Click here to switch to the map view.

The map label for this gene is betP

Identifier: 62389782

GI number: 62389782

Start: 946465

End: 948252

Strand: Direct

Name: betP

Synonym: cg1016

Alternate gene names: 62389782

Gene position: 946465-948252 (Clockwise)

Preceding gene: 62389781

Following gene: 62389783

Centisome position: 28.83

GC content: 51.57

Gene sequence:

>1788_bases
ATGACTACATCTGACCCAAATCCGAAACCGATAGTGGAGGATGCTCAGCCAGAGCAAATTACCGCAACCGAAGAACTGGC
GGGCTTGCTTGAGAATCCAACTAACCTGGAAGGGAAACTGGCCGACGCCGAAGAGGAAATTATCCTCGAAGGCGAAGACA
CCCAGGCCTCACTTAACTGGTCAGTCATCGTTCCAGCCCTAGTCATTGTCCTAGCGACAGTGGTGTGGGGTATCGGATTC
AAAGATAGCTTTACCAACTTTGCTAGTTCTGCGTTGTCAGCAGTAGTTGACAATCTCGGCTGGGCCTTCATTTTGTTTGG
CACAGTCTTTGTATTTTTTATCGTTGTTATCGCCGCTAGTAAATTCGGCACGATTCGCTTAGGCCGCATTGATGAAGCAC
CAGAGTTTCGCACGGTGTCATGGATTTCCATGATGTTTGCTGCAGGTATGGGTATTGGTTTGATGTTCTACGGAACCACA
GAACCTTTAACCTTCTACCGCAATGGTGTACCTGGACATGATGAACACAATGTTGGCGTTGCTATGTCCACGACAATGTT
CCACTGGACCTTGCATCCATGGGCTATCTACGCAATTGTGGGCCTAGCCATTGCCTATTCGACCTTCCGAGTGGGCCGTA
AACAGCTTCTAAGCTCTGCATTCGTGCCACTCATTGGTGAAAAAGGTGCAGAAGGATGGTTGGGCAAGCTCATCGACATC
CTGGCGATTATCGCCACCGTATTCGGCACGGCATGTTCCCTTGGCCTTGGTGCCCTGCAGATTGGTGCAGGCCTGTCCGC
AGCAAACATCATTGAAGATCCAAGCGATTGGACCATCGTTGGCATTGTTTCTGTTTTGACCCTGGCATTTATCTTCTCCG
CTATTTCTGGTGTGGGCAAGGGAATCCAGTACCTCTCCAACGCCAACATGGTTCTGGCAGCTCTGCTCGCGATTTTCGTG
TTCGTTGTCGGACCAACCGTGTCGATTTTGAACCTGCTGCCAGGTTCTATTGGCAACTACCTGTCCAACTTCTTCCAAAT
GGCAGGCCGCACTGCCATGAGTGCCGACGGCACAGCAGGTGAGTGGCTAGGTAGCTGGACCATCTTCTACTGGGCATGGT
GGATCTCTTGGTCACCATTCGTAGGAATGTTCTTGGCACGTATTTCCCGTGGCCGCTCCATCCGTGAGTTCATCCTGGGC
GTGTTGCTCGTCCCAGCAGGTGTGTCCACCGTATGGTTCTCCATTTTTGGTGGCACTGCGATTGTCTTCGAACAAAATGG
GGAATCCATTTGGGGTGATGGTGCAGCAGAAGAGCAGCTTTTTGGATTGCTTCATGCACTTCCAGGTGGGCAAATCATGG
GCATCATCGCCATGATTTTGCTGGGTACTTTCTTCATTACCTCTGCTGACTCTGCTTCCACCGTCATGGGCACCATGAGT
CAGCACGGCCAGCTGGAAGCCAACAAGTGGGTGACAGCTGCCTGGGGTGTTGCTACCGCAGCTATTGGACTAACGCTATT
GCTTTCTGGTGGTGACAATGCCTTGAGCAACTTGCAAAACGTCACCATCGTGGCTGCAACACCATTCTTGTTTGTGGTTA
TTGGATTGATGTTTGCGTTAGTCAAGGACTTAAGCAATGATGTGATCTACCTCGAGTACCGTGAGCAGCAACGCTTCAAC
GCGCGCCTTGCCCGTGAACGTCGTGTTCACAATGAACACCGCAAGCGTGAACTGGCTGCAAAGCGACGCAGGGAGCGTAA
GGCGAGTGGCGCGGGGAAGCGTCGATAG

Upstream 100 bases:

>100_bases
TAACAGCTATGTAAAAGACCAGGTCAGGTTCGGGTCGGTTTAGGTACGAAACCCATTTTTCGGTTTGCTTTCCAGGTTTC
CCCAAGTAAAGGTGAGTTTT

Downstream 100 bases:

