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The map label for this gene is yrkL [H]

Identifier: 59714093

GI number: 59714093

Start: 1034434

End: 1034991

Strand: Reverse

Name: yrkL [H]

Synonym: VF_A0910

Alternate gene names: 59714093

Gene position: 1034991-1034434 (Counterclockwise)

Preceding gene: 172087821

Following gene: 59714092

Centisome position: 77.8

GC content: 33.15

Gene sequence:

>558_bases
ATGAAGAAAATTACGATTATTTCTGGTCACCCAAATCATGAAAGTTCCATTAGTAATAAAGCGATTCTTGAATACTTAGA
AAGTAACGTTATGGAAAGTCAGCTAAACATAAGAAAGCTCGAAGATTTAAATACGCATTTTGAGTTTAATGTTATTCAGG
AGCAAGAGGCTTTATTACAGGCTGATACCATCATCTTTCAGTTCCCTCTATTTTGGTATTCATTCCCTGCTCTGATGAAA
AAGTGGATTGATGATGTGATTTGCTATGGGTTTGCGTTTGGTGGTGAAAAGGGGGCGCAATTAAAAGATAAACAGTTTAT
TTTTTCTTTTACGATTGGTGGACAAGAGTCTGCGTATGGTAATGAAAAGGAAATCGCATTAACAATAGATGAACTGTTAA
AACCATTAAAGCAAATGTTGAGATATTGTCAGGTTAAAGATATTAACTATGTTTATAGTCATAATATGCTTTATATCCCT
GATATGTATGGTTCGATTGAAGATATTAATGTTCGTTCTGAATGCCATGCGATCAAGCTATTATCTATGGTTAATTAA

Upstream 100 bases:

>100_bases
TATTATCCCATAAATGGAAAAGTGAAGCCCAACAATACCATATTATCAAAGTGAAATATTCATTTTATCCTACTCACTTA
CCCACATAAGAGGCGATAAA

Downstream 100 bases:

>100_bases
CTGTGACTAAAAGACTGTATTAAATCATTAGGTACAGTCTTTTTATTTTAATTAACGACAATATATCAGAGGTATTTTCA
ATTTGTCGTAGTAACCAAAG

Product: hypothetical protein

Products: NAD(P); reduced acceptor [C]

Alternate protein names: NA

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MKKITIISGHPNHESSISNKAILEYLESNVMESQLNIRKLEDLNTHFEFNVIQEQEALLQADTIIFQFPLFWYSFPALMK
KWIDDVICYGFAFGGEKGAQLKDKQFIFSFTIGGQESAYGNEKEIALTIDELLKPLKQMLRYCQVKDINYVYSHNMLYIP
DMYGSIEDINVRSECHAIKLLSMVN

Sequences:

>Translated_185_residues
MKKITIISGHPNHESSISNKAILEYLESNVMESQLNIRKLEDLNTHFEFNVIQEQEALLQADTIIFQFPLFWYSFPALMK
KWIDDVICYGFAFGGEKGAQLKDKQFIFSFTIGGQESAYGNEKEIALTIDELLKPLKQMLRYCQVKDINYVYSHNMLYIP
DMYGSIEDINVRSECHAIKLLSMVN
>Mature_185_residues
MKKITIISGHPNHESSISNKAILEYLESNVMESQLNIRKLEDLNTHFEFNVIQEQEALLQADTIIFQFPLFWYSFPALMK
KWIDDVICYGFAFGGEKGAQLKDKQFIFSFTIGGQESAYGNEKEIALTIDELLKPLKQMLRYCQVKDINYVYSHNMLYIP
DMYGSIEDINVRSECHAIKLLSMVN

Specific function: Unknown

COG id: COG2249

COG function: function code R; Putative NADPH-quinone reductase (modulator of drug activity B)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD(P)H dehydrogenase (quinone) family [H]

Homologues:

Organism=Homo sapiens, GI156564357, Length=73, Percent_Identity=42.4657534246575, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1786231, Length=140, Percent_Identity=38.5714285714286, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1789750, Length=146, Percent_Identity=30.8219178082192, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787129, Length=173, Percent_Identity=25.4335260115607, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003680 [H]

Pfam domain/function: PF02525 Flavodoxin_2 [H]

EC number: 1.6.99.- [C]

Molecular weight: Translated: 21434; Mature: 21434

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKITIISGHPNHESSISNKAILEYLESNVMESQLNIRKLEDLNTHFEFNVIQEQEALLQ
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHH
ADTIIFQFPLFWYSFPALMKKWIDDVICYGFAFGGEKGAQLKDKQFIFSFTIGGQESAYG
HHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCC
NEKEIALTIDELLKPLKQMLRYCQVKDINYVYSHNMLYIPDMYGSIEDINVRSECHAIKL
CCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCCCCCCHHHHHHHHH
LSMVN
HHHCC
>Mature Secondary Structure
MKKITIISGHPNHESSISNKAILEYLESNVMESQLNIRKLEDLNTHFEFNVIQEQEALLQ
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHH
ADTIIFQFPLFWYSFPALMKKWIDDVICYGFAFGGEKGAQLKDKQFIFSFTIGGQESAYG
HHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCC
NEKEIALTIDELLKPLKQMLRYCQVKDINYVYSHNMLYIPDMYGSIEDINVRSECHAIKL
CCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCCCCCCHHHHHHHHH
LSMVN
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NAD(P)H2; acceptor [C]

Specific reaction: NAD(P)H2 + acceptor = NAD(P) + reduced acceptor [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]