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The map label for this gene is ptrB [H]

Identifier: 59713516

GI number: 59713516

Start: 368975

End: 370978

Strand: Reverse

Name: ptrB [H]

Synonym: VF_A0333

Alternate gene names: 59713516

Gene position: 370978-368975 (Counterclockwise)

Preceding gene: 59713517

Following gene: 59713515

Centisome position: 27.89

GC content: 34.48

Gene sequence:

>2004_bases
ATGAAATTTCTTAATGTTCTTTACTGCTTAGTTCTATTTTCTTCTTTAACTTTCGCTCAAGATAATTTGAATTGGCTAAA
AGATAGTTCACGATCTAATCCTGAGGTTTTAAAGTATTTAAATAATGAAAATAAATTAACTTATGAATTCAAAACAAAAG
TTAAGCCTAAAACGGATGCATTGGTCGAAGAGTGGCAACATAACCAACCAATAAAATCGGAGTCTCCGTGGAAAATAATT
GGTGATTCAGAATACACAGTGACTCAATATAATGGTCTGCGCCAAATACTTTCGCGTTCATTAAAAACAAAAAAGATCAC
TGTATTATTCAATATCTCTAACCGAGCGAATCAATTCGATTACTATCACCTTGGTGGCTGGGATTTAAGTAATGATCATA
ATAAACTCGTCATTACCGAAGATTTGACAGGAACTGAACAATACCAAGCCAGTATTGTTGATTTAAGAACACAATCGATA
ACAACGTTAACACATCACGTTGAGCCTACTGTTACTTGGTCTAAAGATGACCGTTATGTGTACCTTATCAAACAAGAAAA
ATATTCATTACGACCTTTTGAATTAATTCAGTTTGATACACAGCAACAAAACATAACGTCTCTTTTCACTGAAAAAGATA
AAGAATGGCTACTGTCTTTTTATCTTTCAAGTGATCATCAATATGCGATGGTACAATCTAATAACAGCAATAGCACTGAA
CAAAGAATTTTAAACTTAACAAGTACACATCTCTCTTTACCAATAAAGACTCGACAAGAAGGTGTTGAATATTACGCAGA
TATTGCTAAAAACAAAGCCATAATAAATAGCAATCATGAACACAACCTGTTTATATTATATTCAGCAAACATTGCACATA
TATCAATTATAAACAATTGGTTACCACTTTATCGACCACAGAAAAACAAAAGAATTACAGACTTTTATTTATTTAAATCA
GGTCCCGTTGTTTCTGTTAACGATAATAAAAGCTCGCAGTTAATTTATCTAAATACTGCTGGAGAAATCAGACTAAGAAC
CTCTTTATCCACCTCTGGCCAAGTTGCTTGGATCAGTCGTGTTGGTGATTTTAATAGTGATACCTTTTACTTACGTAGTA
TGTCTATGGTGCAAAGCCCAAAATGGGAAAAAGTAAATACTGCGACCTTAAATAGAGCGCTGTACTTAGAAGATCAATAT
CCAAATATTGATGCTTCTTTGTATGCAACAGAACAGATAATCGTAACAAATAATGGAATTGAACTACCGGTAACTCTTGC
TTATAGGAAAGATAAGCTAACCGATACCAATCCTGTTTTTTTATACGGTTACGGTGCTTACGGCGTCACGATGAAACCCT
ATTTCATGCCACAAATAATCAGCTTATTAGATCGTGGAGTAATTTATGCCATTGCTCATGTTCGAGGTGGTGGTTACAAA
GGTGAAGATTGGTATCAAGCAGGTCGAGGGATAAACCGTCAAAATGCCGCAACTGATTTTATAAATGCAGCAAAATCGAT
GAAGTTATATCGCAATGGGGAACGAAAAATCTACGCATTGGGGTCAAGTGCAGGCGGTACTCTAATTGCAACTGCACTGA
ATCAAGAGCCAAAGTTATTTCAAGGCGCAGCTCTCAATGTACCTTTTGTCGATGTCATTAATAGTATGTCTGATAGCTCT
TTACCACTGACACTACAACAATATAGTGAATGGGGAAATCCAACAATTCAAGATGAATTAAATATCATGAAGAAAACGGA
TCCTTATTTAAATATCTCTAAACAAGAGTACCCCCCACTTCTTGTTCAAGTTGGTTTTAATGATAGTCGAGTGCCTTATT
GGGAAGGCGCTAAATACCTAACCAAAATAAGAAGAAACAGTTCAGGTAAAGGTCCTTATTTACTTGAAACCCATTTTAAT
CAAGGACACTCAACAAATAGACGGGATGCTTTAAAACAACAAGCGTTTGAATATATTTTTCTTTTATCTCTAATAAATAA
TTAA

Upstream 100 bases:

>100_bases
AATAACAATAAAAAGAAATGAAAATGATAATTGATCTCATTCGTATTAATGTGTAGCATTCGCCGTGTTAATTAAATTGA
CTCATGGATTTGCTGTACTT

Downstream 100 bases:

>100_bases
AAAAGCGGAGCTACAAATGAAGCTTTCACCAATAACAGCGGCAGTACTTAGCGTACTGACTGCCAACTTCGTACACGCTA
ATTCTGAGGTTACACAATTT

Product: protease II

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MKFLNVLYCLVLFSSLTFAQDNLNWLKDSSRSNPEVLKYLNNENKLTYEFKTKVKPKTDALVEEWQHNQPIKSESPWKII
GDSEYTVTQYNGLRQILSRSLKTKKITVLFNISNRANQFDYYHLGGWDLSNDHNKLVITEDLTGTEQYQASIVDLRTQSI
TTLTHHVEPTVTWSKDDRYVYLIKQEKYSLRPFELIQFDTQQQNITSLFTEKDKEWLLSFYLSSDHQYAMVQSNNSNSTE
QRILNLTSTHLSLPIKTRQEGVEYYADIAKNKAIINSNHEHNLFILYSANIAHISIINNWLPLYRPQKNKRITDFYLFKS
GPVVSVNDNKSSQLIYLNTAGEIRLRTSLSTSGQVAWISRVGDFNSDTFYLRSMSMVQSPKWEKVNTATLNRALYLEDQY
PNIDASLYATEQIIVTNNGIELPVTLAYRKDKLTDTNPVFLYGYGAYGVTMKPYFMPQIISLLDRGVIYAIAHVRGGGYK
GEDWYQAGRGINRQNAATDFINAAKSMKLYRNGERKIYALGSSAGGTLIATALNQEPKLFQGAALNVPFVDVINSMSDSS
LPLTLQQYSEWGNPTIQDELNIMKKTDPYLNISKQEYPPLLVQVGFNDSRVPYWEGAKYLTKIRRNSSGKGPYLLETHFN
QGHSTNRRDALKQQAFEYIFLLSLINN

Sequences:

>Translated_667_residues
MKFLNVLYCLVLFSSLTFAQDNLNWLKDSSRSNPEVLKYLNNENKLTYEFKTKVKPKTDALVEEWQHNQPIKSESPWKII
GDSEYTVTQYNGLRQILSRSLKTKKITVLFNISNRANQFDYYHLGGWDLSNDHNKLVITEDLTGTEQYQASIVDLRTQSI
TTLTHHVEPTVTWSKDDRYVYLIKQEKYSLRPFELIQFDTQQQNITSLFTEKDKEWLLSFYLSSDHQYAMVQSNNSNSTE
QRILNLTSTHLSLPIKTRQEGVEYYADIAKNKAIINSNHEHNLFILYSANIAHISIINNWLPLYRPQKNKRITDFYLFKS
GPVVSVNDNKSSQLIYLNTAGEIRLRTSLSTSGQVAWISRVGDFNSDTFYLRSMSMVQSPKWEKVNTATLNRALYLEDQY
PNIDASLYATEQIIVTNNGIELPVTLAYRKDKLTDTNPVFLYGYGAYGVTMKPYFMPQIISLLDRGVIYAIAHVRGGGYK
GEDWYQAGRGINRQNAATDFINAAKSMKLYRNGERKIYALGSSAGGTLIATALNQEPKLFQGAALNVPFVDVINSMSDSS
LPLTLQQYSEWGNPTIQDELNIMKKTDPYLNISKQEYPPLLVQVGFNDSRVPYWEGAKYLTKIRRNSSGKGPYLLETHFN
QGHSTNRRDALKQQAFEYIFLLSLINN
>Mature_667_residues
MKFLNVLYCLVLFSSLTFAQDNLNWLKDSSRSNPEVLKYLNNENKLTYEFKTKVKPKTDALVEEWQHNQPIKSESPWKII
GDSEYTVTQYNGLRQILSRSLKTKKITVLFNISNRANQFDYYHLGGWDLSNDHNKLVITEDLTGTEQYQASIVDLRTQSI
TTLTHHVEPTVTWSKDDRYVYLIKQEKYSLRPFELIQFDTQQQNITSLFTEKDKEWLLSFYLSSDHQYAMVQSNNSNSTE
QRILNLTSTHLSLPIKTRQEGVEYYADIAKNKAIINSNHEHNLFILYSANIAHISIINNWLPLYRPQKNKRITDFYLFKS
GPVVSVNDNKSSQLIYLNTAGEIRLRTSLSTSGQVAWISRVGDFNSDTFYLRSMSMVQSPKWEKVNTATLNRALYLEDQY
PNIDASLYATEQIIVTNNGIELPVTLAYRKDKLTDTNPVFLYGYGAYGVTMKPYFMPQIISLLDRGVIYAIAHVRGGGYK
GEDWYQAGRGINRQNAATDFINAAKSMKLYRNGERKIYALGSSAGGTLIATALNQEPKLFQGAALNVPFVDVINSMSDSS
LPLTLQQYSEWGNPTIQDELNIMKKTDPYLNISKQEYPPLLVQVGFNDSRVPYWEGAKYLTKIRRNSSGKGPYLLETHFN
QGHSTNRRDALKQQAFEYIFLLSLINN

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI284172420, Length=500, Percent_Identity=26.8, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI284172413, Length=500, Percent_Identity=26.8, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI70778815, Length=500, Percent_Identity=26.8, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI284172438, Length=496, Percent_Identity=27.0161290322581, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI284172431, Length=496, Percent_Identity=27.0161290322581, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI108860692, Length=219, Percent_Identity=34.2465753424658, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI108860686, Length=212, Percent_Identity=34.9056603773585, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI41349456, Length=292, Percent_Identity=26.7123287671233, Blast_Score=105, Evalue=2e-22,
Organism=Escherichia coli, GI1788150, Length=661, Percent_Identity=29.6520423600605, Blast_Score=297, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24583414, Length=253, Percent_Identity=30.0395256916996, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221510989, Length=260, Percent_Identity=26.9230769230769, Blast_Score=99, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 76575; Mature: 76575

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLNVLYCLVLFSSLTFAQDNLNWLKDSSRSNPEVLKYLNNENKLTYEFKTKVKPKTDA
CCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHCCCCEEEEEEEECCCCCHHH
LVEEWQHNQPIKSESPWKIIGDSEYTVTQYNGLRQILSRSLKTKKITVLFNISNRANQFD
HHHHHHCCCCCCCCCCEEEECCCCEEEEHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCC
YYHLGGWDLSNDHNKLVITEDLTGTEQYQASIVDLRTQSITTLTHHVEPTVTWSKDDRYV
EEEECCCCCCCCCCEEEEEECCCCCHHHHHHHEEECCCCEEEEEEECCCEEEECCCCCEE
YLIKQEKYSLRPFELIQFDTQQQNITSLFTEKDKEWLLSFYLSSDHQYAMVQSNNSNSTE
EEEECCCCCCCCEEEEEECCCHHHHHHHHHCCCHHEEEEEEECCCCEEEEEECCCCCCHH
QRILNLTSTHLSLPIKTRQEGVEYYADIAKNKAIINSNHEHNLFILYSANIAHISIINNW
HHHHHEEHHEEEECCHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCEEEEEEECCC
LPLYRPQKNKRITDFYLFKSGPVVSVNDNKSSQLIYLNTAGEIRLRTSLSTSGQVAWISR
CCCCCCCCCCEEEEEEEEECCCEEEECCCCCCEEEEEECCCCEEEEEECCCCCCEEEEEE
VGDFNSDTFYLRSMSMVQSPKWEKVNTATLNRALYLEDQYPNIDASLYATEQIIVTNNGI
CCCCCCCEEEEEEEHHHCCCCCCCCCCEEECEEEEEECCCCCCCEEEEEEEEEEEECCCC
ELPVTLAYRKDKLTDTNPVFLYGYGAYGVTMKPYFMPQIISLLDRGVIYAIAHVRGGGYK
EEEEEEEEECCCCCCCCCEEEEEECCCCCEECCHHHHHHHHHHCCCEEEEEEEECCCCCC
GEDWYQAGRGINRQNAATDFINAAKSMKLYRNGERKIYALGSSAGGTLIATALNQEPKLF
CHHHHHHCCCCCCCHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCEEEEEECCCCCCEE
QGAALNVPFVDVINSMSDSSLPLTLQQYSEWGNPTIQDELNIMKKTDPYLNISKQEYPPL
CCCCCCCCHHHHHHCCCCCCCCEEHHHHHHCCCCCCHHHHHHHCCCCCCEECCCCCCCCE
LVQVGFNDSRVPYWEGAKYLTKIRRNSSGKGPYLLETHFNQGHSTNRRDALKQQAFEYIF
EEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHH
LLSLINN
HHHHHCC
>Mature Secondary Structure
MKFLNVLYCLVLFSSLTFAQDNLNWLKDSSRSNPEVLKYLNNENKLTYEFKTKVKPKTDA
CCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHCCCCEEEEEEEECCCCCHHH
LVEEWQHNQPIKSESPWKIIGDSEYTVTQYNGLRQILSRSLKTKKITVLFNISNRANQFD
HHHHHHCCCCCCCCCCEEEECCCCEEEEHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCC
YYHLGGWDLSNDHNKLVITEDLTGTEQYQASIVDLRTQSITTLTHHVEPTVTWSKDDRYV
EEEECCCCCCCCCCEEEEEECCCCCHHHHHHHEEECCCCEEEEEEECCCEEEECCCCCEE
YLIKQEKYSLRPFELIQFDTQQQNITSLFTEKDKEWLLSFYLSSDHQYAMVQSNNSNSTE
EEEECCCCCCCCEEEEEECCCHHHHHHHHHCCCHHEEEEEEECCCCEEEEEECCCCCCHH
QRILNLTSTHLSLPIKTRQEGVEYYADIAKNKAIINSNHEHNLFILYSANIAHISIINNW
HHHHHEEHHEEEECCHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCEEEEEEECCC
LPLYRPQKNKRITDFYLFKSGPVVSVNDNKSSQLIYLNTAGEIRLRTSLSTSGQVAWISR
CCCCCCCCCCEEEEEEEEECCCEEEECCCCCCEEEEEECCCCEEEEEECCCCCCEEEEEE
VGDFNSDTFYLRSMSMVQSPKWEKVNTATLNRALYLEDQYPNIDASLYATEQIIVTNNGI
CCCCCCCEEEEEEEHHHCCCCCCCCCCEEECEEEEEECCCCCCCEEEEEEEEEEEECCCC
ELPVTLAYRKDKLTDTNPVFLYGYGAYGVTMKPYFMPQIISLLDRGVIYAIAHVRGGGYK
EEEEEEEEECCCCCCCCCEEEEEECCCCCEECCHHHHHHHHHHCCCEEEEEEEECCCCCC
GEDWYQAGRGINRQNAATDFINAAKSMKLYRNGERKIYALGSSAGGTLIATALNQEPKLF
CHHHHHHCCCCCCCHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCEEEEEECCCCCCEE
QGAALNVPFVDVINSMSDSSLPLTLQQYSEWGNPTIQDELNIMKKTDPYLNISKQEYPPL
CCCCCCCCHHHHHHCCCCCCCCEEHHHHHHCCCCCCHHHHHHHCCCCCCEECCCCCCCCE
LVQVGFNDSRVPYWEGAKYLTKIRRNSSGKGPYLLETHFNQGHSTNRRDALKQQAFEYIF
EEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHH
LLSLINN
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1769955; 9097040; 9278503 [H]