>100_bases
GCAATTTTTAACCCCTGATACCCCTTTCCGGCCGGGCATAAATTAAGGTGGTACGCATGACGAAGAACGTGCTCGTATCT
GTTGCCTGGCCGTATGCCAA

Product: glycine betaine transporter

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MTTSDPNPKPIVEDAQPEQITATEELAGLLENPTNLEGKLADAEEEIILEGEDTQASLNWSVIVPALVIVLATVVWGIGF
KDSFTNFASSALSAVVDNLGWAFILFGTVFVFFIVVIAASKFGTIRLGRIDEAPEFRTVSWISMMFAAGMGIGLMFYGTT
EPLTFYRNGVPGHDEHNVGVAMSTTMFHWTLHPWAIYAIVGLAIAYSTFRVGRKQLLSSAFVPLIGEKGAEGWLGKLIDI
LAIIATVFGTACSLGLGALQIGAGLSAANIIEDPSDWTIVGIVSVLTLAFIFSAISGVGKGIQYLSNANMVLAALLAIFV
FVVGPTVSILNLLPGSIGNYLSNFFQMAGRTAMSADGTAGEWLGSWTIFYWAWWISWSPFVGMFLARISRGRSIREFILG
VLLVPAGVSTVWFSIFGGTAIVFEQNGESIWGDGAAEEQLFGLLHALPGGQIMGIIAMILLGTFFITSADSASTVMGTMS
QHGQLEANKWVTAAWGVATAAIGLTLLLSGGDNALSNLQNVTIVAATPFLFVVIGLMFALVKDLSNDVIYLEYREQQRFN
ARLARERRVHNEHRKRELAAKRRRERKASGAGKRR

Sequences:

>Translated_595_residues
MTTSDPNPKPIVEDAQPEQITATEELAGLLENPTNLEGKLADAEEEIILEGEDTQASLNWSVIVPALVIVLATVVWGIGF
KDSFTNFASSALSAVVDNLGWAFILFGTVFVFFIVVIAASKFGTIRLGRIDEAPEFRTVSWISMMFAAGMGIGLMFYGTT
EPLTFYRNGVPGHDEHNVGVAMSTTMFHWTLHPWAIYAIVGLAIAYSTFRVGRKQLLSSAFVPLIGEKGAEGWLGKLIDI
LAIIATVFGTACSLGLGALQIGAGLSAANIIEDPSDWTIVGIVSVLTLAFIFSAISGVGKGIQYLSNANMVLAALLAIFV
FVVGPTVSILNLLPGSIGNYLSNFFQMAGRTAMSADGTAGEWLGSWTIFYWAWWISWSPFVGMFLARISRGRSIREFILG
VLLVPAGVSTVWFSIFGGTAIVFEQNGESIWGDGAAEEQLFGLLHALPGGQIMGIIAMILLGTFFITSADSASTVMGTMS
QHGQLEANKWVTAAWGVATAAIGLTLLLSGGDNALSNLQNVTIVAATPFLFVVIGLMFALVKDLSNDVIYLEYREQQRFN
ARLARERRVHNEHRKRELAAKRRRERKASGAGKRR
>Mature_594_residues
TTSDPNPKPIVEDAQPEQITATEELAGLLENPTNLEGKLADAEEEIILEGEDTQASLNWSVIVPALVIVLATVVWGIGFK
DSFTNFASSALSAVVDNLGWAFILFGTVFVFFIVVIAASKFGTIRLGRIDEAPEFRTVSWISMMFAAGMGIGLMFYGTTE
PLTFYRNGVPGHDEHNVGVAMSTTMFHWTLHPWAIYAIVGLAIAYSTFRVGRKQLLSSAFVPLIGEKGAEGWLGKLIDIL
AIIATVFGTACSLGLGALQIGAGLSAANIIEDPSDWTIVGIVSVLTLAFIFSAISGVGKGIQYLSNANMVLAALLAIFVF
VVGPTVSILNLLPGSIGNYLSNFFQMAGRTAMSADGTAGEWLGSWTIFYWAWWISWSPFVGMFLARISRGRSIREFILGV
LLVPAGVSTVWFSIFGGTAIVFEQNGESIWGDGAAEEQLFGLLHALPGGQIMGIIAMILLGTFFITSADSASTVMGTMSQ
HGQLEANKWVTAAWGVATAAIGLTLLLSGGDNALSNLQNVTIVAATPFLFVVIGLMFALVKDLSNDVIYLEYREQQRFNA
RLARERRVHNEHRKRELAAKRRRERKASGAGKRR

Specific function: High-affinity uptake of glycine betaine

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family

Homologues:

Organism=Escherichia coli, GI1786506, Length=528, Percent_Identity=34.6590909090909, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1788102, Length=471, Percent_Identity=28.8747346072187, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1786224, Length=524, Percent_Identity=28.2442748091603, Blast_Score=166, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BETP_CORGL (P54582)

Other databases:

- EMBL:   X93514
- EMBL:   BA000036
- EMBL:   BX927150
- RefSeq:   NP_600119.1
- RefSeq:   YP_225184.1
- PDB:   2WIT
- PDBsum:   2WIT
- ProteinModelPortal:   P54582
- GeneID:   1018885
- GeneID:   3342778
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1016
- KEGG:   cgl:NCgl0856
- HOGENOM:   HBG682943
- OMA:   GSAIFVE
- PhylomeDB:   P54582
- ProtClustDB:   CLSK633097
- BioCyc:   CGLU196627:CG1016-MONOMER
- InterPro:   IPR000060
- InterPro:   IPR018093
- TIGRFAMs:   TIGR00842

Pfam domain/function: PF02028 BCCT

EC number: NA

Molecular weight: Translated: 64210; Mature: 64079

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x129e31ac)-; HASH(0x12a751d8)-; HASH(0x11c112b0)-; HASH(0x12365358)-; HASH(0x126f2f50)-; HASH(0x12bed6e8)-; HASH(0x10c52224)-; HASH(0x12a9514c)-; HASH(0x11fe55fc)-; HASH(0x11924778)-; HASH(0x12000f8c)-; HASH(0x11c411b8)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSDPNPKPIVEDAQPEQITATEELAGLLENPTNLEGKLADAEEEIILEGEDTQASLNW
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCH
SVIVPALVIVLATVVWGIGFKDSFTNFASSALSAVVDNLGWAFILFGTVFVFFIVVIAAS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
KFGTIRLGRIDEAPEFRTVSWISMMFAAGMGIGLMFYGTTEPLTFYRNGVPGHDEHNVGV
CCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCCCCCCCCE
AMSTTMFHWTLHPWAIYAIVGLAIAYSTFRVGRKQLLSSAFVPLIGEKGAEGWLGKLIDI
EEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHH
LAIIATVFGTACSLGLGALQIGAGLSAANIIEDPSDWTIVGIVSVLTLAFIFSAISGVGK
HHHHHHHHHHHHHHCCHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GIQYLSNANMVLAALLAIFVFVVGPTVSILNLLPGSIGNYLSNFFQMAGRTAMSADGTAG
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCH
EWLGSWTIFYWAWWISWSPFVGMFLARISRGRSIREFILGVLLVPAGVSTVWFSIFGGTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCEE
IVFEQNGESIWGDGAAEEQLFGLLHALPGGQIMGIIAMILLGTFFITSADSASTVMGTMS
EEEECCCCEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QHGQLEANKWVTAAWGVATAAIGLTLLLSGGDNALSNLQNVTIVAATPFLFVVIGLMFAL
HCCCCCCCCEEEHHHHHHHHHHHHHEEEECCCHHHHCCCCEEEEEHHHHHHHHHHHHHHH
VKDLSNDVIYLEYREQQRFNARLARERRVHNEHRKRELAAKRRRERKASGAGKRR
HHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
TTSDPNPKPIVEDAQPEQITATEELAGLLENPTNLEGKLADAEEEIILEGEDTQASLNW
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCH
SVIVPALVIVLATVVWGIGFKDSFTNFASSALSAVVDNLGWAFILFGTVFVFFIVVIAAS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
KFGTIRLGRIDEAPEFRTVSWISMMFAAGMGIGLMFYGTTEPLTFYRNGVPGHDEHNVGV
CCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCCCCCCCCE
AMSTTMFHWTLHPWAIYAIVGLAIAYSTFRVGRKQLLSSAFVPLIGEKGAEGWLGKLIDI
EEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHH
LAIIATVFGTACSLGLGALQIGAGLSAANIIEDPSDWTIVGIVSVLTLAFIFSAISGVGK
HHHHHHHHHHHHHHCCHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GIQYLSNANMVLAALLAIFVFVVGPTVSILNLLPGSIGNYLSNFFQMAGRTAMSADGTAG
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCH
EWLGSWTIFYWAWWISWSPFVGMFLARISRGRSIREFILGVLLVPAGVSTVWFSIFGGTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCEE
IVFEQNGESIWGDGAAEEQLFGLLHALPGGQIMGIIAMILLGTFFITSADSASTVMGTMS
EEEECCCCEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QHGQLEANKWVTAAWGVATAAIGLTLLLSGGDNALSNLQNVTIVAATPFLFVVIGLMFAL
HCCCCCCCCEEEHHHHHHHHHHHHHEEEECCCHHHHCCCCEEEEEHHHHHHHHHHHHHHH
VKDLSNDVIYLEYREQQRFNARLARERRVHNEHRKRELAAKRRRERKASGAGKRR
HHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12948626