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The map label for this gene is glpA [H]

Identifier: 59713433

GI number: 59713433

Start: 277867

End: 279519

Strand: Reverse

Name: glpA [H]

Synonym: VF_A0250

Alternate gene names: 59713433

Gene position: 279519-277867 (Counterclockwise)

Preceding gene: 59713436

Following gene: 59713432

Centisome position: 21.01

GC content: 42.23

Gene sequence:

>1653_bases
ATGAACAAAACTTCTCGATTAGAAACTTCCGTTATCATTATTGGTGGCGGAGCAACAGGCTCCGGAATTATGCGTGATTG
TGCTTTGCGAGGTATCGATTGTATTTTAATTGAGAAAGACGATTTAGCTTCTGGTACCACAGGTCGCAACCATGGCTTAC
TTCACTCTGGCGCCCGCTATGCCGTGACAGATAACGAATCAGCAAAAGAATGTATCCATGAAAACAAGATCTTAAAAACC
ATTGCTAAGCATTGTGTTGAAGATACGCAAGGCTTATTTATCTCACTTCCTGATGATGACTTAGATTTTCAAAAACAGTT
TATTGATTCATGCGGATCTGCTGGTATTGAGGCAAAACAACTTACACCAAAAGAAGCGTTATTACTTGAGCCAAACGTGA
ATCCTGATTTAATTGGCGCCGTTCAAGTCCCAGATGGAACGCTCGATCCTTTTCGTTTATGTGCAGCGAATGTCCTGGAT
GCGAAAGAAAATGGTGCGCGTTTGCTCACACATACCCATGTAACTTCCCTTATTCGACATCAAGATACGGTGCTCGGAGT
GAACTGTATTGATGTAAAGACCAATCAGAAAATTGAAATCTTTGCACAACAAGTGATTAATGCCGCTGGTATTTGGGGAC
AAAATATTTGTGAATACGCCGATTTGAGCATCAAAATGTTTCCAGCAAAAGGTTCATTACTGATCTTAGATTATCGTATT
AATAACTTAGTGATTAACCGTTGCCGTAAACCCTCTGATGCCGATATTTTAGTACCAGGGGATACGATTTCTCTTATCGG
AACCACATCAGAACACATTGATTATGACAAGATTGATGATTTGCATGTAAGTGCTAAAGAAGTTGATATTCTCATGCGTG
AAGGAGCAAAACTCGCACCAATCATGGCAAATACACGAGTTTTACGCGCCTATGCTGGAGTCCGCCCATTAGTTGCTGTT
GACGACGACGGTACAGGCCGAAACATCAGTCGCGGCATAGTGCTACTCGACCACGGTGAAAAAGACGGTTTAGACGGATT
TACAACCATTACCGGCGGTAAACTAATGACCTCTCGTTTAATGGCAGAAATGACAACAGATCTTGTGGCTAATAAGCTAG
GAAATACACAAGAGTGTACCACTCATATTCGTCCACTACCGGGATCAAATGGCGCATCAATTACCGCAAAAAAAACCGCA
AGTATTGCAAAACCGGTTTACCAAAGTGCGATTTATCGACACGGTGAACGTGCTCAACAGTTTTTAACCGATGAAGCTAA
AGATCAAGCCGTGATCTGTGAATGCGAAATGGTAACCCAAGGTGAAATTAACTACGCCATTAACCAATTAGATGTTCACA
ACCTAGTTGATCTTCGTCGTCGTACTCGCTTAGGTATGGGCCCCTGCCAAGGGGAACTATGTACCTATCGTGCCGCTGGA
CTATTTGAAGAATGCGGACAAATCAGTGGTAACCAATCAAGCCAACTATTGACTCACTTTTTAGAAGAACGCTGGAAAGG
CATCAAACCTGTATTCTGGGGAGATGCACTACGAGAAGCAGAATTTAGCTATTGGATTTATGAAGGTCTGTTCGGAGCAA
GTGACATTCCAAACCAACACTCTGAACAAGAATCAAAAGAGGCAACATTATGA

Upstream 100 bases:

>100_bases
ATGCGCGAACGAGCATTTTTGCGTTAGATCAAAGAATGTGTCGAACATTAATATCATGATGATTTCATACATCAAAAGTG
GTAAAAAAAGAGACTAAATT

Downstream 100 bases:

>100_bases
ATTTCGACACCATTATCATCGGCGGCGGCATGGCTGGTTTAAGCTGTGCTTTACGTTGCTTAGAAGCAGGACTAAAGACC
GCAGTGATTGCCTCAGGTCA

Product: sn-glycerol-3-phosphate dehydrogenase subunit A

Products: NA

Alternate protein names: G-3-P dehydrogenase [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MNKTSRLETSVIIIGGGATGSGIMRDCALRGIDCILIEKDDLASGTTGRNHGLLHSGARYAVTDNESAKECIHENKILKT
IAKHCVEDTQGLFISLPDDDLDFQKQFIDSCGSAGIEAKQLTPKEALLLEPNVNPDLIGAVQVPDGTLDPFRLCAANVLD
AKENGARLLTHTHVTSLIRHQDTVLGVNCIDVKTNQKIEIFAQQVINAAGIWGQNICEYADLSIKMFPAKGSLLILDYRI
NNLVINRCRKPSDADILVPGDTISLIGTTSEHIDYDKIDDLHVSAKEVDILMREGAKLAPIMANTRVLRAYAGVRPLVAV
DDDGTGRNISRGIVLLDHGEKDGLDGFTTITGGKLMTSRLMAEMTTDLVANKLGNTQECTTHIRPLPGSNGASITAKKTA
SIAKPVYQSAIYRHGERAQQFLTDEAKDQAVICECEMVTQGEINYAINQLDVHNLVDLRRRTRLGMGPCQGELCTYRAAG
LFEECGQISGNQSSQLLTHFLEERWKGIKPVFWGDALREAEFSYWIYEGLFGASDIPNQHSEQESKEATL

Sequences:

>Translated_550_residues
MNKTSRLETSVIIIGGGATGSGIMRDCALRGIDCILIEKDDLASGTTGRNHGLLHSGARYAVTDNESAKECIHENKILKT
IAKHCVEDTQGLFISLPDDDLDFQKQFIDSCGSAGIEAKQLTPKEALLLEPNVNPDLIGAVQVPDGTLDPFRLCAANVLD
AKENGARLLTHTHVTSLIRHQDTVLGVNCIDVKTNQKIEIFAQQVINAAGIWGQNICEYADLSIKMFPAKGSLLILDYRI
NNLVINRCRKPSDADILVPGDTISLIGTTSEHIDYDKIDDLHVSAKEVDILMREGAKLAPIMANTRVLRAYAGVRPLVAV
DDDGTGRNISRGIVLLDHGEKDGLDGFTTITGGKLMTSRLMAEMTTDLVANKLGNTQECTTHIRPLPGSNGASITAKKTA
SIAKPVYQSAIYRHGERAQQFLTDEAKDQAVICECEMVTQGEINYAINQLDVHNLVDLRRRTRLGMGPCQGELCTYRAAG
LFEECGQISGNQSSQLLTHFLEERWKGIKPVFWGDALREAEFSYWIYEGLFGASDIPNQHSEQESKEATL
>Mature_550_residues
MNKTSRLETSVIIIGGGATGSGIMRDCALRGIDCILIEKDDLASGTTGRNHGLLHSGARYAVTDNESAKECIHENKILKT
IAKHCVEDTQGLFISLPDDDLDFQKQFIDSCGSAGIEAKQLTPKEALLLEPNVNPDLIGAVQVPDGTLDPFRLCAANVLD
AKENGARLLTHTHVTSLIRHQDTVLGVNCIDVKTNQKIEIFAQQVINAAGIWGQNICEYADLSIKMFPAKGSLLILDYRI
NNLVINRCRKPSDADILVPGDTISLIGTTSEHIDYDKIDDLHVSAKEVDILMREGAKLAPIMANTRVLRAYAGVRPLVAV
DDDGTGRNISRGIVLLDHGEKDGLDGFTTITGGKLMTSRLMAEMTTDLVANKLGNTQECTTHIRPLPGSNGASITAKKTA
SIAKPVYQSAIYRHGERAQQFLTDEAKDQAVICECEMVTQGEINYAINQLDVHNLVDLRRRTRLGMGPCQGELCTYRAAG
LFEECGQISGNQSSQLLTHFLEERWKGIKPVFWGDALREAEFSYWIYEGLFGASDIPNQHSEQESKEATL

Specific function: Conversion Of Glycerol 3-Phosphate To Dihydroxyacetone. Uses Fumarate Or Nitrate As Electron Acceptor. [C]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=399, Percent_Identity=29.0726817042606, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI285002231, Length=399, Percent_Identity=29.0726817042606, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI197927446, Length=286, Percent_Identity=25.8741258741259, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI21361378, Length=286, Percent_Identity=25.8741258741259, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788574, Length=525, Percent_Identity=63.0476190476191, Blast_Score=679, Evalue=0.0,
Organism=Caenorhabditis elegans, GI115534726, Length=418, Percent_Identity=25.3588516746411, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322036, Length=466, Percent_Identity=25.5364806866953, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI161077125, Length=402, Percent_Identity=28.3582089552239, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24653942, Length=402, Percent_Identity=28.3582089552239, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24653944, Length=402, Percent_Identity=28.3582089552239, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20130025, Length=402, Percent_Identity=28.3582089552239, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20130091, Length=233, Percent_Identity=27.8969957081545, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 60145; Mature: 60145

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTSRLETSVIIIGGGATGSGIMRDCALRGIDCILIEKDDLASGTTGRNHGLLHSGARY
CCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEECCCEE
AVTDNESAKECIHENKILKTIAKHCVEDTQGLFISLPDDDLDFQKQFIDSCGSAGIEAKQ
EEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHH
LTPKEALLLEPNVNPDLIGAVQVPDGTLDPFRLCAANVLDAKENGARLLTHTHVTSLIRH
CCCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
QDTVLGVNCIDVKTNQKIEIFAQQVINAAGIWGQNICEYADLSIKMFPAKGSLLILDYRI
CCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCCEEEEEEEH
NNLVINRCRKPSDADILVPGDTISLIGTTSEHIDYDKIDDLHVSAKEVDILMREGAKLAP
HHHHHHHCCCCCCCEEEECCCEEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCC
IMANTRVLRAYAGVRPLVAVDDDGTGRNISRGIVLLDHGEKDGLDGFTTITGGKLMTSRL
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCHHHHHHH
MAEMTTDLVANKLGNTQECTTHIRPLPGSNGASITAKKTASIAKPVYQSAIYRHGERAQQ
HHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCHHHHHH
FLTDEAKDQAVICECEMVTQGEINYAINQLDVHNLVDLRRRTRLGMGPCQGELCTYRAAG
HHHHCCCCCEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LFEECGQISGNQSSQLLTHFLEERWKGIKPVFWGDALREAEFSYWIYEGLFGASDIPNQH
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHEEHHHHCCCCCCCCCCC
SEQESKEATL
CHHHHHCCCC
>Mature Secondary Structure
MNKTSRLETSVIIIGGGATGSGIMRDCALRGIDCILIEKDDLASGTTGRNHGLLHSGARY
CCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEECCCEE
AVTDNESAKECIHENKILKTIAKHCVEDTQGLFISLPDDDLDFQKQFIDSCGSAGIEAKQ
EEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHH
LTPKEALLLEPNVNPDLIGAVQVPDGTLDPFRLCAANVLDAKENGARLLTHTHVTSLIRH
CCCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
QDTVLGVNCIDVKTNQKIEIFAQQVINAAGIWGQNICEYADLSIKMFPAKGSLLILDYRI
CCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCCEEEEEEEH
NNLVINRCRKPSDADILVPGDTISLIGTTSEHIDYDKIDDLHVSAKEVDILMREGAKLAP
HHHHHHHCCCCCCCEEEECCCEEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCC
IMANTRVLRAYAGVRPLVAVDDDGTGRNISRGIVLLDHGEKDGLDGFTTITGGKLMTSRL
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCHHHHHHH
MAEMTTDLVANKLGNTQECTTHIRPLPGSNGASITAKKTASIAKPVYQSAIYRHGERAQQ
HHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCHHHHHH
FLTDEAKDQAVICECEMVTQGEINYAINQLDVHNLVDLRRRTRLGMGPCQGELCTYRAAG
HHHHCCCCCEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LFEECGQISGNQSSQLLTHFLEERWKGIKPVFWGDALREAEFSYWIYEGLFGASDIPNQH
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHEEHHHHCCCCCCCCCCC
SEQESKEATL
CHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]