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The map label for this gene is yiaV [H]

Identifier: 59713562

GI number: 59713562

Start: 428255

End: 429385

Strand: Reverse

Name: yiaV [H]

Synonym: VF_A0379

Alternate gene names: 59713562

Gene position: 429385-428255 (Counterclockwise)

Preceding gene: 59713563

Following gene: 59713561

Centisome position: 32.28

GC content: 38.82

Gene sequence:

>1131_bases
ATGGATTTATTGCTTATTTTGACGTACACCGCGTTATGTATTGCGGTATTTAAAATCTTTAATATTCCACTAAACAAATG
GACAGTGCCTACCGCAGGTTTAGGCGGCGTTGTATTAGTTGGAACTCTAGTTCTATTAATGAACTACAACCACCCATTTA
CTCAATTTGGTGGACAATTTTATGTAACCACGCCAATTGTTCCAAGTGTTAGAGGCAAAGTTATCGAGGTTAACGTTACA
CCAAACCAACCTGTTGCCGCTGGTGATGTTTTATTTAAAATTGACCCAATTCCTTTTCAAGCTGAAGTTATTCGTAAACA
AGCTGCTTTAAGTGAAGCTGAACAAGCAGCACTTCAGTTAGAATCAGTTTATAAGTCAGCACAATCAAACACAATAAAAG
CGACAGCAGATAAAGATAAAGCCTATCGTGAATTTAAACGTTATGAAAAAGGCTATAAAAAAGGTGCTTTCACTGCTCAA
CAACTTGATACTCGTAAACAAACATACAAAGCTTCTGAAGCAACATTAGAATCGGTTCAAGCTCAAGAGCAACAAGCAAA
GCTTGCACTAGAGTCTGAAATAAACGGGGAAAACACTACTGTAGCTCGTATGCGTGCAGAGTTAGAACAAGCGCAATTTA
ATCTTGACGAAACAATTGTAAAAGCACCAACAGATGGGTATGTAACTCAAATGGCGCTACGTCCAGGTATGATGGCAGTC
CCTATTCCACTTCGCCCTGTAATGACGTTTGTACATACAGAAGATCAATACTTTGTTGGTGCTTTCAGACAAAACTCATT
ACAACGATTACGAGCAGGCTTTGAAGCTGAGTTTCTTTTCAGAGCGATTCCTGGACGTGTGTTTAAAGGAGAAGTCGTCG
AAGTTATTCCTGCAATTGGTGAAGGTCAAATCCAAGCATCTGGAGCTCTTTTAGGAACAAATGCAATCCGTACAAATGGT
CGAGCATTAGTAAAACTGAAACTGACTGATGATGTATCTGAATTTCACCTTCCAGCTGGTTCAAACGCTGAGATTTCCGT
TTACTCTGATAGCTTCGAACATGTTTCAATTATGCGTAAAGTATTAATTCGTATGAAATCTTGGCAAAACTATCTATACC
TTGACCACTAA

Upstream 100 bases:

>100_bases
TTAATGACCAAGTAGAGCTATTAACTGAAAAACTCTCTCAAATAGAAGTCAATCAAGTTAAACAGGCGCCTCAAAAACCA
TCTCAAGAGGAGCAAGCATA

Downstream 100 bases:

>100_bases
TCACCTTTAATCTGTATCAAAACGCCTTAAAACACTGTTTTAAGGCGTTTTTATTTATATCAATAAAAAAATTATATATG
TTATTGGATTCTCAACTCTG

Product: membrane fusion protein (MFP) component of efflux pump, signal anchor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MDLLLILTYTALCIAVFKIFNIPLNKWTVPTAGLGGVVLVGTLVLLMNYNHPFTQFGGQFYVTTPIVPSVRGKVIEVNVT
PNQPVAAGDVLFKIDPIPFQAEVIRKQAALSEAEQAALQLESVYKSAQSNTIKATADKDKAYREFKRYEKGYKKGAFTAQ
QLDTRKQTYKASEATLESVQAQEQQAKLALESEINGENTTVARMRAELEQAQFNLDETIVKAPTDGYVTQMALRPGMMAV
PIPLRPVMTFVHTEDQYFVGAFRQNSLQRLRAGFEAEFLFRAIPGRVFKGEVVEVIPAIGEGQIQASGALLGTNAIRTNG
RALVKLKLTDDVSEFHLPAGSNAEISVYSDSFEHVSIMRKVLIRMKSWQNYLYLDH

Sequences:

>Translated_376_residues
MDLLLILTYTALCIAVFKIFNIPLNKWTVPTAGLGGVVLVGTLVLLMNYNHPFTQFGGQFYVTTPIVPSVRGKVIEVNVT
PNQPVAAGDVLFKIDPIPFQAEVIRKQAALSEAEQAALQLESVYKSAQSNTIKATADKDKAYREFKRYEKGYKKGAFTAQ
QLDTRKQTYKASEATLESVQAQEQQAKLALESEINGENTTVARMRAELEQAQFNLDETIVKAPTDGYVTQMALRPGMMAV
PIPLRPVMTFVHTEDQYFVGAFRQNSLQRLRAGFEAEFLFRAIPGRVFKGEVVEVIPAIGEGQIQASGALLGTNAIRTNG
RALVKLKLTDDVSEFHLPAGSNAEISVYSDSFEHVSIMRKVLIRMKSWQNYLYLDH
>Mature_376_residues
MDLLLILTYTALCIAVFKIFNIPLNKWTVPTAGLGGVVLVGTLVLLMNYNHPFTQFGGQFYVTTPIVPSVRGKVIEVNVT
PNQPVAAGDVLFKIDPIPFQAEVIRKQAALSEAEQAALQLESVYKSAQSNTIKATADKDKAYREFKRYEKGYKKGAFTAQ
QLDTRKQTYKASEATLESVQAQEQQAKLALESEINGENTTVARMRAELEQAQFNLDETIVKAPTDGYVTQMALRPGMMAV
PIPLRPVMTFVHTEDQYFVGAFRQNSLQRLRAGFEAEFLFRAIPGRVFKGEVVEVIPAIGEGQIQASGALLGTNAIRTNG
RALVKLKLTDDVSEFHLPAGSNAEISVYSDSFEHVSIMRKVLIRMKSWQNYLYLDH

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790012, Length=378, Percent_Identity=44.4444444444444, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI1790024, Length=380, Percent_Identity=43.9473684210526, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI1790519, Length=259, Percent_Identity=28.957528957529, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87081951, Length=319, Percent_Identity=25.705329153605, Blast_Score=92, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41772; Mature: 41772

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLLILTYTALCIAVFKIFNIPLNKWTVPTAGLGGVVLVGTLVLLMNYNHPFTQFGGQF
CCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCEE
YVTTPIVPSVRGKVIEVNVTPNQPVAAGDVLFKIDPIPFQAEVIRKQAALSEAEQAALQL
EEECCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ESVYKSAQSNTIKATADKDKAYREFKRYEKGYKKGAFTAQQLDTRKQTYKASEATLESVQ
HHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQEQQAKLALESEINGENTTVARMRAELEQAQFNLDETIVKAPTDGYVTQMALRPGMMAV
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHEEECCCCCHHHHHHHCCCCEEE
PIPLRPVMTFVHTEDQYFVGAFRQNSLQRLRAGFEAEFLFRAIPGRVFKGEVVEVIPAIG
CCCHHHHHHHEECCCCCEEHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHCCCC
EGQIQASGALLGTNAIRTNGRALVKLKLTDDVSEFHLPAGSNAEISVYSDSFEHVSIMRK
CCCEEECCEEEECCEEECCCEEEEEEEECCCHHHHCCCCCCCCEEEEECCCHHHHHHHHH
VLIRMKSWQNYLYLDH
HHHHHHCCCCEEEECC
>Mature Secondary Structure
MDLLLILTYTALCIAVFKIFNIPLNKWTVPTAGLGGVVLVGTLVLLMNYNHPFTQFGGQF
CCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCEE
YVTTPIVPSVRGKVIEVNVTPNQPVAAGDVLFKIDPIPFQAEVIRKQAALSEAEQAALQL
EEECCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ESVYKSAQSNTIKATADKDKAYREFKRYEKGYKKGAFTAQQLDTRKQTYKASEATLESVQ
HHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQEQQAKLALESEINGENTTVARMRAELEQAQFNLDETIVKAPTDGYVTQMALRPGMMAV
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHEEECCCCCHHHHHHHCCCCEEE
PIPLRPVMTFVHTEDQYFVGAFRQNSLQRLRAGFEAEFLFRAIPGRVFKGEVVEVIPAIG
CCCHHHHHHHEECCCCCEEHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHCCCC
EGQIQASGALLGTNAIRTNGRALVKLKLTDDVSEFHLPAGSNAEISVYSDSFEHVSIMRK
CCCEEECCEEEECCEEECCCEEEEEEEECCCHHHHCCCCCCCCEEEEECCCHHHHHHHHH
VLIRMKSWQNYLYLDH
HHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503 [H]