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The map label for this gene is crtE [H]

Identifier: 62389517

GI number: 62389517

Start: 639775

End: 640893

Strand: Reverse

Name: crtE [H]

Synonym: cg0723

Alternate gene names: 62389517

Gene position: 640893-639775 (Counterclockwise)

Preceding gene: 62389519

Following gene: 62389516

Centisome position: 19.52

GC content: 45.04

Gene sequence:

>1119_bases
ATGGACAATGGCATGACAATCACCACAGAACATTCAACTCATCCTGATCTTGATTTCAATGATGAGATTTATCGGGAACT
AAACCGCATCTGCGCTTCGCTATCTCAACAGTGCAGCACATATCAACCAGAGTTCCGTACCTGCCTAGATGCTGCTTTCC
AAGCTTTGCGAGGTGGCAAGTTAATCCGCCCTCGAATGCTACTGGGGCTATACAACACGCTTGTAGACGATGACATTGAG
GTCAAACTCAACACCGTTTTACAGGTAGCAGTGGCTTTAGAACTACTGCATTTTTCCCTTTTGGTTCATGACGATGTTAT
TGACGGAGACCTCTATCGCCGAGGCAAACTTAATTTTATTGGGCAGATTCTCATGCATCGCACACCTGAAAGTTTTGCAC
AAATCCAGCGCGATCCAGAGCATCTAGATTGGGCACAATCTAATGGACTGCTTATGGGAAATCTTTTTCTTGCTGCCACC
CATCAAATCTTCGCGCGCCTTGACCTTCCACATCACCAACGGGTTCGACTTTTAGATTTACTCAACCACACGATAAATGA
CACTATTGTGGGTGAGTTTCTTGATGTGGGATTAAGCAGCAAAGCCATCAGCCCCAATATGGACATTGCTCTAGAAATGA
GTCGGCTAAAAACAGCCACATACACTTTTGAACTTCCAATGAGAGCAGCGGCAATTCTCGCGGAACTACCTCAGGAGATT
GAAACAAAGATAGGTGAGATAGGCACAAACTTGGGCATCGCTTATCAATTGCAGGACGATTACTTATCTACTTTTGGTGA
CGCAGCCGAACACGGCAAAGATGCCTTTTCTGACCTTCGAGAAGGAAAAGAAACTACAATTATCGCCTTCGCTCGAGATA
CTGCTAAATGGACTGATATTCAAGACAACTTCGGCTCCGCAGATCTGAGCACCTCTCAGGCAGAGCGAATTCAACATCTT
CTCATACAGTGTGGAGCAAAGAATCACTCCTTGAATGCCATCTCCGACCACTTAAATATCTGCCGTTCGATGATCAAAAC
ACTAAGCCCCCAGGTAGATCCCAAGGCTCAAAATTTATTACTTAAACAAGTTGAGCAACTAGCCAGCCGCAAATCTTAG

Upstream 100 bases:

>100_bases
TTTATGGACCCAAATTCACACTTTCTGTACTTCATCAAAATAAAGCGCCATATACAACGATTGGGAATTTTTGCGAGATA
ACTGGCCGTGTGATACTCGA

Downstream 100 bases:

>100_bases
AACTAACCTTTACGCCTTTAACGGAAGTGAATTTGATGTCTACTAGCATCACAACAGAGAACAAGAAGAAATCTGGTCCT
CCTCGCTTGATGAGAATCTT

Product: geranylgeranyl-pyrophosphate sythase

Products: NA

Alternate protein names: (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl pyrophosphate synthase; FPP synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MDNGMTITTEHSTHPDLDFNDEIYRELNRICASLSQQCSTYQPEFRTCLDAAFQALRGGKLIRPRMLLGLYNTLVDDDIE
VKLNTVLQVAVALELLHFSLLVHDDVIDGDLYRRGKLNFIGQILMHRTPESFAQIQRDPEHLDWAQSNGLLMGNLFLAAT
HQIFARLDLPHHQRVRLLDLLNHTINDTIVGEFLDVGLSSKAISPNMDIALEMSRLKTATYTFELPMRAAAILAELPQEI
ETKIGEIGTNLGIAYQLQDDYLSTFGDAAEHGKDAFSDLREGKETTIIAFARDTAKWTDIQDNFGSADLSTSQAERIQHL
LIQCGAKNHSLNAISDHLNICRSMIKTLSPQVDPKAQNLLLKQVEQLASRKS

Sequences:

>Translated_372_residues
MDNGMTITTEHSTHPDLDFNDEIYRELNRICASLSQQCSTYQPEFRTCLDAAFQALRGGKLIRPRMLLGLYNTLVDDDIE
VKLNTVLQVAVALELLHFSLLVHDDVIDGDLYRRGKLNFIGQILMHRTPESFAQIQRDPEHLDWAQSNGLLMGNLFLAAT
HQIFARLDLPHHQRVRLLDLLNHTINDTIVGEFLDVGLSSKAISPNMDIALEMSRLKTATYTFELPMRAAAILAELPQEI
ETKIGEIGTNLGIAYQLQDDYLSTFGDAAEHGKDAFSDLREGKETTIIAFARDTAKWTDIQDNFGSADLSTSQAERIQHL
LIQCGAKNHSLNAISDHLNICRSMIKTLSPQVDPKAQNLLLKQVEQLASRKS
>Mature_372_residues
MDNGMTITTEHSTHPDLDFNDEIYRELNRICASLSQQCSTYQPEFRTCLDAAFQALRGGKLIRPRMLLGLYNTLVDDDIE
VKLNTVLQVAVALELLHFSLLVHDDVIDGDLYRRGKLNFIGQILMHRTPESFAQIQRDPEHLDWAQSNGLLMGNLFLAAT
HQIFARLDLPHHQRVRLLDLLNHTINDTIVGEFLDVGLSSKAISPNMDIALEMSRLKTATYTFELPMRAAAILAELPQEI
ETKIGEIGTNLGIAYQLQDDYLSTFGDAAEHGKDAFSDLREGKETTIIAFARDTAKWTDIQDNFGSADLSTSQAERIQHL
LIQCGAKNHSLNAISDHLNICRSMIKTLSPQVDPKAQNLLLKQVEQLASRKS

Specific function: Supplies Octaprenyl Diphosphate, The Precursor For The Side Chain Of The Isoprenoid Quinones Ubiquinone And Menaquinone. [C]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=207, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1789578, Length=288, Percent_Identity=23.9583333333333, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17505681, Length=259, Percent_Identity=28.1853281853282, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24651612, Length=258, Percent_Identity=26.3565891472868, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.10 [H]

Molecular weight: Translated: 41749; Mature: 41749

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNGMTITTEHSTHPDLDFNDEIYRELNRICASLSQQCSTYQPEFRTCLDAAFQALRGGK
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
LIRPRMLLGLYNTLVDDDIEVKLNTVLQVAVALELLHFSLLVHDDVIDGDLYRRGKLNFI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHH
GQILMHRTPESFAQIQRDPEHLDWAQSNGLLMGNLFLAATHQIFARLDLPHHQRVRLLDL
HHHHHHCCHHHHHHHHCCHHHCCHHHCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHH
LNHTINDTIVGEFLDVGLSSKAISPNMDIALEMSRLKTATYTFELPMRAAAILAELPQEI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHEEEEEEECHHHHHHHHHHHHHHH
ETKIGEIGTNLGIAYQLQDDYLSTFGDAAEHGKDAFSDLREGKETTIIAFARDTAKWTDI
HHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
QDNFGSADLSTSQAERIQHLLIQCGAKNHSLNAISDHLNICRSMIKTLSPQVDPKAQNLL
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LKQVEQLASRKS
HHHHHHHHHCCC
>Mature Secondary Structure
MDNGMTITTEHSTHPDLDFNDEIYRELNRICASLSQQCSTYQPEFRTCLDAAFQALRGGK
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
LIRPRMLLGLYNTLVDDDIEVKLNTVLQVAVALELLHFSLLVHDDVIDGDLYRRGKLNFI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHH
GQILMHRTPESFAQIQRDPEHLDWAQSNGLLMGNLFLAATHQIFARLDLPHHQRVRLLDL
HHHHHHCCHHHHHHHHCCHHHCCHHHCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHH
LNHTINDTIVGEFLDVGLSSKAISPNMDIALEMSRLKTATYTFELPMRAAAILAELPQEI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHEEEEEEECHHHHHHHHHHHHHHH
ETKIGEIGTNLGIAYQLQDDYLSTFGDAAEHGKDAFSDLREGKETTIIAFARDTAKWTDI
HHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
QDNFGSADLSTSQAERIQHLLIQCGAKNHSLNAISDHLNICRSMIKTLSPQVDPKAQNLL
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LKQVEQLASRKS
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]