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The map label for this gene is cadA [H]

Identifier: 62389380

GI number: 62389380

Start: 505697

End: 507649

Strand: Direct

Name: cadA [H]

Synonym: cg0569

Alternate gene names: 62389380

Gene position: 505697-507649 (Clockwise)

Preceding gene: 62389379

Following gene: 62389381

Centisome position: 15.4

GC content: 52.38

Gene sequence:

>1953_bases
ATGCTGGTCAGGGACATTTTTATGGGTGATAATGGGGTTATGAATAAAAAACTTAATACCCCAAATCCCTGGATGTTATT
CATCCGCTCATTTGATGGCATCATCACTGTCGCAGCCCTTGTTGCCATCGCAATACATCTCATTTTATGGCTGGCTCTAG
ATCTAGATGGCCTTGCTAAAAACTGGCCTTTAATAGCCATCGTTATCGTAGGTGGCATTCCGTTGATGTGGGATGTGCTG
AAATCAGCCATTAAAACTCGCGGTGGCGCGGATACTTTAGCAGCAGTCTCCATCATTACTTCTGTGTTGTTAGGGGAGTG
GTTGGTTGCCGCGATCATCGTGCTCATGCTCTCTGGTGGTGAAGCGCTAGAAGAGGCAGCATCACGGCGAGCCAGTGGCA
CCTTGGACGCACTTGCCCGGCGCGCACCAAGTACAGCTCACCGCCTGTTGGGTGCAACCATTCTTGATGGAACCGAAGAG
ATCGCCGTGGAAGAGATCACGGTTGGTGATTTAGTGGCGGTGCTCCCGCATGAACTTTGTCCCGTGGATGGTGAAATCGT
GGCAGGCCACGGCACCATGGATGAGTCTTATCTCACGGGTGAGCCCTATGTGGTGAGTAAATCTAAAGGTTCGCAAGCAA
TGTCGGGTGCAGTCAATGGTGATACTCCGCTGACGATTGTTGCCACAAAGCTTGCCCATGATTCCAGATACGCCCAAATT
GTTGGTGTACTCCATGAAGCAGAAAACAACCGCCCAGAAATGCGCAGGATGGCTGACCGTCTTGGCGCGTGGTATACGGT
GATTGCACTTGCCCTCGGTGGTCTTGGCTGGATTGTCTCCGGCGACCCAGTGAGGTTCTTGGCTGTTGTCGTTGTCGCCA
CCCCATGTCCATTGCTCATTGCAGTGCCAGTGGCGATCATCGGTGCGATTTCTCTTGCGGCTCGTCGGGGCATCATCGTG
AAGAACCCTGGAATGCTGGAAAACGCTTCAGGAGTAAAGACAGTGATGTTCGATAAGACTGGAACGCTCACCTATGGCAG
GCCAGTGATTACTGATATCCACACTGCTCCCGGAGTTGAGGAAGATACAGTCCTAGCTTTGGCTGCTTCAGTAGAGCGCT
ACTCCAGACACCCGTTGGCTGACGCGATTCGTGAGGGCGCAAAAGCCAGGGAACTTCATCTGCCTGATGTAGTGGAAGTA
TCGGAACGTCCAGGACAGGGACTAACCGGCACGGTGGGCGAGCACCTGGTTCGAATAACCAATAGGCGCAGCACACTAGA
AATTGATCCAGACAGCAAGAACTACATTCCGGTGACAAGTTCCGGCATGGAATCTGTGGTGCTTGTTGATGATAAATATG
CAGCACTCATTCGCCTCCGGGATGAACCTCGTGCATCTGCCAGTGAGTTCATCGCGCACTTGCCCAAGAAGCACAAAGTG
GACAAGCTCATGATTATCTCTGGTGATCGCGCATCTGAGGTTCGTTACCTTGCGGACAAGGTTGGCATTGATGAGGTACA
CGCAGAGGCCTCACCGGAAGACAAGCTGAACATTGTTAATCGGCATAATGAGCACGGCGCCACCATGTTCTTAGGTGATG
GAATCAACGATGCGCCAGCCATGGCCGTTGCCACCGTTGGTGTCGCGATGGGAGCAGACTCCGATGTCACGTCCGAAGCA
GCAGATGCTGTGATTTTGGATTCTTCCCTGGAACGTCTCGACGATCTGCTCCACATCAGTGCACGGATGCGTCGAATAGC
GTTGCAATCTGCGGGCGGTGGCATGGCGTTGAGTGTCATAGGAATGATCCTCGCGGTATTTGGATTCTTGACGCCACTGA
TGGGTGCGATCTTCCAAGAGGTCATTGACGTGCTGGCTATCCTCAATTCCGCTCGGGTCGCACTGCCACGCGGAGCGATT
AGTGATTTTGATACGCAAGAAAAAGTTTCTTAG

Upstream 100 bases:

>100_bases
GCAGCCAAATACGGCCAACGGCTCCTTGGAAATTTAAGGGGTCGTTGGCCTTATTATTTTAGGGAAAGCCCATCCTTACC
TTGCCAAGGGAAGCCTGTAC

Downstream 100 bases:

>100_bases
CAGGGTAACCTAAATGTCGTGACATTTCGAGGCGGAAACACTGGCGCAAAGCACGCGGTCGTTGTTGGTTCTGGCCCCAA
TGGGTTGACCACGGCGGCGG

Product: cation-transporting ATPase

Products: NA

Alternate protein names: Cadmium efflux ATPase [H]

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MLVRDIFMGDNGVMNKKLNTPNPWMLFIRSFDGIITVAALVAIAIHLILWLALDLDGLAKNWPLIAIVIVGGIPLMWDVL
KSAIKTRGGADTLAAVSIITSVLLGEWLVAAIIVLMLSGGEALEEAASRRASGTLDALARRAPSTAHRLLGATILDGTEE
IAVEEITVGDLVAVLPHELCPVDGEIVAGHGTMDESYLTGEPYVVSKSKGSQAMSGAVNGDTPLTIVATKLAHDSRYAQI
VGVLHEAENNRPEMRRMADRLGAWYTVIALALGGLGWIVSGDPVRFLAVVVVATPCPLLIAVPVAIIGAISLAARRGIIV
KNPGMLENASGVKTVMFDKTGTLTYGRPVITDIHTAPGVEEDTVLALAASVERYSRHPLADAIREGAKARELHLPDVVEV
SERPGQGLTGTVGEHLVRITNRRSTLEIDPDSKNYIPVTSSGMESVVLVDDKYAALIRLRDEPRASASEFIAHLPKKHKV
DKLMIISGDRASEVRYLADKVGIDEVHAEASPEDKLNIVNRHNEHGATMFLGDGINDAPAMAVATVGVAMGADSDVTSEA
ADAVILDSSLERLDDLLHISARMRRIALQSAGGGMALSVIGMILAVFGFLTPLMGAIFQEVIDVLAILNSARVALPRGAI
SDFDTQEKVS

Sequences:

>Translated_650_residues
MLVRDIFMGDNGVMNKKLNTPNPWMLFIRSFDGIITVAALVAIAIHLILWLALDLDGLAKNWPLIAIVIVGGIPLMWDVL
KSAIKTRGGADTLAAVSIITSVLLGEWLVAAIIVLMLSGGEALEEAASRRASGTLDALARRAPSTAHRLLGATILDGTEE
IAVEEITVGDLVAVLPHELCPVDGEIVAGHGTMDESYLTGEPYVVSKSKGSQAMSGAVNGDTPLTIVATKLAHDSRYAQI
VGVLHEAENNRPEMRRMADRLGAWYTVIALALGGLGWIVSGDPVRFLAVVVVATPCPLLIAVPVAIIGAISLAARRGIIV
KNPGMLENASGVKTVMFDKTGTLTYGRPVITDIHTAPGVEEDTVLALAASVERYSRHPLADAIREGAKARELHLPDVVEV
SERPGQGLTGTVGEHLVRITNRRSTLEIDPDSKNYIPVTSSGMESVVLVDDKYAALIRLRDEPRASASEFIAHLPKKHKV
DKLMIISGDRASEVRYLADKVGIDEVHAEASPEDKLNIVNRHNEHGATMFLGDGINDAPAMAVATVGVAMGADSDVTSEA
ADAVILDSSLERLDDLLHISARMRRIALQSAGGGMALSVIGMILAVFGFLTPLMGAIFQEVIDVLAILNSARVALPRGAI
SDFDTQEKVS
>Mature_650_residues
MLVRDIFMGDNGVMNKKLNTPNPWMLFIRSFDGIITVAALVAIAIHLILWLALDLDGLAKNWPLIAIVIVGGIPLMWDVL
KSAIKTRGGADTLAAVSIITSVLLGEWLVAAIIVLMLSGGEALEEAASRRASGTLDALARRAPSTAHRLLGATILDGTEE
IAVEEITVGDLVAVLPHELCPVDGEIVAGHGTMDESYLTGEPYVVSKSKGSQAMSGAVNGDTPLTIVATKLAHDSRYAQI
VGVLHEAENNRPEMRRMADRLGAWYTVIALALGGLGWIVSGDPVRFLAVVVVATPCPLLIAVPVAIIGAISLAARRGIIV
KNPGMLENASGVKTVMFDKTGTLTYGRPVITDIHTAPGVEEDTVLALAASVERYSRHPLADAIREGAKARELHLPDVVEV
SERPGQGLTGTVGEHLVRITNRRSTLEIDPDSKNYIPVTSSGMESVVLVDDKYAALIRLRDEPRASASEFIAHLPKKHKV
DKLMIISGDRASEVRYLADKVGIDEVHAEASPEDKLNIVNRHNEHGATMFLGDGINDAPAMAVATVGVAMGADSDVTSEA
ADAVILDSSLERLDDLLHISARMRRIALQSAGGGMALSVIGMILAVFGFLTPLMGAIFQEVIDVLAILNSARVALPRGAI
SDFDTQEKVS

Specific function: This electroneutral antiporter ejects one cadmium ion while accumulating two protons by an energy-dependent efflux mechanism [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=556, Percent_Identity=28.4172661870504, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI55743071, Length=510, Percent_Identity=30.3921568627451, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI55743073, Length=485, Percent_Identity=30.7216494845361, Blast_Score=169, Evalue=6e-42,
Organism=Escherichia coli, GI1789879, Length=589, Percent_Identity=32.258064516129, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1786691, Length=530, Percent_Identity=32.6415094339623, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1786914, Length=514, Percent_Identity=27.8210116731518, Blast_Score=109, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17556548, Length=572, Percent_Identity=27.6223776223776, Blast_Score=152, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6320475, Length=519, Percent_Identity=28.7090558766859, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319772, Length=580, Percent_Identity=27.4137931034483, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321430, Length=557, Percent_Identity=23.1597845601436, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221329854, Length=374, Percent_Identity=29.9465240641711, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3 [H]

Molecular weight: Translated: 69083; Mature: 69083

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVRDIFMGDNGVMNKKLNTPNPWMLFIRSFDGIITVAALVAIAIHLILWLALDLDGLAK
CCEEEEEECCCCCCCCCCCCCCCCEEEEEHHCHHHHHHHHHHHHHHHHHHHHHCHHHHCC
NWPLIAIVIVGGIPLMWDVLKSAIKTRGGADTLAAVSIITSVLLGEWLVAAIIVLMLSGG
CCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EALEEAASRRASGTLDALARRAPSTAHRLLGATILDGTEEIAVEEITVGDLVAVLPHELC
HHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHC
PVDGEIVAGHGTMDESYLTGEPYVVSKSKGSQAMSGAVNGDTPLTIVATKLAHDSRYAQI
CCCCEEEECCCCCCCCEECCCCEEEECCCCCHHHCCCCCCCCCEEEEEEHHHCCHHHHHH
VGVLHEAENNRPEMRRMADRLGAWYTVIALALGGLGWIVSGDPVRFLAVVVVATPCPLLI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCHHHH
AVPVAIIGAISLAARRGIIVKNPGMLENASGVKTVMFDKTGTLTYGRPVITDIHTAPGVE
HHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEECCCCEECCCCCEEECCCCCCCC
EDTVLALAASVERYSRHPLADAIREGAKARELHLPDVVEVSERPGQGLTGTVGEHLVRIT
CCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHH
NRRSTLEIDPDSKNYIPVTSSGMESVVLVDDKYAALIRLRDEPRASASEFIAHLPKKHKV
CCCCEEEECCCCCCEEEEECCCCCEEEEECCCEEEEEEECCCCCCCHHHHHHHCCCCCCC
DKLMIISGDRASEVRYLADKVGIDEVHAEASPEDKLNIVNRHNEHGATMFLGDGINDAPA
CEEEEEECCCHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCHH
MAVATVGVAMGADSDVTSEAADAVILDSSLERLDDLLHISARMRRIALQSAGGGMALSVI
HHHHHHHHHCCCCCCCHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
GMILAVFGFLTPLMGAIFQEVIDVLAILNSARVALPRGAISDFDTQEKVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHCCC
>Mature Secondary Structure
MLVRDIFMGDNGVMNKKLNTPNPWMLFIRSFDGIITVAALVAIAIHLILWLALDLDGLAK
CCEEEEEECCCCCCCCCCCCCCCCEEEEEHHCHHHHHHHHHHHHHHHHHHHHHCHHHHCC
NWPLIAIVIVGGIPLMWDVLKSAIKTRGGADTLAAVSIITSVLLGEWLVAAIIVLMLSGG
CCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EALEEAASRRASGTLDALARRAPSTAHRLLGATILDGTEEIAVEEITVGDLVAVLPHELC
HHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHC
PVDGEIVAGHGTMDESYLTGEPYVVSKSKGSQAMSGAVNGDTPLTIVATKLAHDSRYAQI
CCCCEEEECCCCCCCCEECCCCEEEECCCCCHHHCCCCCCCCCEEEEEEHHHCCHHHHHH
VGVLHEAENNRPEMRRMADRLGAWYTVIALALGGLGWIVSGDPVRFLAVVVVATPCPLLI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCHHHH
AVPVAIIGAISLAARRGIIVKNPGMLENASGVKTVMFDKTGTLTYGRPVITDIHTAPGVE
HHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEECCCCEECCCCCEEECCCCCCCC
EDTVLALAASVERYSRHPLADAIREGAKARELHLPDVVEVSERPGQGLTGTVGEHLVRIT
CCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHH
NRRSTLEIDPDSKNYIPVTSSGMESVVLVDDKYAALIRLRDEPRASASEFIAHLPKKHKV
CCCCEEEECCCCCCEEEEECCCCCEEEEECCCEEEEEEECCCCCCCHHHHHHHCCCCCCC
DKLMIISGDRASEVRYLADKVGIDEVHAEASPEDKLNIVNRHNEHGATMFLGDGINDAPA
CEEEEEECCCHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCHH
MAVATVGVAMGADSDVTSEAADAVILDSSLERLDDLLHISARMRRIALQSAGGGMALSVI
HHHHHHHHHCCCCCCCHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
GMILAVFGFLTPLMGAIFQEVIDVLAILNSARVALPRGAISDFDTQEKVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1321115 [H]