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The map label for this gene is uhpA [H]

Identifier: 59713224

GI number: 59713224

Start: 44954

End: 45562

Strand: Reverse

Name: uhpA [H]

Synonym: VF_A0041

Alternate gene names: 59713224

Gene position: 45562-44954 (Counterclockwise)

Preceding gene: 59713225

Following gene: 172087792

Centisome position: 3.42

GC content: 42.2

Gene sequence:

>609_bases
ATGATTAATGTTGCACTTGTTGATGACCACATCATTGTCCGCTCTGGTTTCGCTCAATTACTTAGTTTGGAATCAGATAT
CTCTGTCGTTGGGGAATTTAGCTCAGCAGCAGAAGCGCGTCGTGGACTACCAAGTTGTCATCCTGATGTCGTCATTTTAG
ATATTTCGATGCAAGATGAGAGTGGATTGAGCCTGTTAGAAGATATTCCATCTGGTATTGCGAGCATCATGCTCAGTGTG
CATGACTCTCCAGCCATGGTTGAGAAATCACTAGAGTTGGGAGCAAAAGGCTATCTAAGTAAACGTTGCAGCCCTGATGA
GCTCATTCAAGCGGTAAGAACCAGTGCTAATGGCGGTTGTTACCTTACGCCAGATATTGCGATTAAACTGGCCACACCTG
TTAAAAATAAAACCGCATTAAATCATCTAACTCGCCGTGAAAACGAAGTTTGTCAATTACTTGCAACTGGGTTAGACGTA
AAATCCATTGCCATTGAATTAGGCCTTAGCCATAAAACCGTCCATGTTCACCGCGCTAATGCAATGGATAAACTTAACGT
AAAAAATAACGTTGAGCTGGCTAAACTCTTCACTCAAGATTCATACTAA

Upstream 100 bases:

>100_bases
AACGTTCTCAATTCAGTATCATTACCCCACCTTATATTTATATTCTTGTCGCTCCCATTGGGGCTATTTTGCTTTTCATT
CCCAATTTTGGTTACTTATC

Downstream 100 bases:

>100_bases
TGCGCTCTTATTTAGCCACATCACTGTGCGGTGCTTTTATGGCCGCTTGTGCTTGGTTTTGCTTATGGGTCATTGCTTAT
TACTTTATTAATGACCCTGA

Product: DNA-binding response regulator in two-component regulatory system wtih UhpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MINVALVDDHIIVRSGFAQLLSLESDISVVGEFSSAAEARRGLPSCHPDVVILDISMQDESGLSLLEDIPSGIASIMLSV
HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVRTSANGGCYLTPDIAIKLATPVKNKTALNHLTRRENEVCQLLATGLDV
KSIAIELGLSHKTVHVHRANAMDKLNVKNNVELAKLFTQDSY

Sequences:

>Translated_202_residues
MINVALVDDHIIVRSGFAQLLSLESDISVVGEFSSAAEARRGLPSCHPDVVILDISMQDESGLSLLEDIPSGIASIMLSV
HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVRTSANGGCYLTPDIAIKLATPVKNKTALNHLTRRENEVCQLLATGLDV
KSIAIELGLSHKTVHVHRANAMDKLNVKNNVELAKLFTQDSY
>Mature_202_residues
MINVALVDDHIIVRSGFAQLLSLESDISVVGEFSSAAEARRGLPSCHPDVVILDISMQDESGLSLLEDIPSGIASIMLSV
HDSPAMVEKSLELGAKGYLSKRCSPDELIQAVRTSANGGCYLTPDIAIKLATPVKNKTALNHLTRRENEVCQLLATGLDV
KSIAIELGLSHKTVHVHRANAMDKLNVKNNVELAKLFTQDSY

Specific function: Appears to be the positive activator of uhpT transcription [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=195, Percent_Identity=64.6153846153846, Blast_Score=244, Evalue=4e-66,
Organism=Escherichia coli, GI1788222, Length=203, Percent_Identity=36.9458128078818, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1788521, Length=204, Percent_Identity=34.8039215686275, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788712, Length=196, Percent_Identity=26.0204081632653, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=35.1648351648352, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1788546, Length=199, Percent_Identity=30.6532663316583, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786747, Length=206, Percent_Identity=27.6699029126214, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 21786; Mature: 21786

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVALVDDHIIVRSGFAQLLSLESDISVVGEFSSAAEARRGLPSCHPDVVILDISMQDE
CEEEEEECCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCC
SGLSLLEDIPSGIASIMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVRTSANGGC
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCE
YLTPDIAIKLATPVKNKTALNHLTRRENEVCQLLATGLDVKSIAIELGLSHKTVHVHRAN
EECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCEEEEEEECC
AMDKLNVKNNVELAKLFTQDSY
CHHHCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MINVALVDDHIIVRSGFAQLLSLESDISVVGEFSSAAEARRGLPSCHPDVVILDISMQDE
CEEEEEECCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCC
SGLSLLEDIPSGIASIMLSVHDSPAMVEKSLELGAKGYLSKRCSPDELIQAVRTSANGGC
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCE
YLTPDIAIKLATPVKNKTALNHLTRRENEVCQLLATGLDVKSIAIELGLSHKTVHVHRAN
EECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCEEEEEEECC
AMDKLNVKNNVELAKLFTQDSY
CHHHCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]