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The map label for this gene is accB [H]

Identifier: 59712993

GI number: 59712993

Start: 2675397

End: 2675855

Strand: Direct

Name: accB [H]

Synonym: VF_2386

Alternate gene names: 59712993

Gene position: 2675397-2675855 (Clockwise)

Preceding gene: 59712992

Following gene: 59712994

Centisome position: 92.33

GC content: 45.1

Gene sequence:

>459_bases
ATGGATATCCGCAAAATTAAAAAACTGATTGAACTAGTTGAAGAGTCTGGCATTGCAGAACTTGAAATCGCGGAAGGTGA
AGAATCAGTACGCATCAGCCGTGCTATCGCACCAATTGCTCAAGTAGCTCCTGTTCAAGCAGTTGCGGCTCCTGCTGCAC
CAGTAGCAGCGGCAGCTCCAGTTGCATCAGCACCTGCAGCAGTTGAAGCTCCAGCAGAAATTGCTGGCCATAAAGTTTGT
TCTCCAATGGTTGGTACTTTCTACGGTGCACCAAGCCCTGATGCAAAACCATTTATTAAAGTTGGCCAACAAGTAACTGC
TGGCGATACACTATGTATCGTTGAAGCAATGAAAATGATGAACCAAATCGAAGCAGACAAATCAGGCGTTGTAACTGCAA
TTCTTCTTGAAGATGGTCAACCGGTTGAGTTCGACCAACCTCTTGTTATCATCGAATAA

Upstream 100 bases:

>100_bases
TTGTGGTTTAGGGGCCGATGGTTACGAATTTGCTTTGAATGCAGCAGCAAAACGTCTGCGTTCAAATTGATCACTGAATA
TAAACAGAAGAGATTACAAA

Downstream 100 bases:

>100_bases
TAGAGGCTGTTATGTTAGATAAATTAGTTATCGCAAACCGTGGTGAAATTGCACTACGTATTTTGCGAGCATGTAAAGAG
CTTGGCATCAAAACGGTTGC

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: ADP; phosphate; malonyl-CoA

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MDIRKIKKLIELVEESGIAELEIAEGEESVRISRAIAPIAQVAPVQAVAAPAAPVAAAAPVASAPAAVEAPAEIAGHKVC
SPMVGTFYGAPSPDAKPFIKVGQQVTAGDTLCIVEAMKMMNQIEADKSGVVTAILLEDGQPVEFDQPLVIIE

Sequences:

>Translated_152_residues
MDIRKIKKLIELVEESGIAELEIAEGEESVRISRAIAPIAQVAPVQAVAAPAAPVAAAAPVASAPAAVEAPAEIAGHKVC
SPMVGTFYGAPSPDAKPFIKVGQQVTAGDTLCIVEAMKMMNQIEADKSGVVTAILLEDGQPVEFDQPLVIIE
>Mature_152_residues
MDIRKIKKLIELVEESGIAELEIAEGEESVRISRAIAPIAQVAPVQAVAAPAAPVAAAAPVASAPAAVEAPAEIAGHKVC
SPMVGTFYGAPSPDAKPFIKVGQQVTAGDTLCIVEAMKMMNQIEADKSGVVTAILLEDGQPVEFDQPLVIIE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=160, Percent_Identity=73.75, Blast_Score=199, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: 6.4.1.2

Molecular weight: Translated: 15709; Mature: 15709

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRKIKKLIELVEESGIAELEIAEGEESVRISRAIAPIAQVAPVQAVAAPAAPVAAAAP
CCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHCC
VASAPAAVEAPAEIAGHKVCSPMVGTFYGAPSPDAKPFIKVGQQVTAGDTLCIVEAMKMM
CCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHH
NQIEADKSGVVTAILLEDGQPVEFDQPLVIIE
HHHCCCCCCCEEEEEECCCCCCCCCCCEEEEC
>Mature Secondary Structure
MDIRKIKKLIELVEESGIAELEIAEGEESVRISRAIAPIAQVAPVQAVAAPAAPVAAAAP
CCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHCC
VASAPAAVEAPAEIAGHKVCSPMVGTFYGAPSPDAKPFIKVGQQVTAGDTLCIVEAMKMM
CCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHH
NQIEADKSGVVTAILLEDGQPVEFDQPLVIIE
HHHCCCCCCCEEEEEECCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetyl-CoA; HCO3-

Specific reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]