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The map label for this gene is tcpE [H]

Identifier: 59714050

GI number: 59714050

Start: 979538

End: 980584

Strand: Reverse

Name: tcpE [H]

Synonym: VF_A0867

Alternate gene names: 59714050

Gene position: 980584-979538 (Counterclockwise)

Preceding gene: 59714051

Following gene: 59714049

Centisome position: 73.71

GC content: 28.84

Gene sequence:

>1047_bases
ATGATGATGAATCGCTTGTTTTTTCAGTTTATCAATCAGAAAAATAGATTGATTTTATATAGATTGTTATCAGATTTGAT
TGATGATGGCATTCCAGTATTTGACGCTTTAGTTTTAGTTAAGAATGAAGGTGGTCAATCTGTTTATGGTCGAAATTTTA
TTAAAAGTTTAGATCGTATAATTTTTAATATGAAAACGGTTTCTTCTGTCACAAAAGCACTTGACGGAATTATTCCTCCG
CAAGATCTTACTGTTCTTAATGCTGCTGAGCAATCAGGACAATTATCTAATGGCTTAAGAATGCTAGTCTCAATGATTGA
AAAGAATAATAATATTAGCTCATTATTAAAAAAATCATTATTAACACCTACTATCTTAGTGATTGTTGTTTTATTTGTTA
TTATGGGATATTCACTTCAAGTATTCCCAACATTTTTAGGTGTTTTACCTATCACGCAGTGGCCTGAAGTAACGAGAGCT
CTATATACATTTGGTATATATTTATCTAATGGTGGTTTAATCACAATATTTATTTCATCTATAGTTATTGGTTTTTTTGT
ATGGATATCAATGCCATTAATGTCAGGGAAGGTTAGGAATGAAATGTTGGATAAAATACCACCATATAATTATTATAAAG
AGATTCAAGTTGGATTATTTTTGAGAATGCTATCTACATTAATGCTTAATGGTGTTCCTATGGTTGATAGTATATCTTTA
ATACAAGAACGAGCCTCTATTTGGTTAAAATCACATTTGTCATTATTTGAAACTAATATGAAAAAAGGGGTAAGTTATAA
GGAAGCCTTAAATACAGGTTTTCTAACAAATGAAATGTTATTAACAATTGCACTTTATGCTAATTTAGATTCTTTTTCTT
TAACTGTAAAAAAAATGTCAGATATCAGCGAAATTAAAATAATTGGTGATATTGAAAAGCTAAGCGGAATATTAAAAAAT
ATATCATTAATTATGTTGGCAGGTTCAGTAATCTGGATCTTTGGTGCGATATTTAGCTTGGTTGATAAATTAGGTTCAGG
ATTTTAG

Upstream 100 bases:

>100_bases
CTTACTCAAGGTTATTCCATAAAAGATAAAATTTATTATTTATCTTTAACCGGACAAGTTTGTGGGAATTATTTTAGATC
TTATTTTGGGTATATGGAAA

Downstream 100 bases:

>100_bases
ATTATGTATTGTTTAAATAAATCATGTTTTTTTTTATTATTAACATCTTTTAATATATTCGCATTTGATAGTAGCTATGA
ATCAGTATCATCTTATGATG

Product: toxin coregulated pilus biosynthesis protein TcpE

Products: NA

Alternate protein names: TCP pilus biosynthesis protein tcpE [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MMMNRLFFQFINQKNRLILYRLLSDLIDDGIPVFDALVLVKNEGGQSVYGRNFIKSLDRIIFNMKTVSSVTKALDGIIPP
QDLTVLNAAEQSGQLSNGLRMLVSMIEKNNNISSLLKKSLLTPTILVIVVLFVIMGYSLQVFPTFLGVLPITQWPEVTRA
LYTFGIYLSNGGLITIFISSIVIGFFVWISMPLMSGKVRNEMLDKIPPYNYYKEIQVGLFLRMLSTLMLNGVPMVDSISL
IQERASIWLKSHLSLFETNMKKGVSYKEALNTGFLTNEMLLTIALYANLDSFSLTVKKMSDISEIKIIGDIEKLSGILKN
ISLIMLAGSVIWIFGAIFSLVDKLGSGF

