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The map label for this gene is hemD [H]

Identifier: 62389329

GI number: 62389329

Start: 452636

End: 454432

Strand: Direct

Name: hemD [H]

Synonym: cg0510

Alternate gene names: 62389329

Gene position: 452636-454432 (Clockwise)

Preceding gene: 62389324

Following gene: 62389330

Centisome position: 13.79

GC content: 56.48

Gene sequence:

>1797_bases
ATGACTATCGCCCATAAGCCCGAGATGGCTGAAACTACCGGGATCGAGACCAACCAGGTTTCCGAAACCATCGGGGTTGA
ATCGCTCACGCACGGAAACTTACGTCCTGTTTCATCTTTTGAGGGACAGCATGAGGGACAAACGGAAGAGTTACTTCCAG
GCAAAGTCATTTTTGTTGGGGCCGGTCCCGGTAACCCTGATCTTCTTACAGTTCGTGCCCGTGAAGTTCTGGGCAACGCG
GTTCGTGCGATTACTGATGAACAAGTACTAAGCGGCGTTCGAGCTTTTGTCGCCACTGAAATTCCTGTGCCGGAAGATAA
GCTTCAGGCTGCGGAAGATGAGTACGAGCGCATCTGCATTGAAGCGAAGGAGAACGGTGCACGCCGTAAGCCTCCTCGTC
CAGCACCACCAACCGCTGCAGAGATCACGGAAGTTTCTGAGGCGACTCCAGCTCAGATTGTTGAGCTTGTGCAGGATGCT
CTTTCTTATGGTGGAGATGTTATTCGTCTTGTCACCGGCAACCCATTGAGCAGCGATGCCACACTGGCTGAGATCTCTGC
AGTTTCCGAGGCTGGCCTGGAGTTCCAGGTGGTTCCAGGTATGTCTTTGCCTGCAACGGTTCCTGCATTTGCGGGAATTG
CGTTGGGTTCTACCTACACCGAAACTGATGTCAACGGTCAAAACTTGGACTGGGATCAGTTGGCTAGCGCACCTCAGCCT
TTGGTGCTGCAGGCCCGCGTGGATGACCTTTCCCGTATTGCACAGGAACTAAAGGCCCGCAATATGTCTTTGGAAACTCC
TGTTTCTGTCACCGCTAACGGCACCACCCGTTTGCAGCGCACCTATGACACCACTTTAGGTCTGTTGCACAAGCTTGATG
CTGAACTAAGCGGACCTTTGGTTGTTACCTTGGGCAAGGGTGTGGATGATCGCTCCAAGTACTCTTGGTGGGAAAACCGC
GCTCTGTACGGTTGGCGTGTGCTGGTGCCTCGCGCTCGGGAGCAAGCGGCATCCATGTCCGCACGTCTGAGCAGCCACGG
CGCTATCCCGCAGGAAGTCCCTACCATTTCTGTCGAACCACCGCGCAACCCAGCGCAAATGGAACGCGCCATCAAGGGCA
TCGTCGAAGGACGCTACCAGTGGGTTGTCCTCACCAGCGTCAACGCAGTGAAGGCAGTCTGGGAGAAAATCACCGAATTC
GGCCTCGATTCACGTTCCTTCGCGGGCGTCCGCATCGCCGCAGTCGGTGAAAAAACCGCCGCTGAGATCCGCGCGCTCGG
CATCACGCCGGAGCTTCTGCCTGCACGTACCAGGCAAAATGCGCAAGGGCTTGTCGACGTGTTCCCCGAATATTTCGAAG
AACTCGATCCAGTCGGCCGTGTCCTCTTGCCGCGCGCAGATATCGCAACCGACGTGCTTGTCGACGGCCTGACCCACCTT
GGTTGGGAAGTCGAAGACGTGGTGGCTTACCGCACCGTCCGCGCAGCACCACCAAGCGCTGATATCCGAGATATGATCAA
GACCGGCGGATTTGATGCAGTTGCCTTCACCTCTTCGTCGACCGTGAAGAACCTCGTTGGTATCGCGGGTAAACCACACC
CACGCACCATCGTCGCGTGCATCGGACCCATGACTGCAGCGACCGCTGAAGAACTGGGACTGCGCGTTGATGTCATGCCA
GAGATCGCCGAAGTACCAGAACTGATCGACGCTCTTGCGGAACACGTGGCGGATCTGCGCGCTAAGGGCGAGCTGCCGCC
GCCGAGGAAGAAACGCAGGCGTCGAAAAGCGTCTTAA

