Click here to switch to the map view.

The map label for this gene is tcpA [H]

Identifier: 59714058

GI number: 59714058

Start: 987057

End: 987683

Strand: Reverse

Name: tcpA [H]

Synonym: VF_A0875

Alternate gene names: 59714058

Gene position: 987683-987057 (Counterclockwise)

Preceding gene: 59714060

Following gene: 59714057

Centisome position: 74.24

GC content: 37.32

Gene sequence:

>627_bases
ATGAATTTAAAAAAACAACGAGGTATGACCTTACTAGAAGTGATTATCGTTTTAGGCATTATGGGTGTCATTTCTGCCGG
TGTTGTAATCCTAGCTCAAAGAGCAATCGATAATCAGAATGTATCTAAGTTATCGCAAGCGTTAAATACTATTCAAACCG
CAATGGTTCAAACTTATAGAAGTAAGCAAAGTTATCCTGATGTTCTTCAAGATGCAGTTAAGGCTAAAAAGTTAACTGAT
GCATTAGTGTCTATGGGGAGAGTTACTGAATCAGATTTAATCAACCCATTTACGGGTGCTCCAATGTTGATCTTTACAGC
TAAGGACAACAAGGCGGCTAACCGTGGTTTTGCTATTAAAGTATCTGATTTGTCAAAAGATCAATGTACCTCGTTAATAA
GTAACTCAGCAGATCTATTTAGTTTTATTGAAGTACAAAATAGAGGTACAGCAATGGCGGCGGATTTTTATGTTGACCCA
GATGCAACAAAATCAGTTGGAGTTATTAAATCAACAAAAGGTGGTGCTAAAACTTTAGATCTTACAAATCTTGACCACAT
CTCGGCTCTGTGTGGTGGGCCAGGTGCGGGTGATTCGTACTTTGATGTTTTTGTTGGTAATCGTTAA

Upstream 100 bases:

>100_bases
CTGTAGCATTGAAAAAACAAGATAATCTATTTTTCTTGAAATTGTGGCGTTTTGAACGTTGCTATCTACAAACAAAAAAT
AATCTTCAATTGGTGTAAAA

Downstream 100 bases:

>100_bases
TTACTTTTAGGTTGGAACAATGTTAAAACAACAGCGAGGGGCTACTCTATTAGAAGCTGTTCTTGCTGCTGCGATAATTG
GCTGGGGGTTGGCTTTTGCT

Product: toxin coregulated pilin subunit precursor TcpA

Products: NA

Alternate protein names: Pilus colonization factor [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MNLKKQRGMTLLEVIIVLGIMGVISAGVVILAQRAIDNQNVSKLSQALNTIQTAMVQTYRSKQSYPDVLQDAVKAKKLTD
ALVSMGRVTESDLINPFTGAPMLIFTAKDNKAANRGFAIKVSDLSKDQCTSLISNSADLFSFIEVQNRGTAMAADFYVDP
DATKSVGVIKSTKGGAKTLDLTNLDHISALCGGPGAGDSYFDVFVGNR

Sequences:

>Translated_208_residues
MNLKKQRGMTLLEVIIVLGIMGVISAGVVILAQRAIDNQNVSKLSQALNTIQTAMVQTYRSKQSYPDVLQDAVKAKKLTD
ALVSMGRVTESDLINPFTGAPMLIFTAKDNKAANRGFAIKVSDLSKDQCTSLISNSADLFSFIEVQNRGTAMAADFYVDP
DATKSVGVIKSTKGGAKTLDLTNLDHISALCGGPGAGDSYFDVFVGNR
>Mature_208_residues
MNLKKQRGMTLLEVIIVLGIMGVISAGVVILAQRAIDNQNVSKLSQALNTIQTAMVQTYRSKQSYPDVLQDAVKAKKLTD
ALVSMGRVTESDLINPFTGAPMLIFTAKDNKAANRGFAIKVSDLSKDQCTSLISNSADLFSFIEVQNRGTAMAADFYVDP
DATKSVGVIKSTKGGAKTLDLTNLDHISALCGGPGAGDSYFDVFVGNR

Specific function: Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium [H]

COG id: COG2165

COG function: function code NU; Type II secretory pathway, pseudopilin PulG

Gene ontology:

Cell location: Fimbrium [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012902
- InterPro:   IPR001120
- InterPro:   IPR010271 [H]

Pfam domain/function: PF05946 TcpA [H]

EC number: NA

Molecular weight: Translated: 22197; Mature: 22197

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00409 PROKAR_NTER_METHYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKKQRGMTLLEVIIVLGIMGVISAGVVILAQRAIDNQNVSKLSQALNTIQTAMVQTYR
CCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
SKQSYPDVLQDAVKAKKLTDALVSMGRVTESDLINPFTGAPMLIFTAKDNKAANRGFAIK
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEEEECCCCCCCCCEEEE
VSDLSKDQCTSLISNSADLFSFIEVQNRGTAMAADFYVDPDATKSVGVIKSTKGGAKTLD
ECCCCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEECCCCCCEEEE
LTNLDHISALCGGPGAGDSYFDVFVGNR
CCCHHHHHHHHCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MNLKKQRGMTLLEVIIVLGIMGVISAGVVILAQRAIDNQNVSKLSQALNTIQTAMVQTYR
CCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
SKQSYPDVLQDAVKAKKLTDALVSMGRVTESDLINPFTGAPMLIFTAKDNKAANRGFAIK
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEEEECCCCCCCCCEEEE
VSDLSKDQCTSLISNSADLFSFIEVQNRGTAMAADFYVDPDATKSVGVIKSTKGGAKTLD
ECCCCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEECCCCCCEEEE
LTNLDHISALCGGPGAGDSYFDVFVGNR
CCCHHHHHHHHCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2576015; 8621096; 2883655 [H]