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The map label for this gene is accC [H]

Identifier: 59712994

GI number: 59712994

Start: 2675867

End: 2677210

Strand: Direct

Name: accC [H]

Synonym: VF_2387

Alternate gene names: 59712994

Gene position: 2675867-2677210 (Clockwise)

Preceding gene: 59712993

Following gene: 59712995

Centisome position: 92.35

GC content: 43.53

Gene sequence:

>1344_bases
ATGTTAGATAAATTAGTTATCGCAAACCGTGGTGAAATTGCACTACGTATTTTGCGAGCATGTAAAGAGCTTGGCATCAA
AACGGTTGCTGTGCACTCTACTGCTGACCGTGATTTAAAACACGTACTGCTTGCAGATGAAACGATTTGTATCGGTCCTG
CACGTGGTATCGACAGCTACCTAAACATCCCTCGTATCATCAGTGCTGCTGAAGTTACAGGTGCGGTTGCGGTTCACCCA
GGTTACGGTTTCTTATCTGAAAATGCTGACTTCGCAGAGCAAGTTGAGCGTTCTGGCTTTATCTTTGTTGGTCCAAAAGC
AGAAACTATCCGCATGATGGGCGACAAAGTATCAGCAATCACTGCAATGAAAAAAGCAGGCGTACCTTGTGTACCTGGTT
CTGATGGTCCACTAGATAACGATGAAGCGAAAAACAAAGCACACGCAAAACGCATTGGTTACCCAGTAATCATTAAAGCG
TCTGGCGGCGGCGGTGGTCGTGGTATGCGTGTTGTTCGCGCAGAAAAAGACCTTGTTGAAGCAATTGCAATGACTCGTGC
AGAAGCAAAAGCATGTTTCAATAACGAAATGGTTTACATGGAAAAATTCCTTGAAAACCCTCGTCACATTGAAGTTCAAG
TTCTTGCTGATGGCCAAGGTAACGCAATTCACTTAGGTGAACGTGACTGTTCTATGCAACGTCGCCACCAAAAAGTAGTT
GAAGAAGCGCCAGCTCCAGGTATTACTGAAGAGATGCGTAAATACATCGGTGAACGTTGTACTCGTGCATGTCTTGAAAT
TGGTTACCGTGGTGCAGGTACATTTGAATTCCTATATGAAAACGGCGAATTCTACTTCATCGAAATGAATACACGTATTC
AGGTTGAGCACACTATTACCGAAATGGTAACAGGTATCGACCTAGTGAAAGAGCAACTACGTATTGCTGCGGGTCAACCG
CTATCTTACACACAAGATGATATCAAACTGCGTGGTCACTCAATTGAGTGTCGTATCAATGCTGAAGATCCAGTTCGTTT
CCTACCTTCACCAGGTAAGATTGAACGCTTCCATGCTCCAGGTGGTATGGGTGTACGTTGGGAATCTCACATCTACACAG
GCTACACAGTTCCACCTCATTACGATTCAATGATCGGTAAGCTAATTACTTACGGTGAAAACCGTGACGTTGCTATCGCT
CGTATGAAAAACGCATTAGGTGAAATGATTGTTGAAGGTATTCACGTGAATACACCACTTCAATTAGCAATCATGAATGA
TGAAAACTTCCAACATGGTGGTGCAAATATTCACTATCTTGAGAAGAAACTAGGCCTACAATAA

Upstream 100 bases:

>100_bases
AAGCAGACAAATCAGGCGTTGTAACTGCAATTCTTCTTGAAGATGGTCAACCGGTTGAGTTCGACCAACCTCTTGTTATC
ATCGAATAATAGAGGCTGTT

Downstream 100 bases:

>100_bases
GCCTTTTCTAATCATTCAATAAATAAGAACGAATTAAAGACGGTGAGTATGATTACTCACCGTCTTTTTTTGTGTTAAAA
TCGCCCACATTTTCGACTAA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLDKLVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPARGIDSYLNIPRIISAAEVTGAVAVHP
GYGFLSENADFAEQVERSGFIFVGPKAETIRMMGDKVSAITAMKKAGVPCVPGSDGPLDNDEAKNKAHAKRIGYPVIIKA
SGGGGGRGMRVVRAEKDLVEAIAMTRAEAKACFNNEMVYMEKFLENPRHIEVQVLADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEEMRKYIGERCTRACLEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHTITEMVTGIDLVKEQLRIAAGQP
LSYTQDDIKLRGHSIECRINAEDPVRFLPSPGKIERFHAPGGMGVRWESHIYTGYTVPPHYDSMIGKLITYGENRDVAIA
RMKNALGEMIVEGIHVNTPLQLAIMNDENFQHGGANIHYLEKKLGLQ

Sequences:

>Translated_447_residues
MLDKLVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPARGIDSYLNIPRIISAAEVTGAVAVHP
GYGFLSENADFAEQVERSGFIFVGPKAETIRMMGDKVSAITAMKKAGVPCVPGSDGPLDNDEAKNKAHAKRIGYPVIIKA
SGGGGGRGMRVVRAEKDLVEAIAMTRAEAKACFNNEMVYMEKFLENPRHIEVQVLADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEEMRKYIGERCTRACLEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHTITEMVTGIDLVKEQLRIAAGQP
LSYTQDDIKLRGHSIECRINAEDPVRFLPSPGKIERFHAPGGMGVRWESHIYTGYTVPPHYDSMIGKLITYGENRDVAIA
RMKNALGEMIVEGIHVNTPLQLAIMNDENFQHGGANIHYLEKKLGLQ
>Mature_447_residues
MLDKLVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPARGIDSYLNIPRIISAAEVTGAVAVHP
GYGFLSENADFAEQVERSGFIFVGPKAETIRMMGDKVSAITAMKKAGVPCVPGSDGPLDNDEAKNKAHAKRIGYPVIIKA
SGGGGGRGMRVVRAEKDLVEAIAMTRAEAKACFNNEMVYMEKFLENPRHIEVQVLADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEEMRKYIGERCTRACLEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHTITEMVTGIDLVKEQLRIAAGQP
LSYTQDDIKLRGHSIECRINAEDPVRFLPSPGKIERFHAPGGMGVRWESHIYTGYTVPPHYDSMIGKLITYGENRDVAIA
RMKNALGEMIVEGIHVNTPLQLAIMNDENFQHGGANIHYLEKKLGLQ

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=47.9545454545455, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=45.5981941309255, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=45.5981941309255, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=45.5981941309255, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049528, Length=452, Percent_Identity=44.4690265486726, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI106049295, Length=452, Percent_Identity=44.4690265486726, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI106049292, Length=452, Percent_Identity=44.4690265486726, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI38679977, Length=504, Percent_Identity=30.3571428571429, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI38679967, Length=504, Percent_Identity=30.3571428571429, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI38679971, Length=504, Percent_Identity=30.3571428571429, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679960, Length=504, Percent_Identity=30.3571428571429, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679974, Length=504, Percent_Identity=30.3571428571429, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI134142062, Length=504, Percent_Identity=29.3650793650794, Blast_Score=222, Evalue=5e-58,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=82.9977628635347, Blast_Score=765, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=238, Percent_Identity=23.9495798319328, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=46.5011286681716, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=44.7963800904977, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=43.4298440979955, Blast_Score=355, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI71997168, Length=518, Percent_Identity=28.957528957529, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71997163, Length=518, Percent_Identity=28.957528957529, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=27.5510204081633, Blast_Score=192, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6319695, Length=441, Percent_Identity=46.2585034013605, Blast_Score=348, Evalue=7e-97,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.5349887133183, Blast_Score=345, Evalue=8e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=441, Percent_Identity=46.9387755102041, Blast_Score=339, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=30.9803921568627, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6323863, Length=453, Percent_Identity=32.6710816777042, Blast_Score=223, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24651757, Length=441, Percent_Identity=46.031746031746, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=47.6404494382022, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=47.6404494382022, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=47.6404494382022, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=47.6404494382022, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=47.6404494382022, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=47.6404494382022, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=47.6404494382022, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=47.6404494382022, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=47.6404494382022, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=47.6404494382022, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651759, Length=402, Percent_Identity=46.0199004975124, Blast_Score=357, Evalue=8e-99,
Organism=Drosophila melanogaster, GI24586458, Length=473, Percent_Identity=31.2896405919662, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI161076409, Length=473, Percent_Identity=31.2896405919662, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI161076407, Length=473, Percent_Identity=31.2896405919662, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24586460, Length=473, Percent_Identity=31.2896405919662, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49356; Mature: 49356

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKLVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPARGIDSY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHEEEEECCEEEEECCCCCHHH
LNIPRIISAAEVTGAVAVHPGYGFLSENADFAEQVERSGFIFVGPKAETIRMMGDKVSAI
CCCHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
TAMKKAGVPCVPGSDGPLDNDEAKNKAHAKRIGYPVIIKASGGGGGRGMRVVRAEKDLVE
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AIAMTRAEAKACFNNEMVYMEKFLENPRHIEVQVLADGQGNAIHLGERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITEEMRKYIGERCTRACLEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHTIT
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEEHHHHH
EMVTGIDLVKEQLRIAAGQPLSYTQDDIKLRGHSIECRINAEDPVRFLPSPGKIERFHAP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEEECCCCCEEECCCCCCEEEEECC
GGMGVRWESHIYTGYTVPPHYDSMIGKLITYGENRDVAIARMKNALGEMIVEGIHVNTPL
CCCCEEEECEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEECCCE
QLAIMNDENFQHGGANIHYLEKKLGLQ
EEEEECCCCCCCCCCEEEEEHHHHCCC
>Mature Secondary Structure
MLDKLVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPARGIDSY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHEEEEECCEEEEECCCCCHHH
LNIPRIISAAEVTGAVAVHPGYGFLSENADFAEQVERSGFIFVGPKAETIRMMGDKVSAI
CCCHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
TAMKKAGVPCVPGSDGPLDNDEAKNKAHAKRIGYPVIIKASGGGGGRGMRVVRAEKDLVE
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AIAMTRAEAKACFNNEMVYMEKFLENPRHIEVQVLADGQGNAIHLGERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITEEMRKYIGERCTRACLEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHTIT
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEEHHHHH
EMVTGIDLVKEQLRIAAGQPLSYTQDDIKLRGHSIECRINAEDPVRFLPSPGKIERFHAP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEEECCCCCEEECCCCCCEEEEECC
GGMGVRWESHIYTGYTVPPHYDSMIGKLITYGENRDVAIARMKNALGEMIVEGIHVNTPL
CCCCEEEECEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEECCCE
QLAIMNDENFQHGGANIHYLEKKLGLQ
EEEEECCCCCCCCCCEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]