Upstream 100 bases:

>100_bases
GTCGTGGACAATCCCGGATCGAAAATTTGATTCGGCTTTTTTCATGGCTGTTGATGGAGTACGTTGGTCGTTTTCGAGAC
AAGTACTAGAAAAGATATTG

Downstream 100 bases:

>100_bases
AAGGTTTTTCACTAGGGTGTTGTCCATGGACATCCAGCAGCTAGACGCCGAAACAACAGCATGGAAAGACAGCCTCCTGC
GCGCCGCACAGGAGGCTGGT

Product: uroporphyrinogen III synthase/methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MTIAHKPEMAETTGIETNQVSETIGVESLTHGNLRPVSSFEGQHEGQTEELLPGKVIFVGAGPGNPDLLTVRAREVLGNA
VRAITDEQVLSGVRAFVATEIPVPEDKLQAAEDEYERICIEAKENGARRKPPRPAPPTAAEITEVSEATPAQIVELVQDA
LSYGGDVIRLVTGNPLSSDATLAEISAVSEAGLEFQVVPGMSLPATVPAFAGIALGSTYTETDVNGQNLDWDQLASAPQP
LVLQARVDDLSRIAQELKARNMSLETPVSVTANGTTRLQRTYDTTLGLLHKLDAELSGPLVVTLGKGVDDRSKYSWWENR
ALYGWRVLVPRAREQAASMSARLSSHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLTSVNAVKAVWEKITEF
GLDSRSFAGVRIAAVGEKTAAEIRALGITPELLPARTRQNAQGLVDVFPEYFEELDPVGRVLLPRADIATDVLVDGLTHL
GWEVEDVVAYRTVRAAPPSADIRDMIKTGGFDAVAFTSSSTVKNLVGIAGKPHPRTIVACIGPMTAATAEELGLRVDVMP
EIAEVPELIDALAEHVADLRAKGELPPPRKKRRRRKAS

Sequences:

>Translated_598_residues
MTIAHKPEMAETTGIETNQVSETIGVESLTHGNLRPVSSFEGQHEGQTEELLPGKVIFVGAGPGNPDLLTVRAREVLGNA
VRAITDEQVLSGVRAFVATEIPVPEDKLQAAEDEYERICIEAKENGARRKPPRPAPPTAAEITEVSEATPAQIVELVQDA
LSYGGDVIRLVTGNPLSSDATLAEISAVSEAGLEFQVVPGMSLPATVPAFAGIALGSTYTETDVNGQNLDWDQLASAPQP
LVLQARVDDLSRIAQELKARNMSLETPVSVTANGTTRLQRTYDTTLGLLHKLDAELSGPLVVTLGKGVDDRSKYSWWENR
ALYGWRVLVPRAREQAASMSARLSSHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLTSVNAVKAVWEKITEF
GLDSRSFAGVRIAAVGEKTAAEIRALGITPELLPARTRQNAQGLVDVFPEYFEELDPVGRVLLPRADIATDVLVDGLTHL
GWEVEDVVAYRTVRAAPPSADIRDMIKTGGFDAVAFTSSSTVKNLVGIAGKPHPRTIVACIGPMTAATAEELGLRVDVMP
EIAEVPELIDALAEHVADLRAKGELPPPRKKRRRRKAS
>Mature_597_residues
TIAHKPEMAETTGIETNQVSETIGVESLTHGNLRPVSSFEGQHEGQTEELLPGKVIFVGAGPGNPDLLTVRAREVLGNAV
RAITDEQVLSGVRAFVATEIPVPEDKLQAAEDEYERICIEAKENGARRKPPRPAPPTAAEITEVSEATPAQIVELVQDAL
SYGGDVIRLVTGNPLSSDATLAEISAVSEAGLEFQVVPGMSLPATVPAFAGIALGSTYTETDVNGQNLDWDQLASAPQPL
VLQARVDDLSRIAQELKARNMSLETPVSVTANGTTRLQRTYDTTLGLLHKLDAELSGPLVVTLGKGVDDRSKYSWWENRA
LYGWRVLVPRAREQAASMSARLSSHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLTSVNAVKAVWEKITEFG
LDSRSFAGVRIAAVGEKTAAEIRALGITPELLPARTRQNAQGLVDVFPEYFEELDPVGRVLLPRADIATDVLVDGLTHLG
WEVEDVVAYRTVRAAPPSADIRDMIKTGGFDAVAFTSSSTVKNLVGIAGKPHPRTIVACIGPMTAATAEELGLRVDVMPE
IAEVPELIDALAEHVADLRAKGELPPPRKKRRRRKAS

Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=275, Percent_Identity=28.3636363636364, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR003754
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =4.2.1.75 [H]

Molecular weight: Translated: 64382; Mature: 64251

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAHKPEMAETTGIETNQVSETIGVESLTHGNLRPVSSFEGQHEGQTEELLPGKVIFVG
CCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEEE
AGPGNPDLLTVRAREVLGNAVRAITDEQVLSGVRAFVATEIPVPEDKLQAAEDEYERICI
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEE
EAKENGARRKPPRPAPPTAAEITEVSEATPAQIVELVQDALSYGGDVIRLVTGNPLSSDA
ECCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
TLAEISAVSEAGLEFQVVPGMSLPATVPAFAGIALGSTYTETDVNGQNLDWDQLASAPQP
HHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCC
LVLQARVDDLSRIAQELKARNMSLETPVSVTANGTTRLQRTYDTTLGLLHKLDAELSGPL
EEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCE
VVTLGKGVDDRSKYSWWENRALYGWRVLVPRAREQAASMSARLSSHGAIPQEVPTISVEP
EEEECCCCCCCHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEECCC
PRNPAQMERAIKGIVEGRYQWVVLTSVNAVKAVWEKITEFGLDSRSFAGVRIAAVGEKTA
CCCHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHH
AEIRALGITPELLPARTRQNAQGLVDVFPEYFEELDPVGRVLLPRADIATDVLVDGLTHL
HHHEEECCCHHHHCHHHCCCCCHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHC
GWEVEDVVAYRTVRAAPPSADIRDMIKTGGFDAVAFTSSSTVKNLVGIAGKPHPRTIVAC
CCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCCEEEEE
IGPMTAATAEELGLRVDVMPEIAEVPELIDALAEHVADLRAKGELPPPRKKRRRRKAS
ECCHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
TIAHKPEMAETTGIETNQVSETIGVESLTHGNLRPVSSFEGQHEGQTEELLPGKVIFVG
CCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEEE
AGPGNPDLLTVRAREVLGNAVRAITDEQVLSGVRAFVATEIPVPEDKLQAAEDEYERICI
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEE
EAKENGARRKPPRPAPPTAAEITEVSEATPAQIVELVQDALSYGGDVIRLVTGNPLSSDA
ECCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
TLAEISAVSEAGLEFQVVPGMSLPATVPAFAGIALGSTYTETDVNGQNLDWDQLASAPQP
HHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCC
LVLQARVDDLSRIAQELKARNMSLETPVSVTANGTTRLQRTYDTTLGLLHKLDAELSGPL
EEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCE
VVTLGKGVDDRSKYSWWENRALYGWRVLVPRAREQAASMSARLSSHGAIPQEVPTISVEP
EEEECCCCCCCHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEECCC
PRNPAQMERAIKGIVEGRYQWVVLTSVNAVKAVWEKITEFGLDSRSFAGVRIAAVGEKTA
CCCHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHH
AEIRALGITPELLPARTRQNAQGLVDVFPEYFEELDPVGRVLLPRADIATDVLVDGLTHL
HHHEEECCCHHHHCHHHCCCCCHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHC
GWEVEDVVAYRTVRAAPPSADIRDMIKTGGFDAVAFTSSSTVKNLVGIAGKPHPRTIVAC
CCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCCEEEEE
IGPMTAATAEELGLRVDVMPEIAEVPELIDALAEHVADLRAKGELPPPRKKRRRRKAS
ECCHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7665501 [H]