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The map label for this gene is lipP [H]

Identifier: 62390056

GI number: 62390056

Start: 1229331

End: 1230107

Strand: Direct

Name: lipP [H]

Synonym: cg1320

Alternate gene names: 62390056

Gene position: 1229331-1230107 (Clockwise)

Preceding gene: 62390055

Following gene: 62390057

Centisome position: 37.45

GC content: 53.67

Gene sequence:

>777_bases
GTGGCTAGTGAAGCTACCCGGCATCTCATGGGGGAGAAGACTTCTGTCGCGTATGTTCACGATGTTCTGATCAAGGGCGT
GCCAGTGCGGATATACAATCCGCACCCCAACGACGGGCCGCTTCCTGTCTTTATCTACTTCCATGGTGGCGGATGGGTTT
TGGGGGACCTTGAATCAGTGGATTCCACCGTGCGCGATATTGCCGTTGCTTCAGGCGCCCTGTGTATCAGTGTGGATTAT
CGCCGTGCACCGGAACATCCTTTTCTCGCTGCATTGGATGATTGCCAAGTGGTCACGGAAGCTGTCCTCAATGGTGAACT
CGCCAGTGCTAACCAGCATCTAGTGGCAGTCGGCGGGGACAGCGCCGGTGGCAATATTGCGGCGGTCATCGCTCAACAGC
TGCGCGATCAGATCACCCACCAAGTTCTTGTGTATCCGGTGATGGACGTAATCTTGCTGGTGATTTGTTCTATCATTACC
ACTGGTTTTGCGCTGCTCATGCATCCAAAGAGCAAGGACAAGACGGAGACGATTTCTGATGAATTCCTCGCAGAGATCCA
AGCGGGAAGTGAAAAGATCTCCATTCTGCGTTCGACCCCTGCTGAAAAAGCCAATGCGAGCCGCTGGATCATGTACTTCG
TTGGCGGAATTGGCCTGCTCTACAGCGTGTTCAGCCTGTGGACAGGTGGCGTAACCGGACTGACGTTGAACTCCTTCAAC
TTCCTGTTCCTGTCACTCGGCATGGTGCTCACCGCTAATTACGGGCCAGAGTATTAA

Upstream 100 bases:

>100_bases
CGGAGCATTTCCCATGAGTCTTCATCCAGAAGCCCAGCATTTTGTTTAGCTCACCTCTAAAGCTCCTGATCTGGATACGA
GGACTCCTGCGGAAAACCGT

Downstream 100 bases:

>100_bases
GCAAAGCTTATTCGCGAAGGCATCCAAGGAACGTGGGGATTCATTCTTCAATTCCCGTTCTACGCAGGCATTTTCGGGTT
GATTTCCTTCACCGGTCTGG

Product: lipase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MASEATRHLMGEKTSVAYVHDVLIKGVPVRIYNPHPNDGPLPVFIYFHGGGWVLGDLESVDSTVRDIAVASGALCISVDY
RRAPEHPFLAALDDCQVVTEAVLNGELASANQHLVAVGGDSAGGNIAAVIAQQLRDQITHQVLVYPVMDVILLVICSIIT
TGFALLMHPKSKDKTETISDEFLAEIQAGSEKISILRSTPAEKANASRWIMYFVGGIGLLYSVFSLWTGGVTGLTLNSFN
FLFLSLGMVLTANYGPEY

Sequences:

>Translated_258_residues
MASEATRHLMGEKTSVAYVHDVLIKGVPVRIYNPHPNDGPLPVFIYFHGGGWVLGDLESVDSTVRDIAVASGALCISVDY
RRAPEHPFLAALDDCQVVTEAVLNGELASANQHLVAVGGDSAGGNIAAVIAQQLRDQITHQVLVYPVMDVILLVICSIIT
TGFALLMHPKSKDKTETISDEFLAEIQAGSEKISILRSTPAEKANASRWIMYFVGGIGLLYSVFSLWTGGVTGLTLNSFN
FLFLSLGMVLTANYGPEY
>Mature_257_residues
ASEATRHLMGEKTSVAYVHDVLIKGVPVRIYNPHPNDGPLPVFIYFHGGGWVLGDLESVDSTVRDIAVASGALCISVDYR
RAPEHPFLAALDDCQVVTEAVLNGELASANQHLVAVGGDSAGGNIAAVIAQQLRDQITHQVLVYPVMDVILLVICSIITT
GFALLMHPKSKDKTETISDEFLAEIQAGSEKISILRSTPAEKANASRWIMYFVGGIGLLYSVFSLWTGGVTGLTLNSFNF
LFLSLGMVLTANYGPEY

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157041239, Length=142, Percent_Identity=33.0985915492958, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI206597554, Length=144, Percent_Identity=31.25, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI68051721, Length=146, Percent_Identity=30.1369863013699, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17567059, Length=121, Percent_Identity=45.4545454545455, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI72001146, Length=150, Percent_Identity=34, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71996133, Length=136, Percent_Identity=35.2941176470588, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540028, Length=134, Percent_Identity=35.8208955223881, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 27766; Mature: 27635

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASEATRHLMGEKTSVAYVHDVLIKGVPVRIYNPHPNDGPLPVFIYFHGGGWVLGDLESV
CCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEECCCEEECCHHHH
DSTVRDIAVASGALCISVDYRRAPEHPFLAALDDCQVVTEAVLNGELASANQHLVAVGGD
HHHHHHHHHHCCEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
SAGGNIAAVIAQQLRDQITHQVLVYPVMDVILLVICSIITTGFALLMHPKSKDKTETISD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHH
EFLAEIQAGSEKISILRSTPAEKANASRWIMYFVGGIGLLYSVFSLWTGGVTGLTLNSFN
HHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHH
FLFLSLGMVLTANYGPEY
HHHHHHHHHEEECCCCCC
>Mature Secondary Structure 
ASEATRHLMGEKTSVAYVHDVLIKGVPVRIYNPHPNDGPLPVFIYFHGGGWVLGDLESV
CCHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEECCCEEECCHHHH
DSTVRDIAVASGALCISVDYRRAPEHPFLAALDDCQVVTEAVLNGELASANQHLVAVGGD
HHHHHHHHHHCCEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
SAGGNIAAVIAQQLRDQITHQVLVYPVMDVILLVICSIITTGFALLMHPKSKDKTETISD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHH
EFLAEIQAGSEKISILRSTPAEKANASRWIMYFVGGIGLLYSVFSLWTGGVTGLTLNSFN
HHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHH
FLFLSLGMVLTANYGPEY
HHHHHHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]