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The map label for this gene is cgtS2 [H]

Identifier: 62389764

GI number: 62389764

Start: 930282

End: 931721

Strand: Direct

Name: cgtS2 [H]

Synonym: cg0997

Alternate gene names: 62389764

Gene position: 930282-931721 (Clockwise)

Preceding gene: 62389763

Following gene: 62389765

Centisome position: 28.34

GC content: 49.58

Gene sequence:

>1440_bases
GTGACATTAAGGCGAATCGGCGCAGGGGAAAATGGGCCTGCCCCTACCGAAAGTGATGACTCCGACGGTTCAATGTCGTT
GCGTTGGCGCTTGGCTTTGCTGAGCGCCACTTTGGTAGCTTTCGCCGTTGGTGTTATTACTGTTGCTGCATATTGGTCTG
TCTCCAGCTATGTCACCAACTCAATCGATCGTGATCTGGAAAAACAAGCGGATGCAATGCTTGGACGAGCCAGTGAAGCG
GGATTCTATGCAACCGCAGAAACCGAAATTGCTCTGTTAGGTGAATATGCCAGTGACACTCGAATCGCCTTAATCCCACC
TGGGTGGGAATACGTCATCGGTGAATCCATATCACTGCCTGATTCAGATTTCCTTAAGAGTAAAGAAGCGGGGAAACAGA
TCCTCGTAACAAGTGCTGAGCGCATTCTCATGAAACGAGATAGCTCGGGCACAGTGGTGGTTTTTGCTAAAGATATGGTG
GATACCGATCGGCAGCTCACGGTGCTTGGCGTCATTCTCTTGATCATTGGCGGCAGTGGTGTTTTGGCGTCGATTCTGCT
TGGTTTCATCATTGCGAAGGAGGGGCTGAAACCACTGTCAAAGCTGCAGCGTGCCGTCGAAGAGATCGAACGAACTGATG
AGCTTCGTGCGATTCCCGTGGTGGGAAATGATGAGTTCGCTAAGTTGACTCGTAGTTTCAATGACATGCTCAAGGCACTG
CGGGAGTCTCGTACCCGGCAATCTCAGTTGGTGGCAGATGCAGGACACGAGCTGAAAACTCCACTGACCTCAATGCGGAC
AAATATTGAATTGCTGTTGATGGCAACCAACAGTGGAGGATCGGGAATCCCCAAGGAAGAATTGGATGGCCTTCAGCGTG
ATGTATTGGCGCAGATGACCGAAATGTCTGATTTGATTGGTGATCTTGTTGATCTTGCGCGTGAAGAAACCGCCGAAACG
TCAAGCATTGTAGATCTCAACCAAGTGTTGGAAATTGCGCTTGACCGAATGGAAAGCCGTCGCATGACGGTGCGGATAGA
TGTTTCCGAGACTGTGGATTGGAAACTGCTGGGCGATGATTTTTCCTTAACCAGGGCATTAGTAAATGTTTTGGATAATG
CCATTAAATGGTCGCCTGAGAATGGCATTGTTCGAGTGTCGATGTCACAGATCGACAAAGCAACGGTCCGCATTGTTATT
GATGATTCAGGGCCTGGAATTGCTGAAAAAGAACGAGGATTAGTTTTGGAACGGTTCTATCGCGCCGTCAGCTCCCGTTC
CATGCCGGGATCGGGATTAGGTCTTGCCATCGTGAATCAGGTTGTGAATCGGCATGGTGGCCAACTCGTTGTGGGTGAAT
CAGATGATGGCGGAACGAGAATCACTATTGATTTGCCAGGGGAACCCATTCGCAGCGGGTTCGAAAATGTCGATGATTAA

Upstream 100 bases:

>100_bases
TCTACATTGGATACCTTCGACGCAAGACTGAATTGGAAGGAGAAGACCGCCTGATCCATACAGTACGAGGAGTCGGATAC
GTCCTGCGAGAGACCGCTCC

Downstream 100 bases:

>100_bases
ACCACTAAAGAGCTCACAGGAAGTGTTCAGACTACTTAGAGTGACGCCCCAGCCACAGGGTTCATAATCAAATCATGACA
AATCAATTCCCCACAAACAA

Product: two component sensor kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MTLRRIGAGENGPAPTESDDSDGSMSLRWRLALLSATLVAFAVGVITVAAYWSVSSYVTNSIDRDLEKQADAMLGRASEA
GFYATAETEIALLGEYASDTRIALIPPGWEYVIGESISLPDSDFLKSKEAGKQILVTSAERILMKRDSSGTVVVFAKDMV
DTDRQLTVLGVILLIIGGSGVLASILLGFIIAKEGLKPLSKLQRAVEEIERTDELRAIPVVGNDEFAKLTRSFNDMLKAL
RESRTRQSQLVADAGHELKTPLTSMRTNIELLLMATNSGGSGIPKEELDGLQRDVLAQMTEMSDLIGDLVDLAREETAET
SSIVDLNQVLEIALDRMESRRMTVRIDVSETVDWKLLGDDFSLTRALVNVLDNAIKWSPENGIVRVSMSQIDKATVRIVI
DDSGPGIAEKERGLVLERFYRAVSSRSMPGSGLGLAIVNQVVNRHGGQLVVGESDDGGTRITIDLPGEPIRSGFENVDD

Sequences:

>Translated_479_residues
MTLRRIGAGENGPAPTESDDSDGSMSLRWRLALLSATLVAFAVGVITVAAYWSVSSYVTNSIDRDLEKQADAMLGRASEA
GFYATAETEIALLGEYASDTRIALIPPGWEYVIGESISLPDSDFLKSKEAGKQILVTSAERILMKRDSSGTVVVFAKDMV
DTDRQLTVLGVILLIIGGSGVLASILLGFIIAKEGLKPLSKLQRAVEEIERTDELRAIPVVGNDEFAKLTRSFNDMLKAL
RESRTRQSQLVADAGHELKTPLTSMRTNIELLLMATNSGGSGIPKEELDGLQRDVLAQMTEMSDLIGDLVDLAREETAET
SSIVDLNQVLEIALDRMESRRMTVRIDVSETVDWKLLGDDFSLTRALVNVLDNAIKWSPENGIVRVSMSQIDKATVRIVI
DDSGPGIAEKERGLVLERFYRAVSSRSMPGSGLGLAIVNQVVNRHGGQLVVGESDDGGTRITIDLPGEPIRSGFENVDD
>Mature_478_residues
TLRRIGAGENGPAPTESDDSDGSMSLRWRLALLSATLVAFAVGVITVAAYWSVSSYVTNSIDRDLEKQADAMLGRASEAG
FYATAETEIALLGEYASDTRIALIPPGWEYVIGESISLPDSDFLKSKEAGKQILVTSAERILMKRDSSGTVVVFAKDMVD
TDRQLTVLGVILLIIGGSGVLASILLGFIIAKEGLKPLSKLQRAVEEIERTDELRAIPVVGNDEFAKLTRSFNDMLKALR
ESRTRQSQLVADAGHELKTPLTSMRTNIELLLMATNSGGSGIPKEELDGLQRDVLAQMTEMSDLIGDLVDLAREETAETS
SIVDLNQVLEIALDRMESRRMTVRIDVSETVDWKLLGDDFSLTRALVNVLDNAIKWSPENGIVRVSMSQIDKATVRIVID
DSGPGIAEKERGLVLERFYRAVSSRSMPGSGLGLAIVNQVVNRHGGQLVVGESDDGGTRITIDLPGEPIRSGFENVDD

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=297, Percent_Identity=30.3030303030303, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788393, Length=282, Percent_Identity=30.1418439716312, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1790346, Length=279, Percent_Identity=32.258064516129, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1789808, Length=301, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787374, Length=297, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790861, Length=254, Percent_Identity=27.9527559055118, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788279, Length=308, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=28.8888888888889, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789403, Length=286, Percent_Identity=27.972027972028, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=303, Percent_Identity=26.0726072607261, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=26.0869565217391, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=25.2212389380531, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=27.027027027027, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787894, Length=247, Percent_Identity=28.7449392712551, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788549, Length=249, Percent_Identity=26.9076305220884, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=25.8964143426295, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=26.8085106382979, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789149, Length=249, Percent_Identity=25.7028112449799, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51954; Mature: 51823

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRRIGAGENGPAPTESDDSDGSMSLRWRLALLSATLVAFAVGVITVAAYWSVSSYVTN
CCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIDRDLEKQADAMLGRASEAGFYATAETEIALLGEYASDTRIALIPPGWEYVIGESISLP
HHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEECCCCCCEEEEECCCCCEECCCCCCCC
DSDFLKSKEAGKQILVTSAERILMKRDSSGTVVVFAKDMVDTDRQLTVLGVILLIIGGSG
CHHHHHHHHCCCEEEHHHHHHHHHEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCH
VLASILLGFIIAKEGLKPLSKLQRAVEEIERTDELRAIPVVGNDEFAKLTRSFNDMLKAL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHH
RESRTRQSQLVADAGHELKTPLTSMRTNIELLLMATNSGGSGIPKEELDGLQRDVLAQMT
HHHHHHHHHHHHHCCCHHHCCHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
EMSDLIGDLVDLAREETAETSSIVDLNQVLEIALDRMESRRMTVRIDVSETVDWKLLGDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCC
FSLTRALVNVLDNAIKWSPENGIVRVSMSQIDKATVRIVIDDSGPGIAEKERGLVLERFY
HHHHHHHHHHHHHHHEECCCCCEEEEEHHHCCCEEEEEEEECCCCCCCCHHCCHHHHHHH
RAVSSRSMPGSGLGLAIVNQVVNRHGGQLVVGESDDGGTRITIDLPGEPIRSGFENVDD
HHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCHHHHHHHCCCCC
>Mature Secondary Structure 
TLRRIGAGENGPAPTESDDSDGSMSLRWRLALLSATLVAFAVGVITVAAYWSVSSYVTN
CCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIDRDLEKQADAMLGRASEAGFYATAETEIALLGEYASDTRIALIPPGWEYVIGESISLP
HHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEECCCCCCEEEEECCCCCEECCCCCCCC
DSDFLKSKEAGKQILVTSAERILMKRDSSGTVVVFAKDMVDTDRQLTVLGVILLIIGGSG
CHHHHHHHHCCCEEEHHHHHHHHHEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCH
VLASILLGFIIAKEGLKPLSKLQRAVEEIERTDELRAIPVVGNDEFAKLTRSFNDMLKAL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHH
RESRTRQSQLVADAGHELKTPLTSMRTNIELLLMATNSGGSGIPKEELDGLQRDVLAQMT
HHHHHHHHHHHHHCCCHHHCCHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
EMSDLIGDLVDLAREETAETSSIVDLNQVLEIALDRMESRRMTVRIDVSETVDWKLLGDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCC
FSLTRALVNVLDNAIKWSPENGIVRVSMSQIDKATVRIVIDDSGPGIAEKERGLVLERFY
HHHHHHHHHHHHHHHEECCCCCEEEEEHHHCCCEEEEEEEECCCCCCCCHHCCHHHHHHH
RAVSSRSMPGSGLGLAIVNQVVNRHGGQLVVGESDDGGTRITIDLPGEPIRSGFENVDD
HHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA