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The map label for this gene is uhpB [H]

Identifier: 172087792

GI number: 172087792

Start: 43458

End: 44915

Strand: Reverse

Name: uhpB [H]

Synonym: VF_A0040

Alternate gene names: 172087792

Gene position: 44915-43458 (Counterclockwise)

Preceding gene: 59713224

Following gene: 59713222

Centisome position: 3.38

GC content: 41.22

Gene sequence:

>1458_bases
ATGGCCGCTTGTGCTTGGTTTTGCTTATGGGTCATTGCTTATTACTTTATTAATGACCCTGAGCTTGCCATTTTGTTATT
TCCCTTCTCCCTACGCTTAGGAATGACTCTGCACACTCGCCCTTCCTATTGGCCTGCGATTTACATTGCAGAATGGGGGC
TAACCATCGCTTTAGCTCTACTACTTGATGAACCACAATGGCTAACCGTTCTTATTGCTAGTGCCTTAAGTATTCCCATT
ACGTGGTTTGCAAAACGGTATTACTACGGCGATCAAAACCGTCATCTTCTCATCATGGCAAGCGTCATTATGATCACCGC
ACTCATCAATATTGCGGTCGTGGGATCTCATGTTCCTTCGATTTACATGGTATGGCTTGTGAGCATTACTGGCGGGTTAA
TGCTGGTTCCGATGTGCTATTTAGTGTGGAACTATCTATTTCAAAATAAATGGGCACCACTGAGCTCCCACCTAATCAAT
ACCGCTGTTGAATTTAAAATACGTCATATCGCTTTATACAGTCTATTGTTGGTTGCTAGCATTTTAATACAAACCAGTTT
ACCTGATGAGTTAAGACGCTTCGCTCCTTTTTGTATGGCAATTCCGATTATTTTGCTTGCGGTACGATACGGGTGGCAAG
GGGCGTTATTAGCGACATTATTTAATAGTGTGGCATTAATTGCAGCTCACAGTGGCGTATCTAAACTTGAAATTACCGAT
TTACTTTTATCGCTTTCAGCCCAAACCATTACGGGTATTTTACTTGGATTAGCGGTTCAAAAGCAGAAAGATCTCAATCA
AAAATTACGTAATGAACTGTCTCGTAATCAAAATCTATCACGCCAATTAATTACAGCAGAGGAATCGGTTCGTCGTGATA
TTGCACGTGAATTGCATGATGAAATAGGCCAAAACATCACGGCTATCCGTACTCAAGCAAGCATAATTAAACGCATTGAT
GCCGCTGAGATGAGTGTTCGTTGCGCCGATACTATCGAGACACTCTCACTCAATGTTTATGACACAACCAAGCGATTATT
AACCAAGTTAAGACCCAAAATGTTGGATGATTTGGATTTAAAAGAATCCGTTGAGCAACTCATCCGTGAAATGGAGTTTT
CCGATCACGGCGTTGATATACAACTAAACTGGCAAGGTGATTATTCATGCTTAAGCGATACGCTTAAAGTCACTATCTTC
CGCTTATGCCAAGAGTCACTCAATAACGCTTATAAATACGCACAAGCCAGTGAAATTAGAATCGAGCTTACTCTTGATGA
GCAAGTGAGCCTTTTTATTACCGACAATGGTATTGGATTTAAAACCCAAGATTTAATGAATGGAATGGGAGTAAGAGGTA
TGCAAGAGCGAGTTCAAGCACTCGGTGGGAAAATGGCCATCAATTCCAATACCTCGATTCCTGGCACTCAAATTAGCATT
GCACTACCAAAAATGTGA

Upstream 100 bases:

>100_bases
ATAAACTTAACGTAAAAAATAACGTTGAGCTGGCTAAACTCTTCACTCAAGATTCATACTAATGCGCTCTTATTTAGCCA
CATCACTGTGCGGTGCTTTT

Downstream 100 bases:

>100_bases
GTATGACTATGTTTGGATTTTTACGCTCAACCACATCAAATGACAACACACTTAGTGATACTCAAGTAAACGAAAGTTAT
CGCTATTGGCGTTTACATAT

Product: sensory histidine kinase UhpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MAACAWFCLWVIAYYFINDPELAILLFPFSLRLGMTLHTRPSYWPAIYIAEWGLTIALALLLDEPQWLTVLIASALSIPI
TWFAKRYYYGDQNRHLLIMASVIMITALINIAVVGSHVPSIYMVWLVSITGGLMLVPMCYLVWNYLFQNKWAPLSSHLIN
TAVEFKIRHIALYSLLLVASILIQTSLPDELRRFAPFCMAIPIILLAVRYGWQGALLATLFNSVALIAAHSGVSKLEITD
LLLSLSAQTITGILLGLAVQKQKDLNQKLRNELSRNQNLSRQLITAEESVRRDIARELHDEIGQNITAIRTQASIIKRID
AAEMSVRCADTIETLSLNVYDTTKRLLTKLRPKMLDDLDLKESVEQLIREMEFSDHGVDIQLNWQGDYSCLSDTLKVTIF
RLCQESLNNAYKYAQASEIRIELTLDEQVSLFITDNGIGFKTQDLMNGMGVRGMQERVQALGGKMAINSNTSIPGTQISI
ALPKM

Sequences:

>Translated_485_residues
MAACAWFCLWVIAYYFINDPELAILLFPFSLRLGMTLHTRPSYWPAIYIAEWGLTIALALLLDEPQWLTVLIASALSIPI
TWFAKRYYYGDQNRHLLIMASVIMITALINIAVVGSHVPSIYMVWLVSITGGLMLVPMCYLVWNYLFQNKWAPLSSHLIN
TAVEFKIRHIALYSLLLVASILIQTSLPDELRRFAPFCMAIPIILLAVRYGWQGALLATLFNSVALIAAHSGVSKLEITD
LLLSLSAQTITGILLGLAVQKQKDLNQKLRNELSRNQNLSRQLITAEESVRRDIARELHDEIGQNITAIRTQASIIKRID
AAEMSVRCADTIETLSLNVYDTTKRLLTKLRPKMLDDLDLKESVEQLIREMEFSDHGVDIQLNWQGDYSCLSDTLKVTIF
RLCQESLNNAYKYAQASEIRIELTLDEQVSLFITDNGIGFKTQDLMNGMGVRGMQERVQALGGKMAINSNTSIPGTQISI
ALPKM
>Mature_484_residues
AACAWFCLWVIAYYFINDPELAILLFPFSLRLGMTLHTRPSYWPAIYIAEWGLTIALALLLDEPQWLTVLIASALSIPIT
WFAKRYYYGDQNRHLLIMASVIMITALINIAVVGSHVPSIYMVWLVSITGGLMLVPMCYLVWNYLFQNKWAPLSSHLINT
AVEFKIRHIALYSLLLVASILIQTSLPDELRRFAPFCMAIPIILLAVRYGWQGALLATLFNSVALIAAHSGVSKLEITDL
LLSLSAQTITGILLGLAVQKQKDLNQKLRNELSRNQNLSRQLITAEESVRRDIARELHDEIGQNITAIRTQASIIKRIDA
AEMSVRCADTIETLSLNVYDTTKRLLTKLRPKMLDDLDLKESVEQLIREMEFSDHGVDIQLNWQGDYSCLSDTLKVTIFR
LCQESLNNAYKYAQASEIRIELTLDEQVSLFITDNGIGFKTQDLMNGMGVRGMQERVQALGGKMAINSNTSIPGTQISIA
LPKM

Specific function: Member of the two-component regulatory system uhpB/uhpA involved in the regulation of the uptake of hexose phosphates. UhpB functions as a membrane-associated protein kinase that phosphorylates uhpA in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=484, Percent_Identity=44.4214876033058, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI1788812, Length=208, Percent_Identity=30.2884615384615, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787474, Length=212, Percent_Identity=30.188679245283, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR007895
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; PF05231 MASE1 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54617; Mature: 54486

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAACAWFCLWVIAYYFINDPELAILLFPFSLRLGMTLHTRPSYWPAIYIAEWGLTIALAL
CCHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHCCCEEECCCCCCCEEEEEHHHHHHHHHH
LLDEPQWLTVLIASALSIPITWFAKRYYYGDQNRHLLIMASVIMITALINIAVVGSHVPS
HHCCCHHHHHHHHHHHHCCHHHHHHHHEECCCCCEEHHHHHHHHHHHHHHHHHHCCCCHH
IYMVWLVSITGGLMLVPMCYLVWNYLFQNKWAPLSSHLINTAVEFKIRHIALYSLLLVAS
HHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILIQTSLPDELRRFAPFCMAIPIILLAVRYGWQGALLATLFNSVALIAAHSGVSKLEITD
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
LLLSLSAQTITGILLGLAVQKQKDLNQKLRNELSRNQNLSRQLITAEESVRRDIARELHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
EIGQNITAIRTQASIIKRIDAAEMSVRCADTIETLSLNVYDTTKRLLTKLRPKMLDDLDL
HHCCCHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHEEEEHHHHHHHHHHHCHHHHCCCCH
KESVEQLIREMEFSDHGVDIQLNWQGDYSCLSDTLKVTIFRLCQESLNNAYKYAQASEIR
HHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
IELTLDEQVSLFITDNGIGFKTQDLMNGMGVRGMQERVQALGGKMAINSNTSIPGTQISI
EEEEECCCEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHCCCCEEECCCCCCCCCEEEE
ALPKM
ECCCC
>Mature Secondary Structure 
AACAWFCLWVIAYYFINDPELAILLFPFSLRLGMTLHTRPSYWPAIYIAEWGLTIALAL
CHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHCCCEEECCCCCCCEEEEEHHHHHHHHHH
LLDEPQWLTVLIASALSIPITWFAKRYYYGDQNRHLLIMASVIMITALINIAVVGSHVPS
HHCCCHHHHHHHHHHHHCCHHHHHHHHEECCCCCEEHHHHHHHHHHHHHHHHHHCCCCHH
IYMVWLVSITGGLMLVPMCYLVWNYLFQNKWAPLSSHLINTAVEFKIRHIALYSLLLVAS
HHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILIQTSLPDELRRFAPFCMAIPIILLAVRYGWQGALLATLFNSVALIAAHSGVSKLEITD
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
LLLSLSAQTITGILLGLAVQKQKDLNQKLRNELSRNQNLSRQLITAEESVRRDIARELHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
EIGQNITAIRTQASIIKRIDAAEMSVRCADTIETLSLNVYDTTKRLLTKLRPKMLDDLDL
HHCCCHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHEEEEHHHHHHHHHHHCHHHHCCCCH
KESVEQLIREMEFSDHGVDIQLNWQGDYSCLSDTLKVTIFRLCQESLNNAYKYAQASEIR
HHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
IELTLDEQVSLFITDNGIGFKTQDLMNGMGVRGMQERVQALGGKMAINSNTSIPGTQISI
EEEEECCCEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHCCCCEEECCCCCCCCCEEEE
ALPKM
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3301805; 1569007; 7686882; 9278503 [H]