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The map label for this gene is glmS

Identifier: 59712979

GI number: 59712979

Start: 2658388

End: 2660220

Strand: Reverse

Name: glmS

Synonym: VF_2372

Alternate gene names: 59712979

Gene position: 2660220-2658388 (Counterclockwise)

Preceding gene: 59712980

Following gene: 172087767

Centisome position: 91.81

GC content: 43.32

Gene sequence:

>1833_bases
ATGTGTGGGATTGTTGGTGCGGTAGCACAAAGAGATGTTGCAGAGATCTTAGTTGAAGGCCTACGTCGTTTAGAGTATCG
CGGTTATGACTCTGCTGGAGTTGCCGTTGTTGATGCTGAGCATAATTACACGCGTATTCGCCGTTTAGGTAAGGTAAAAG
AACTTGCTGATGCGGTTGAAACTGCGCATGTTGTTGGTGGTACAGGTATCGCTCACACACGTTGGGCTACACATGGTGAA
CCATCAGAAGTGAACGCACACCCACACGTATCAGGGGATATTACTCTGGTTCACAACGGTATTATTGAGAATCACGAGTC
ATTACGTACTTTATTACAAGAGCGTGGCTATATTTTTGAATCTCAAACCGATACCGAAGTGATCGCTCATCTGGTTGAAT
GGGAATTGCGTTCGTCTGGTTCATTGCTTGAAGCGGTTCAGAAAACAGCAACTCAGCTAGAAGGTGCTTACGGTACAGTA
GTAATGGACCGTCGTGAGCCAGAACGTTTGGTTGTTGCTCGATCGGGTAGTCCAATTGTTATTGGTTGTGGTGTTGGTGA
AAACTTTCTAGCGTCCGATCAACTGGCACTATTAAATGTAACTCGTCGCTTTATGTATCTTGAAGAAGGGGATGTTGCAG
AGATTACTCGTCGTGAAATCCGTGTATTTGACGCTCGTGGTGAGCAGGTTGAACGTGCCATTACGGAATCAAATGCAGAG
CATGATGCGGGCGATAAAGGGCAATATCGTCACTTCATGCAAAAAGAAGTTTTTGAGCAACCAAAAGCGTTAATTAATAC
CATGGAAGGGCGCATTACTAATGATTCTGTTGTAACAGAAAGTATTGGTGTAAATGCGGTTGAGATTTTAAATAAAGTTG
AACACGTACAAATTATTGCTTGTGGTACCTCTTACAACGCAGGGATGACAGCACGCTACTGGTTTGAGTCATTAGCTGGT
GTTAGTTGTGATGTGGAAATTGCTTCTGAGTTCCGTTACCGCAAATTTGTAACCCGTCCAAATAGTTTATTAATTACGTT
ATCGCAATCAGGTGAAACGGCGGATACGTTAGCAGCACTTCGCTTAGCTAAAGAGCGTGGCTACATGGGAGCTATGACGG
TATGTAACGTAGCGGGTTCTTCTCTGGTTCGTGAGTCAGATTTTGCCTTTATGACACGAGCAGGAACTGAAATTGGTGTA
GCGTCAACCAAAGCATTTACGACTCAGCTTGCTGCATTACTTATGTTGGTAACGGCATTAGGTAAACAACAAAATCGTAT
TTCAAAAGAGAAAGAAAAAGAGATTGTTGAAGCGCTGCATGCGTTACCTGCTCAAATTGAGCAAGCATTGTCGTTTGATA
AAGAGATTGAAGCGTTAGCCCCAGATTTTGCAGATAAACATCACACATTATTTTTAGGTCGTGGGGAGTTTTATCCAATT
GCTGTTGAAGCATCTCTGAAATTAAAAGAAATTTCTTATATTCATGCTGAAGCATATGCAGCAGGTGAGTTAAAGCATGG
TCCATTAGCGCTTATTGATGCAGAAATGCCAGTTGTGGTGGTTGCACCGACTAATGATTTACTAGAGAAGCTAAAATCAA
ACGTAGAAGAAGTGCGTGCCCGTGGTGGCTTGCTGTATGTATTTGCTGATGAGCAAGCGGGCTTTGAAGCGGATGAAAGC
ATGAAGATCATTACCATGCCTCATGTGAGTGATATTACTGCTCCAATTTACTACACGATTCCGATGCAGTTGCTTTCGTA
CCATGTTGCACTAATCAAAGGAACGGATGTCGATCAGCCTCGTAACTTAGCTAAAGCGGTGACGGTGGAGTAG

Upstream 100 bases:

>100_bases
GAGCTTAACTATTACGTTTCGTTTTAACCGTTGTTTTTATTGCTGTCGAGTTACGGTTAAAAGTAAAAAATTTATATATT
TAGAATAATGGAGTGTCGCC

Downstream 100 bases:

>100_bases
AGAAAGCTTCTTACAAAAATGGCAGCGCTACTTATATACGCTGCCATTTTTCATATCTAGAACAGAATAATTGTTCTAAG
AGAGACAATAGTTTTGAAGA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDAEHNYTRIRRLGKVKELADAVETAHVVGGTGIAHTRWATHGE
PSEVNAHPHVSGDITLVHNGIIENHESLRTLLQERGYIFESQTDTEVIAHLVEWELRSSGSLLEAVQKTATQLEGAYGTV
VMDRREPERLVVARSGSPIVIGCGVGENFLASDQLALLNVTRRFMYLEEGDVAEITRREIRVFDARGEQVERAITESNAE
HDAGDKGQYRHFMQKEVFEQPKALINTMEGRITNDSVVTESIGVNAVEILNKVEHVQIIACGTSYNAGMTARYWFESLAG
VSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAALRLAKERGYMGAMTVCNVAGSSLVRESDFAFMTRAGTEIGV
ASTKAFTTQLAALLMLVTALGKQQNRISKEKEKEIVEALHALPAQIEQALSFDKEIEALAPDFADKHHTLFLGRGEFYPI
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDAEMPVVVVAPTNDLLEKLKSNVEEVRARGGLLYVFADEQAGFEADES
MKIITMPHVSDITAPIYYTIPMQLLSYHVALIKGTDVDQPRNLAKAVTVE

Sequences:

>Translated_610_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDAEHNYTRIRRLGKVKELADAVETAHVVGGTGIAHTRWATHGE
PSEVNAHPHVSGDITLVHNGIIENHESLRTLLQERGYIFESQTDTEVIAHLVEWELRSSGSLLEAVQKTATQLEGAYGTV
VMDRREPERLVVARSGSPIVIGCGVGENFLASDQLALLNVTRRFMYLEEGDVAEITRREIRVFDARGEQVERAITESNAE
HDAGDKGQYRHFMQKEVFEQPKALINTMEGRITNDSVVTESIGVNAVEILNKVEHVQIIACGTSYNAGMTARYWFESLAG
VSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAALRLAKERGYMGAMTVCNVAGSSLVRESDFAFMTRAGTEIGV
ASTKAFTTQLAALLMLVTALGKQQNRISKEKEKEIVEALHALPAQIEQALSFDKEIEALAPDFADKHHTLFLGRGEFYPI
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDAEMPVVVVAPTNDLLEKLKSNVEEVRARGGLLYVFADEQAGFEADES
MKIITMPHVSDITAPIYYTIPMQLLSYHVALIKGTDVDQPRNLAKAVTVE
>Mature_610_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDAEHNYTRIRRLGKVKELADAVETAHVVGGTGIAHTRWATHGE
PSEVNAHPHVSGDITLVHNGIIENHESLRTLLQERGYIFESQTDTEVIAHLVEWELRSSGSLLEAVQKTATQLEGAYGTV
VMDRREPERLVVARSGSPIVIGCGVGENFLASDQLALLNVTRRFMYLEEGDVAEITRREIRVFDARGEQVERAITESNAE
HDAGDKGQYRHFMQKEVFEQPKALINTMEGRITNDSVVTESIGVNAVEILNKVEHVQIIACGTSYNAGMTARYWFESLAG
VSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAALRLAKERGYMGAMTVCNVAGSSLVRESDFAFMTRAGTEIGV
ASTKAFTTQLAALLMLVTALGKQQNRISKEKEKEIVEALHALPAQIEQALSFDKEIEALAPDFADKHHTLFLGRGEFYPI
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDAEMPVVVVAPTNDLLEKLKSNVEEVRARGGLLYVFADEQAGFEADES
MKIITMPHVSDITAPIYYTIPMQLLSYHVALIKGTDVDQPRNLAKAVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=38.5964912280702, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=37.1720116618076, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI29570798, Length=258, Percent_Identity=24.4186046511628, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=71.6393442622951, Blast_Score=912, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=174, Percent_Identity=31.0344827586207, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=38.7470997679814, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17532899, Length=430, Percent_Identity=37.6744186046512, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=37.6744186046512, Blast_Score=273, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6322745, Length=459, Percent_Identity=38.562091503268, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6323731, Length=437, Percent_Identity=33.6384439359268, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=35.2941176470588, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=37.155297532656, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI28573187, Length=266, Percent_Identity=25.9398496240602, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24659598, Length=263, Percent_Identity=23.9543726235741, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_VIBF1 (Q5E279)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_205755.1
- ProteinModelPortal:   Q5E279
- SMR:   Q5E279
- STRING:   Q5E279
- GeneID:   3279607
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_2372
- NMPDR:   fig|312309.3.peg.2372
- eggNOG:   COG0449
- HOGENOM:   HBG645312
- OMA:   QDISFTT
- PhylomeDB:   Q5E279
- ProtClustDB:   PRK00331
- BioCyc:   VFIS312309:VF2372-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67037; Mature: 67037

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 605-605

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDAEHNYTRIRRLGKVKELADAVE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
TAHVVGGTGIAHTRWATHGEPSEVNAHPHVSGDITLVHNGIIENHESLRTLLQERGYIFE
HHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEECCHHCCHHHHHHHHHHCCCEEE
SQTDTEVIAHLVEWELRSSGSLLEAVQKTATQLEGAYGTVVMDRREPERLVVARSGSPIV
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEE
IGCGVGENFLASDQLALLNVTRRFMYLEEGDVAEITRREIRVFDARGEQVERAITESNAE
EECCCCCCCCCCCCHHHHHHHHHHEEECCCCHHHHHHHHHEEECCCCHHHHHHHHHCCCC
HDAGDKGQYRHFMQKEVFEQPKALINTMEGRITNDSVVTESIGVNAVEILNKVEHVQIIA
CCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHCEEEEEE
CGTSYNAGMTARYWFESLAGVSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAAL
ECCCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKERGYMGAMTVCNVAGSSLVRESDFAFMTRAGTEIGVASTKAFTTQLAALLMLVTAL
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
GKQQNRISKEKEKEIVEALHALPAQIEQALSFDKEIEALAPDFADKHHTLFLGRGEFYPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCEEEEECCCEEEE
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDAEMPVVVVAPTNDLLEKLKSNVEEVRA
EEECCEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHH
RGGLLYVFADEQAGFEADESMKIITMPHVSDITAPIYYTIPMQLLSYHVALIKGTDVDQP
CCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEHHHHHHHHHEEEEECCCCCCC
RNLAKAVTVE
HHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDAEHNYTRIRRLGKVKELADAVE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
TAHVVGGTGIAHTRWATHGEPSEVNAHPHVSGDITLVHNGIIENHESLRTLLQERGYIFE
HHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEECCHHCCHHHHHHHHHHCCCEEE
SQTDTEVIAHLVEWELRSSGSLLEAVQKTATQLEGAYGTVVMDRREPERLVVARSGSPIV
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEE
IGCGVGENFLASDQLALLNVTRRFMYLEEGDVAEITRREIRVFDARGEQVERAITESNAE
EECCCCCCCCCCCCHHHHHHHHHHEEECCCCHHHHHHHHHEEECCCCHHHHHHHHHCCCC
HDAGDKGQYRHFMQKEVFEQPKALINTMEGRITNDSVVTESIGVNAVEILNKVEHVQIIA
CCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHCEEEEEE
CGTSYNAGMTARYWFESLAGVSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAAL
ECCCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKERGYMGAMTVCNVAGSSLVRESDFAFMTRAGTEIGVASTKAFTTQLAALLMLVTAL
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
GKQQNRISKEKEKEIVEALHALPAQIEQALSFDKEIEALAPDFADKHHTLFLGRGEFYPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCEEEEECCCEEEE
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDAEMPVVVVAPTNDLLEKLKSNVEEVRA
EEECCEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHH
RGGLLYVFADEQAGFEADESMKIITMPHVSDITAPIYYTIPMQLLSYHVALIKGTDVDQP
CCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEHHHHHHHHHEEEEECCCCCCC
RNLAKAVTVE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA