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The map label for this gene is dtsR2 [H]

Identifier: 62389596

GI number: 62389596

Start: 728212

End: 729825

Strand: Reverse

Name: dtsR2 [H]

Synonym: cg0811

Alternate gene names: 62389596

Gene position: 729825-728212 (Counterclockwise)

Preceding gene: 62389597

Following gene: 62389595

Centisome position: 22.23

GC content: 54.71

Gene sequence:

>1614_bases
ATGACTGCAGCACAGACCAAACCTGACCTCACCACCACGGCTGGAAAGCTGTCCGATCTTCGCTCCCGTCTTGCAGAAGC
TCAAGCTCCAATGGGCGAAGCAACTGTAGAAAAAGTGCACGCTGCTGGCAGGAAGACTGCCCGCGAACGTATCGAGTATT
TGCTCGATGAGGGCTCTTTCGTAGAGATCGATGCTCTTGCTCGTCACCGTTCCAAGAACTTCGGCCTGGATGCCAAGCGT
CCAGTTACTGACGGTGTTGTGACTGGTTACGGCACCATCGATGGCCGTAAGGTCTGTGTGTTCTCCCAGGACGGCGCTGT
ATTCGGTGGCGCTTTGGGTGAAGTTTATGGTGAAAAGATCGTTAAGGTTATGGATCTTGCGATCAAGACCGGTGTGCCTT
TGATCGGAATCAATGAGGGTGCTGGTGCGCGTATCCAGGAAGGTGTTGTGTCTCTGGGTCTGTACTCACAGATCTTCTAC
CGCAACACCCAGGCGTCTGGCGTTATCCCACAGATCTCTTTGATCATGGGTGCCTGCGCTGGTGGTCACGTGTACTCCCC
TGCTCTGACTGACTTCATCGTCATGGTGGATCAGACTTCCAAGATGTTTATCACCGGCCCTGATGTCATCAAGACTGTCA
CCGGTGAAGATGTCACCCAGGAGGAGCTCGGTGGCGCTCACACCCACATGGCTACCTCCGGTACCTCCCATTACTCTGCT
TCTGATGATTCAGATGCTTTGGATTGGGTTCGCGAGCTGACCTCTTATCTTCCATCCAACAACCGTGCGGAAACTCCTCG
CCAGGAGGCCGACATCATGATCGGTTCCATCCAGGAAAACATCAACGATGTGGATCTGGAATTGGACACCATCATCCCGG
ATTCCCCGAACCAGCCTTATGACATGAAGGAAGTTATTTCCCGCATCGTCGACGACGCCGAGTTCTTCGAGATCCAGGAA
GACTACGCAGAGAACATCCTGTGTGGCTTCGCTCGCGTTGAGGGCCGTTCTGTTGGCATCGTGGCTAACCAGCCAACCCA
GTTCGCTGGCTGCTTGGATATTAAGGCATCTGAGAAGGCTGCCCGTTTCATCCGCACCTGCGATGCCTTCAACATCCCAA
TCCTTGAGTTCGTGGACGTTCCAGGCTTCCTGCCTGGCACCAACCAGGAATTCGACGGCATCATCCGCCGCGGCGCAAAG
CTGCTTTACGCTTACGCTGAAGCAACCGTCGGCAAGATCACCGTCATCACCCGCAAGTCCTACGGCGGAGCGTACTGCGT
GATGGGTTCCAAGGATATGGGCGCTGACCTCGTATTCGCTTGGCCTACCGCACAGATCGCCGTCATGGGCGCTTCAGGTG
CTGTTGGATTTATCTACCGTAAGGAACTCAAGCAGGCTGCCACCGAAGGCAAGGACGTTGCTGAGGTCATGAAGGGCTAC
GAGCAGGAGTACGAAGAAACTCTGGTCAACCCTTATGTCGCAGCTGAGCGTGGCCTGGTTGATGCCGTTATCCCACCTTC
TGAGACCCGCGGCCAGATCATTGAGGGTCTGCGTCTGCTGGATCGCAAGGTGGTCAATGTTCCTGCTAAAAAGCACGGTA
ACATTCCACTATAG

Upstream 100 bases:

>100_bases
GTATGTTCACACAAGAACCCTGCACAACGCCTTCAAAGTACGTCGACCACGACCAAGCGCATTATTCACTCTCACCCTTC
AGGATTTAGACTAAGAAACC

Downstream 100 bases:

>100_bases
AAACTGTTTTTTAAAGGAGAACCATGTCTGAAGAAACCACTCAGGACACCAAGGCTGCAGAGAAGCCTTTTCTGCAGATC
GTATCTGGCAACCCAACCGA

Product: acetyl/propionyl CoA carboxylase subunit beta

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MTAAQTKPDLTTTAGKLSDLRSRLAEAQAPMGEATVEKVHAAGRKTARERIEYLLDEGSFVEIDALARHRSKNFGLDAKR
PVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKIVKVMDLAIKTGVPLIGINEGAGARIQEGVVSLGLYSQIFY
RNTQASGVIPQISLIMGACAGGHVYSPALTDFIVMVDQTSKMFITGPDVIKTVTGEDVTQEELGGAHTHMATSGTSHYSA
SDDSDALDWVRELTSYLPSNNRAETPRQEADIMIGSIQENINDVDLELDTIIPDSPNQPYDMKEVISRIVDDAEFFEIQE
DYAENILCGFARVEGRSVGIVANQPTQFAGCLDIKASEKAARFIRTCDAFNIPILEFVDVPGFLPGTNQEFDGIIRRGAK
LLYAYAEATVGKITVITRKSYGGAYCVMGSKDMGADLVFAWPTAQIAVMGASGAVGFIYRKELKQAATEGKDVAEVMKGY
EQEYEETLVNPYVAAERGLVDAVIPPSETRGQIIEGLRLLDRKVVNVPAKKHGNIPL

Sequences:

>Translated_537_residues
MTAAQTKPDLTTTAGKLSDLRSRLAEAQAPMGEATVEKVHAAGRKTARERIEYLLDEGSFVEIDALARHRSKNFGLDAKR
PVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKIVKVMDLAIKTGVPLIGINEGAGARIQEGVVSLGLYSQIFY
RNTQASGVIPQISLIMGACAGGHVYSPALTDFIVMVDQTSKMFITGPDVIKTVTGEDVTQEELGGAHTHMATSGTSHYSA
SDDSDALDWVRELTSYLPSNNRAETPRQEADIMIGSIQENINDVDLELDTIIPDSPNQPYDMKEVISRIVDDAEFFEIQE
DYAENILCGFARVEGRSVGIVANQPTQFAGCLDIKASEKAARFIRTCDAFNIPILEFVDVPGFLPGTNQEFDGIIRRGAK
LLYAYAEATVGKITVITRKSYGGAYCVMGSKDMGADLVFAWPTAQIAVMGASGAVGFIYRKELKQAATEGKDVAEVMKGY
EQEYEETLVNPYVAAERGLVDAVIPPSETRGQIIEGLRLLDRKVVNVPAKKHGNIPL
>Mature_536_residues
TAAQTKPDLTTTAGKLSDLRSRLAEAQAPMGEATVEKVHAAGRKTARERIEYLLDEGSFVEIDALARHRSKNFGLDAKRP
VTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKIVKVMDLAIKTGVPLIGINEGAGARIQEGVVSLGLYSQIFYR
NTQASGVIPQISLIMGACAGGHVYSPALTDFIVMVDQTSKMFITGPDVIKTVTGEDVTQEELGGAHTHMATSGTSHYSAS
DDSDALDWVRELTSYLPSNNRAETPRQEADIMIGSIQENINDVDLELDTIIPDSPNQPYDMKEVISRIVDDAEFFEIQED
YAENILCGFARVEGRSVGIVANQPTQFAGCLDIKASEKAARFIRTCDAFNIPILEFVDVPGFLPGTNQEFDGIIRRGAKL
LYAYAEATVGKITVITRKSYGGAYCVMGSKDMGADLVFAWPTAQIAVMGASGAVGFIYRKELKQAATEGKDVAEVMKGYE
QEYEETLVNPYVAAERGLVDAVIPPSETRGQIIEGLRLLDRKVVNVPAKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=508, Percent_Identity=54.5275590551181, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI295821216, Length=528, Percent_Identity=52.4621212121212, Blast_Score=523, Evalue=1e-148,
Organism=Homo sapiens, GI11545863, Length=549, Percent_Identity=30.2367941712204, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI1788655, Length=189, Percent_Identity=30.1587301587302, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=506, Percent_Identity=53.9525691699605, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI25147359, Length=506, Percent_Identity=53.9525691699605, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17552936, Length=512, Percent_Identity=32.2265625, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24586065, Length=539, Percent_Identity=33.0241187384045, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 57997; Mature: 57866

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAQTKPDLTTTAGKLSDLRSRLAEAQAPMGEATVEKVHAAGRKTARERIEYLLDEGSF
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VEIDALARHRSKNFGLDAKRPVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKI
EEHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEECHHHHHHHHHHH
VKVMDLAIKTGVPLIGINEGAGARIQEGVVSLGLYSQIFYRNTQASGVIPQISLIMGACA
HHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
GGHVYSPALTDFIVMVDQTSKMFITGPDVIKTVTGEDVTQEELGGAHTHMATSGTSHYSA
CCCEECHHHHEEEEEEECCCEEEEECCHHHEECCCCCCCHHHCCCCHHEEECCCCCCCCC
SDDSDALDWVRELTSYLPSNNRAETPRQEADIMIGSIQENINDVDLELDTIIPDSPNQPY
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHEEEEHHHCCCCCCCEEEEEECCCCCCCCC
DMKEVISRIVDDAEFFEIQEDYAENILCGFARVEGRSVGIVANQPTQFAGCLDIKASEKA
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCEEEEECCCHHHH
ARFIRTCDAFNIPILEFVDVPGFLPGTNQEFDGIIRRGAKLLYAYAEATVGKITVITRKS
HHHHHHCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
YGGAYCVMGSKDMGADLVFAWPTAQIAVMGASGAVGFIYRKELKQAATEGKDVAEVMKGY
CCCEEEEECCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
EQEYEETLVNPYVAAERGLVDAVIPPSETRGQIIEGLRLLDRKVVNVPAKKHGNIPL
HHHHHHHHCCCHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TAAQTKPDLTTTAGKLSDLRSRLAEAQAPMGEATVEKVHAAGRKTARERIEYLLDEGSF
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VEIDALARHRSKNFGLDAKRPVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKI
EEHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEECHHHHHHHHHHH
VKVMDLAIKTGVPLIGINEGAGARIQEGVVSLGLYSQIFYRNTQASGVIPQISLIMGACA
HHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
GGHVYSPALTDFIVMVDQTSKMFITGPDVIKTVTGEDVTQEELGGAHTHMATSGTSHYSA
CCCEECHHHHEEEEEEECCCEEEEECCHHHEECCCCCCCHHHCCCCHHEEECCCCCCCCC
SDDSDALDWVRELTSYLPSNNRAETPRQEADIMIGSIQENINDVDLELDTIIPDSPNQPY
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHEEEEHHHCCCCCCCEEEEEECCCCCCCCC
DMKEVISRIVDDAEFFEIQEDYAENILCGFARVEGRSVGIVANQPTQFAGCLDIKASEKA
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCEEEEECCCHHHH
ARFIRTCDAFNIPILEFVDVPGFLPGTNQEFDGIIRRGAKLLYAYAEATVGKITVITRKS
HHHHHHCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
YGGAYCVMGSKDMGADLVFAWPTAQIAVMGASGAVGFIYRKELKQAATEGKDVAEVMKGY
CCCEEEEECCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
EQEYEETLVNPYVAAERGLVDAVIPPSETRGQIIEGLRLLDRKVVNVPAKKHGNIPL
HHHHHHHHCCCHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]