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The map label for this gene is rnb [H]

Identifier: 59713566

GI number: 59713566

Start: 431738

End: 433780

Strand: Reverse

Name: rnb [H]

Synonym: VF_A0383

Alternate gene names: 59713566

Gene position: 433780-431738 (Counterclockwise)

Preceding gene: 59713569

Following gene: 59713564

Centisome position: 32.61

GC content: 39.75

Gene sequence:

>2043_bases
ATGTTTCAAGATAACCCACTACTTGCGCAATTGAAGCAGCAAATACAAGAAAAACTTCCAAAAAAAGAAGGCACCATTAA
AGCAACTGAACGTGGCTTTGGCTTCTTAGAATCAGATGATAAGAAAAAAAGCATCTTTATCCCACCAGCACAAATGAAAA
AAGTTATGCATGGTGACAAAGTAGTGGCTCTTATTCGTACAGAGAATGAAAAAGAGCAAGCAGAACCGGATCAATTAATC
GAACAATCAATTACCCGATTCATTGGCCGTATTCAGATGTTTAAAAAACGTCTACAAGTAATGCCTGATCACCCTAGTTT
AAAAAATGCTATTAAGGCAAAAACTCGCAAAGGCGTAAACCCTGAAACACTTAAAGAAGGTGACTGGGTTGTTGCAGAGT
TAACTCAACACCCATTAAAAGGGGATCAAGGTTTTCAATGTGATATTACCCATAAAATCACTGACAGCGATGACAAAATT
GCACCTTGGTGGGTAACTCTAGCTCAAAACGATTTACCTAACTCAGAGCCTGAAGGTATTGAACATTGGGAGATCAAAGA
CGACGCTGATTTAGTTCGTGTCGATATGACAGCAACCCCATTCGTAACCATTGATGGCGAATCAACCAAAGACATGGATG
ATGCGTTATATATCAAAAAGCTTGAAAATGGTTCATTTGAACTAACTATTGCTATTGCAGATCCTACCGCTTATATCACA
CCAGATGACAGTATGGATAAAGTGGCGCGTGAACGTGGTTATACGATCTACCTACCGGGTCGTAATATTCCTATGTTACC
TCGTGACTTAAGTGATGAGTTATGTTCTTTAATTGAAGGCCAAGAACGCCCTGCTCTTTGCTGTACAGTATTGGTTGATG
CAAACGGCAATATCCAAGAAGATAGCATCAACTTTTTTGCGGCAACGATCAAATCACACGCTCGTTTAGCTTATGACCAT
GTTTCTGATTTCTTAGAAACGGGCTCCTGTGATAAATGGCAACCAAATGACACCATCGCACAAGTAGTAACTGAACTGTA
TGAGTTTGCTCAAGTACGTACAACTTGGAGAGAAACTCACGCGGTTATTTTCCCAGATCGTCCTGATTACCGTTTTGAAT
TAAGCGAAGACAACGATGTTATCGCTATTCATGCTGATATGCGCCGTACAGCGAACAAGCTTGTTGAAGAAGCAATGGTA
ACGGCAAACATTTGTGCAGGTAAAACATTACGTGCAGCATTTAATATGGGCGTATTTAACTCTCATGCTGGTATTAAATC
TGACAAATTAAAAGATGTTGTTGAAATTGTTAATCAATTGGAAGGCGTCGACTTTACAGAAGAACAAATTGCTACTCTTG
AAGGCTTCAGTGAATTACGTCGTCTATTAGGAAAGCAACCAACGTCTTATTTAGATGCTCGTATTCGCAAATTCCAAACC
TACAGCGAAACAGGTAATGAACCACTACCTCACTATGCTATGGGATTAGATATTTACGCAACATGGACTTCTCCAATCCG
TAAATACAGCGATATGATCAACCATCGTATGCTTAAAGCTCATATTTTAGGAAAAGAGCCTGTTCAACGCCCTGATGATA
TCGTTGGAGAAGAACTCGCAATTAGCCGCCGCTTCCATCGCATGGCAGAACGAAATGTAAGTGATTGGTTATACTGTCGA
ACATTAGCATCAGAAGTTGAAAAAGAGACTAAATACACTGCTGAAATTTTTGATATTAATCGTGCCGGTATGCGTGTACG
TTTAATTGAAAATGGCGCAGCAGCATTTATTCCGGGTTCATTAATCGTTGATAATAAAGAACGTATCGAATGCAATGCTG
ACCAAGGCATTATCTCTATTGATAAACATGAAACGTTTAAACTTGGCGATCAACTTCATGTCGTATTAGCTGAAGTAAAA
GAAGACACTCGTAATATGGTTGCTAAACCACTTCAGGCTTTTCCTGCGCCTGAACCAGAGGAAGCACCTGTTGTTGAAAA
TGAAGACGCAACAACAAATGCAACTACAAGTGCAGACGCATAA