Sequences:

>Translated_348_residues
MMMNRLFFQFINQKNRLILYRLLSDLIDDGIPVFDALVLVKNEGGQSVYGRNFIKSLDRIIFNMKTVSSVTKALDGIIPP
QDLTVLNAAEQSGQLSNGLRMLVSMIEKNNNISSLLKKSLLTPTILVIVVLFVIMGYSLQVFPTFLGVLPITQWPEVTRA
LYTFGIYLSNGGLITIFISSIVIGFFVWISMPLMSGKVRNEMLDKIPPYNYYKEIQVGLFLRMLSTLMLNGVPMVDSISL
IQERASIWLKSHLSLFETNMKKGVSYKEALNTGFLTNEMLLTIALYANLDSFSLTVKKMSDISEIKIIGDIEKLSGILKN
ISLIMLAGSVIWIFGAIFSLVDKLGSGF
>Mature_348_residues
MMMNRLFFQFINQKNRLILYRLLSDLIDDGIPVFDALVLVKNEGGQSVYGRNFIKSLDRIIFNMKTVSSVTKALDGIIPP
QDLTVLNAAEQSGQLSNGLRMLVSMIEKNNNISSLLKKSLLTPTILVIVVLFVIMGYSLQVFPTFLGVLPITQWPEVTRA
LYTFGIYLSNGGLITIFISSIVIGFFVWISMPLMSGKVRNEMLDKIPPYNYYKEIQVGLFLRMLSTLMLNGVPMVDSISL
IQERASIWLKSHLSLFETNMKKGVSYKEALNTGFLTNEMLLTIALYANLDSFSLTVKKMSDISEIKIIGDIEKLSGILKN
ISLIMLAGSVIWIFGAIFSLVDKLGSGF

Specific function: Probably involved in cholera toxin receptor (GM1) interaction in order to bring the cells within close proximity of the ganglioside for efficient toxin delivery [H]

COG id: COG1459

COG function: function code NU; Type II secretory pathway, component PulF

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP F family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018076
- InterPro:   IPR001992 [H]

Pfam domain/function: PF00482 GSPII_F [H]

EC number: NA

Molecular weight: Translated: 38942; Mature: 38942

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMNRLFFQFINQKNRLILYRLLSDLIDDGIPVFDALVLVKNEGGQSVYGRNFIKSLDRI
CCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHEEEECCCCCCHHHHHHHHHHHHH
IFNMKTVSSVTKALDGIIPPQDLTVLNAAEQSGQLSNGLRMLVSMIEKNNNISSLLKKSL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
LTPTILVIVVLFVIMGYSLQVFPTFLGVLPITQWPEVTRALYTFGIYLSNGGLITIFISS
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCHHHHHHH
IVIGFFVWISMPLMSGKVRNEMLDKIPPYNYYKEIQVGLFLRMLSTLMLNGVPMVDSISL
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
IQERASIWLKSHLSLFETNMKKGVSYKEALNTGFLTNEMLLTIALYANLDSFSLTVKKMS
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
DISEIKIIGDIEKLSGILKNISLIMLAGSVIWIFGAIFSLVDKLGSGF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMMNRLFFQFINQKNRLILYRLLSDLIDDGIPVFDALVLVKNEGGQSVYGRNFIKSLDRI
CCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHEEEECCCCCCHHHHHHHHHHHHH
IFNMKTVSSVTKALDGIIPPQDLTVLNAAEQSGQLSNGLRMLVSMIEKNNNISSLLKKSL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
LTPTILVIVVLFVIMGYSLQVFPTFLGVLPITQWPEVTRALYTFGIYLSNGGLITIFISS
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCHHHHHHH
IVIGFFVWISMPLMSGKVRNEMLDKIPPYNYYKEIQVGLFLRMLSTLMLNGVPMVDSISL
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
IQERASIWLKSHLSLFETNMKKGVSYKEALNTGFLTNEMLLTIALYANLDSFSLTVKKMS
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
DISEIKIIGDIEKLSGILKNISLIMLAGSVIWIFGAIFSLVDKLGSGF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11179381 [H]