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The map label for this gene is ndh [H]

Identifier: 59712971

GI number: 59712971

Start: 2652687

End: 2653913

Strand: Direct

Name: ndh [H]

Synonym: VF_2364

Alternate gene names: 59712971

Gene position: 2652687-2653913 (Clockwise)

Preceding gene: 59712969

Following gene: 59712974

Centisome position: 91.55

GC content: 41.4

Gene sequence:

>1227_bases
ATGTCCCGAATCATTGTTGTAGGCGGTGGCGCTGCTGGTCTAGAGCTATCAACCTTATTAACTAAATCAACCCGTAAAGA
AGATGAAATTATTCTAGTTGAGCCTGAAACACATCACTACTGGAAACCTCGTCTGCACGAAATCGCAGCAGGCACATTTG
ATAGTGATTTAGATTCGGTTTGTTATTTCACTCACGGAGCTCATCACGGTTACCAACATTATCAAGGTGCGATGACGGGA
ATCGATCGTGAAAATCAAACACTATTAGTTCGTCGTCCAGATGGCACAGAATCAGGCTTAAGTTATGATTATCTTGTGGT
TGCTATTGGCGCAATCAGTAATGATTTTAATACCTTAGGCGCTCAAGACCACTGCCTATTTTTAGATTCAGCAGGTCAAG
CACGCCAAGCGTGGAATCAAATTAGTCAAATCTTACGTGAAGGCAAAAACAGCACAATAAACATTGTAGGAGCTGGTGCT
ACTGGTGTTGAGTTAGCAGCTGAATTAGCTCGAGTAAGTAAAAAATTAAAACGCTATAACGCGTCATCTCTTAATATTAA
TTTAATTGAGGCGGCGCATCGTGTATTACCTAACAGCCCACAAAAAATGTCTGATAAGGTATTAAAAGAATTAGAAAAAA
ATGGCGTAAATGTATTACTAGAAACTCGCATTAGTGAAGTAACTGAAAACGGTATGCGAACGGATGTTGATAAGTTTCTT
GGTGCTGATATCCAATTTTGGGCTGCGGGTGTAAAAGCGCCGGATTGGCTAAATGGTATTGGGAACTTAAGCTACAACCG
TATGAACCAAATTAACGTGAACCAAAACTTAAGTTCAACCGAAGATCCTCGTATCTTTGCTATTGGTGATTGCGCAGCTA
TTCCACAGCCTGATGGTTCTTTTGTTCCACCAAAAGCTCAAGCGGCTAACCGTGCAGCAGTTCACTTAGCGAAGAGCTTA
GGTCGTTATTTACGTGGAAAAGAGCTAACGGATTTTATCTTCCAAGACAGTGGAATGGTGGTTGCTGTTGGTCATCATTT
TGCCGTTGGTACTTTTGCTCCGGGGACACGTTTAGAAGGAAAATTAGTGTTACAAGGTCGATTAATTCGCCGTTTATACG
ACACGATTTTCCGTCTACACCAACGCACAGTGACAGGAATGTTTACGGTCTCTCGTTTAATGATCACTAAACGCTTAAAG
GCCTTCTTTAAACCGGCAGGAATTTAA

Upstream 100 bases:

>100_bases
CTCAGCACACACTGTTGCGCTCTGTAATAAAGATTATTCTTTGGTTTATTTTCGAGTGATTTAGCTCCTCTTTAAGCCAA
AATATTGTGAGAAAAATGCT

Downstream 100 bases:

>100_bases
TTTCATGGTTCTAAAGAGATAAATAAAAAACGGCAACCTTATTTTAGGTTGCCGTTTTTATTGGTAAGAAACAAATATCA
CGGTTTACACTGACTTAGAC

Product: NADH dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSRIIVVGGGAAGLELSTLLTKSTRKEDEIILVEPETHHYWKPRLHEIAAGTFDSDLDSVCYFTHGAHHGYQHYQGAMTG
IDRENQTLLVRRPDGTESGLSYDYLVVAIGAISNDFNTLGAQDHCLFLDSAGQARQAWNQISQILREGKNSTINIVGAGA
TGVELAAELARVSKKLKRYNASSLNINLIEAAHRVLPNSPQKMSDKVLKELEKNGVNVLLETRISEVTENGMRTDVDKFL
GADIQFWAAGVKAPDWLNGIGNLSYNRMNQINVNQNLSSTEDPRIFAIGDCAAIPQPDGSFVPPKAQAANRAAVHLAKSL
GRYLRGKELTDFIFQDSGMVVAVGHHFAVGTFAPGTRLEGKLVLQGRLIRRLYDTIFRLHQRTVTGMFTVSRLMITKRLK
AFFKPAGI

Sequences:

>Translated_408_residues
MSRIIVVGGGAAGLELSTLLTKSTRKEDEIILVEPETHHYWKPRLHEIAAGTFDSDLDSVCYFTHGAHHGYQHYQGAMTG
IDRENQTLLVRRPDGTESGLSYDYLVVAIGAISNDFNTLGAQDHCLFLDSAGQARQAWNQISQILREGKNSTINIVGAGA
TGVELAAELARVSKKLKRYNASSLNINLIEAAHRVLPNSPQKMSDKVLKELEKNGVNVLLETRISEVTENGMRTDVDKFL
GADIQFWAAGVKAPDWLNGIGNLSYNRMNQINVNQNLSSTEDPRIFAIGDCAAIPQPDGSFVPPKAQAANRAAVHLAKSL
GRYLRGKELTDFIFQDSGMVVAVGHHFAVGTFAPGTRLEGKLVLQGRLIRRLYDTIFRLHQRTVTGMFTVSRLMITKRLK
AFFKPAGI
>Mature_407_residues
SRIIVVGGGAAGLELSTLLTKSTRKEDEIILVEPETHHYWKPRLHEIAAGTFDSDLDSVCYFTHGAHHGYQHYQGAMTGI
DRENQTLLVRRPDGTESGLSYDYLVVAIGAISNDFNTLGAQDHCLFLDSAGQARQAWNQISQILREGKNSTINIVGAGAT
GVELAAELARVSKKLKRYNASSLNINLIEAAHRVLPNSPQKMSDKVLKELEKNGVNVLLETRISEVTENGMRTDVDKFLG
ADIQFWAAGVKAPDWLNGIGNLSYNRMNQINVNQNLSSTEDPRIFAIGDCAAIPQPDGSFVPPKAQAANRAAVHLAKSLG
RYLRGKELTDFIFQDSGMVVAVGHHFAVGTFAPGTRLEGKLVLQGRLIRRLYDTIFRLHQRTVTGMFTVSRLMITKRLKA
FFKPAGI

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=426, Percent_Identity=38.2629107981221, Blast_Score=300, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6320118, Length=361, Percent_Identity=25.4847645429363, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323515, Length=468, Percent_Identity=23.9316239316239, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323794, Length=363, Percent_Identity=24.2424242424242, Blast_Score=63, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 44882; Mature: 44751

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIIVVGGGAAGLELSTLLTKSTRKEDEIILVEPETHHYWKPRLHEIAAGTFDSDLDSV
CCEEEEEECCCCCCHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCCHHHH
CYFTHGAHHGYQHYQGAMTGIDRENQTLLVRRPDGTESGLSYDYLVVAIGAISNDFNTLG
EEEECCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEHHCCCCHHCC
AQDHCLFLDSAGQARQAWNQISQILREGKNSTINIVGAGATGVELAAELARVSKKLKRYN
CCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCC
ASSLNINLIEAAHRVLPNSPQKMSDKVLKELEKNGVNVLLETRISEVTENGMRTDVDKFL
CCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCHHCHHHHH
GADIQFWAAGVKAPDWLNGIGNLSYNRMNQINVNQNLSSTEDPRIFAIGDCAAIPQPDGS
CCCCEEEECCCCCCHHHHHCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCCC
FVPPKAQAANRAAVHLAKSLGRYLRGKELTDFIFQDSGMVVAVGHHFAVGTFAPGTRLEG
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEECCCEEEEECCCCCCCCC
KLVLQGRLIRRLYDTIFRLHQRTVTGMFTVSRLMITKRLKAFFKPAGI
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRIIVVGGGAAGLELSTLLTKSTRKEDEIILVEPETHHYWKPRLHEIAAGTFDSDLDSV
CEEEEEECCCCCCHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCCHHHH
CYFTHGAHHGYQHYQGAMTGIDRENQTLLVRRPDGTESGLSYDYLVVAIGAISNDFNTLG
EEEECCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEHHCCCCHHCC
AQDHCLFLDSAGQARQAWNQISQILREGKNSTINIVGAGATGVELAAELARVSKKLKRYN
CCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCC
ASSLNINLIEAAHRVLPNSPQKMSDKVLKELEKNGVNVLLETRISEVTENGMRTDVDKFL
CCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCHHCHHHHH
GADIQFWAAGVKAPDWLNGIGNLSYNRMNQINVNQNLSSTEDPRIFAIGDCAAIPQPDGS
CCCCEEEECCCCCCHHHHHCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCCC
FVPPKAQAANRAAVHLAKSLGRYLRGKELTDFIFQDSGMVVAVGHHFAVGTFAPGTRLEG
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEECCCEEEEECCCCCCCCC
KLVLQGRLIRRLYDTIFRLHQRTVTGMFTVSRLMITKRLKAFFKPAGI
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]