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The map label for this gene is degP [H]

Identifier: 62389765

GI number: 62389765

Start: 931796

End: 933121

Strand: Direct

Name: degP [H]

Synonym: cg0998

Alternate gene names: 62389765

Gene position: 931796-933121 (Clockwise)

Preceding gene: 62389764

Following gene: 62389766

Centisome position: 28.38

GC content: 51.06

Gene sequence:

>1326_bases
ATGACAAATCAATTCCCCACAAACAACGGTGAGAACCCGGACCGTGCATCGGAAACTCCATCAGAAACCAACTCCTTCGA
ACATGTGCGTAGTTCATATCCGCAGTGGGGTAACACTGCTTCCAATCAAAACCCCTATCCTGGTGCGGGCTTCGGCTCTG
AACAAAACACTCAACAAGGAAATGAGCAACAAGCTCCAGCCTGGACCAGTTGGGATAATCAGCCTCTAAGCACAGATGTA
AAGCCAGCTAAAGAAAAGCGAAAAGTTGGCATCGGAACGGCACTCGCGTTAATGCTTGTTGGTTCTATTGCTACCGGTAG
CGTTGTGGGTGTTGCAGCAACCCAGCTTGGTTCGGACTCTTCAACCCCAGTTAATGCTCTTGAGCAGCCCAGCGTGCAGC
GCACCACTAATGCTGAACCAGGTTCAGCGGAACAGGTTGCTGCCGCAGTTTTGCCTTCTGTCGTCTCTATTCAGGCCATT
ACTAGGACGTCTGCTTCTGAGGGCTCTGGATCCATTATTTCCTCTGATGGTTACGTCATGACCAATAATCACGTCGTGGC
AGGCATTGAACAATCTGGTGTGTTAGAAGTAAGTTTCTCCGATGGAACTACAGCGCAAGCTGATTTTATTGCTGGTGATC
CTTCCACAGATATTGCTGTGATCAAGATTAGGGATGTGTCCAACCTTCCAGTTATGAGCTTTGGAGATTCGGACGCATTA
GGCGTTGGACAAAGTGTGATGGCTGTTGGTTCTCCACTGGGTCTGAGCTCCACTGTGACCACCGGTATTGTGTCGGCCGT
GAACCGTCCTGTGCGAGCTTCTGGTGATGGCGGAGAGTCGTCCCTCATCGATGCTATCCAGACCGATGCTGCGATCAACC
CTGGTAACTCTGGTGGTCCGCTGGTTGATATGGATGGCAACCTCATTGGCATGAATTCGGTAATTGCATCGATTTCGAGC
ACCAGCGATTCCGCAGGTTCCATTGGTCTTGGTTTTTCTATCCCATCCAACTTTGCCAAGCGCGTGGCCGATCAATTGAT
CAGCACCGGCCAGGTAACTCAGCCGATGATCGGTGTGCAGGTTGGCACTGACAACTCAGTGACAGGCGCTGTGATTGCCA
GTGTTCAAGATGGTGGACCGGCCGCAGATGCTGGACTTCAGCCAGGCGATATCGTGACCAAGCTCAATGATCGAGTTATT
GATAGCCCAGACTCCTTGATCGCTGCTGTTCGTTCGCATGATTTTGGCGAAACCGTCACTTTAACAATTACACAGCCAGA
TACCTCGCAGAGCCGGGAGGTAGAGGTTACTCTGACGAGTGAGTAG

Upstream 100 bases:

>100_bases
GCGGGTTCGAAAATGTCGATGATTAAACCACTAAAGAGCTCACAGGAAGTGTTCAGACTACTTAGAGTGACGCCCCAGCC
ACAGGGTTCATAATCAAATC

Downstream 100 bases:

>100_bases
GTTTAAAAGAGTTAATCTGCATCTAATCAAGTAGCCAAGTATGAGTGAGGAACAATGAGCAAGGATCCATTGGGAAGTCT
TACCGATGTTGTAGACACAC

Product: trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTNQFPTNNGENPDRASETPSETNSFEHVRSSYPQWGNTASNQNPYPGAGFGSEQNTQQGNEQQAPAWTSWDNQPLSTDV
KPAKEKRKVGIGTALALMLVGSIATGSVVGVAATQLGSDSSTPVNALEQPSVQRTTNAEPGSAEQVAAAVLPSVVSIQAI
TRTSASEGSGSIISSDGYVMTNNHVVAGIEQSGVLEVSFSDGTTAQADFIAGDPSTDIAVIKIRDVSNLPVMSFGDSDAL
GVGQSVMAVGSPLGLSSTVTTGIVSAVNRPVRASGDGGESSLIDAIQTDAAINPGNSGGPLVDMDGNLIGMNSVIASISS
TSDSAGSIGLGFSIPSNFAKRVADQLISTGQVTQPMIGVQVGTDNSVTGAVIASVQDGGPAADAGLQPGDIVTKLNDRVI
DSPDSLIAAVRSHDFGETVTLTITQPDTSQSREVEVTLTSE

Sequences:

>Translated_441_residues
MTNQFPTNNGENPDRASETPSETNSFEHVRSSYPQWGNTASNQNPYPGAGFGSEQNTQQGNEQQAPAWTSWDNQPLSTDV
KPAKEKRKVGIGTALALMLVGSIATGSVVGVAATQLGSDSSTPVNALEQPSVQRTTNAEPGSAEQVAAAVLPSVVSIQAI
TRTSASEGSGSIISSDGYVMTNNHVVAGIEQSGVLEVSFSDGTTAQADFIAGDPSTDIAVIKIRDVSNLPVMSFGDSDAL
GVGQSVMAVGSPLGLSSTVTTGIVSAVNRPVRASGDGGESSLIDAIQTDAAINPGNSGGPLVDMDGNLIGMNSVIASISS
TSDSAGSIGLGFSIPSNFAKRVADQLISTGQVTQPMIGVQVGTDNSVTGAVIASVQDGGPAADAGLQPGDIVTKLNDRVI
DSPDSLIAAVRSHDFGETVTLTITQPDTSQSREVEVTLTSE
>Mature_440_residues
TNQFPTNNGENPDRASETPSETNSFEHVRSSYPQWGNTASNQNPYPGAGFGSEQNTQQGNEQQAPAWTSWDNQPLSTDVK
PAKEKRKVGIGTALALMLVGSIATGSVVGVAATQLGSDSSTPVNALEQPSVQRTTNAEPGSAEQVAAAVLPSVVSIQAIT
RTSASEGSGSIISSDGYVMTNNHVVAGIEQSGVLEVSFSDGTTAQADFIAGDPSTDIAVIKIRDVSNLPVMSFGDSDALG
VGQSVMAVGSPLGLSSTVTTGIVSAVNRPVRASGDGGESSLIDAIQTDAAINPGNSGGPLVDMDGNLIGMNSVIASISST
SDSAGSIGLGFSIPSNFAKRVADQLISTGQVTQPMIGVQVGTDNSVTGAVIASVQDGGPAADAGLQPGDIVTKLNDRVID
SPDSLIAAVRSHDFGETVTLTITQPDTSQSREVEVTLTSE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=291, Percent_Identity=34.7079037800687, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI4506141, Length=279, Percent_Identity=34.0501792114695, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI7019477, Length=310, Percent_Identity=33.2258064516129, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24308541, Length=309, Percent_Identity=31.3915857605178, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1786356, Length=286, Percent_Identity=39.8601398601399, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1789629, Length=283, Percent_Identity=39.9293286219081, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789630, Length=322, Percent_Identity=31.6770186335404, Blast_Score=135, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24646839, Length=304, Percent_Identity=34.5394736842105, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 44877; Mature: 44745

Theoretical pI: Translated: 3.95; Mature: 3.95

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQFPTNNGENPDRASETPSETNSFEHVRSSYPQWGNTASNQNPYPGAGFGSEQNTQQG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NEQQAPAWTSWDNQPLSTDVKPAKEKRKVGIGTALALMLVGSIATGSVVGVAATQLGSDS
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCEEEEHHHHCCCCC
STPVNALEQPSVQRTTNAEPGSAEQVAAAVLPSVVSIQAITRTSASEGSGSIISSDGYVM
CCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCEEE
TNNHVVAGIEQSGVLEVSFSDGTTAQADFIAGDPSTDIAVIKIRDVSNLPVMSFGDSDAL
ECCEEEEEECCCCEEEEEECCCCCCCEEEECCCCCCCEEEEEEECCCCCCEEECCCCCCC
GVGQSVMAVGSPLGLSSTVTTGIVSAVNRPVRASGDGGESSLIDAIQTDAAINPGNSGGP
CCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
LVDMDGNLIGMNSVIASISSTSDSAGSIGLGFSIPSNFAKRVADQLISTGQVTQPMIGVQ
EEECCCCEEEHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
VGTDNSVTGAVIASVQDGGPAADAGLQPGDIVTKLNDRVIDSPDSLIAAVRSHDFGETVT
ECCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEE
LTITQPDTSQSREVEVTLTSE
EEEECCCCCCCCEEEEEEECC
>Mature Secondary Structure 
TNQFPTNNGENPDRASETPSETNSFEHVRSSYPQWGNTASNQNPYPGAGFGSEQNTQQG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NEQQAPAWTSWDNQPLSTDVKPAKEKRKVGIGTALALMLVGSIATGSVVGVAATQLGSDS
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCEEEEHHHHCCCCC
STPVNALEQPSVQRTTNAEPGSAEQVAAAVLPSVVSIQAITRTSASEGSGSIISSDGYVM
CCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCEEE
TNNHVVAGIEQSGVLEVSFSDGTTAQADFIAGDPSTDIAVIKIRDVSNLPVMSFGDSDAL
ECCEEEEEECCCCEEEEEECCCCCCCEEEECCCCCCCEEEEEEECCCCCCEEECCCCCCC
GVGQSVMAVGSPLGLSSTVTTGIVSAVNRPVRASGDGGESSLIDAIQTDAAINPGNSGGP
CCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
LVDMDGNLIGMNSVIASISSTSDSAGSIGLGFSIPSNFAKRVADQLISTGQVTQPMIGVQ
EEECCCCEEEHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
VGTDNSVTGAVIASVQDGGPAADAGLQPGDIVTKLNDRVIDSPDSLIAAVRSHDFGETVT
ECCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEE
LTITQPDTSQSREVEVTLTSE
EEEECCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]