Upstream 100 bases:

>100_bases
TTTAAATGTTCTTTTTTGTACATTTCGTCCAAGTTTTCTAGTAATCAATTAGGTGCAATAGTAAAATTACCTCGTTATTT
CTCTATTATAATGAAGGCTC

Downstream 100 bases:

>100_bases
GTAACCTTTTATTTCGTACAAACAAAAACCCATACTTCATAGTATGGGTTTTCTTTTTATTACTTAGCACTAATCTAAAT
TCAATGTACCTGAAAATGGA

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 680; Mature: 680

Protein sequence:

>680_residues
MFQDNPLLAQLKQQIQEKLPKKEGTIKATERGFGFLESDDKKKSIFIPPAQMKKVMHGDKVVALIRTENEKEQAEPDQLI
EQSITRFIGRIQMFKKRLQVMPDHPSLKNAIKAKTRKGVNPETLKEGDWVVAELTQHPLKGDQGFQCDITHKITDSDDKI
APWWVTLAQNDLPNSEPEGIEHWEIKDDADLVRVDMTATPFVTIDGESTKDMDDALYIKKLENGSFELTIAIADPTAYIT
PDDSMDKVARERGYTIYLPGRNIPMLPRDLSDELCSLIEGQERPALCCTVLVDANGNIQEDSINFFAATIKSHARLAYDH
VSDFLETGSCDKWQPNDTIAQVVTELYEFAQVRTTWRETHAVIFPDRPDYRFELSEDNDVIAIHADMRRTANKLVEEAMV
TANICAGKTLRAAFNMGVFNSHAGIKSDKLKDVVEIVNQLEGVDFTEEQIATLEGFSELRRLLGKQPTSYLDARIRKFQT
YSETGNEPLPHYAMGLDIYATWTSPIRKYSDMINHRMLKAHILGKEPVQRPDDIVGEELAISRRFHRMAERNVSDWLYCR
TLASEVEKETKYTAEIFDINRAGMRVRLIENGAAAFIPGSLIVDNKERIECNADQGIISIDKHETFKLGDQLHVVLAEVK
EDTRNMVAKPLQAFPAPEPEEAPVVENEDATTNATTSADA

Sequences:

