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The map label for this gene is dtsR1 [H]

Identifier: 62389597

GI number: 62389597

Start: 730166

End: 731797

Strand: Reverse

Name: dtsR1 [H]

Synonym: cg0812

Alternate gene names: 62389597

Gene position: 731797-730166 (Counterclockwise)

Preceding gene: 62389606

Following gene: 62389596

Centisome position: 22.29

GC content: 58.58

Gene sequence:

>1632_bases
ATGACCATTTCCTCACCTTTGATTGACGTCGCCAACCTTCCAGACATCAACACCACTGCCGGCAAGATCGCCGACCTTAA
GGCTCGCCGCGCGGAAGCCCATTTCCCCATGGGTGAAAAGGCAGTAGAGAAGGTCCACGCTGCTGGACGCCTCACTGCCC
GTGAGCGCTTGGATTACTTACTCGATGAGGGCTCCTTCATCGAGACCGATCAGCTGGCTCGCCACCGCACCACCGCTTTC
GGCCTGGGCGCTAAGCGTCCTGCAACCGACGGCATCGTGACCGGCTGGGGCACCATTGATGGACGCGAAGTCTGCATCTT
CTCGCAGGACGGCACCGTATTCGGTGGCGCGCTTGGTGAGGTGTACGGCGAAAAGATGATCAAGATCATGGAGCTGGCAA
TCGACACCGGCCGCCCATTGATCGGTCTTTACGAAGGCGCTGGCGCTCGTATTCAGGACGGCGCTGTCTCCCTGGACTTC
ATTTCCCAGACCTTCTACCAAAACATTCAGGCTTCTGGCGTTATCCCACAGATCTCCGTCATCATGGGCGCATGTGCAGG
TGGCAACGCTTACGGCCCAGCTCTGACCGACTTCGTGGTCATGGTGGACAAGACCTCCAAGATGTTCGTTACCGGCCCAG
ACGTGATCAAGACCGTCACCGGCGAGGAAATCACCCAGGAAGAGCTTGGCGGAGCAACCACCCACATGGTGACCGCTGGT
AACTCCCACTACACCGCTGCGACCGATGAGGAAGCACTGGATTGGGTACAGGACCTGGTGTCCTTCCTCCCATCCAACAA
TCGCTCCTACGCACCGATGGAAGACTTCGACGAGGAAGAAGGCGGCGTTGAAGAAAACATCACCGCTGACGATCTGAAGC
TCGACGAGATCATCCCAGATTCCGCGACCGTTCCTTACGACGTCCGCGATGTCATCGAATGCCTCACCGACGATGGCGAA
TACCTGGAAATCCAGGCAGACCGCGCAGAAAACGTTGTTATTGCATTCGGCCGCATCGAAGGCCAGTCCGTTGGCTTTGT
TGCCAACCAGCCAACCCAGTTCGCTGGCTGCCTGGACATCGACTCCTCTGAGAAGGCAGCTCGCTTCGTCCGCACCTGCG
ACGCGTTCAACATCCCAATCGTCATGCTTGTCGACGTCCCCGGCTTCCTCCCAGGCGCAGGCCAGGAGTACGGTGGCATT
CTGCGTCGTGGCGCAAAGCTGCTCTACGCATACGGCGAAGCAACCGTTCCAAAGATCACCGTCACCATGCGTAAGGCTTA
CGGCGGAGCGTACTGCGTGATGGGTTCCAAGGGCTTGGGCTCTGACATCAACCTTGCATGGCCAACCGCACAGATCGCCG
TCATGGGCGCTGCTGGCGCAGTTGGATTCATCTACCGCAAGGAGCTCATGGCAGCTGATGCCAAGGGCCTCGATACCGTA
GCTCTGGCTAAGTCCTTCGAGCGCGAGTATGAAGACCACATGCTCAACCCGTACCACGCTGCAGAACGTGGCCTGATCGA
CGCCGTGATCCTGCCAAGCGAAACCCGCGGACAGATTTCCCGCAACCTTCGCCTGCTCAAGCACAAGAACGTCACTCGCC
CTGCTCGCAAGCACGGCAACATGCCACTGTAA

Upstream 100 bases:

>100_bases
TTTAAAAACTACCCGCACGCAGCACGAACCTGTTCAGTGATGTAAATCACCGCGGAAATATTGTGGACGTTACCCCCGCC
TACCGCTACGATTTCAAAAC

Downstream 100 bases:

>100_bases
ATCGGCGAATCCATAAAGGTTCAAAAGAATTCAATAAGAATTCAATAAGAATTCAATAAGGGTTCAATAAGGGCCGTCTT
AAATGATTGGGTGTAAAGAA

Product: acetyl/propionyl-COA carboxylase subunit beta

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MTISSPLIDVANLPDINTTAGKIADLKARRAEAHFPMGEKAVEKVHAAGRLTARERLDYLLDEGSFIETDQLARHRTTAF
GLGAKRPATDGIVTGWGTIDGREVCIFSQDGTVFGGALGEVYGEKMIKIMELAIDTGRPLIGLYEGAGARIQDGAVSLDF
ISQTFYQNIQASGVIPQISVIMGACAGGNAYGPALTDFVVMVDKTSKMFVTGPDVIKTVTGEEITQEELGGATTHMVTAG
NSHYTAATDEEALDWVQDLVSFLPSNNRSYAPMEDFDEEEGGVEENITADDLKLDEIIPDSATVPYDVRDVIECLTDDGE
YLEIQADRAENVVIAFGRIEGQSVGFVANQPTQFAGCLDIDSSEKAARFVRTCDAFNIPIVMLVDVPGFLPGAGQEYGGI
LRRGAKLLYAYGEATVPKITVTMRKAYGGAYCVMGSKGLGSDINLAWPTAQIAVMGAAGAVGFIYRKELMAADAKGLDTV
ALAKSFEREYEDHMLNPYHAAERGLIDAVILPSETRGQISRNLRLLKHKNVTRPARKHGNMPL

Sequences:

>Translated_543_residues
MTISSPLIDVANLPDINTTAGKIADLKARRAEAHFPMGEKAVEKVHAAGRLTARERLDYLLDEGSFIETDQLARHRTTAF
GLGAKRPATDGIVTGWGTIDGREVCIFSQDGTVFGGALGEVYGEKMIKIMELAIDTGRPLIGLYEGAGARIQDGAVSLDF
ISQTFYQNIQASGVIPQISVIMGACAGGNAYGPALTDFVVMVDKTSKMFVTGPDVIKTVTGEEITQEELGGATTHMVTAG
NSHYTAATDEEALDWVQDLVSFLPSNNRSYAPMEDFDEEEGGVEENITADDLKLDEIIPDSATVPYDVRDVIECLTDDGE
YLEIQADRAENVVIAFGRIEGQSVGFVANQPTQFAGCLDIDSSEKAARFVRTCDAFNIPIVMLVDVPGFLPGAGQEYGGI
LRRGAKLLYAYGEATVPKITVTMRKAYGGAYCVMGSKGLGSDINLAWPTAQIAVMGAAGAVGFIYRKELMAADAKGLDTV
ALAKSFEREYEDHMLNPYHAAERGLIDAVILPSETRGQISRNLRLLKHKNVTRPARKHGNMPL
>Mature_542_residues
TISSPLIDVANLPDINTTAGKIADLKARRAEAHFPMGEKAVEKVHAAGRLTARERLDYLLDEGSFIETDQLARHRTTAFG
LGAKRPATDGIVTGWGTIDGREVCIFSQDGTVFGGALGEVYGEKMIKIMELAIDTGRPLIGLYEGAGARIQDGAVSLDFI
SQTFYQNIQASGVIPQISVIMGACAGGNAYGPALTDFVVMVDKTSKMFVTGPDVIKTVTGEEITQEELGGATTHMVTAGN
SHYTAATDEEALDWVQDLVSFLPSNNRSYAPMEDFDEEEGGVEENITADDLKLDEIIPDSATVPYDVRDVIECLTDDGEY
LEIQADRAENVVIAFGRIEGQSVGFVANQPTQFAGCLDIDSSEKAARFVRTCDAFNIPIVMLVDVPGFLPGAGQEYGGIL
RRGAKLLYAYGEATVPKITVTMRKAYGGAYCVMGSKGLGSDINLAWPTAQIAVMGAAGAVGFIYRKELMAADAKGLDTVA
LAKSFEREYEDHMLNPYHAAERGLIDAVILPSETRGQISRNLRLLKHKNVTRPARKHGNMPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=522, Percent_Identity=50.1915708812261, Blast_Score=502, Evalue=1e-142,
Organism=Homo sapiens, GI295821216, Length=542, Percent_Identity=48.3394833948339, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI11545863, Length=489, Percent_Identity=33.9468302658487, Blast_Score=213, Evalue=4e-55,
Organism=Escherichia coli, GI1788655, Length=189, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=514, Percent_Identity=50.5836575875486, Blast_Score=516, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI25147359, Length=514, Percent_Identity=50.5836575875486, Blast_Score=516, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17552936, Length=504, Percent_Identity=33.531746031746, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24586065, Length=531, Percent_Identity=32.391713747646, Blast_Score=228, Evalue=6e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 58477; Mature: 58346

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISSPLIDVANLPDINTTAGKIADLKARRAEAHFPMGEKAVEKVHAAGRLTARERLDYL
CCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHH
LDEGSFIETDQLARHRTTAFGLGAKRPATDGIVTGWGTIDGREVCIFSQDGTVFGGALGE
HCCCCEECHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCCEECHHHHH
VYGEKMIKIMELAIDTGRPLIGLYEGAGARIQDGAVSLDFISQTFYQNIQASGVIPQISV
HHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCEEHHHHHHHHHHCCCCCCCCCCHHH
IMGACAGGNAYGPALTDFVVMVDKTSKMFVTGPDVIKTVTGEEITQEELGGATTHMVTAG
HHHHCCCCCCCCCHHEEEEEEEECCCEEEEECCHHHHCCCCCHHHHHHHCCCEEEEEECC
NSHYTAATDEEALDWVQDLVSFLPSNNRSYAPMEDFDEEEGGVEENITADDLKLDEIIPD
CCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCCEEHHHCCCC
SATVPYDVRDVIECLTDDGEYLEIQADRAENVVIAFGRIEGQSVGFVANQPTQFAGCLDI
CCCCCCCHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCEEEEEECCCCCEEEEECC
DSSEKAARFVRTCDAFNIPIVMLVDVPGFLPGAGQEYGGILRRGAKLLYAYGEATVPKIT
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCEEE
VTMRKAYGGAYCVMGSKGLGSDINLAWPTAQIAVMGAAGAVGFIYRKELMAADAKGLDTV
EEEECCCCCEEEEECCCCCCCCCEEECCCEEEEEEECCCHHHHHHHHHHHHHCCCCCHHH
ALAKSFEREYEDHMLNPYHAAERGLIDAVILPSETRGQISRNLRLLKHKNVTRPARKHGN
HHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHCCC
MPL
CCC
>Mature Secondary Structure 
TISSPLIDVANLPDINTTAGKIADLKARRAEAHFPMGEKAVEKVHAAGRLTARERLDYL
CCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHH
LDEGSFIETDQLARHRTTAFGLGAKRPATDGIVTGWGTIDGREVCIFSQDGTVFGGALGE
HCCCCEECHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCCEECHHHHH
VYGEKMIKIMELAIDTGRPLIGLYEGAGARIQDGAVSLDFISQTFYQNIQASGVIPQISV
HHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCEEHHHHHHHHHHCCCCCCCCCCHHH
IMGACAGGNAYGPALTDFVVMVDKTSKMFVTGPDVIKTVTGEEITQEELGGATTHMVTAG
HHHHCCCCCCCCCHHEEEEEEEECCCEEEEECCHHHHCCCCCHHHHHHHCCCEEEEEECC
NSHYTAATDEEALDWVQDLVSFLPSNNRSYAPMEDFDEEEGGVEENITADDLKLDEIIPD
CCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCCEEHHHCCCC
SATVPYDVRDVIECLTDDGEYLEIQADRAENVVIAFGRIEGQSVGFVANQPTQFAGCLDI
CCCCCCCHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCEEEEEECCCCCEEEEECC
DSSEKAARFVRTCDAFNIPIVMLVDVPGFLPGAGQEYGGILRRGAKLLYAYGEATVPKIT
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCEEE
VTMRKAYGGAYCVMGSKGLGSDINLAWPTAQIAVMGAAGAVGFIYRKELMAADAKGLDTV
EEEECCCCCEEEEECCCCCCCCCEEECCCEEEEEEECCCHHHHHHHHHHHHHCCCCCHHH
ALAKSFEREYEDHMLNPYHAAERGLIDAVILPSETRGQISRNLRLLKHKNVTRPARKHGN
HHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHCCC
MPL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]