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The map label for this gene is aroE [H]

Identifier: 62389324

GI number: 62389324

Start: 446537

End: 447388

Strand: Direct

Name: aroE [H]

Synonym: cg0504

Alternate gene names: 62389324

Gene position: 446537-447388 (Clockwise)

Preceding gene: 62389323

Following gene: 62389329

Centisome position: 13.6

GC content: 61.85

Gene sequence:

>852_bases
ATGAACGACAGTATTCTCCTCGGCCTAATCGGCCAGGGCCTCGACCTATCGCGCACCCCCGCAATGCACGAGGCGGAAGG
CCTCGCGCAGGGACGTGCGACGGTGTACAGGCGCATCGACACGCTTGGGTCGCGTGCTTCCGGGCAAGATTTAAAGACGC
TTCTCGACGCCGCCCTCTACCTTGGCTTCAACGGCCTGAACATCACTCACCCGTACAAACAAGCAGTATTACCCCTGCTT
GACGAAGTCTCCGAACAAGCCACCCAACTCGGCGCAGTGAATACTGTCGTTATCGACGCCACCGGCCACACCACCGGCCA
CAACACCGACGTCTCCGGATTTGGCCGCGGAATGGAAGAAGGCCTCCCCAACGCCAAGCTCGATTCCGTCGTGCAGGTCG
GCGCCGGCGGCGTAGGAAACGCAGTGGCATACGCCCTGGTCACCCACGGTGTGCAGAAACTTCAGGTCGCTGACCTCGAC
ACTTCCCGCGCGCAGGCACTGGCAGATGTCATCAACAACGCAGTCGGCCGTGAAGCCGTCGTGGGAGTAGACGCCCGCGG
CATCGAAGACGTCATCGCCGCCGCCGACGGAGTAGTCAACGCAACCCCCATGGGAATGCCAGCACACCCCGGCACCGCCT
TTGATGTCAGCTGCCTCACCAAGGATCACTGGGTTGGCGACGTCGTGTACATGCCCATCGAAACTGAACTTCTCAAAGCC
GCCCGTGCCCTCGGCTGCGAAACCCTCGACGGAACCCGCATGGCAATCCACCAAGCCGTCGATGCCTTCCGACTGTTCAC
CGGCCTCGAACCCGACGTCTCCCGCATGCGGGAAACTTTCCTGTCCCTCTAA

Upstream 100 bases:

>100_bases
TCCCTCGCCGCGGTCTCCGTTATCGCTGGCGCTGGCATCCAGGGTTACCGTTTCGCGGTCGATATCCTGGCAAATCTCAA
AAAGTAGAAAGCCCAAAAAT

Downstream 100 bases:

>100_bases
AAGAGTCAGTAAAACCTCGACGCTTCGACCGTTTCCTTCGCTTCCTTCAACCCTGCCCCGGTAAGTTCACGGTGACGTTT
GATCGCCGCGATCTTCTTAC

Product: quinate/shikimate dehydrogenase

Products: NA

Alternate protein names: NAD(+)-dependent quinate dehydrogenase; QDH [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MNDSILLGLIGQGLDLSRTPAMHEAEGLAQGRATVYRRIDTLGSRASGQDLKTLLDAALYLGFNGLNITHPYKQAVLPLL
DEVSEQATQLGAVNTVVIDATGHTTGHNTDVSGFGRGMEEGLPNAKLDSVVQVGAGGVGNAVAYALVTHGVQKLQVADLD
TSRAQALADVINNAVGREAVVGVDARGIEDVIAAADGVVNATPMGMPAHPGTAFDVSCLTKDHWVGDVVYMPIETELLKA
ARALGCETLDGTRMAIHQAVDAFRLFTGLEPDVSRMRETFLSL

Sequences:

>Translated_283_residues
MNDSILLGLIGQGLDLSRTPAMHEAEGLAQGRATVYRRIDTLGSRASGQDLKTLLDAALYLGFNGLNITHPYKQAVLPLL
DEVSEQATQLGAVNTVVIDATGHTTGHNTDVSGFGRGMEEGLPNAKLDSVVQVGAGGVGNAVAYALVTHGVQKLQVADLD
TSRAQALADVINNAVGREAVVGVDARGIEDVIAAADGVVNATPMGMPAHPGTAFDVSCLTKDHWVGDVVYMPIETELLKA
ARALGCETLDGTRMAIHQAVDAFRLFTGLEPDVSRMRETFLSL
>Mature_283_residues
MNDSILLGLIGQGLDLSRTPAMHEAEGLAQGRATVYRRIDTLGSRASGQDLKTLLDAALYLGFNGLNITHPYKQAVLPLL
DEVSEQATQLGAVNTVVIDATGHTTGHNTDVSGFGRGMEEGLPNAKLDSVVQVGAGGVGNAVAYALVTHGVQKLQVADLD
TSRAQALADVINNAVGREAVVGVDARGIEDVIAAADGVVNATPMGMPAHPGTAFDVSCLTKDHWVGDVVYMPIETELLKA
ARALGCETLDGTRMAIHQAVDAFRLFTGLEPDVSRMRETFLSL

Specific function: Catalyzes the NAD(+)-dependent oxidation of both quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate, respectively. Seems to play a key role in the quinate degradation pathway [H]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=227, Percent_Identity=29.9559471365639, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789675, Length=270, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320332, Length=293, Percent_Identity=25.2559726962457, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.24 [H]

Molecular weight: Translated: 29697; Mature: 29697

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00962 RIBOSOMAL_S2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSILLGLIGQGLDLSRTPAMHEAEGLAQGRATVYRRIDTLGSRASGQDLKTLLDAALY
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LGFNGLNITHPYKQAVLPLLDEVSEQATQLGAVNTVVIDATGHTTGHNTDVSGFGRGMEE
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCHHH
GLPNAKLDSVVQVGAGGVGNAVAYALVTHGVQKLQVADLDTSRAQALADVINNAVGREAV
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHCHHHEEEECCCHHHHHHHHHHHHHHCCCHHE
VGVDARGIEDVIAAADGVVNATPMGMPAHPGTAFDVSCLTKDHWVGDVVYMPIETELLKA
EECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCHHHHHHH
ARALGCETLDGTRMAIHQAVDAFRLFTGLEPDVSRMRETFLSL
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNDSILLGLIGQGLDLSRTPAMHEAEGLAQGRATVYRRIDTLGSRASGQDLKTLLDAALY
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LGFNGLNITHPYKQAVLPLLDEVSEQATQLGAVNTVVIDATGHTTGHNTDVSGFGRGMEE
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCHHH
GLPNAKLDSVVQVGAGGVGNAVAYALVTHGVQKLQVADLDTSRAQALADVINNAVGREAV
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHCHHHEEEECCCHHHHHHHHHHHHHHCCCHHE
VGVDARGIEDVIAAADGVVNATPMGMPAHPGTAFDVSCLTKDHWVGDVVYMPIETELLKA
EECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCHHHHHHH
ARALGCETLDGTRMAIHQAVDAFRLFTGLEPDVSRMRETFLSL
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA