLAGIAVNALGHAHPAIIEAVTNQIGQLGHVSNLFASRPVV
EVAEELIKRFSLDDATLAAQTRVFFCNSGAEANEAAFKIARLTGRSRILAAVHGFHGRTMGSLALTGQPDKREAFLPMPS
GVEFYPYGDTDYLRKMVETNPTDVAAIFLEPIQGETGVVPAPEGFLKAVRELCDEYGILMITDEVQTGVGRTGDFFAHQH
DGVVPDVVTMAKGLGGGLPIGACLATGRAAELMTPGKHGTTFGGNPVACAAAKAVLSVVDDAFCAEVARKGELFKELLAK
VDGVVDVRGRGLMLGVVLERDVAKQAVLDGFKHGVILNAPADNIIRLTPPLVITDEEIADAVKAIAETIA

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=394, Percent_Identity=35.2791878172589, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI284507298, Length=299, Percent_Identity=37.123745819398, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI13994255, Length=437, Percent_Identity=31.8077803203661, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI37574042, Length=406, Percent_Identity=28.5714285714286, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI24119277, Length=402, Percent_Identity=30.5970149253731, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI226442709, Length=371, Percent_Identity=29.3800539083558, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI226442705, Length=406, Percent_Identity=27.8325123152709, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1788044, Length=400, Percent_Identity=41.75, Blast_Score=297, Evalue=7e-82,
Organism=Escherichia coli, GI1789759, Length=404, Percent_Identity=38.1188118811881, Blast_Score=274, Evalue=6e-75,
Organism=Escherichia coli, GI145693181, Length=397, Percent_Identity=37.7833753148615, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1787560, Length=401, Percent_Identity=35.4114713216958, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1789016, Length=403, Percent_Identity=33.9950372208437, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=29.3556085918854, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786349, Length=320, Percent_Identity=32.5, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=392, Percent_Identity=33.9285714285714, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=31.6397228637413, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25144274, Length=267, Percent_Identity=35.9550561797753, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=428, Percent_Identity=30.8411214953271, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17541228, Length=421, Percent_Identity=25.8907363420428, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71981843, Length=180, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324432, Length=396, Percent_Identity=34.3434343434343, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6323470, Length=419, Percent_Identity=35.5608591885441, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6324386, Length=418, Percent_Identity=26.0765550239234, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6321456, Length=427, Percent_Identity=26.463700234192, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI21357415, Length=392, Percent_Identity=35.7142857142857, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=32.7146171693735, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI161085790, Length=431, Percent_Identity=32.0185614849188, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI21356575, Length=407, Percent_Identity=29.7297297297297, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI281366494, Length=416, Percent_Identity=25.2403846153846, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24667139, Length=416, Percent_Identity=25.2403846153846, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24667143, Length=416, Percent_Identity=25.2403846153846, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGD_CORGL (Q59282)

Other databases:

- EMBL:   X86157
- EMBL:   AF049897
- EMBL:   BA000036
- EMBL:   BX927152
- RefSeq:   NP_600616.1
- RefSeq:   YP_225684.1
- ProteinModelPortal:   Q59282
- SMR:   Q59282
- GeneID:   1019373
- GeneID:   3344455
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1583
- KEGG:   cgl:NCgl1343
- HOGENOM:   HBG725944
- OMA:   FRIDWQE
- PhylomeDB:   Q59282
- ProtClustDB:   PRK03244
- BioCyc:   CGLU196627:CG1583-MONOMER
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 41207; Mature: 41076

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 136-136 BINDING 139-139 BINDING 281-281 BINDING 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLETWPQVIINTYGTPPVELVSGKGATVTDDQGNVYIDLLAGIAVNALGHAHPAIIEA
CCCHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCEEEEEHHHHHHHHHCCCCHHHHHH
VTNQIGQLGHVSNLFASRPVVEVAEELIKRFSLDDATLAAQTRVFFCNSGAEANEAAFKI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHEEEEEEEECCCCCCHHHHHHH
ARLTGRSRILAAVHGFHGRTMGSLALTGQPDKREAFLPMPSGVEFYPYGDTDYLRKMVET
HHHCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCEECCCCCCCEEEECCCHHHHHHHHHC
NPTDVAAIFLEPIQGETGVVPAPEGFLKAVRELCDEYGILMITDEVQTGVGRTGDFFAHQ
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHCCCCCCCHHHCC
HDGVVPDVVTMAKGLGGGLPIGACLATGRAAELMTPGKHGTTFGGNPVACAAAKAVLSVV
CCCCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
DDAFCAEVARKGELFKELLAKVDGVVDVRGRGLMLGVVLERDVAKQAVLDGFKHGVILNA
HHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEC
PADNIIRLTPPLVITDEEIADAVKAIAETIA
CCCCEEEECCCEEEECHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STLETWPQVIINTYGTPPVELVSGKGATVTDDQGNVYIDLLAGIAVNALGHAHPAIIEA
CCHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCEEEEEHHHHHHHHHCCCCHHHHHH
VTNQIGQLGHVSNLFASRPVVEVAEELIKRFSLDDATLAAQTRVFFCNSGAEANEAAFKI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHEEEEEEEECCCCCCHHHHHHH
ARLTGRSRILAAVHGFHGRTMGSLALTGQPDKREAFLPMPSGVEFYPYGDTDYLRKMVET
HHHCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCEECCCCCCCEEEECCCHHHHHHHHHC
NPTDVAAIFLEPIQGETGVVPAPEGFLKAVRELCDEYGILMITDEVQTGVGRTGDFFAHQ
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHCCCCCCCHHHCC
HDGVVPDVVTMAKGLGGGLPIGACLATGRAAELMTPGKHGTTFGGNPVACAAAKAVLSVV
CCCCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
DDAFCAEVARKGELFKELLAKVDGVVDVRGRGLMLGVVLERDVAKQAVLDGFKHGVILNA
HHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEC
PADNIIRLTPPLVITDEEIADAVKAIAETIA
CCCCEEEECCCEEEECHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8581175; 12948626