>Translated_680_residues
MFQDNPLLAQLKQQIQEKLPKKEGTIKATERGFGFLESDDKKKSIFIPPAQMKKVMHGDKVVALIRTENEKEQAEPDQLI
EQSITRFIGRIQMFKKRLQVMPDHPSLKNAIKAKTRKGVNPETLKEGDWVVAELTQHPLKGDQGFQCDITHKITDSDDKI
APWWVTLAQNDLPNSEPEGIEHWEIKDDADLVRVDMTATPFVTIDGESTKDMDDALYIKKLENGSFELTIAIADPTAYIT
PDDSMDKVARERGYTIYLPGRNIPMLPRDLSDELCSLIEGQERPALCCTVLVDANGNIQEDSINFFAATIKSHARLAYDH
VSDFLETGSCDKWQPNDTIAQVVTELYEFAQVRTTWRETHAVIFPDRPDYRFELSEDNDVIAIHADMRRTANKLVEEAMV
TANICAGKTLRAAFNMGVFNSHAGIKSDKLKDVVEIVNQLEGVDFTEEQIATLEGFSELRRLLGKQPTSYLDARIRKFQT
YSETGNEPLPHYAMGLDIYATWTSPIRKYSDMINHRMLKAHILGKEPVQRPDDIVGEELAISRRFHRMAERNVSDWLYCR
TLASEVEKETKYTAEIFDINRAGMRVRLIENGAAAFIPGSLIVDNKERIECNADQGIISIDKHETFKLGDQLHVVLAEVK
EDTRNMVAKPLQAFPAPEPEEAPVVENEDATTNATTSADA
>Mature_680_residues
MFQDNPLLAQLKQQIQEKLPKKEGTIKATERGFGFLESDDKKKSIFIPPAQMKKVMHGDKVVALIRTENEKEQAEPDQLI
EQSITRFIGRIQMFKKRLQVMPDHPSLKNAIKAKTRKGVNPETLKEGDWVVAELTQHPLKGDQGFQCDITHKITDSDDKI
APWWVTLAQNDLPNSEPEGIEHWEIKDDADLVRVDMTATPFVTIDGESTKDMDDALYIKKLENGSFELTIAIADPTAYIT
PDDSMDKVARERGYTIYLPGRNIPMLPRDLSDELCSLIEGQERPALCCTVLVDANGNIQEDSINFFAATIKSHARLAYDH
VSDFLETGSCDKWQPNDTIAQVVTELYEFAQVRTTWRETHAVIFPDRPDYRFELSEDNDVIAIHADMRRTANKLVEEAMV
TANICAGKTLRAAFNMGVFNSHAGIKSDKLKDVVEIVNQLEGVDFTEEQIATLEGFSELRRLLGKQPTSYLDARIRKFQT
YSETGNEPLPHYAMGLDIYATWTSPIRKYSDMINHRMLKAHILGKEPVQRPDDIVGEELAISRRFHRMAERNVSDWLYCR
TLASEVEKETKYTAEIFDINRAGMRVRLIENGAAAFIPGSLIVDNKERIECNADQGIISIDKHETFKLGDQLHVVLAEVK
EDTRNMVAKPLQAFPAPEPEEAPVVENEDATTNATTSADA

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=491, Percent_Identity=25.6619144602851, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI190014625, Length=362, Percent_Identity=27.9005524861878, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI190014623, Length=362, Percent_Identity=27.9005524861878, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI219521928, Length=404, Percent_Identity=24.2574257425743, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI19115966, Length=404, Percent_Identity=24.2574257425743, Blast_Score=100, Evalue=7e-21,
Organism=Escherichia coli, GI1787542, Length=652, Percent_Identity=50.6134969325153, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=674, Percent_Identity=26.2611275964392, Blast_Score=218, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17553506, Length=408, Percent_Identity=29.656862745098, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI212645896, Length=387, Percent_Identity=28.9405684754522, Blast_Score=126, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324552, Length=441, Percent_Identity=26.0770975056689, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24649634, Length=382, Percent_Identity=30.6282722513089, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI19922976, Length=428, Percent_Identity=26.6355140186916, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24654597, Length=428, Percent_Identity=26.6355140186916, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24654592, Length=428, Percent_Identity=26.6355140186916, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 76879; Mature: 76879

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDNPLLAQLKQQIQEKLPKKEGTIKATERGFGFLESDDKKKSIFIPPAQMKKVMHGDK
CCCCCHHHHHHHHHHHHHCCCCCCCEEEHHCCCCCCCCCCCCCEEECCHHHHHHHHCCCE
VVALIRTENEKEQAEPDQLIEQSITRFIGRIQMFKKRLQVMPDHPSLKNAIKAKTRKGVN
EEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
PETLKEGDWVVAELTQHPLKGDQGFQCDITHKITDSDDKIAPWWVTLAQNDLPNSEPEGI
HHHCCCCCEEEEEHHHCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCC
EHWEIKDDADLVRVDMTATPFVTIDGESTKDMDDALYIKKLENGSFELTIAIADPTAYIT
CCEECCCCCCEEEEEECCCCEEEECCCCCCCCHHHHHHEEECCCCEEEEEEEECCEEEEC
PDDSMDKVARERGYTIYLPGRNIPMLPRDLSDELCSLIEGQERPALCCTVLVDANGNIQE
CCCHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCC
DSINFFAATIKSHARLAYDHVSDFLETGSCDKWQPNDTIAQVVTELYEFAQVRTTWRETH
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCE
AVIFPDRPDYRFELSEDNDVIAIHADMRRTANKLVEEAMVTANICAGKTLRAAFNMGVFN
EEECCCCCCCEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
SHAGIKSDKLKDVVEIVNQLEGVDFTEEQIATLEGFSELRRLLGKQPTSYLDARIRKFQT
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
YSETGNEPLPHYAMGLDIYATWTSPIRKYSDMINHRMLKAHILGKEPVQRPDDIVGEELA
HHHCCCCCCCCHHCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
ISRRFHRMAERNVSDWLYCRTLASEVEKETKYTAEIFDINRAGMRVRLIENGAAAFIPGS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEHEEEECCCCEEEEEEECCCEEEECCC
LIVDNKERIECNADQGIISIDKHETFKLGDQLHVVLAEVKEDTRNMVAKPLQAFPAPEPE
EEECCCHHEEECCCCCEEEECCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EAPVVENEDATTNATTSADA
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFQDNPLLAQLKQQIQEKLPKKEGTIKATERGFGFLESDDKKKSIFIPPAQMKKVMHGDK
CCCCCHHHHHHHHHHHHHCCCCCCCEEEHHCCCCCCCCCCCCCEEECCHHHHHHHHCCCE
VVALIRTENEKEQAEPDQLIEQSITRFIGRIQMFKKRLQVMPDHPSLKNAIKAKTRKGVN
EEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
PETLKEGDWVVAELTQHPLKGDQGFQCDITHKITDSDDKIAPWWVTLAQNDLPNSEPEGI
HHHCCCCCEEEEEHHHCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCC
EHWEIKDDADLVRVDMTATPFVTIDGESTKDMDDALYIKKLENGSFELTIAIADPTAYIT
CCEECCCCCCEEEEEECCCCEEEECCCCCCCCHHHHHHEEECCCCEEEEEEEECCEEEEC
PDDSMDKVARERGYTIYLPGRNIPMLPRDLSDELCSLIEGQERPALCCTVLVDANGNIQE
CCCHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCC
DSINFFAATIKSHARLAYDHVSDFLETGSCDKWQPNDTIAQVVTELYEFAQVRTTWRETH
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCE
AVIFPDRPDYRFELSEDNDVIAIHADMRRTANKLVEEAMVTANICAGKTLRAAFNMGVFN
EEECCCCCCCEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
SHAGIKSDKLKDVVEIVNQLEGVDFTEEQIATLEGFSELRRLLGKQPTSYLDARIRKFQT
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
YSETGNEPLPHYAMGLDIYATWTSPIRKYSDMINHRMLKAHILGKEPVQRPDDIVGEELA
HHHCCCCCCCCHHCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
ISRRFHRMAERNVSDWLYCRTLASEVEKETKYTAEIFDINRAGMRVRLIENGAAAFIPGS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEHEEEECCCCEEEEEEECCCEEEECCC
LIVDNKERIECNADQGIISIDKHETFKLGDQLHVVLAEVKEDTRNMVAKPLQAFPAPEPE
EEECCCHHEEECCCCCEEEECCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EAPVVENEDATTNATTSADA
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA