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The map label for this gene is betT [C]

Identifier: 59713561

GI number: 59713561

Start: 426464

End: 428065

Strand: Reverse

Name: betT [C]

Synonym: VF_A0378

Alternate gene names: 59713561

Gene position: 428065-426464 (Counterclockwise)

Preceding gene: 59713562

Following gene: 59713554

Centisome position: 32.18

GC content: 40.45

Gene sequence:

>1602_bases
ATGAGTACTACGGATAAGTACAGTATAGACAGTACTGACTACGAGGTTGGACAGGACAATATCCAAAAATGGGGTTTTGA
TATTCATAATCAGGTTTTTGGTATTAGTGCTGGTTCCATTATTCTTTTTCTTACTGTGCTTCTAGTTATGGACCCAACAG
AAGCAAAATCCCTTCTTGACGGTGTTAAGTGGCAAATCATCAACAATTTTGATGGCCTCTTTATGTGGTCTAGTAATATC
TTTCTGATATTCTGTTTAGCGCTAATCATTTCTCCTTTTGGCAAAATTCGCATTGGTGGCGACAAGGCAAAACCTGAACA
CTCTACAATCTCATGGATGGCAATGCTATTTGCTGCTGGTATGGGTATTGGTTTAATGTTCTATGGCGTTGCTGAGCCTC
TTGCTTATTTTACTGATTGGTATGGCACCCCTTTAGATGTTGAACCATTTACCGAAGAAGCTAAAAAACTAGCATTGGGC
GGCACTATGTACCACTGGGGTATCCACCCATGGGCAATATATGGCTTAGTGGCCCTCTCTTTAGCATTCTTTACTTTTAA
TAAAGGCTTACCACTATCAATGCGCTCTGTCTTCTATCCAATTTTAGGTGATAGAACATGGGGTTGGTTCGGTCATATCA
TTGATATTCTAACCGTACTAGCGACACTATTTGGCCTTGCAACCTCTCTTGGTCTAGGAGCTCAACAAGCTGCTGGTGGT
ATCAATCATGTATTTGGTACCGATGGTGGCGTTAACATGCAAATTGGCGTAATCATTTTTGTGACCATGCTTGCTATGAT
CTCGGTAATACGAGGCATTGATGGCGGTGTAAAACTATTAAGTAACGTCAACATGCTTGTGGCTGTTGCTTTATTATTCT
TCATTATTTTCATTGGTTTCTCTGATGTAATGAGTGCATTACCATTAACAGTGACAGGGTATATTGAAAACATCATTCCA
CTAAGTAATCCTCATGGTCGTGAAGATGAAGGTTGGATGCACGGTTGGACAGTATTCTACTGGGCTTGGTGGATTTCATG
GTCCCCATTCGTAGGTATGTTCATTGCTCGTGTATCTAAAGGTCGTACTGTTCGTCAATTCTTGATCTCTGTAATGATCA
TTCCAACGTTGGCAACTGCATTATGGATGTCTGCATTCGGTGGTATTGCAATTGAACAAGTCGTAAATAAAGTTGGTGAG
TTGGGTGAGAATGGTCTACAAGACATCACTATGGCACTGTTTAATATGTATGATGCGATTCCTATGAGCACTGCTCTTTC
AGTTATTTCTATCGTACTGATTATGGTGTTTTTTGTAACATCATCAGATTCTGGCTCATTAGTTATCGATAGTATTACTG
CTGGTGGTAAAGTTGATGCACCAGTTCCTCAGCGTATTTTCTGGGCAACTGTTCAAGGATCGATTGCAGCGGTACTACTG
TGGGTTGGTGGTACAGAAGCTATGCAAGCGCTACAAGCAGGTACTGTATCAACAGCACTACCATTTACGTTTATTCTTCT
TATGATGTGTGTCAGTTTAATTAAAGGCTTTAGCACTGAAAAATTTGGTACGACACCAAATATGGGTAAAGCAAAAGCGT
AA

Upstream 100 bases:

>100_bases
TCTCAACTCTGATATTATCCTCATGAAAAAACTGTTACATTGATGTTGCAGTCATTTGATGGTCTCCAATGGGAGCCATT
ATATTTTAATGTGAGGACAC

Downstream 100 bases:

>100_bases
GTTGTTTAATGTTATAATTAAAAATAAAGCCCTGATACGAGAAATCGAAACAGGGCTTTTATTATTAATAAAGCGATATT
ATTTATTTTTTGCTTGCTCT

Product: glycine betaine transporter

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MSTTDKYSIDSTDYEVGQDNIQKWGFDIHNQVFGISAGSIILFLTVLLVMDPTEAKSLLDGVKWQIINNFDGLFMWSSNI
FLIFCLALIISPFGKIRIGGDKAKPEHSTISWMAMLFAAGMGIGLMFYGVAEPLAYFTDWYGTPLDVEPFTEEAKKLALG
GTMYHWGIHPWAIYGLVALSLAFFTFNKGLPLSMRSVFYPILGDRTWGWFGHIIDILTVLATLFGLATSLGLGAQQAAGG
INHVFGTDGGVNMQIGVIIFVTMLAMISVIRGIDGGVKLLSNVNMLVAVALLFFIIFIGFSDVMSALPLTVTGYIENIIP
LSNPHGREDEGWMHGWTVFYWAWWISWSPFVGMFIARVSKGRTVRQFLISVMIIPTLATALWMSAFGGIAIEQVVNKVGE
LGENGLQDITMALFNMYDAIPMSTALSVISIVLIMVFFVTSSDSGSLVIDSITAGGKVDAPVPQRIFWATVQGSIAAVLL
WVGGTEAMQALQAGTVSTALPFTFILLMMCVSLIKGFSTEKFGTTPNMGKAKA

Sequences:

>Translated_533_residues
MSTTDKYSIDSTDYEVGQDNIQKWGFDIHNQVFGISAGSIILFLTVLLVMDPTEAKSLLDGVKWQIINNFDGLFMWSSNI
FLIFCLALIISPFGKIRIGGDKAKPEHSTISWMAMLFAAGMGIGLMFYGVAEPLAYFTDWYGTPLDVEPFTEEAKKLALG
GTMYHWGIHPWAIYGLVALSLAFFTFNKGLPLSMRSVFYPILGDRTWGWFGHIIDILTVLATLFGLATSLGLGAQQAAGG
INHVFGTDGGVNMQIGVIIFVTMLAMISVIRGIDGGVKLLSNVNMLVAVALLFFIIFIGFSDVMSALPLTVTGYIENIIP
LSNPHGREDEGWMHGWTVFYWAWWISWSPFVGMFIARVSKGRTVRQFLISVMIIPTLATALWMSAFGGIAIEQVVNKVGE
LGENGLQDITMALFNMYDAIPMSTALSVISIVLIMVFFVTSSDSGSLVIDSITAGGKVDAPVPQRIFWATVQGSIAAVLL
WVGGTEAMQALQAGTVSTALPFTFILLMMCVSLIKGFSTEKFGTTPNMGKAKA
>Mature_532_residues
STTDKYSIDSTDYEVGQDNIQKWGFDIHNQVFGISAGSIILFLTVLLVMDPTEAKSLLDGVKWQIINNFDGLFMWSSNIF
LIFCLALIISPFGKIRIGGDKAKPEHSTISWMAMLFAAGMGIGLMFYGVAEPLAYFTDWYGTPLDVEPFTEEAKKLALGG
TMYHWGIHPWAIYGLVALSLAFFTFNKGLPLSMRSVFYPILGDRTWGWFGHIIDILTVLATLFGLATSLGLGAQQAAGGI
NHVFGTDGGVNMQIGVIIFVTMLAMISVIRGIDGGVKLLSNVNMLVAVALLFFIIFIGFSDVMSALPLTVTGYIENIIPL
SNPHGREDEGWMHGWTVFYWAWWISWSPFVGMFIARVSKGRTVRQFLISVMIIPTLATALWMSAFGGIAIEQVVNKVGEL
GENGLQDITMALFNMYDAIPMSTALSVISIVLIMVFFVTSSDSGSLVIDSITAGGKVDAPVPQRIFWATVQGSIAAVLLW
VGGTEAMQALQAGTVSTALPFTFILLMMCVSLIKGFSTEKFGTTPNMGKAKA

Specific function: High-Affinity Uptake Of Choline Driven By A Proton- Motive Force. [C]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=504, Percent_Identity=35.515873015873, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1786224, Length=488, Percent_Identity=27.6639344262295, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1788102, Length=446, Percent_Identity=28.2511210762332, Blast_Score=167, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 58043; Mature: 57912

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTDKYSIDSTDYEVGQDNIQKWGFDIHNQVFGISAGSIILFLTVLLVMDPTEAKSLLD
CCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHEECCCCHHHHHHHHHHHHCCCHHHHHHHC
GVKWQIINNFDGLFMWSSNIFLIFCLALIISPFGKIRIGGDKAKPEHSTISWMAMLFAAG
CHHEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHH
MGIGLMFYGVAEPLAYFTDWYGTPLDVEPFTEEAKKLALGGTMYHWGIHPWAIYGLVALS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHH
LAFFTFNKGLPLSMRSVFYPILGDRTWGWFGHIIDILTVLATLFGLATSLGLGAQQAAGG
HHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCC
INHVFGTDGGVNMQIGVIIFVTMLAMISVIRGIDGGVKLLSNVNMLVAVALLFFIIFIGF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
SDVMSALPLTVTGYIENIIPLSNPHGREDEGWMHGWTVFYWAWWISWSPFVGMFIARVSK
HHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GRTVRQFLISVMIIPTLATALWMSAFGGIAIEQVVNKVGELGENGLQDITMALFNMYDAI
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
PMSTALSVISIVLIMVFFVTSSDSGSLVIDSITAGGKVDAPVPQRIFWATVQGSIAAVLL
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCEEEEEE
WVGGTEAMQALQAGTVSTALPFTFILLMMCVSLIKGFSTEKFGTTPNMGKAKA
ECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STTDKYSIDSTDYEVGQDNIQKWGFDIHNQVFGISAGSIILFLTVLLVMDPTEAKSLLD
CCCCCCCCCCCCCCCCHHHHHHCCCHHHHHEECCCCHHHHHHHHHHHHCCCHHHHHHHC
GVKWQIINNFDGLFMWSSNIFLIFCLALIISPFGKIRIGGDKAKPEHSTISWMAMLFAAG
CHHEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHH
MGIGLMFYGVAEPLAYFTDWYGTPLDVEPFTEEAKKLALGGTMYHWGIHPWAIYGLVALS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHH
LAFFTFNKGLPLSMRSVFYPILGDRTWGWFGHIIDILTVLATLFGLATSLGLGAQQAAGG
HHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCC
INHVFGTDGGVNMQIGVIIFVTMLAMISVIRGIDGGVKLLSNVNMLVAVALLFFIIFIGF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
SDVMSALPLTVTGYIENIIPLSNPHGREDEGWMHGWTVFYWAWWISWSPFVGMFIARVSK
HHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GRTVRQFLISVMIIPTLATALWMSAFGGIAIEQVVNKVGELGENGLQDITMALFNMYDAI
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
PMSTALSVISIVLIMVFFVTSSDSGSLVIDSITAGGKVDAPVPQRIFWATVQGSIAAVLL
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCEEEEEE
WVGGTEAMQALQAGTVSTALPFTFILLMMCVSLIKGFSTEKFGTTPNMGKAKA
ECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]